Construct: sgRNA BRDN0001146874
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GTGACAATGCCATAGTTGGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- MAP3K20 (51776)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75598
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000002.12 |
2 |
173169874 |
- |
MAP3K20 |
NNNACAATGCCATAGTTGGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000020.11 |
20 |
36793513 |
+ |
MTCL2 |
NNNACAATGCCGTACTTGGG |
NGG |
2 |
0.197 |
Tier I |
3 |
NC_000017.11 |
17 |
1145583 |
- |
ABR |
NNNACAAAGCCATAGATGGG |
NGG |
2 |
0.7273 |
Tier II |
4 |
NC_000023.11 |
X |
73586938 |
- |
CHIC1 |
NNNACAATGCCACAGTTGAG |
NGG |
2 |
0.5639 |
Tier II |
5 |
NC_000003.12 |
3 |
183312245 |
- |
MCF2L2 |
NNNACAAGGCCATAGTTGGT |
NGG |
2 |
0.5133 |
Tier II |
6 |
NC_000022.11 |
22 |
25622876 |
+ |
GRK3 |
NNNTCAATGCCATAGTTTGG |
NGG |
2 |
0.4242 |
Tier II |
7 |
NC_000008.11 |
8 |
1131304 |
+ |
DLGAP2 |
NNNACATTGCCATAGATGGG |
NGG |
2 |
0.3977 |
Tier II |
8 |
NC_000017.11 |
17 |
61102546 |
- |
BCAS3 |
NNNACACTGCCAAAGTTGGG |
NGG |
2 |
0.3029 |
Tier II |
9 |
NC_000001.11 |
1 |
5863744 |
- |
NPHP4 |
NNNACCATCCCATAGTTGGG |
NGG |
2 |
0.2448 |
Tier II |
10 |
NC_000005.10 |
5 |
133397041 |
- |
FSTL4 |
NNNACAATGTCATAGTTGGG |
NAG |
2 |
0.244 |
Tier II |
11 |
NC_000008.11 |
8 |
118326622 |
- |
SAMD12 |
NNNACAATTCCTTAGTTGGG |
NGG |
2 |
0.1778 |
Tier II |
12 |
NC_000013.11 |
13 |
41614419 |
+ |
VWA8 |
NNNACAATGCCCTAGTTGGG |
NAG |
2 |
0.0682 |
Tier II |
13 |
NC_000007.14 |
7 |
34756536 |
- |
NPSR1 |
NNNACAATGCCAGAGTTGGG |
NAG |
2 |
0.0676 |
Tier II |
14 |
NC_000001.11 |
1 |
187318947 |
+ |
LINC01036 |
NNNAGAATACCATAGTTGGG |
NGG |
2 |
0.3857 |
Tier III |
15 |
NC_000017.11 |
17 |
61102546 |
- |
BCAS3-AS1 |
NNNACACTGCCAAAGTTGGG |
NGG |
2 |
0.3029 |
Tier III |
16 |
NC_000017.11 |
17 |
61102546 |
- |
LOC124904041 |
NNNACACTGCCAAAGTTGGG |
NGG |
2 |
0.3029 |
Tier III |
17 |
NC_000008.11 |
8 |
118326622 |
- |
LOC105375724 |
NNNACAATTCCTTAGTTGGG |
NGG |
2 |
0.1778 |
Tier III |
18 |
NC_000018.10 |
18 |
14997661 |
+ |
LOC100887076 |
NNNACACTGCGATAGTTGGG |
NGG |
2 |
0.1094 |
Tier III |
19 |
NC_000003.12 |
3 |
59438150 |
+ |
CFAP20DC-DT |
NNNACAATGGCAGAGTTGGG |
NGG |
2 |
0.1014 |
Tier III |
20 |
NC_000017.11 |
17 |
36006142 |
- |
LOC107985068 |
NNNACAATGCCCTACTTGGG |
NGG |
2 |
0.0718 |
Tier III |
21 |
NC_000007.14 |
7 |
34756536 |
- |
NPSR1-AS1 |
NNNACAATGCCAGAGTTGGG |
NAG |
2 |
0.0676 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000068.7 |
2 |
72355627 |
- |
Map3k20 |
NNNACGATGCCATAGTTGGG |
NGG |
1 |
0.7143 |
Tier I |
2 |
NC_000068.7 |
2 |
157020454 |
+ |
Soga1 |
NNNACAATGCCATACTTGGG |
NGG |
1 |
0.2727 |
Tier I |
3 |
NC_000074.6 |
8 |
70786195 |
+ |
Mast3 |
NNNACAATGCCATAGTTGTG |
NAG |
2 |
0.1728 |
Tier I |
4 |
NC_000071.6 |
5 |
8623395 |
+ |
Abcb1a |
NNNAGAATGCCATAGTTGGG |
NGG |
1 |
0.6 |
Tier II |
5 |
NC_000071.6 |
5 |
150627686 |
- |
N4bp2l2 |
NNNAAAATGTCATAGTTGGG |
NGG |
2 |
0.5378 |
Tier II |
6 |
NC_000068.7 |
2 |
181406396 |
+ |
Zbtb46 |
NNNACAATGCCAAAGTTGGT |
NGG |
2 |
0.4846 |
Tier II |
7 |
NC_000070.6 |
4 |
124992068 |
+ |
Rspo1 |
NNNACAATGCCAAAGTTGGT |
NGG |
2 |
0.4846 |
Tier II |
8 |
NC_000070.6 |
4 |
153971176 |
- |
Dffb |
NNNACATTGCCATAATTGGG |
NGG |
2 |
0.4118 |
Tier II |
9 |
NC_000085.6 |
19 |
44782901 |
+ |
Pax2 |
NNNACAATTCCAAAGTTGGG |
NGG |
2 |
0.3692 |
Tier II |
10 |
NC_000083.6 |
17 |
5319222 |
+ |
Arid1b |
NNNATAATTCCATAGTTGGG |
NGG |
2 |
0.3394 |
Tier II |
11 |
NC_000080.6 |
14 |
55763149 |
- |
Ltb4r2 |
NNNACAATGCCATGGTTTGG |
NGG |
2 |
0.3111 |
Tier II |
12 |
NC_000085.6 |
19 |
9130356 |
+ |
Asrgl1 |
NNNACAAAGCCAGAGTTGGG |
NGG |
2 |
0.2087 |
Tier II |
13 |
NC_000073.6 |
7 |
123109750 |
+ |
Tnrc6a |
NNNACAATGCCAGTGTTGGG |
NGG |
2 |
0.1391 |
Tier II |
14 |
NC_000073.6 |
7 |
96345095 |
+ |
Tenm4 |
NNNACAATGGCATCGTTGGG |
NGG |
2 |
0.0833 |
Tier II |
15 |
NC_000075.6 |
9 |
117315859 |
+ |
Rbms3 |
NNNACAATGCCATCGTTGGG |
NAG |
2 |
0.0556 |
Tier II |
16 |
NC_000074.6 |
8 |
23846932 |
+ |
Zmat4 |
NNNACAATGCCATCTTTGGG |
NGG |
2 |
0.0306 |
Tier II |
17 |
NC_000083.6 |
17 |
66997362 |
- |
Ptprm |
NNNACAAAGCCATAGTTGGG |
NGC |
2 |
0.0178 |
Tier II |
18 |
NC_000075.6 |
9 |
80991650 |
- |
Gm39381 |
NNNACAATGTCATAGTTGGC |
NGG |
2 |
0.4034 |
Tier III |
19 |
NC_000075.6 |
9 |
117315859 |
+ |
Gm39451 |
NNNACAATGCCATCGTTGGG |
NAG |
2 |
0.0556 |
Tier III |
Other clones with same target sequence:
(none)