Construct: sgRNA BRDN0001146550
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CGTCAGGCAGATCCAGACAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- EPHA8 (2046)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 22595257 | - | EPHA8 | NNNCAGGCAGATCCAGACAA | NGG | 0 | 1.0 | Tier I |
2 | NC_000009.12 | 9 | 34622505 | + | ARID3C | NNNCAGGCAGTGCCAGACAA | NGG | 2 | 0.1538 | Tier I |
3 | NC_000011.10 | 11 | 75730250 | + | MOGAT2 | NNNCAGGCAGAACCAGAGAA | NGG | 2 | 0.1067 | Tier I |
4 | NC_000003.12 | 3 | 123101823 | - | PDIA5 | NNNCAGACAGGTCCAGACAA | NGG | 2 | 0.65 | Tier II |
5 | NC_000010.11 | 10 | 71368509 | - | SLC29A3 | NNNCAGGGAGATCCAGACAG | NGG | 2 | 0.4916 | Tier II |
6 | NC_000007.14 | 7 | 105975737 | - | CDHR3 | NNNTAGGCAGATCCAGACAT | NGG | 2 | 0.48 | Tier II |
7 | NC_000005.10 | 5 | 128424156 | + | FBN2 | NNNCAGGCAGCTCCAGACAA | NGG | 1 | 0.4 | Tier II |
8 | NC_000003.12 | 3 | 195142338 | + | XXYLT1 | NNNCAGGCAGATCTAGAAAA | NGG | 2 | 0.3949 | Tier II |
9 | NC_000011.10 | 11 | 125225138 | - | PKNOX2 | NNNCAGGCACATCCAGACAG | NGG | 2 | 0.3059 | Tier II |
10 | NC_000003.12 | 3 | 134713701 | + | CEP63 | NNNCAGTCAGAGCCAGACAA | NGG | 2 | 0.2857 | Tier II |
11 | NC_000017.11 | 17 | 68522254 | + | PRKAR1A | NNNCTGGCAGATCCAGAAAA | NGG | 2 | 0.1958 | Tier II |
12 | NC_000011.10 | 11 | 125927284 | - | DDX25 | NNNCAGGCAGTTCCAGACAT | NGG | 2 | 0.1846 | Tier II |
13 | NC_000006.12 | 6 | 25399298 | - | CARMIL1 | NNNCTGGCAGAGCCAGACAA | NGG | 2 | 0.1818 | Tier II |
14 | NC_000011.10 | 11 | 44819903 | + | TSPAN18 | NNNCAGACAGATCCAGGCAA | NGG | 2 | 0.1765 | Tier II |
15 | NC_000022.11 | 22 | 44028518 | - | PARVB | NNNCTGGCACATCCAGACAA | NGG | 2 | 0.1455 | Tier II |
16 | NC_000020.11 | 20 | 34016785 | - | RALY | NNNCAGGCAGACCCAGAGAA | NGG | 2 | 0.1263 | Tier II |
17 | NC_000006.12 | 6 | 166645640 | - | RPS6KA2 | NNNCAGGTAGATCCAGAGAA | NGG | 2 | 0.1167 | Tier II |
18 | NC_000015.10 | 15 | 27866152 | + | OCA2 | NNNAAGGCAGATCCAGAGAA | NGG | 2 | 0.1123 | Tier II |
19 | NC_000006.12 | 6 | 130995750 | - | EPB41L2 | NNNCAGGCAGATCATGACAA | NGG | 2 | 0.07 | Tier II |
20 | NC_000002.12 | 2 | 161920028 | - | SLC4A10 | NNNCAGGCAGTTCCAGACAC | NGG | 2 | 0.0699 | Tier II |
21 | NC_000006.12 | 6 | 69973278 | - | COL19A1 | NNNCAGGCAGATCCTGAGAA | NGG | 2 | 0.0267 | Tier II |
22 | NC_000019.10 | 19 | 6819576 | - | VAV1 | NNNCAGGCAAATCCACACAA | NGG | 2 | 0.0 | Tier II |
23 | NC_000013.11 | 13 | 66308577 | + | PCDH9 | NNNCAGGCAGAGCCATACAA | NGG | 2 | 0.0 | Tier II |
24 | NC_000002.12 | 2 | 25246567 | - | DNMT3A | NNNCAGGCAGATCCACACCA | NGG | 2 | 0.0 | Tier II |
25 | NC_000003.12 | 3 | 140259841 | - | CLSTN2 | NNNCAGGCATATCCATACAA | NGG | 2 | 0.0 | Tier II |
26 | NC_000003.12 | 3 | 130752883 | + | LOC107986023 | NNNCAGACAGATCCAGAAAA | NGG | 2 | 0.5385 | Tier III |
27 | NC_000008.11 | 8 | 85855147 | + | LINC02849 | NNNCAGCCAGATCTAGACAA | NGG | 2 | 0.5042 | Tier III |
28 | NC_000012.12 | 12 | 53785133 | - | LOC105378250 | NNNCAGGCAGAGCCAAACAA | NGG | 2 | 0.5 | Tier III |
29 | NC_000018.10 | 18 | 24979319 | + | LINC01894 | NNNCAGGAAGATCCAGACAG | NGG | 2 | 0.4971 | Tier III |
30 | NC_000006.12 | 6 | 2261664 | - | GMDS-DT | NNNCTGGTAGATCCAGACAA | NGG | 2 | 0.3182 | Tier III |
31 | NC_000014.9 | 14 | 76238627 | - | LOC105370575 | NNNCAGACAGATCCAGACAC | NGG | 2 | 0.2273 | Tier III |
32 | NC_000006.12 | 6 | 25399298 | - | LOC124901281 | NNNCTGGCAGAGCCAGACAA | NGG | 2 | 0.1818 | Tier III |
33 | NC_000006.12 | 6 | 7443695 | - | LOC102724234 | NNNCAGACAGATGCAGACAA | NGG | 2 | 0.1364 | Tier III |
34 | NC_000011.10 | 11 | 22152285 | + | LOC124902645 | NNNCAGACAGATCCAGAGAA | NGG | 2 | 0.1333 | Tier III |
35 | NC_000006.12 | 6 | 166645640 | - | LOC107986671 | NNNCAGGTAGATCCAGAGAA | NGG | 2 | 0.1167 | Tier III |
36 | NC_000008.11 | 8 | 76629334 | + | ZFHX4-AS1 | NNNCAGGGAGATCCAGTCAA | NGG | 2 | 0.0857 | Tier III |
37 | NC_000013.11 | 13 | 66308577 | + | PCDH9-AS1 | NNNCAGGCAGAGCCATACAA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000070.6 | 4 | 136935118 | + | Epha8 | NNNCAGGCAGATCCAGACGA | NGG | 1 | 0.375 | Tier I |
2 | NC_000073.6 | 7 | 80232397 | + | Cib1 | NNNAAGGCAAATCCAGACAA | NGG | 2 | 0.786 | Tier II |
3 | NC_000076.6 | 10 | 82673731 | - | Glt8d2 | NNNCAGGGAAATCCAGACAA | NGG | 2 | 0.6 | Tier II |
4 | NC_000071.6 | 5 | 145456986 | - | Cyp3a16 | NNNAAGGCAGATCCAGATAA | NGG | 2 | 0.5414 | Tier II |
5 | NC_000085.6 | 19 | 56908803 | + | Vwa2 | NNNCAGCCAGATCTAGACAA | NGG | 2 | 0.5042 | Tier II |
6 | NC_000071.6 | 5 | 122983500 | + | Kdm2b | NNNCAGACAGAGCCAGACAA | NGG | 2 | 0.5 | Tier II |
7 | NC_000084.6 | 18 | 60941123 | - | Camk2a | NNNCAGGAAGATCCAGACAG | NGG | 2 | 0.4971 | Tier II |
8 | NC_000067.6 | 1 | 152572259 | + | Rgl1 | NNNCAGGCTGATCTAGACAA | NGG | 2 | 0.44 | Tier II |
9 | NC_000071.6 | 5 | 30712165 | + | Dpysl5 | NNNCAGGCAGATCCGGACTA | NGG | 2 | 0.35 | Tier II |
10 | NC_000084.6 | 18 | 35657122 | - | Spata24 | NNNCAGGGAGAGCCAGACAA | NGG | 2 | 0.3214 | Tier II |
11 | NC_000067.6 | 1 | 63242038 | + | Zdbf2 | NNNCAGGCAGTTCCAAACAA | NGG | 2 | 0.3077 | Tier II |
12 | NC_000082.6 | 16 | 37378627 | - | Stxbp5l | NNNCAGGCAGATATAGACAA | NGG | 2 | 0.2821 | Tier II |
13 | NC_000068.7 | 2 | 113399286 | + | Fmn1 | NNNCAGGCAGTTCCAGACAG | NGG | 2 | 0.2353 | Tier II |
14 | NC_000069.6 | 3 | 90501827 | + | Chtop | NNNCAGGCAGATACAGAAAA | NGG | 2 | 0.2071 | Tier II |
15 | NC_000071.6 | 5 | 134445536 | + | Gtf2ird1 | NNNCAGGCAGAGACAGACAA | NGG | 2 | 0.1923 | Tier II |
16 | NC_000076.6 | 10 | 81149310 | + | Zbtb7a | NNNCAGGCAGAGACAGACAA | NGG | 2 | 0.1923 | Tier II |
17 | NC_000070.6 | 4 | 128800424 | + | Zfp362 | NNNCAAGCAGATCCAGGCAA | NGG | 2 | 0.1765 | Tier II |
18 | NC_000070.6 | 4 | 130572824 | + | Nkain1 | NNNAAGGCAGATCCAGACCA | NGG | 2 | 0.1742 | Tier II |
19 | NC_000084.6 | 18 | 82961374 | - | Zfp516 | NNNCAGGCAGATCCAGAAAA | NAG | 2 | 0.1396 | Tier II |
20 | NC_000079.6 | 13 | 11855885 | + | Ryr2 | NNNCAGACAGATGCAGACAA | NGG | 2 | 0.1364 | Tier II |
21 | NC_000070.6 | 4 | 99715980 | - | Alg6 | NNNCAGGCACATCCCGACAA | NGG | 2 | 0.1091 | Tier II |
22 | NC_000079.6 | 13 | 68875927 | + | Adcy2 | NNNCAGGCAGATCCAGGAAA | NGG | 2 | 0.095 | Tier II |
23 | NC_000082.6 | 16 | 26012032 | + | P3h2 | NNNCAGGCAGATACAGACAC | NGG | 2 | 0.0874 | Tier II |
24 | NC_000074.6 | 8 | 17153674 | + | Csmd1 | NNNCAGGCAGCTCCAGCCAA | NGG | 2 | 0.0706 | Tier II |
25 | NC_000084.6 | 18 | 37850218 | + | Diaph1 | NNNCAGACAGATCCAGACAA | NGA | 2 | 0.0694 | Tier II |
26 | NC_000083.6 | 17 | 88013236 | + | Fbxo11 | NNNCAGGCAGATCCAGACAC | NAG | 2 | 0.0589 | Tier II |
27 | NC_000078.6 | 12 | 75177147 | + | Kcnh5 | NNNCAGGAAGATCCAGACAA | NTG | 2 | 0.0253 | Tier II |
28 | NC_000067.6 | 1 | 11200078 | - | Prex2 | NNNCAGGCAGATGCAGGCAA | NGG | 2 | 0.0241 | Tier II |
29 | NC_000080.6 | 14 | 64807139 | - | Kif13b | NNNCTGGCAGATCCAGACAA | NGT | 2 | 0.0059 | Tier II |
30 | NC_000085.6 | 19 | 53228993 | + | Add3 | NNNCAGGCAGATCCAGAGAA | NTG | 2 | 0.0052 | Tier II |
31 | NC_000070.6 | 4 | 140075565 | - | Igsf21 | NNNCAGCCAGATCCACACAA | NGG | 2 | 0.0 | Tier II |
32 | NC_000084.6 | 18 | 25715254 | + | Celf4 | NNNCAGGCAGATCCACACCA | NGG | 2 | 0.0 | Tier II |
33 | NC_000077.6 | 11 | 61716602 | + | Slc5a10 | NNNCAGGCATATCCACACAA | NGG | 2 | 0.0 | Tier II |
34 | NC_000069.6 | 3 | 52549958 | + | Gm30173 | NNNCAGGAAGATCCAAACAA | NGG | 2 | 0.65 | Tier III |
35 | NC_000084.6 | 18 | 8416282 | - | Gm5500 | NNNCAGGCAGGCCCAGACAA | NGG | 2 | 0.6158 | Tier III |
36 | NC_000073.6 | 7 | 117258694 | + | Gm39075 | NNNCTGGCAGATCCAGACAG | NGG | 2 | 0.2781 | Tier III |
37 | NC_000074.6 | 8 | 116252553 | - | Gm31278 | NNNCAGGCAGCTCCAGGCAA | NGG | 2 | 0.0706 | Tier III |
38 | NC_000068.7 | 2 | 95446658 | - | Gm13794 | NNNCAGGCAGATCCAGAAAA | NGA | 2 | 0.0374 | Tier III |