Construct: sgRNA BRDN0001146979
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGCGGATCATATCATCACCA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- PRPS1L1 (221823)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75840
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000007.14 |
7 |
18027407 |
- |
PRPS1L1 |
NNNGGATCATATCATCACCA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000023.11 |
X |
107640972 |
+ |
PRPS1 |
NNNAGATCATATTATCACCA |
NGG |
2 |
0.63 |
Tier I |
3 |
NC_000023.11 |
X |
12809304 |
+ |
PRPS2 |
NNNGGATCACATCATCACCA |
NGG |
1 |
0.5333 |
Tier I |
4 |
NC_000009.12 |
9 |
125151019 |
+ |
PPP6C |
NNNAGATCATATTATCACCA |
NGG |
2 |
0.63 |
Tier II |
5 |
NC_000006.12 |
6 |
158144797 |
- |
SERAC1 |
NNNGCACCATATCATCACCA |
NGG |
2 |
0.5402 |
Tier II |
6 |
NC_000002.12 |
2 |
47572147 |
- |
MSH2 |
NNNCCATCATATCATCACCA |
NGG |
2 |
0.416 |
Tier II |
7 |
NC_000012.12 |
12 |
51512143 |
- |
SLC4A8 |
NNNGCATCATATCATCACTA |
NGG |
2 |
0.3626 |
Tier II |
8 |
NC_000016.10 |
16 |
71532445 |
- |
CHST4 |
NNNGGATCATCTCATCATCA |
NGG |
2 |
0.2571 |
Tier II |
9 |
NC_000016.10 |
16 |
47435096 |
- |
ITFG1 |
NNNGGATCATCTCATCACCT |
NGG |
2 |
0.24 |
Tier II |
10 |
NC_000005.10 |
5 |
10303649 |
+ |
CMBL |
NNNGGATCATCTCTTCACCA |
NGG |
2 |
0.2133 |
Tier II |
11 |
NC_000003.12 |
3 |
167511613 |
+ |
WDR49 |
NNNGGATCAGATCACCACCA |
NGG |
2 |
0.1364 |
Tier II |
12 |
NC_000003.12 |
3 |
39071459 |
+ |
WDR48 |
NNNGGATCATATCATCTCCA |
NGG |
1 |
0.1333 |
Tier II |
13 |
NC_000023.11 |
X |
70774439 |
- |
TEX11 |
NNNAGATCATATCATCAGCA |
NGG |
2 |
0.12 |
Tier II |
14 |
NC_000002.12 |
2 |
72399522 |
- |
EXOC6B |
NNNGAATCATATCATCAGCA |
NGG |
2 |
0.1156 |
Tier II |
15 |
NC_000014.9 |
14 |
61214372 |
+ |
PRKCH |
NNNGGATCATATGATCATCA |
NGG |
2 |
0.0877 |
Tier II |
16 |
NC_000014.9 |
14 |
61209611 |
- |
PRKCH |
NNNGGATCATATGATCACTA |
NGG |
2 |
0.0629 |
Tier II |
17 |
NC_000011.10 |
11 |
85517504 |
- |
DLG2 |
NNNTGATCATATCATCACCA |
NGA |
2 |
0.0253 |
Tier II |
18 |
NC_000003.12 |
3 |
175347607 |
- |
NAALADL2 |
NNNGGATCATATCATCATCA |
NTG |
2 |
0.025 |
Tier II |
19 |
NC_000009.12 |
9 |
125151019 |
+ |
PRPS1P2 |
NNNAGATCATATTATCACCA |
NGG |
2 |
0.63 |
Tier III |
20 |
NC_000006.12 |
6 |
113197446 |
+ |
LOC105377953 |
NNNGGATCAGATCATCACAA |
NGG |
2 |
0.2143 |
Tier III |
21 |
NC_000016.10 |
16 |
72605502 |
- |
LINC01572 |
NNNGGATCATATCATCTCCA |
NGG |
1 |
0.1333 |
Tier III |
22 |
NC_000020.11 |
20 |
17187393 |
- |
LOC105372544 |
NNNGGATCATTTAATCACCA |
NGG |
2 |
0.1183 |
Tier III |
23 |
NC_000001.11 |
1 |
101156203 |
- |
LOC101928334 |
NNNGGGTCATATGATCACCA |
NGG |
2 |
0.0974 |
Tier III |
24 |
NC_000004.12 |
4 |
117337165 |
+ |
LINC02262 |
NNNGGATCATCTCATCACCC |
NGG |
2 |
0.0909 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000078.6 |
12 |
57238802 |
+ |
Prps1l3 |
NNNGGATCATATTATCACCA |
NGG |
1 |
0.7 |
Tier I |
2 |
NC_000086.7 |
X |
140467742 |
+ |
Prps1 |
NNNAGATCATATTATCACCA |
NGG |
2 |
0.63 |
Tier I |
3 |
NC_000077.6 |
11 |
77467820 |
+ |
Coro6 |
NNNGGGTCATATCTTCACCA |
NGG |
2 |
0.381 |
Tier I |
4 |
NC_000082.6 |
16 |
6695593 |
- |
Rbfox1 |
NNNGAAACATATCATCACCA |
NGG |
2 |
0.7583 |
Tier II |
5 |
NC_000078.6 |
12 |
57238802 |
+ |
Mipol1 |
NNNGGATCATATTATCACCA |
NGG |
1 |
0.7 |
Tier II |
6 |
NC_000073.6 |
7 |
16870387 |
- |
Prkd2 |
NNNGGATTATATTATCACCA |
NGG |
2 |
0.6125 |
Tier II |
7 |
NC_000074.6 |
8 |
73183844 |
+ |
Large1 |
NNNGAATGATATCATCACCA |
NGG |
2 |
0.5571 |
Tier II |
8 |
NC_000077.6 |
11 |
105749878 |
- |
Tanc2 |
NNNGGATTATCTCATCACCA |
NGG |
2 |
0.35 |
Tier II |
9 |
NC_000084.6 |
18 |
67422630 |
+ |
Afg3l2 |
NNNGCATCATCTCATCACCA |
NGG |
2 |
0.3143 |
Tier II |
10 |
NC_000086.7 |
X |
51201855 |
+ |
Mbnl3 |
NNNGTATCATATCATAACCA |
NGG |
2 |
0.3 |
Tier II |
11 |
NC_000085.6 |
19 |
4561112 |
- |
Pcx |
NNNGTATAATATCATCACCA |
NGG |
2 |
0.195 |
Tier II |
12 |
NC_000071.6 |
5 |
30127307 |
+ |
Hadha |
NNNGGATCATTTCATCGCCA |
NGG |
2 |
0.0543 |
Tier II |
13 |
NC_000073.6 |
7 |
65997332 |
+ |
Pcsk6 |
NNNGGATCATATCATCTGCA |
NGG |
2 |
0.0178 |
Tier II |
14 |
NC_000078.6 |
12 |
46088644 |
- |
Gm33811 |
NNNGCATCATATCATCATCA |
NGG |
2 |
0.5051 |
Tier III |
15 |
NC_000068.7 |
2 |
180294339 |
+ |
Gm29943 |
NNNGGATCCTAACATCACCA |
NGG |
2 |
0.4571 |
Tier III |
16 |
NC_000081.6 |
15 |
74346578 |
+ |
Gm19859 |
NNNGGATCATATCATCACAT |
NGG |
2 |
0.2571 |
Tier III |
Other clones with same target sequence:
(none)