Construct: sgRNA BRDN0001146482
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCCAGATAAATGTAAAATCG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- AGK (55750)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000007.14 | 7 | 141601243 | - | AGK | NNNAGATAAATGTAAAATCG | NGG | 0 | 1.0 | Tier I |
2 | NC_000003.12 | 3 | 85902588 | - | CADM2 | NNNAGATAAATGTAAAATCA | NGG | 1 | 0.9375 | Tier II |
3 | NC_000004.12 | 4 | 42142335 | + | BEND4 | NNNAGATAAAAGTAAAATCA | NGG | 2 | 0.7031 | Tier II |
4 | NC_000013.11 | 13 | 77126823 | - | MYCBP2 | NNNAGATAAAAGTAAAATCA | NGG | 2 | 0.7031 | Tier II |
5 | NC_000012.12 | 12 | 104002552 | - | GLT8D2 | NNNAGATAATTGTAAAATCT | NGG | 2 | 0.6176 | Tier II |
6 | NC_000007.14 | 7 | 24798329 | - | OSBPL3 | NNNGGATAAATGTAGAATCG | NGG | 2 | 0.4063 | Tier II |
7 | NC_000014.9 | 14 | 52565542 | - | GPR137C | NNNAAATAAATGTAAAATAG | NGG | 2 | 0.3714 | Tier II |
8 | NC_000005.10 | 5 | 77330157 | - | PDE8B | NNNAGATAAATGTAAAAAAG | NGG | 2 | 0.2857 | Tier II |
9 | NC_000001.11 | 1 | 150811394 | + | ARNT | NNNAGACAAAGGTAAAATCG | NGG | 2 | 0.275 | Tier II |
10 | NC_000003.12 | 3 | 33184348 | - | SUSD5 | NNNAGATAAATTTAAAATCT | NGG | 2 | 0.2692 | Tier II |
11 | NC_000010.11 | 10 | 112662076 | - | VTI1A | NNNAGATAAATTTAAAATCT | NGG | 2 | 0.2692 | Tier II |
12 | NC_000016.10 | 16 | 85429821 | - | GSE1 | NNNAGAAAAATGGAAAATCG | NGG | 2 | 0.2283 | Tier II |
13 | NC_000002.12 | 2 | 162172270 | - | FAP | NNNAGCTAAATGTAAAATCC | NGG | 2 | 0.1948 | Tier II |
14 | NC_000013.11 | 13 | 21503481 | + | MICU2 | NNNAGATAAATTTAAAATTG | NGG | 2 | 0.1775 | Tier II |
15 | NC_000003.12 | 3 | 157361012 | - | VEPH1 | NNNAGATAAAGGTAAAATAG | NGG | 2 | 0.1714 | Tier II |
16 | NC_000006.12 | 6 | 6598334 | - | LY86 | NNNAGATAAATGTAAACTCA | NGG | 2 | 0.1654 | Tier II |
17 | NC_000011.10 | 11 | 84142414 | + | DLG2 | NNNAGATAAATTTAAAATCC | NGG | 2 | 0.1648 | Tier II |
18 | NC_000004.12 | 4 | 142381068 | - | INPP4B | NNNAGATATATGGAAAATCG | NGG | 2 | 0.1565 | Tier II |
19 | NC_000003.12 | 3 | 267422 | - | CHL1 | NNNATATAAATGTAAAATAG | NGG | 2 | 0.1286 | Tier II |
20 | NC_000002.12 | 2 | 204704678 | - | PARD3B | NNNAGATAAATGTAAAATCT | NTG | 2 | 0.0273 | Tier II |
21 | NC_000002.12 | 2 | 205818009 | - | LOC105373847 | NNNAGATAAATGTAAAATCA | NGG | 1 | 0.9375 | Tier III |
22 | NC_000023.11 | X | 132131094 | + | AGKP2 | NNNGGATAAATGTAAAATCG | NGG | 1 | 0.625 | Tier III |
23 | NC_000002.12 | 2 | 34312526 | - | LOC105374457 | NNNAAATAAATGTAAAATCC | NGG | 2 | 0.3714 | Tier III |
24 | NC_000002.12 | 2 | 80927068 | - | LOC105374827 | NNNAGATTAATGTAAAATCT | NGG | 2 | 0.3 | Tier III |
25 | NC_000013.11 | 13 | 111422876 | + | LOC107984618 | NNNAGAGAAATGTAAAATTG | NGG | 2 | 0.2715 | Tier III |
26 | NC_000002.12 | 2 | 162172270 | - | LOC101929532 | NNNAGCTAAATGTAAAATCC | NGG | 2 | 0.1948 | Tier III |
27 | NC_000003.12 | 3 | 157361012 | - | LOC101928236 | NNNAGATAAAGGTAAAATAG | NGG | 2 | 0.1714 | Tier III |
28 | NC_000006.12 | 6 | 6598334 | - | LY86-AS1 | NNNAGATAAATGTAAACTCA | NGG | 2 | 0.1654 | Tier III |
29 | NC_000008.11 | 8 | 127830506 | - | PVT1 | NNNAGATAAATGTAAAATCT | NCG | 2 | 0.075 | Tier III |
30 | NC_000011.10 | 11 | 39707839 | - | LOC105376637 | NNNAGATAAGTGTAAAATGG | NGG | 2 | 0.0694 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000076.6 | 10 | 107023847 | + | Acss3 | NNNGTATAAATGTAAAATCG | NGG | 2 | 0.1875 | Tier I |
2 | NC_000067.6 | 1 | 110923833 | - | Cdh19 | NNNAAATAAATATAAAATCG | NGG | 2 | 0.8089 | Tier II |
3 | NC_000086.7 | X | 95930089 | - | Las1l | NNNAGACAGATGTAAAATCG | NGG | 2 | 0.4583 | Tier II |
4 | NC_000086.7 | X | 95930089 | - | Zc3h12b | NNNAGACAGATGTAAAATCG | NGG | 2 | 0.4583 | Tier II |
5 | NC_000072.6 | 6 | 66926840 | - | Gng12 | NNNAGATAAATGTGAAATCA | NGG | 2 | 0.4375 | Tier II |
6 | NC_000072.6 | 6 | 92523306 | + | Prickle2 | NNNAACTAAATGTAAAATCG | NGG | 2 | 0.3939 | Tier II |
7 | NC_000075.6 | 9 | 28121957 | + | Opcml | NNNAGATAAATCTAAAATCT | NGG | 2 | 0.3706 | Tier II |
8 | NC_000085.6 | 19 | 57812300 | - | Atrnl1 | NNNGGATACATGTAAAATCG | NGG | 2 | 0.3571 | Tier II |
9 | NC_000069.6 | 3 | 146516541 | + | Rpf1 | NNNAGATAAATGAAAAATAG | NGG | 2 | 0.2967 | Tier II |
10 | NC_000067.6 | 1 | 3212440 | - | Xkr4 | NNNGGATAAATGTAAAATAG | NGG | 2 | 0.2679 | Tier II |
11 | NC_000068.7 | 2 | 38906950 | + | Nr6a1 | NNNAGATAAATGTAAAAGCT | NGG | 2 | 0.2333 | Tier II |
12 | NC_000068.7 | 2 | 60860042 | + | Rbms1 | NNNAGATAAAGGTAAAACCG | NGG | 2 | 0.1714 | Tier II |
13 | NC_000084.6 | 18 | 7456226 | - | Mpp7 | NNNAGATGAATGTATAATCG | NGG | 2 | 0.1467 | Tier II |
14 | NC_000074.6 | 8 | 38426190 | - | Sgcz | NNNAGATAAATGTAAAATGA | NGG | 2 | 0.1172 | Tier II |
15 | NC_000084.6 | 18 | 75442632 | + | Ctif | NNNAGATAAATGTCAAAGCG | NGG | 2 | 0.0714 | Tier II |
16 | NC_000080.6 | 14 | 100097558 | - | Klf12 | NNNAGATAAATGTAAATTCC | NGG | 2 | 0.0571 | Tier II |
17 | NC_000078.6 | 12 | 57994757 | + | Gm46329 | NNNAGATAGATGTAAAATCC | NGG | 2 | 0.2857 | Tier III |
18 | NC_000068.7 | 2 | 38906950 | + | Nr6a1os | NNNAGATAAATGTAAAAGCT | NGG | 2 | 0.2333 | Tier III |
19 | NC_000081.6 | 15 | 40120242 | - | Gm33251 | NNNCGATAAATGTAAAATCG | NAG | 2 | 0.0915 | Tier III |