Construct: sgRNA BRDN0001146911
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TACTGCATGGGAGTTAACTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- AK9 (221264)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77689
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000006.12 |
6 |
109563683 |
- |
AK9 |
NNNTGCATGGGAGTTAACTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000009.12 |
9 |
8887084 |
+ |
PTPRD |
NNNTACATGTGAGTTAACTG |
NGG |
2 |
0.7042 |
Tier II |
3 |
NC_000020.11 |
20 |
48651197 |
+ |
PREX1 |
NNNTGCACGGGAGTAAACTG |
NGG |
2 |
0.5789 |
Tier II |
4 |
NC_000005.10 |
5 |
741907 |
- |
ZDHHC11B |
NNNTGCGTGGGAGTTAAATG |
NGG |
2 |
0.3801 |
Tier II |
5 |
NC_000009.12 |
9 |
83391976 |
- |
FRMD3 |
NNNTGCATGCGAATTAACTG |
NGG |
2 |
0.3692 |
Tier II |
6 |
NC_000022.11 |
22 |
50032563 |
- |
TTLL8 |
NNNTGCAGGGGAGTTAACTC |
NGG |
2 |
0.3143 |
Tier II |
7 |
NC_000001.11 |
1 |
54272195 |
+ |
SSBP3 |
NNNTGCCTGGGAGTTAACTT |
NGG |
2 |
0.3062 |
Tier II |
8 |
NC_000017.11 |
17 |
39828338 |
+ |
IKZF3 |
NNNTGTATGGGAGTTGACTG |
NGG |
2 |
0.1786 |
Tier II |
9 |
NC_000003.12 |
3 |
1298721 |
+ |
CNTN6 |
NNNTGCATGTGAGTTACCTG |
NGG |
2 |
0.1434 |
Tier II |
10 |
NC_000014.9 |
14 |
71367843 |
- |
SIPA1L1 |
NNNTGCAGGGGAGTTACCTG |
NGG |
2 |
0.1294 |
Tier II |
11 |
NC_000012.12 |
12 |
25120919 |
+ |
DNAI7 |
NNNTGCATAGGAGTTACCTG |
NGG |
2 |
0.1134 |
Tier II |
12 |
NC_000008.11 |
8 |
39227537 |
+ |
ADAM32 |
NNNTGCATGGGAGCTGACTG |
NGG |
2 |
0.0549 |
Tier II |
13 |
NC_000006.12 |
6 |
143176654 |
- |
AIG1 |
NNNTGCATGGGAGCTAAGTG |
NGG |
2 |
0.0381 |
Tier II |
14 |
NC_000003.12 |
3 |
120662468 |
+ |
HGD |
NNNTGCATGGGAGTCATCTG |
NGG |
2 |
0.0364 |
Tier II |
15 |
NC_000005.10 |
5 |
168109700 |
- |
TENM2 |
NNNTGCATGGGAGTCATCTG |
NGG |
2 |
0.0364 |
Tier II |
16 |
NC_000008.11 |
8 |
28480899 |
+ |
FBXO16 |
NNNTGCATGGGAGTTGACTG |
NGA |
2 |
0.0134 |
Tier II |
17 |
NC_000023.11 |
X |
41657087 |
+ |
CASK |
NNNTGCATGGGAGTGGACTG |
NGG |
2 |
0.0096 |
Tier II |
18 |
NC_000001.11 |
1 |
47882265 |
+ |
TRABD2B |
NNNTGCATGGGACTTCACTG |
NGG |
2 |
0.0 |
Tier II |
19 |
NC_000015.10 |
15 |
77684773 |
- |
LINGO1 |
NNNTGCATGGGAGGTCACTG |
NGG |
2 |
0.0 |
Tier II |
20 |
NC_000005.10 |
5 |
89253780 |
+ |
MEF2C-AS1 |
NNNTGCCTGGGAGATAACTG |
NGG |
2 |
0.2708 |
Tier III |
21 |
NC_000003.12 |
3 |
187491200 |
+ |
LOC124909471 |
NNNTGCATGGGAGTTGAGTG |
NGG |
2 |
0.0256 |
Tier III |
22 |
NC_000001.11 |
1 |
24151759 |
+ |
LOC124903879 |
NNNTGCATGGGAGTAAACTG |
NTG |
2 |
0.0226 |
Tier III |
23 |
NC_000023.11 |
X |
41657087 |
+ |
LOC124905180 |
NNNTGCATGGGAGTGGACTG |
NGG |
2 |
0.0096 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000072.6 |
6 |
12555699 |
- |
Thsd7a |
NNNTGCATGGGAGATGACTG |
NGG |
2 |
0.119 |
Tier I |
2 |
NC_000075.6 |
9 |
76167080 |
- |
Gfral |
NNNTGCATGGCAGTTACCTG |
NGG |
2 |
0.0756 |
Tier I |
3 |
NC_000067.6 |
1 |
134342789 |
- |
Ppfia4 |
NNNTGCAGGGAAGTTAACTG |
NGG |
2 |
0.7333 |
Tier II |
4 |
NC_000078.6 |
12 |
55260914 |
+ |
Srp54c |
NNNTGCATAGGAGTTAAATG |
NGG |
2 |
0.3462 |
Tier II |
5 |
NC_000074.6 |
8 |
102766075 |
- |
Cdh11 |
NNNTGCATGGAAGTTAACTG |
NAG |
2 |
0.2593 |
Tier II |
6 |
NC_000078.6 |
12 |
82627953 |
+ |
Rgs6 |
NNNTGGCTGGGAGTTAACTG |
NGG |
2 |
0.2188 |
Tier II |
7 |
NC_000075.6 |
9 |
21813857 |
+ |
Dock6 |
NNNTGCATGGGAGTTAACAT |
NGG |
2 |
0.2 |
Tier II |
8 |
NC_000076.6 |
10 |
86906640 |
+ |
Stab2 |
NNNTGCTTGGGACTTAACTG |
NGG |
2 |
0.1842 |
Tier II |
9 |
NC_000076.6 |
10 |
122755823 |
- |
Ppm1h |
NNNTGCCTGGGTGTTAACTG |
NGG |
2 |
0.1458 |
Tier II |
10 |
NC_000075.6 |
9 |
101954559 |
+ |
Ephb1 |
NNNTGCATGCGTGTTAACTG |
NGG |
2 |
0.1333 |
Tier II |
11 |
NC_000084.6 |
18 |
65681791 |
+ |
Zfp532 |
NNNTGCTTGGGATTTAACTG |
NGG |
2 |
0.1313 |
Tier II |
12 |
NC_000079.6 |
13 |
59032649 |
+ |
Ntrk2 |
NNNTGCATGGGAGCTATCTG |
NGG |
2 |
0.0381 |
Tier II |
13 |
NC_000084.6 |
18 |
42683525 |
+ |
Ppp2r2b |
NNNTGCATGCGAGTGAACTG |
NGG |
2 |
0.02 |
Tier II |
14 |
NC_000075.6 |
9 |
115116693 |
+ |
Osbpl10 |
NNNTGCATGGAAGTTTACTG |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000075.6 |
9 |
7082388 |
- |
Dync2h1 |
NNNTGCATGGCAGTTTACTG |
NGG |
2 |
0.0 |
Tier II |
16 |
NC_000073.6 |
7 |
100179469 |
+ |
Kcne3 |
NNNTGCATGGGAGGAAACTG |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000083.6 |
17 |
84693957 |
- |
Abcg8 |
NNNTGTATGGGAGTTCACTG |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000073.6 |
7 |
83819421 |
+ |
Gm39043 |
NNNTGCATGGGAGTTGACTG |
NGA |
2 |
0.0134 |
Tier III |
Other clones with same target sequence:
(none)