Construct: sgRNA BRDN0001146504
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GATGATGGCAAACAACCCAG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TTK (7272)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75580
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000006.12 |
6 |
80007854 |
+ |
TTK |
NNNGATGGCAAACAACCCAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000010.11 |
10 |
59840367 |
- |
CCDC6 |
NNNGAAAGCAAACAACCCAG |
NGG |
2 |
0.8667 |
Tier II |
3 |
NC_000016.10 |
16 |
3023128 |
+ |
HCFC1R1 |
NNNGATGGGAAACAACCCAG |
NGG |
1 |
0.619 |
Tier II |
4 |
NC_000020.11 |
20 |
38868100 |
- |
PPP1R16B |
NNNGATGGAAAACAGCCCAG |
NGG |
2 |
0.5571 |
Tier II |
5 |
NC_000017.11 |
17 |
12056784 |
- |
MAP2K4 |
NNNGATGGCAAACAACTCAG |
NGG |
1 |
0.4667 |
Tier II |
6 |
NC_000007.14 |
7 |
108052791 |
- |
LAMB4 |
NNNGATGGAAAAAAACCCAG |
NGG |
2 |
0.3297 |
Tier II |
7 |
NC_000011.10 |
11 |
71100364 |
+ |
SHANK2 |
NNNAATGGCAAACAATCCAG |
NGG |
2 |
0.2769 |
Tier II |
8 |
NC_000010.11 |
10 |
70410504 |
- |
EIF4EBP2 |
NNNTATGGCAAATAACCCAG |
NGG |
2 |
0.2545 |
Tier II |
9 |
NC_000022.11 |
22 |
41125570 |
- |
EP300 |
NNNGATGGCAAAAAACCAAG |
NGG |
2 |
0.2071 |
Tier II |
10 |
NC_000002.12 |
2 |
9384749 |
- |
ASAP2 |
NNNGATGGCAAACCACACAG |
NGG |
2 |
0.1 |
Tier II |
11 |
NC_000001.11 |
1 |
40071548 |
- |
PPT1 |
NNNGAGGGCAAAGAACCCAG |
NGG |
2 |
0.0779 |
Tier II |
12 |
NC_000001.11 |
1 |
40071548 |
- |
CAP1 |
NNNGAGGGCAAAGAACCCAG |
NGG |
2 |
0.0779 |
Tier II |
13 |
NC_000004.12 |
4 |
98044399 |
- |
STPG2 |
NNNGAGGGCAAAGAACCCAG |
NGG |
2 |
0.0779 |
Tier II |
14 |
NC_000012.12 |
12 |
98974633 |
+ |
ANKS1B |
NNNGATGGCAAACAACCCAT |
NGA |
2 |
0.0486 |
Tier II |
15 |
NC_000003.12 |
3 |
8673595 |
- |
SSUH2 |
NNNGATGGCAATCAACCCAG |
NTG |
2 |
0.013 |
Tier II |
16 |
NC_000005.10 |
5 |
173656574 |
+ |
LINC01863 |
NNNAATGGCAAACAACTCAG |
NGG |
2 |
0.42 |
Tier III |
17 |
NC_000010.11 |
10 |
95125121 |
- |
LOC107984257 |
NNNGATGGGAAACTACCCAG |
NGG |
2 |
0.3302 |
Tier III |
18 |
NC_000002.12 |
2 |
9384749 |
- |
LOC124907730 |
NNNGATGGCAAACCACACAG |
NGG |
2 |
0.1 |
Tier III |
19 |
NC_000010.11 |
10 |
43604829 |
+ |
CAP1P2 |
NNNGAGGGCAAAGAACCCAG |
NGG |
2 |
0.0779 |
Tier III |
20 |
NC_000002.12 |
2 |
237134143 |
- |
LOC124906127 |
NNNGATGGCAAACAACCCAT |
NCG |
2 |
0.075 |
Tier III |
21 |
NC_000016.10 |
16 |
13802673 |
+ |
LOC124903646 |
NNNAATGGCAAACAACCCAG |
NTG |
2 |
0.0351 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000070.6 |
4 |
141474867 |
- |
Spen |
NNNGCTGGCAAACAACCCAG |
NCG |
2 |
0.0536 |
Tier I |
2 |
NC_000067.6 |
1 |
51779399 |
- |
Myo1b |
NNNGATGGAAAACAAACCAG |
NGG |
2 |
0.8571 |
Tier II |
3 |
NC_000068.7 |
2 |
7171793 |
+ |
Celf2 |
NNNGCTGGCAAACAAACCAG |
NGG |
2 |
0.5 |
Tier II |
4 |
NC_000068.7 |
2 |
35316882 |
+ |
Stom |
NNNGATGGCAAACAAAACAG |
NGG |
2 |
0.4667 |
Tier II |
5 |
NC_000068.7 |
2 |
124595222 |
+ |
Sema6d |
NNNTATGGCAAACAAACCAG |
NGG |
2 |
0.3636 |
Tier II |
6 |
NC_000074.6 |
8 |
124315746 |
- |
Galnt2 |
NNNGATGGCTCACAACCCAG |
NGG |
2 |
0.3529 |
Tier II |
7 |
NC_000071.6 |
5 |
66939306 |
- |
Limch1 |
NNNTATGGAAAACAACCCAG |
NGG |
2 |
0.3117 |
Tier II |
8 |
NC_000079.6 |
13 |
108335817 |
+ |
Depdc1b |
NNNGATGGCACACAGCCCAG |
NGG |
2 |
0.26 |
Tier II |
9 |
NC_000078.6 |
12 |
84685076 |
+ |
Syndig1l |
NNNGATGGCATACAACCCAT |
NGG |
2 |
0.2154 |
Tier II |
10 |
NC_000077.6 |
11 |
34462193 |
+ |
Dock2 |
NNNCATGGCCAACAACCCAG |
NGG |
2 |
0.1765 |
Tier II |
11 |
NC_000080.6 |
14 |
121962208 |
- |
Ubac2 |
NNNGATGGCCAACGACCCAG |
NGG |
2 |
0.1556 |
Tier II |
12 |
NC_000080.6 |
14 |
121962208 |
- |
Gpr183 |
NNNGATGGCCAACGACCCAG |
NGG |
2 |
0.1556 |
Tier II |
13 |
NC_000071.6 |
5 |
92463705 |
+ |
Scarb2 |
NNNGATGACAAACAAGCCAG |
NGG |
2 |
0.1538 |
Tier II |
14 |
NC_000067.6 |
1 |
170431795 |
- |
Nos1ap |
NNNGACGGCAAACAAGCCAG |
NGG |
2 |
0.1399 |
Tier II |
15 |
NC_000077.6 |
11 |
93922815 |
- |
Mbtd1 |
NNNGATGGCAAACACCACAG |
NGG |
2 |
0.1273 |
Tier II |
16 |
NC_000078.6 |
12 |
66668074 |
- |
Mdga2 |
NNNGATGGCAAACAAGCCAT |
NGG |
2 |
0.1077 |
Tier II |
17 |
NC_000084.6 |
18 |
67994030 |
- |
Ldlrad4 |
NNNGAGGGCAAACAAGCCAG |
NGG |
2 |
0.0879 |
Tier II |
18 |
NC_000072.6 |
6 |
32316769 |
+ |
Plxna4 |
NNNGATGGGAAAGAACCCAG |
NGG |
2 |
0.0844 |
Tier II |
19 |
NC_000073.6 |
7 |
38223465 |
+ |
Plekhf1 |
NNNGATGGCAAACTAGCCAG |
NGG |
2 |
0.0821 |
Tier II |
20 |
NC_000080.6 |
14 |
23738922 |
+ |
Kcnma1 |
NNNGATGGCAAACAATCCAG |
NAG |
2 |
0.0798 |
Tier II |
21 |
NC_000071.6 |
5 |
30521550 |
- |
Cib4 |
NNNGATGGCAAAGTACCCAG |
NGG |
2 |
0.0727 |
Tier II |
22 |
NC_000075.6 |
9 |
110584001 |
- |
Setd2 |
NNNGATGGCAAACAAGACAG |
NGG |
2 |
0.0718 |
Tier II |
23 |
NC_000080.6 |
14 |
101686151 |
- |
Uchl3 |
NNNGATGGCAAAGAACTCAG |
NGG |
2 |
0.0636 |
Tier II |
24 |
NC_000077.6 |
11 |
65220409 |
- |
Myocd |
NNNGATGGCACAGAACCCAG |
NGG |
2 |
0.0545 |
Tier II |
25 |
NC_000075.6 |
9 |
55230978 |
- |
Nrg4 |
NNNGATGGAAAACAACCCAG |
NTG |
2 |
0.0334 |
Tier II |
26 |
NC_000085.6 |
19 |
42180623 |
- |
Zfyve27 |
NNNGATGGCAAACAACACAG |
NGA |
2 |
0.0324 |
Tier II |
27 |
NC_000070.6 |
4 |
155388540 |
+ |
Gabrd |
NNNGATGGCACACAACCCAG |
NGA |
2 |
0.0278 |
Tier II |
28 |
NC_000076.6 |
10 |
19504636 |
- |
Gm33104 |
NNNGATAGCAATCAACCCAG |
NGG |
2 |
0.3333 |
Tier III |
29 |
NC_000073.6 |
7 |
136078988 |
+ |
Gm51502 |
NNNGATGGAAAACAACCCAG |
NCG |
2 |
0.0918 |
Tier III |
30 |
NC_000073.6 |
7 |
48764426 |
+ |
Gm32263 |
NNNCATGGCAAACAACCCAG |
NTG |
2 |
0.0206 |
Tier III |
31 |
NC_000077.6 |
11 |
66189384 |
+ |
Gm12296 |
NNNGATGGCAAACAACCCTG |
NGT |
2 |
0.0087 |
Tier III |
Other clones with same target sequence:
(none)