Construct: sgRNA BRDN0001146810
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAAGTTTGAGCTTTACCTTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- STYK1 (55359)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 10633991 | + | STYK1 | NNNGTTTGAGCTTTACCTTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000019.10 | 19 | 33021572 | + | RHPN2 | NNNCTTTGAGATTTACCTTG | NGG | 2 | 0.3971 | Tier I |
3 | NC_000007.14 | 7 | 128837475 | - | FLNC | NNNGTTTGAGCTTGGCCTTG | NGG | 2 | 0.0 | Tier I |
4 | NC_000013.11 | 13 | 31302140 | - | B3GLCT | NNNGTCTAAGCTTTACCTTG | NGG | 2 | 0.9091 | Tier II |
5 | NC_000009.12 | 9 | 3868721 | - | GLIS3 | NNNGTTTGGGCTTTAACTTG | NGG | 2 | 0.6667 | Tier II |
6 | NC_000009.12 | 9 | 37526502 | - | FBXO10 | NNNGTCTGGGCTTTACCTTG | NGG | 2 | 0.6061 | Tier II |
7 | NC_000008.11 | 8 | 52278968 | - | ST18 | NNNATTGGAGCTTTACCTTG | NGG | 2 | 0.5294 | Tier II |
8 | NC_000002.12 | 2 | 37643630 | + | CDC42EP3 | NNNGTTTCATCTTTACCTTG | NGG | 2 | 0.5 | Tier II |
9 | NC_000009.12 | 9 | 76431255 | - | GCNT1 | NNNGATTGAGCCTTACCTTG | NGG | 2 | 0.4737 | Tier II |
10 | NC_000009.12 | 9 | 42023185 | - | CNTNAP3B | NNNGTTTGACCTTTAACTTG | NGG | 2 | 0.4 | Tier II |
11 | NC_000005.10 | 5 | 111333538 | + | CAMK4 | NNNGTTTTTGCTTTACCTTG | NGG | 2 | 0.375 | Tier II |
12 | NC_000022.11 | 22 | 31229193 | + | LIMK2 | NNNGTTGCAGCTTTACCTTG | NGG | 2 | 0.362 | Tier II |
13 | NC_000016.10 | 16 | 3612222 | + | DNASE1 | NNNGTTTGAGCTTCAACTTG | NGG | 2 | 0.2857 | Tier II |
14 | NC_000013.11 | 13 | 43708373 | - | ENOX1 | NNNGTTTGACCTTTGCCTTG | NGG | 2 | 0.26 | Tier II |
15 | NC_000006.12 | 6 | 40396997 | + | LRFN2 | NNNGTTTGAACTTTCCCTTG | NGG | 2 | 0.2545 | Tier II |
16 | NC_000005.10 | 5 | 137627669 | - | KLHL3 | NNNTTTTGAGCTTTGCCTTG | NGG | 2 | 0.2364 | Tier II |
17 | NC_000020.11 | 20 | 42271109 | - | PTPRT | NNNGTTTGAAGTTTACCTTG | NGG | 2 | 0.2333 | Tier II |
18 | NC_000011.10 | 11 | 121100675 | + | TBCEL-TECTA | NNNGTTTGAGATTTCCCTTG | NGG | 2 | 0.2045 | Tier II |
19 | NC_000009.12 | 9 | 83132320 | - | RASEF | NNNGTTAGAGCTTTTCCTTG | NGG | 2 | 0.175 | Tier II |
20 | NC_000002.12 | 2 | 10573054 | - | NOL10 | NNNTTTTGAGCTTTACCTTC | NGG | 2 | 0.1558 | Tier II |
21 | NC_000002.12 | 2 | 197843571 | - | PLCL1 | NNNGTTTGAGATTTTCCTTG | NGG | 2 | 0.15 | Tier II |
22 | NC_000005.10 | 5 | 9229761 | - | SEMA5A | NNNGTTTGTGGTTTACCTTG | NGG | 2 | 0.15 | Tier II |
23 | NC_000016.10 | 16 | 67390685 | - | TPPP3 | NNNGTTTGAGCTTTCCCCTG | NGG | 2 | 0.1169 | Tier II |
24 | NC_000003.12 | 3 | 71461094 | + | FOXP1 | NNNGTTTGAGTTTTATCTTG | NGG | 2 | 0.0947 | Tier II |
25 | NC_000006.12 | 6 | 123033534 | - | CLVS2 | NNNGTTTGAGCTTTAAGTTG | NGG | 2 | 0.0588 | Tier II |
26 | NC_000015.10 | 15 | 45185404 | + | SHF | NNNGTTTGAGCTTTTCCTAG | NGG | 2 | 0.0571 | Tier II |
27 | NC_000019.10 | 19 | 50381587 | + | NR1H2 | NNNGTTTGGGCTTTACCTTG | NGC | 2 | 0.0148 | Tier II |
28 | NC_000005.10 | 5 | 94194038 | - | KIAA0825 | NNNGTTTGACCTTTACCTTG | NGT | 2 | 0.0065 | Tier II |
29 | NC_000018.10 | 18 | 6773106 | + | ARHGAP28 | NNNGTTTGAGTTTTACCTTG | NGT | 2 | 0.005 | Tier II |
30 | NC_000016.10 | 16 | 14873187 | + | NOMO1 | NNNCTTTGAGCTTGACCTTG | NGG | 2 | 0.0 | Tier II |
31 | NC_000016.10 | 16 | 16271687 | + | NOMO3 | NNNCTTTGAGCTTGACCTTG | NGG | 2 | 0.0 | Tier II |
32 | NC_000016.10 | 16 | 18522986 | - | NOMO2 | NNNCTTTGAGCTTGACCTTG | NGG | 2 | 0.0 | Tier II |
33 | NC_000004.12 | 4 | 140649074 | - | TBC1D9 | NNNGATTGAGCTTGACCTTG | NGG | 2 | 0.0 | Tier II |
34 | NC_000009.12 | 9 | 132826518 | - | AK8 | NNNGTTTGAGCCTGACCTTG | NGG | 2 | 0.0 | Tier II |
35 | NC_000010.11 | 10 | 101755200 | + | LOC105378458 | NNNATTTGAACTTTACCTTG | NGG | 2 | 0.84 | Tier III |
36 | NC_000009.12 | 9 | 67164231 | + | CNTNAP3P2 | NNNGTTTGACCTTTAACTTG | NGG | 2 | 0.4 | Tier III |
37 | NC_000009.12 | 9 | 72047303 | - | LOC101927108 | NNNGTTTGACCTTTAACTTG | NGG | 2 | 0.4 | Tier III |
38 | NC_000015.10 | 15 | 20271670 | + | RHPN2P1 | NNNCTTTGAGATTTACCTTG | NGG | 2 | 0.3971 | Tier III |
39 | NC_000018.10 | 18 | 38728198 | + | LOC105372076 | NNNCATTGAGCTTTACCTTG | NGG | 2 | 0.2647 | Tier III |
40 | NC_000005.10 | 5 | 72624280 | - | TNPO1-DT | NNNGTTTGATTTTTACCTTG | NGG | 2 | 0.25 | Tier III |
41 | NC_000004.12 | 4 | 97224357 | - | LOC124900737 | NNNGTTTGAGTATTACCTTG | NGG | 2 | 0.2462 | Tier III |
42 | NC_000010.11 | 10 | 5617932 | + | LINC02677 | NNNGTTTGGGTTTTACCTTG | NGG | 2 | 0.2051 | Tier III |
43 | NC_000010.11 | 10 | 10059418 | + | LINC02670 | NNNGTTTGAGCTCTTCCTTG | NGG | 2 | 0.1579 | Tier III |
44 | NC_000016.10 | 16 | 67390685 | - | RNU1-123P | NNNGTTTGAGCTTTCCCCTG | NGG | 2 | 0.1169 | Tier III |
45 | NC_000016.10 | 16 | 60044471 | + | LINC02141 | NNNGTTTGAGCTGTATCTTG | NGG | 2 | 0.0803 | Tier III |
46 | NC_000015.10 | 15 | 45185404 | + | LOC124903481 | NNNGTTTGAGCTTTTCCTAG | NGG | 2 | 0.0571 | Tier III |
47 | NC_000009.12 | 9 | 123321491 | - | LOC105376265 | NNNGGTTGAGCTTTACCTTG | NGA | 2 | 0.0444 | Tier III |
48 | NC_000017.11 | 17 | 36712698 | - | LOC105371750 | NNNGTTTGAGCTTTACCATG | NTG | 2 | 0.026 | Tier III |
49 | NC_000005.10 | 5 | 94194038 | - | LOC105379087 | NNNGTTTGACCTTTACCTTG | NGT | 2 | 0.0065 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000081.6 | 15 | 36234900 | + | Spag1 | NNNGTATGAGCTTTAACTTG | NGG | 2 | 0.8667 | Tier I |
2 | NC_000072.6 | 6 | 131312452 | + | Styk1 | NNNGTTTGAGCCTTACCTCG | NGG | 2 | 0.2613 | Tier I |
3 | NC_000073.6 | 7 | 27900167 | - | Zfp607a | NNNGTTTGATCTTTACCATG | NGG | 2 | 0.5417 | Tier II |
4 | NC_000067.6 | 1 | 81288532 | + | Nyap2 | NNNGTTTGAGCATTACTTTG | NGG | 2 | 0.3733 | Tier II |
5 | NC_000077.6 | 11 | 98819879 | + | Casc3 | NNNGTTTGAGCTATACATTG | NGG | 2 | 0.3231 | Tier II |
6 | NC_000075.6 | 9 | 119677474 | - | Scn10a | NNNGTTTGAGTCTTACCTTG | NGG | 2 | 0.2915 | Tier II |
7 | NC_000080.6 | 14 | 48198927 | + | Peli2 | NNNGTTTGACCTTTACCCTG | NGG | 2 | 0.1714 | Tier II |
8 | NC_000079.6 | 13 | 45531800 | - | Gmpr | NNNGTTTGACCTTTACCTTG | NAG | 2 | 0.1037 | Tier II |
9 | NC_000071.6 | 5 | 96400402 | - | Fras1 | NNNGTTTGATCTTTACGTTG | NGG | 2 | 0.0478 | Tier II |
10 | NC_000082.6 | 16 | 6299922 | + | Rbfox1 | NNNGTTTGAGCTTTGCCTTG | NGA | 2 | 0.0451 | Tier II |
11 | NC_000071.6 | 5 | 28321884 | + | Rbm33 | NNNGTTTTAGCTTTACCTTG | NGA | 2 | 0.0434 | Tier II |
12 | NC_000070.6 | 4 | 87075225 | + | Slc24a2 | NNNGTTTGAGCTGTACCTTG | NGT | 2 | 0.0042 | Tier II |
13 | NC_000071.6 | 5 | 39273406 | + | Gm40293 | NNNTTTTGAGCTTTACCTTA | NGG | 2 | 0.3409 | Tier III |
14 | NC_000080.6 | 14 | 48198927 | + | Gm6498 | NNNGTTTGACCTTTACCCTG | NGG | 2 | 0.1714 | Tier III |
15 | NC_000078.6 | 12 | 71619059 | - | 9630002D21Rik | NNNGTTTGAGCTTTTCCTTG | NTG | 2 | 0.0078 | Tier III |