Construct: sgRNA BRDN0001146662
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGTACACCATCACTCCACAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- ABL2 (27)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 179121807 | - | ABL2 | NNNACACCATCACTCCACAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000005.10 | 5 | 36300598 | - | RANBP3L | NNNACATCATCACTCCACAG | NGG | 1 | 0.8125 | Tier II |
3 | NC_000005.10 | 5 | 34723149 | - | RAI14 | NNNTCACCATCACTCCACAG | NGG | 1 | 0.6364 | Tier II |
4 | NC_000009.12 | 9 | 89105134 | + | SHC3 | NNNAGACCATCACACCACAG | NGG | 2 | 0.3714 | Tier II |
5 | NC_000009.12 | 9 | 123756716 | - | DENND1A | NNNACACCCTCACACCACAG | NGG | 2 | 0.3537 | Tier II |
6 | NC_000015.10 | 15 | 77643064 | - | LINGO1 | NNNACACCACCACACCACAG | NGG | 2 | 0.3302 | Tier II |
7 | NC_000015.10 | 15 | 90877788 | - | FURIN | NNNAAACCCTCACTCCACAG | NGG | 2 | 0.3265 | Tier II |
8 | NC_000001.11 | 1 | 30882377 | + | SDC3 | NNNACAGCCTCACTCCACAG | NGG | 2 | 0.2689 | Tier II |
9 | NC_000014.9 | 14 | 59697333 | - | RTN1 | NNNACATCATCACTCTACAG | NGG | 2 | 0.25 | Tier II |
10 | NC_000001.11 | 1 | 3384431 | + | PRDM16 | NNNACACCGTCTCTCCACAG | NGG | 2 | 0.2222 | Tier II |
11 | NC_000002.12 | 2 | 197460985 | + | COQ10B | NNNACACCATCCCTCCATAG | NGG | 2 | 0.1692 | Tier II |
12 | NC_000012.12 | 12 | 41037759 | - | CNTN1 | NNNCCCCCATCACTCCACAG | NGG | 2 | 0.1604 | Tier II |
13 | NC_000003.12 | 3 | 58020044 | + | FLNB | NNNACACCATGACACCACAG | NGG | 2 | 0.1548 | Tier II |
14 | NC_000001.11 | 1 | 161512271 | - | FCGR2A | NNNACCCCATCCCTCCACAG | NGG | 2 | 0.1196 | Tier II |
15 | NC_000001.11 | 1 | 161675761 | - | FCGR2B | NNNACCCCATCCCTCCACAG | NGG | 2 | 0.1196 | Tier II |
16 | NC_000018.10 | 18 | 6781521 | + | ARHGAP28 | NNNACCCCATCACTCCCCAG | NGG | 2 | 0.0802 | Tier II |
17 | NC_000011.10 | 11 | 19396978 | - | NAV2 | NNNACACCCTCACTCCTCAG | NGG | 2 | 0.0762 | Tier II |
18 | NC_000008.11 | 8 | 23144823 | - | TNFRSF10D | NNNACACCATCACTCCACAG | NTG | 1 | 0.039 | Tier II |
19 | NC_000007.14 | 7 | 31773492 | + | PDE1C | NNNACACCATCACTTCACAC | NGG | 2 | 0.0286 | Tier II |
20 | NC_000001.11 | 1 | 40301593 | - | COL9A2 | NNNCCACCATCACTTCACAG | NGG | 2 | 0.0235 | Tier II |
21 | NC_000019.10 | 19 | 43989609 | - | ZNF155 | NNNACACCATCACTCCACAG | NGC | 1 | 0.0222 | Tier II |
22 | NC_000005.10 | 5 | 36300598 | - | LOC124900962 | NNNACATCATCACTCCACAG | NGG | 1 | 0.8125 | Tier III |
23 | NC_000005.10 | 5 | 151965123 | - | LINC01933 | NNNAGACCATCACTCAACAG | NGG | 2 | 0.6 | Tier III |
24 | NC_000015.10 | 15 | 87503210 | + | LOC102724465 | NNNAGACCATCACTCCATAG | NGG | 2 | 0.3857 | Tier III |
25 | NC_000015.10 | 15 | 77643064 | - | LINGO1-AS1 | NNNACACCACCACACCACAG | NGG | 2 | 0.3302 | Tier III |
26 | NC_000012.12 | 12 | 56982133 | + | LOC390332 | NNNACACCTTCACTCCAAAG | NGG | 2 | 0.3231 | Tier III |
27 | NC_000012.12 | 12 | 56982133 | + | LOC124902945 | NNNACACCTTCACTCCAAAG | NGG | 2 | 0.3231 | Tier III |
28 | NC_000007.14 | 7 | 65750435 | + | LINC03006 | NNNACACCATCACTCTACAA | NGG | 2 | 0.2885 | Tier III |
29 | NC_000002.12 | 2 | 217208842 | - | LOC105373872 | NNNACAGCCTCACTCCACAG | NGG | 2 | 0.2689 | Tier III |
30 | NC_000009.12 | 9 | 93964236 | - | LOC124902216 | NNNACACCAACACCCCACAG | NGG | 2 | 0.2449 | Tier III |
31 | NC_000006.12 | 6 | 9945119 | + | OFCC1 | NNNACACCATCACTCTACAT | NGG | 2 | 0.2154 | Tier III |
32 | NC_000013.11 | 13 | 78185860 | - | OBI1-AS1 | NNNACACCATCACACTACAG | NGG | 2 | 0.1905 | Tier III |
33 | NC_000001.11 | 1 | 161593930 | - | FCGR2C | NNNACCCCATCCCTCCACAG | NGG | 2 | 0.1196 | Tier III |
34 | NC_000017.11 | 17 | 34411096 | - | LOC124903986 | NNNACCCCATCACTCCACAG | NGA | 2 | 0.0316 | Tier III |
35 | NC_000013.11 | 13 | 111897430 | - | LINC00354 | NNNACTCCATCACGCCACAG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000068.7 | 2 | 31784568 | + | Abl1 | NNNTCACCATCACTCCACGG | NGG | 2 | 0.2386 | Tier I |
2 | NC_000083.6 | 17 | 33955511 | + | Rps18 | NNNACTCCATCGCTCCACAG | NGG | 2 | 0.5159 | Tier II |
3 | NC_000077.6 | 11 | 66368117 | - | Shisa6 | NNNACACAATCACTCCAAAG | NGG | 2 | 0.35 | Tier II |
4 | NC_000075.6 | 9 | 86785982 | - | Snap91 | NNNACACCATCACTCTACAG | NGG | 1 | 0.3077 | Tier II |
5 | NC_000067.6 | 1 | 34174054 | - | Dst | NNNACAGCTTCACTCCACAG | NGG | 2 | 0.2824 | Tier II |
6 | NC_000073.6 | 7 | 110955645 | - | Mrvi1 | NNNACTCCATCAATCCACAG | NGG | 2 | 0.2747 | Tier II |
7 | NC_000081.6 | 15 | 41493702 | - | Oxr1 | NNNACACCATCACTCCACAG | NAG | 1 | 0.2593 | Tier II |
8 | NC_000074.6 | 8 | 32142281 | + | Nrg1 | NNNACAACATCACTCTACAG | NGG | 2 | 0.2308 | Tier II |
9 | NC_000083.6 | 17 | 10531714 | - | Pacrg | NNNACACCACCCCTCCACAG | NGG | 2 | 0.1404 | Tier II |
10 | NC_000078.6 | 12 | 29965799 | - | Pxdn | NNNACAGCATCACTCCCCAG | NGG | 2 | 0.083 | Tier II |
11 | NC_000077.6 | 11 | 11819961 | - | Ddc | NNNACACCATCACACCAGAG | NGG | 2 | 0.0825 | Tier II |
12 | NC_000081.6 | 15 | 35142395 | - | Stk3 | NNNACACCATCCCTCTACAG | NGG | 2 | 0.081 | Tier II |
13 | NC_000068.7 | 2 | 152443397 | + | 6820408C15Rik | NNNACACCACCAGTCCACAG | NGG | 2 | 0.0727 | Tier II |
14 | NC_000071.6 | 5 | 105782389 | - | Lrrc8d | NNNACAGCATCACTCCACAG | NCG | 2 | 0.0504 | Tier II |
15 | NC_000080.6 | 14 | 13943450 | + | Gm11100 | NNNACACCATCTGTCCACAG | NGG | 2 | 0.0455 | Tier II |
16 | NC_000068.7 | 2 | 112602755 | + | Aven | NNNACACCAACACTGCACAG | NGG | 2 | 0.0429 | Tier II |
17 | NC_000078.6 | 12 | 52918430 | + | Akap6 | NNNACATCATCACTCCACAG | NTG | 2 | 0.0317 | Tier II |
18 | NC_000074.6 | 8 | 11395835 | - | Col4a2 | NNNACACCATCACTCCACTG | NGC | 2 | 0.012 | Tier II |
19 | NC_000070.6 | 4 | 130928586 | - | Laptm5 | NNNACACCAGCACTCCACAG | NGC | 2 | 0.0111 | Tier II |
20 | NC_000071.6 | 5 | 99332276 | + | A930011G23Rik | NNNAGACCAGCACTCCACAG | NGG | 2 | 0.3 | Tier III |
21 | NC_000067.6 | 1 | 34174054 | - | Gm26788 | NNNACAGCTTCACTCCACAG | NGG | 2 | 0.2824 | Tier III |
22 | NC_000083.6 | 17 | 10531714 | - | Gm16168 | NNNACACCACCCCTCCACAG | NGG | 2 | 0.1404 | Tier III |
23 | NC_000083.6 | 17 | 10531714 | - | Gm52294 | NNNACACCACCCCTCCACAG | NGG | 2 | 0.1404 | Tier III |
24 | NC_000078.6 | 12 | 70229582 | - | F730035M05Rik | NNNACACCATCACTACCCAG | NGG | 2 | 0.0392 | Tier III |
25 | NC_000078.6 | 12 | 70229582 | - | Gm38467 | NNNACACCATCACTACCCAG | NGG | 2 | 0.0392 | Tier III |
26 | NC_000068.7 | 2 | 50408027 | - | Gm13483 | NNNACACCATCAGTCCACAG | NGT | 2 | 0.0022 | Tier III |
27 | NC_000068.7 | 2 | 50408027 | - | Gm48908 | NNNACACCATCAGTCCACAG | NGT | 2 | 0.0022 | Tier III |