Construct: sgRNA BRDN0001146944
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCTAAAGTCAGACTACTCTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TEX14 (56155)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76831
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000017.11 |
17 |
58586015 |
+ |
TEX14 |
NNNAAAGTCAGACTACTCTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000009.12 |
9 |
37537670 |
+ |
FBXO10 |
NNNAAAGTCAGAGTCCTCTG |
NGG |
2 |
0.0372 |
Tier I |
3 |
NC_000007.14 |
7 |
102459750 |
+ |
ALKBH4 |
NNNAAAGTCAGACTCCTCTG |
NGC |
2 |
0.0061 |
Tier I |
4 |
NC_000008.11 |
8 |
67199175 |
+ |
ARFGEF1 |
NNNAGAGTCAAACTACTCTG |
NGG |
2 |
0.72 |
Tier II |
5 |
NC_000001.11 |
1 |
111602520 |
+ |
RAP1A |
NNNAGAGTTAGACTACTCTG |
NGG |
2 |
0.63 |
Tier II |
6 |
NC_000001.11 |
1 |
13993811 |
- |
KAZN |
NNNGAAGTCAAACTACTCTG |
NGG |
2 |
0.625 |
Tier II |
7 |
NC_000001.11 |
1 |
239464806 |
+ |
CHRM3 |
NNNAAAGTCTGACTACCCTG |
NGG |
2 |
0.6228 |
Tier II |
8 |
NC_000007.14 |
7 |
86725398 |
- |
GRM3 |
NNNAAAGTCTGACTACCCTG |
NGG |
2 |
0.6228 |
Tier II |
9 |
NC_000010.11 |
10 |
88201463 |
+ |
RNLS |
NNNAAAGTCTGACTACCCTG |
NGG |
2 |
0.6228 |
Tier II |
10 |
NC_000017.11 |
17 |
17097826 |
- |
MPRIP |
NNNAAAGTCAGACAAATCTG |
NGG |
2 |
0.619 |
Tier II |
11 |
NC_000011.10 |
11 |
10145305 |
- |
SBF2 |
NNNGAAGTCTGACTACTCTG |
NGG |
2 |
0.5515 |
Tier II |
12 |
NC_000003.12 |
3 |
130463548 |
+ |
COL6A5 |
NNNAAAGTCAGGCTACTCTC |
NGG |
2 |
0.3095 |
Tier II |
13 |
NC_000013.11 |
13 |
25912735 |
- |
ATP8A2 |
NNNAAAGTAAGACTACTCTG |
NAG |
2 |
0.2222 |
Tier II |
14 |
NC_000023.11 |
X |
11210385 |
- |
ARHGAP6 |
NNNAAAGTCAGACTCCTCTT |
NGG |
2 |
0.1909 |
Tier II |
15 |
NC_000010.11 |
10 |
92208312 |
+ |
CPEB3 |
NNNAAAGTCAGACTCCTTTG |
NGG |
2 |
0.1753 |
Tier II |
16 |
NC_000010.11 |
10 |
71485910 |
- |
CDH23 |
NNNTAAGTCAGACTTCTCTG |
NGG |
2 |
0.1273 |
Tier II |
17 |
NC_000012.12 |
12 |
9052350 |
- |
KLRG1 |
NNNAAAGTCAGACTATGCTG |
NGG |
2 |
0.0362 |
Tier II |
18 |
NC_000020.11 |
20 |
14838404 |
+ |
MACROD2 |
NNNAAAGTCAGACTAATCTG |
NGT |
2 |
0.0161 |
Tier II |
19 |
NC_000003.12 |
3 |
152353118 |
+ |
MBNL1 |
NNNAAAGTCAGAGTACTCTG |
NGA |
2 |
0.0095 |
Tier II |
20 |
NC_000005.10 |
5 |
122455507 |
- |
SNCAIP |
NNNAAAGTCATACTACTCTG |
NGC |
2 |
0.0085 |
Tier II |
21 |
NC_000011.10 |
11 |
132334683 |
- |
NTM |
NNNAAAGTCAGACTACTGTG |
NTG |
2 |
0.0052 |
Tier II |
22 |
NC_000001.11 |
1 |
111602520 |
+ |
LINC01160 |
NNNAGAGTTAGACTACTCTG |
NGG |
2 |
0.63 |
Tier III |
23 |
NC_000010.11 |
10 |
88201463 |
+ |
LOC101929727 |
NNNAAAGTCTGACTACCCTG |
NGG |
2 |
0.6228 |
Tier III |
24 |
NC_000007.14 |
7 |
140927574 |
- |
LOC105375536 |
NNNGAAGTCTGACTACTCTG |
NGG |
2 |
0.5515 |
Tier III |
25 |
NC_000022.11 |
22 |
34212125 |
- |
LINC01643 |
NNNGAAGTCAGACTGCTCTG |
NGG |
2 |
0.4063 |
Tier III |
26 |
NC_000020.11 |
20 |
24315429 |
- |
LOC105372577 |
NNNCAAGTGAGACTACTCTG |
NGG |
2 |
0.2185 |
Tier III |
27 |
NC_000005.10 |
5 |
122455507 |
- |
MGC32805 |
NNNAAAGTCATACTACTCTG |
NGC |
2 |
0.0085 |
Tier III |
28 |
NC_000005.10 |
5 |
122455507 |
- |
LOC107986446 |
NNNAAAGTCATACTACTCTG |
NGC |
2 |
0.0085 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000077.6 |
11 |
29229797 |
+ |
Cfap36 |
NNNAAAATCTGACTACTCTG |
NGG |
2 |
0.8824 |
Tier II |
2 |
NC_000073.6 |
7 |
110823603 |
+ |
Rnf141 |
NNNAGGGTCAGACTACTCTG |
NGG |
2 |
0.5143 |
Tier II |
3 |
NC_000072.6 |
6 |
129658344 |
- |
Klrc2 |
NNNAGAGTCAGATTACTCTG |
NGG |
2 |
0.504 |
Tier II |
4 |
NC_000072.6 |
6 |
129676831 |
- |
Klrc1 |
NNNAGAGTCAGATTACTCTG |
NGG |
2 |
0.504 |
Tier II |
5 |
NC_000068.7 |
2 |
25235612 |
+ |
Rnf224 |
NNNAGAGTCAGACTACTTTG |
NGG |
2 |
0.4629 |
Tier II |
6 |
NC_000081.6 |
15 |
21123468 |
- |
Cdh12 |
NNNAAACTCAGACTGCTCTG |
NGG |
2 |
0.4469 |
Tier II |
7 |
NC_000079.6 |
13 |
117807093 |
+ |
Hcn1 |
NNNAAAGACAGACTACACTG |
NGG |
2 |
0.4267 |
Tier II |
8 |
NC_000082.6 |
16 |
40849443 |
- |
Lsamp |
NNNAAAGTCAAAATACTCTG |
NGG |
2 |
0.3846 |
Tier II |
9 |
NC_000068.7 |
2 |
54656310 |
- |
Galnt13 |
NNNAAAGTGAGACAACTCTG |
NGG |
2 |
0.3832 |
Tier II |
10 |
NC_000081.6 |
15 |
35861170 |
+ |
Vps13b |
NNNAAAGTCACATTACTCTG |
NGG |
2 |
0.3 |
Tier II |
11 |
NC_000080.6 |
14 |
11143462 |
+ |
Fhit |
NNNAAAGTCAGACAACTCTG |
NAG |
2 |
0.1605 |
Tier II |
12 |
NC_000071.6 |
5 |
36248515 |
+ |
Sorcs2 |
NNNAAAGTCACACTACTCAG |
NGG |
2 |
0.1224 |
Tier II |
13 |
NC_000072.6 |
6 |
71615647 |
- |
Kdm3a |
NNNGAAGTCAGACTAGTCTG |
NGG |
2 |
0.0962 |
Tier II |
14 |
NC_000069.6 |
3 |
33120456 |
- |
Pex5l |
NNNAAAGTCAGCCTTCTCTG |
NGG |
2 |
0.0526 |
Tier II |
15 |
NC_000070.6 |
4 |
6815656 |
- |
Tox |
NNNAAAGTCAGAGTTCTCTG |
NGG |
2 |
0.0273 |
Tier II |
16 |
NC_000079.6 |
13 |
94142554 |
- |
Lhfpl2 |
NNNAAAATCAGACTACTCTG |
NGT |
2 |
0.0161 |
Tier II |
17 |
NC_000077.6 |
11 |
94697671 |
+ |
Gm11541 |
NNNGAAGTCAGACTACTCTG |
NGT |
2 |
0.0101 |
Tier II |
18 |
NC_000075.6 |
9 |
7950970 |
- |
Yap1 |
NNNAAAGTCAGACTCCTCTG |
NGC |
2 |
0.0061 |
Tier II |
19 |
NC_000068.7 |
2 |
48346206 |
- |
Gm13481 |
NNNAAAGACAGACTACTCTT |
NGG |
2 |
0.56 |
Tier III |
20 |
NC_000067.6 |
1 |
190195116 |
+ |
Prox1os |
NNNTAAGTCAGGCTACTCTG |
NGG |
2 |
0.4596 |
Tier III |
21 |
NC_000067.6 |
1 |
103340062 |
- |
Gm18728 |
NNNAAAGTCAGACTACTCAA |
NGG |
2 |
0.2679 |
Tier III |
22 |
NC_000069.6 |
3 |
7683601 |
+ |
Gm16685 |
NNNAAAGTCAGAATACTTTG |
NGG |
2 |
0.2473 |
Tier III |
23 |
NC_000068.7 |
2 |
30670551 |
- |
Gm14486 |
NNNAGAGTCAGACCACTCTG |
NGG |
2 |
0.2057 |
Tier III |
Other clones with same target sequence:
(none)