Construct: sgRNA BRDN0001146503
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGCTTGGTGTGCGATCCAGT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NAGK (55577)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000002.12 | 2 | 71073488 | - | NAGK | NNNTTGGTGTGCGATCCAGT | NGG | 0 | 1.0 | Tier I |
2 | NC_000007.14 | 7 | 100631241 | + | TFR2 | NNNTAGGTGTGCAATCCAGT | NGG | 2 | 0.4615 | Tier II |
3 | NC_000016.10 | 16 | 2895336 | + | FLYWCH2 | NNNTTGGTGTGAGAACCAGT | NGG | 2 | 0.4135 | Tier II |
4 | NC_000023.11 | X | 106863233 | + | TBC1D8B | NNNTTGGGCTGCGATCCAGT | NGG | 2 | 0.3949 | Tier II |
5 | NC_000001.11 | 1 | 171928147 | + | DNM3 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier II |
6 | NC_000002.12 | 2 | 205519886 | + | PARD3B | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier II |
7 | NC_000003.12 | 3 | 180634776 | - | CCDC39 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier II |
8 | NC_000004.12 | 4 | 90880031 | + | CCSER1 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier II |
9 | NC_000010.11 | 10 | 125977395 | + | FANK1 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier II |
10 | NC_000001.11 | 1 | 69880463 | + | LRRC7 | NNNTTGGTGTGCTATGCAGT | NGG | 2 | 0.0462 | Tier II |
11 | NC_000023.11 | X | 113345775 | + | LOC101928437 | NNNTTGAGGTGCGATCCAGT | NGG | 2 | 0.7333 | Tier III |
12 | NC_000007.14 | 7 | 100631241 | + | LOC124901709 | NNNTAGGTGTGCAATCCAGT | NGG | 2 | 0.4615 | Tier III |
13 | NC_000003.12 | 3 | 14034996 | + | TPRXL | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
14 | NC_000004.12 | 4 | 19294848 | + | LINC02438 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
15 | NC_000006.12 | 6 | 133864747 | + | TARID | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
16 | NC_000010.11 | 10 | 79748839 | - | NUTM2B-AS1 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
17 | NC_000010.11 | 10 | 87271051 | - | NUTM2A-AS1 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
18 | NC_000010.11 | 10 | 87466923 | + | LOC112268063 | NNNTTGGGGTGTGATCCAGT | NGG | 2 | 0.3949 | Tier III |
19 | NC_000005.10 | 5 | 21061375 | + | LOC105374678 | NNNCTGGTGTGTGATCCAGT | NGG | 2 | 0.3484 | Tier III |
20 | NC_000019.10 | 19 | 35953053 | - | LOC105372383 | NNNTGGGTGTGGGATCCAGT | NGG | 2 | 0.2844 | Tier III |
21 | NC_000023.11 | X | 115901009 | - | DANT2 | NNNTTGGTGTGGGATCCTGT | NGG | 2 | 0.2222 | Tier III |
22 | NC_000023.11 | X | 115901009 | - | DANT1 | NNNTTGGTGTGGGATCCTGT | NGG | 2 | 0.2222 | Tier III |
23 | NC_000019.10 | 19 | 19827251 | + | ZNF56P | NNNTTGGTGTGCGAGCCAGG | NGG | 2 | 0.0088 | Tier III |
24 | NC_000019.10 | 19 | 19827251 | + | ISCA1P5 | NNNTTGGTGTGCGAGCCAGG | NGG | 2 | 0.0088 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 83799277 | - | Nagk | NNNTTGGTGTGCAATCCAGT | NGG | 1 | 0.9231 | Tier I |
2 | NC_000080.6 | 14 | 14011501 | + | Atxn7 | NNNTTGGTGTGCAATCCAGT | NGG | 1 | 0.9231 | Tier II |
3 | NC_000071.6 | 5 | 89875314 | - | Adamts3 | NNNTTGGTATGCGATCTAGT | NGG | 2 | 0.3 | Tier II |
4 | NC_000073.6 | 7 | 118950405 | - | Iqck | NNNTTGGTGTGCCATCCTGT | NGG | 2 | 0.2105 | Tier II |
5 | NC_000082.6 | 16 | 95407069 | - | Erg | NNNTTGGTGTGGGAGCCAGT | NGG | 2 | 0.0222 | Tier II |
6 | NC_000079.6 | 13 | 10564569 | + | Gm26861 | NNNTTGGTGTGCGGTTCAGT | NGG | 2 | 0.1436 | Tier III |
7 | NC_000083.6 | 17 | 36138908 | + | Gm9574 | NNNTTGGTGTGCGGGCCAGT | NGG | 2 | 0.0233 | Tier III |