Construct: sgRNA BRDN0001146856
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TATCTTCCCAGAGTTACTGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CAMK2D (817)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000004.12 | 4 | 113552091 | - | CAMK2D | NNNCTTCCCAGAGTTACTGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000004.12 | 4 | 151662672 | + | FHIP1A | NNNCTTCCCAGAGTTCCTGA | NGG | 2 | 0.0 | Tier I |
3 | NC_000016.10 | 16 | 6458876 | + | RBFOX1 | NNNTTTCCCAGAATTACTGG | NGG | 2 | 0.7385 | Tier II |
4 | NC_000017.11 | 17 | 38568472 | + | SRCIN1 | NNNCCTCGCAGAGTTACTGG | NGG | 2 | 0.6429 | Tier II |
5 | NC_000015.10 | 15 | 53679746 | - | WDR72 | NNNCTTCCCAAAGTAACTGG | NGG | 2 | 0.5789 | Tier II |
6 | NC_000010.11 | 10 | 6423591 | - | PRKCQ | NNNCTTCCCGGAGTTACTGA | NGG | 2 | 0.5208 | Tier II |
7 | NC_000010.11 | 10 | 11196191 | - | CELF2 | NNNCTTCCCAGGGTTACTGT | NGG | 2 | 0.5056 | Tier II |
8 | NC_000016.10 | 16 | 17214302 | - | XYLT1 | NNNCCTCCCAGAGTTAATGG | NGG | 2 | 0.4667 | Tier II |
9 | NC_000010.11 | 10 | 31868599 | + | ARHGAP12 | NNNCATTCCAGAGTTACTGG | NGG | 2 | 0.4063 | Tier II |
10 | NC_000017.11 | 17 | 2376310 | - | SGSM2 | NNNCTTCACAGAGTAACTGG | NGG | 2 | 0.3763 | Tier II |
11 | NC_000008.11 | 8 | 69542574 | + | SULF1 | NNNCTGCCGAGAGTTACTGG | NGG | 2 | 0.3537 | Tier II |
12 | NC_000001.11 | 1 | 33772159 | + | CSMD2 | NNNTTTCCCACAGTTACTGG | NGG | 2 | 0.3429 | Tier II |
13 | NC_000002.12 | 2 | 164812596 | - | COBLL1 | NNNCTTGCCAGAGTTACAGG | NGG | 2 | 0.3137 | Tier II |
14 | NC_000007.14 | 7 | 3886471 | - | SDK1 | NNNCTTCCAAGTGTTACTGG | NGG | 2 | 0.2857 | Tier II |
15 | NC_000012.12 | 12 | 112175986 | - | HECTD4 | NNNATTCCCAGAGTTACGGG | NGG | 2 | 0.2807 | Tier II |
16 | NC_000009.12 | 9 | 132727045 | - | AK8 | NNNCTTCCCATAGTTACAGG | NGG | 2 | 0.2564 | Tier II |
17 | NC_000001.11 | 1 | 1475850 | + | ATAD3B | NNNCTCCCCAGAGTCACTGG | NGG | 2 | 0.2479 | Tier II |
18 | NC_000001.11 | 1 | 1514204 | + | ATAD3A | NNNCTCCCCAGAGTCACTGG | NGG | 2 | 0.2479 | Tier II |
19 | NC_000019.10 | 19 | 18716090 | + | CRTC1 | NNNATTCCCAGAGTCACTGG | NGG | 2 | 0.2297 | Tier II |
20 | NC_000004.12 | 4 | 78455066 | - | FRAS1 | NNNCTTCTCAGAGTTACTGG | NAG | 2 | 0.2269 | Tier II |
21 | NC_000002.12 | 2 | 166485710 | - | SCN7A | NNNTTTCCCAGAGTTACTGG | NAG | 2 | 0.2074 | Tier II |
22 | NC_000007.14 | 7 | 37006372 | - | ELMO1 | NNNCTTCCCAGAGTCACTGT | NGG | 2 | 0.1909 | Tier II |
23 | NC_000011.10 | 11 | 77938549 | + | INTS4 | NNNCTTCCCAGAGTTACTGT | NAG | 2 | 0.1815 | Tier II |
24 | NC_000011.10 | 11 | 35416433 | + | SLC1A2 | NNNCTTCACAGAGTTACTGG | NAG | 2 | 0.1685 | Tier II |
25 | NC_000001.11 | 1 | 66832037 | + | DNAI4 | NNNCTTCCCAGAGATACTGG | NAG | 2 | 0.1605 | Tier II |
26 | NC_000001.11 | 1 | 177018177 | - | ASTN1 | NNNCTTCCCAGAGTTGCTTG | NGG | 2 | 0.1282 | Tier II |
27 | NC_000006.12 | 6 | 142364599 | - | ADGRG6 | NNNCTTCCCAGAGTTATTGG | NAG | 2 | 0.121 | Tier II |
28 | NC_000003.12 | 3 | 2332430 | - | CNTN4 | NNNCTTCTCAGAGTTACTGG | NGA | 2 | 0.0608 | Tier II |
29 | NC_000008.11 | 8 | 120800327 | - | SNTB1 | NNNCTTTCCAGAGTTACTGG | NGA | 2 | 0.0564 | Tier II |
30 | NC_000002.12 | 2 | 179224641 | - | SESTD1 | NNNCTTCTCAGAGTTAGTGG | NGG | 2 | 0.0515 | Tier II |
31 | NC_000004.12 | 4 | 1217209 | - | CTBP1 | NNNCTTCCCAGAGTGACTGG | NGG | 1 | 0.05 | Tier II |
32 | NC_000010.11 | 10 | 48503579 | - | ARHGAP22 | NNNCTTCCCAGAGTTGCTGG | NAG | 2 | 0.0499 | Tier II |
33 | NC_000011.10 | 11 | 126341310 | + | DCPS | NNNCTTCCCAGAGTGACTGA | NGG | 2 | 0.0469 | Tier II |
34 | NC_000007.14 | 7 | 146505497 | + | CNTNAP2 | NNNCTTGCCAGAGTTACTGG | NGA | 2 | 0.0327 | Tier II |
35 | NC_000014.9 | 14 | 68483470 | - | RAD51B | NNNCTTCCCAGAGTTACTTG | NGT | 2 | 0.0108 | Tier II |
36 | NC_000007.14 | 7 | 155710805 | + | RBM33 | NNNCTTACCAGAGTTCCTGG | NGG | 2 | 0.0 | Tier II |
37 | NC_000001.11 | 1 | 46996714 | - | CYP4X1 | NNNCTTCCAAGAGTTTCTGG | NGG | 2 | 0.0 | Tier II |
38 | NC_000004.12 | 4 | 151307519 | + | SH3D19 | NNNCTTCCCAGAGTTCCTGG | NGC | 2 | 0.0 | Tier II |
39 | NC_000012.12 | 12 | 52619033 | + | KRT73 | NNNCTTCCCAGAGTTCCTGG | NGA | 2 | 0.0 | Tier II |
40 | NC_000010.11 | 10 | 11196191 | - | LOC124902375 | NNNCTTCCCAGGGTTACTGT | NGG | 2 | 0.5056 | Tier III |
41 | NC_000011.10 | 11 | 56874257 | - | LINC02735 | NNNCTTCCCAGTGTTACTGG | NGG | 1 | 0.3333 | Tier III |
42 | NC_000018.10 | 18 | 14679457 | - | GTF2IP8 | NNNCTTCCCATAGTTACTGT | NGG | 2 | 0.2692 | Tier III |
43 | NC_000005.10 | 5 | 55603259 | - | LOC124900980 | NNNCTTCCCAGAGTTACTGA | NAG | 2 | 0.2431 | Tier III |
44 | NC_000007.14 | 7 | 37006372 | - | ELMO1-AS1 | NNNCTTCCCAGAGTCACTGT | NGG | 2 | 0.1909 | Tier III |
45 | NC_000007.14 | 7 | 65170464 | - | INTS4P1 | NNNCTTCCCAGAGTTACTGT | NAG | 2 | 0.1815 | Tier III |
46 | NC_000007.14 | 7 | 65525527 | + | LOC101929322 | NNNCTTCCCAGAGTTACTGT | NAG | 2 | 0.1815 | Tier III |
47 | NC_000007.14 | 7 | 65677086 | - | LINC03006 | NNNCTTCCCAGAGTTACTGT | NAG | 2 | 0.1815 | Tier III |
48 | NC_000007.14 | 7 | 65677086 | - | INTS4P2 | NNNCTTCCCAGAGTTACTGT | NAG | 2 | 0.1815 | Tier III |
49 | NC_000004.12 | 4 | 1217209 | - | CTBP1-AS | NNNCTTCCCAGAGTGACTGG | NGG | 1 | 0.05 | Tier III |
50 | NC_000008.11 | 8 | 73329688 | + | RDH10-AS1 | NNNCTTCCCAGAGTTAGTGC | NGG | 2 | 0.0252 | Tier III |
51 | NC_000019.10 | 19 | 54320815 | + | VN1R104P | NNNCTTCCCAGAGATACTGG | NGT | 2 | 0.01 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000084.6 | 18 | 60952140 | + | Camk2a | NNNCTCCCCAGGGTTACTGG | NGG | 2 | 0.6566 | Tier I |
2 | NC_000076.6 | 10 | 80135141 | + | Cbarp | NNNCTCCCCAGAGTCACTGG | NGG | 2 | 0.2479 | Tier I |
3 | NC_000070.6 | 4 | 24503079 | + | Mms22l | NNNCTTCCCAGTGTTACTGT | NGG | 2 | 0.2333 | Tier I |
4 | NC_000084.6 | 18 | 38899815 | + | Gm5820 | NNNCTTCTCAGAGTTACTGG | NAG | 2 | 0.2269 | Tier I |
5 | NC_000069.6 | 3 | 79705714 | + | Rxfp1 | NNNCTTCCGAGAGTGACTGG | NGG | 2 | 0.031 | Tier I |
6 | NC_000069.6 | 3 | 85661048 | - | Fam160a1 | NNNCTTCCCAGAGTTCCTGA | NGG | 2 | 0.0 | Tier I |
7 | NC_000076.6 | 10 | 92884652 | - | Cfap54 | NNNCTTCCCAGAGTAACTGG | NGG | 1 | 0.5789 | Tier II |
8 | NC_000067.6 | 1 | 136925930 | - | Nr5a2 | NNNCTTCCAAGAGATACTGG | NGG | 2 | 0.5306 | Tier II |
9 | NC_000074.6 | 8 | 107155779 | - | Cyb5b | NNNTGTCCCAGAGTTACTGG | NGG | 2 | 0.512 | Tier II |
10 | NC_000073.6 | 7 | 66853198 | + | Adamts17 | NNNCTTCCCAGAGATACTGT | NGG | 2 | 0.4333 | Tier II |
11 | NC_000067.6 | 1 | 22377547 | - | Rims1 | NNNCATCCCAGAGTTACTTG | NGG | 2 | 0.3333 | Tier II |
12 | NC_000084.6 | 18 | 38899815 | + | Fgf1 | NNNCTTCTCAGAGTTACTGG | NAG | 2 | 0.2269 | Tier II |
13 | NC_000084.6 | 18 | 38899815 | + | Arhgap26 | NNNCTTCTCAGAGTTACTGG | NAG | 2 | 0.2269 | Tier II |
14 | NC_000082.6 | 16 | 26048382 | + | P3h2 | NNNCATCCCAGAGCTACTGG | NGG | 2 | 0.1429 | Tier II |
15 | NC_000078.6 | 12 | 83580471 | - | Zfyve1 | NNNCTTCCCAGGGTTGCTGG | NGG | 2 | 0.1389 | Tier II |
16 | NC_000079.6 | 13 | 45564997 | + | Atxn1 | NNNCTTCCCAGAGATACTGG | NGA | 2 | 0.043 | Tier II |
17 | NC_000067.6 | 1 | 170402945 | + | Nos1ap | NNNCTTCCCAGAGTTAGTGG | NGT | 2 | 0.0009 | Tier II |
18 | NC_000083.6 | 17 | 72146044 | + | Alk | NNNCTTCCCAGAGGTACTGG | NGT | 2 | 0.0 | Tier II |
19 | NC_000068.7 | 2 | 49544527 | + | Epc2 | NNNCTTCCCAGAGGTACTGT | NGG | 2 | 0.0 | Tier II |
20 | NC_000072.6 | 6 | 53370754 | + | Creb5 | NNNTTTCCCAGAGTTCCTGG | NGG | 2 | 0.0 | Tier II |
21 | NC_000073.6 | 7 | 17318228 | + | Gm32772 | NNNCTCCTCAGAGTTACTGG | NGG | 2 | 0.7955 | Tier III |
22 | NC_000077.6 | 11 | 18850553 | - | 8430419K02Rik | NNNCTGCCCAGAGTTCCTGG | NGG | 2 | 0.0 | Tier III |
23 | NC_000072.6 | 6 | 66516727 | + | Tpm3-rs3 | NNNCTTCCCAGAGTTCCAGG | NGG | 2 | 0.0 | Tier III |