Construct: sgRNA BRDN0001146665
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TTATTGCCATAAACTCCATG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- SNRK (54861)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 43303604 | + | SNRK | NNNTTGCCATAAACTCCATG | NGG | 0 | 1.0 | Tier I |
2 | NC_000003.12 | 3 | 124298911 | + | KALRN | NNNTTGCCATGAACTCCATG | NTG | 2 | 0.0253 | Tier I |
3 | NC_000023.11 | X | 52974381 | + | FAM156A | NNNTTGACATAAACTCCATG | NGG | 1 | 0.75 | Tier II |
4 | NC_000010.11 | 10 | 107135001 | + | SORCS1 | NNNTTCCCATAAACTCCATG | NGG | 1 | 0.6818 | Tier II |
5 | NC_000011.10 | 11 | 132814745 | - | OPCML | NNNTTACAATAAACTCCATG | NGG | 2 | 0.65 | Tier II |
6 | NC_000006.12 | 6 | 79230305 | + | HMGN3 | NNNTGGCTATAAACTCCATG | NGG | 2 | 0.56 | Tier II |
7 | NC_000009.12 | 9 | 3333942 | + | RFX3 | NNNTTTTCATAAACTCCATG | NGG | 2 | 0.5417 | Tier II |
8 | NC_000009.12 | 9 | 35505553 | + | RUSC2 | NNNTAACCATAAACTCCATG | NGG | 2 | 0.5 | Tier II |
9 | NC_000001.11 | 1 | 91810513 | + | TGFBR3 | NNNTTACCAGAAACTCCATG | NGG | 2 | 0.5 | Tier II |
10 | NC_000001.11 | 1 | 10966213 | + | C1orf127 | NNNTGCCCATAAACTCCATG | NGG | 2 | 0.4364 | Tier II |
11 | NC_000013.11 | 13 | 73929342 | + | KLF12 | NNNTTCCCAGAAACTCCATG | NGG | 2 | 0.3409 | Tier II |
12 | NC_000020.11 | 20 | 16466847 | + | KIF16B | NNNTTGCCAGAAGCTCCATG | NGG | 2 | 0.3261 | Tier II |
13 | NC_000001.11 | 1 | 201054037 | + | CACNA1S | NNNTTGCCACAAACTCAATG | NGG | 2 | 0.2489 | Tier II |
14 | NC_000010.11 | 10 | 66614432 | - | CTNNA3 | NNNAAGCCATAAACTCCATG | NGG | 2 | 0.2381 | Tier II |
15 | NC_000008.11 | 8 | 17062713 | + | MICU3 | NNNTTGCTATAAACTCCATG | NAG | 2 | 0.2269 | Tier II |
16 | NC_000016.10 | 16 | 11131348 | + | CLEC16A | NNNTTTCCATAAACTCCAAG | NGG | 2 | 0.1905 | Tier II |
17 | NC_000014.9 | 14 | 56621198 | + | TMEM260 | NNNTTGCCTTAAACTCCAAG | NGG | 2 | 0.1714 | Tier II |
18 | NC_000022.11 | 22 | 32567479 | - | SYN3 | NNNTTGCCATAAGCTCCATG | NAG | 2 | 0.1691 | Tier II |
19 | NC_000012.12 | 12 | 77912043 | - | NAV3 | NNNTTGCCATAAACTCAATG | NAG | 2 | 0.121 | Tier II |
20 | NC_000009.12 | 9 | 21917130 | + | MTAP | NNNTTGCCATAAACTGAATG | NGG | 2 | 0.0718 | Tier II |
21 | NC_000019.10 | 19 | 19019071 | + | SUGP2 | NNNTTGCCATATACTCCATG | NGA | 2 | 0.0231 | Tier II |
22 | NC_000013.11 | 13 | 94282482 | - | GPC6 | NNNTTCCCATAAACTCCATG | NGT | 2 | 0.011 | Tier II |
23 | NC_000002.12 | 2 | 48768125 | - | STON1-GTF2A1L | NNNTTGCCATAAAATCCATG | NGC | 2 | 0.0078 | Tier II |
24 | NC_000007.14 | 7 | 138079941 | + | AKR1D1 | NNNTTGCCATAAACTCCATG | NCA | 2 | 0.0 | Tier II |
25 | NC_000003.12 | 3 | 81609672 | - | GBE1 | NNNTTGCCATAAAGTCCATG | NGC | 2 | 0.0 | Tier II |
26 | NC_000014.9 | 14 | 59325812 | - | DAAM1 | NNNTTGCCCTAAAGTCCATG | NGG | 2 | 0.0 | Tier II |
27 | NC_000004.12 | 4 | 184898052 | + | LINC01093 | NNNTTGCCAAAAGCTCCATG | NGG | 2 | 0.559 | Tier III |
28 | NC_000011.10 | 11 | 41820598 | - | LINC01499 | NNNTTGCCATAAACTCCATC | NGG | 1 | 0.4286 | Tier III |
29 | NC_000020.11 | 20 | 39776873 | + | LOC105372614 | NNNTCGCCATCAACTCCATG | NGG | 2 | 0.4 | Tier III |
30 | NC_000013.11 | 13 | 44894508 | + | LOC105370187 | NNNTGGCCACAAACTCCATG | NGG | 2 | 0.3413 | Tier III |
31 | NC_000010.11 | 10 | 1990380 | - | LOC105376346 | NNNTTGCCATAAACACCTTG | NGG | 2 | 0.2895 | Tier III |
32 | NC_000001.11 | 1 | 244007125 | - | LINC02774 | NNNTTGCCATAAACTCCACA | NGG | 2 | 0.2586 | Tier III |
33 | NC_000019.10 | 19 | 31900187 | + | LINC01837 | NNNTTGCCATAAACTCCACA | NGG | 2 | 0.2586 | Tier III |
34 | NC_000016.10 | 16 | 11131348 | + | LOC105371081 | NNNTTTCCATAAACTCCAAG | NGG | 2 | 0.1905 | Tier III |
35 | NC_000003.12 | 3 | 186463740 | - | LINC02052 | NNNTTGCCATAAGCTCCACG | NGG | 2 | 0.1799 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 122137413 | + | Snrk | NNNTTGCCATAAACTCCATG | NGG | 0 | 1.0 | Tier I |
2 | NC_000082.6 | 16 | 34332127 | - | Kalrn | NNNTTGCCATGAACTCCATG | NTG | 2 | 0.0253 | Tier I |
3 | NC_000075.6 | 9 | 73987788 | + | Unc13c | NNNTTGCAATAAACTCCATG | NGG | 1 | 0.65 | Tier II |
4 | NC_000075.6 | 9 | 6275429 | + | Pdgfd | NNNCTGCCACAAACTCCATG | NGG | 2 | 0.3451 | Tier II |
5 | NC_000069.6 | 3 | 63951218 | + | Slc33a1 | NNNTGGCCACAAACTCCATG | NGG | 2 | 0.3413 | Tier II |
6 | NC_000080.6 | 14 | 103655164 | + | Slain1 | NNNTTGGAATAAACTCCATG | NGG | 2 | 0.3059 | Tier II |
7 | NC_000073.6 | 7 | 49378952 | - | Nav2 | NNNTTGCTATAAACTCCAAG | NGG | 2 | 0.25 | Tier II |
8 | NC_000077.6 | 11 | 75689097 | + | Crk | NNNTTGCAATAAAATCCATG | NGG | 2 | 0.2275 | Tier II |
9 | NC_000074.6 | 8 | 33364078 | - | Wrn | NNNGTGCCATAAACCCCATG | NGG | 2 | 0.1705 | Tier II |
10 | NC_000076.6 | 10 | 128687486 | - | Rab5b | NNNTTGGCATAAAATCCATG | NGG | 2 | 0.1647 | Tier II |
11 | NC_000068.7 | 2 | 69822509 | - | Klhl23 | NNNTTCCCATAAACTCCATG | NTG | 2 | 0.0266 | Tier II |
12 | NC_000080.6 | 14 | 66993196 | + | Bnip3l | NNNTTGCCATGAACTCCATG | NGC | 2 | 0.0144 | Tier II |
13 | NC_000073.6 | 7 | 99704357 | + | Slco2b1 | NNNTTCCCATAAAGTCCATG | NGG | 2 | 0.0 | Tier II |
14 | NC_000072.6 | 6 | 92174436 | - | Mrps25 | NNNTTGCCATCAAGTCCATG | NGG | 2 | 0.0 | Tier II |
15 | NC_000069.6 | 3 | 6137852 | - | Gm17934 | NNNTTGCCATAAACTCCATG | NGG | 0 | 1.0 | Tier III |
16 | NC_000086.7 | X | 94739456 | - | Gm39526 | NNNTTCCCAGAAACTCCATG | NGG | 2 | 0.3409 | Tier III |
17 | NC_000073.6 | 7 | 127455334 | - | B130055M24Rik | NNNTTGCCATAAACTCTATG | NTG | 2 | 0.0182 | Tier III |
18 | NC_000073.6 | 7 | 99704357 | + | Gm34280 | NNNTTCCCATAAAGTCCATG | NGG | 2 | 0.0 | Tier III |