Construct: sgRNA BRDN0001146999
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCTGAGAGGGTGTAGAACTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- RBKS (64080)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000002.12 | 2 | 27832728 | + | RBKS | NNNGAGAGGGTGTAGAACTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000011.10 | 11 | 65582203 | + | EHBP1L1 | NNNGAGAGGGTGCAGAAGTG | NGG | 2 | 0.1053 | Tier I |
3 | NC_000011.10 | 11 | 78174159 | + | KCTD21 | NNNGAGAGGCTGTAGATCTG | NGG | 2 | 0.0533 | Tier I |
4 | NC_000008.11 | 8 | 11439171 | - | FAM167A | NNNGAAAGGTTGTAGAACTG | NGG | 2 | 0.8125 | Tier II |
5 | NC_000023.11 | X | 84417680 | + | HDX | NNNGAGAAGGTGCAGAACTG | NGG | 2 | 0.7895 | Tier II |
6 | NC_000001.11 | 1 | 17250197 | + | PADI3 | NNNGGGAGGGTGCAGAACTG | NGG | 2 | 0.5684 | Tier II |
7 | NC_000008.11 | 8 | 65722284 | - | PDE7A | NNNAAGAGCGTGTAGAACTG | NGG | 2 | 0.4846 | Tier II |
8 | NC_000008.11 | 8 | 65722284 | - | MTFR1 | NNNAAGAGCGTGTAGAACTG | NGG | 2 | 0.4846 | Tier II |
9 | NC_000007.14 | 7 | 28600013 | + | CREB5 | NNNGAGAGGGTGAAGAACTC | NGG | 2 | 0.2967 | Tier II |
10 | NC_000007.14 | 7 | 28349731 | + | CREB5 | NNNGAGAGGATGTACAACTG | NGG | 2 | 0.2545 | Tier II |
11 | NC_000003.12 | 3 | 121988992 | + | ILDR1 | NNNGTGAGGGTGAAGAACTG | NGG | 2 | 0.2517 | Tier II |
12 | NC_000006.12 | 6 | 127518753 | - | MTCL3 | NNNGAGTGGGTGTGGAACTG | NGG | 2 | 0.2042 | Tier II |
13 | NC_000003.12 | 3 | 165024655 | - | SI | NNNGAGAGGGTGGAGAATTG | NGG | 2 | 0.1677 | Tier II |
14 | NC_000019.10 | 19 | 58573193 | - | MZF1 | NNNGAGAGGGTGTAGAAACG | NGG | 2 | 0.1485 | Tier II |
15 | NC_000004.12 | 4 | 47355848 | + | GABRB1 | NNNGAGAGGCTGTAGAACAG | NGG | 2 | 0.1143 | Tier II |
16 | NC_000022.11 | 22 | 38831744 | - | NPTXR | NNNGAGCGGGTGGAGAACTG | NGG | 2 | 0.1141 | Tier II |
17 | NC_000002.12 | 2 | 201300777 | - | FLACC1 | NNNGAGAGGCTGTAGAACTG | NAG | 2 | 0.1037 | Tier II |
18 | NC_000015.10 | 15 | 87971825 | - | NTRK3 | NNNGAGAGGGTGTGGAGCTG | NGG | 2 | 0.0824 | Tier II |
19 | NC_000007.14 | 7 | 18639274 | + | HDAC9 | NNNGAGTGGGTGTAGAGCTG | NGG | 2 | 0.0772 | Tier II |
20 | NC_000002.12 | 2 | 118983462 | - | MARCO | NNNGAGAGGGTGTAAAACTG | NGC | 2 | 0.0209 | Tier II |
21 | NC_000017.11 | 17 | 17715063 | + | RAI1 | NNNGAGAGGGTGTAGAACTG | NCC | 2 | 0.0 | Tier II |
22 | NC_000012.12 | 12 | 63320168 | + | LINC03056 | NNNGAGAAGGTGTAGAAATG | NGG | 2 | 0.5385 | Tier III |
23 | NC_000007.14 | 7 | 69291621 | - | LOC105375345 | NNNGAGAGGGAGTAGAATTG | NGG | 2 | 0.4821 | Tier III |
24 | NC_000022.11 | 22 | 24475028 | - | ADORA2A-AS1 | NNNGAGAGAGTGTAGAACTC | NGG | 2 | 0.2755 | Tier III |
25 | NC_000003.12 | 3 | 121988992 | + | LOC101927010 | NNNGTGAGGGTGAAGAACTG | NGG | 2 | 0.2517 | Tier III |
26 | NC_000006.12 | 6 | 119611804 | + | LOC105377975 | NNNCAGAGGCTGTAGAACTG | NGG | 2 | 0.2118 | Tier III |
27 | NC_000006.12 | 6 | 127518753 | - | SOGA3-KIAA0408 | NNNGAGTGGGTGTGGAACTG | NGG | 2 | 0.2042 | Tier III |
28 | NC_000019.10 | 19 | 58573193 | - | MZF1-AS1 | NNNGAGAGGGTGTAGAAACG | NGG | 2 | 0.1485 | Tier III |
29 | NC_000004.12 | 4 | 14751326 | + | LINC00504 | NNNGAGAGTGTGTAGAACTG | NAG | 2 | 0.1383 | Tier III |
30 | NC_000002.12 | 2 | 237053793 | - | LOC93463 | NNNGAGAGGGTTGAGAACTG | NGG | 2 | 0.1003 | Tier III |
31 | NC_000002.12 | 2 | 237053793 | - | LOC105373950 | NNNGAGAGGGTTGAGAACTG | NGG | 2 | 0.1003 | Tier III |
32 | NC_000002.12 | 2 | 237053793 | - | COPS8-DT | NNNGAGAGGGTTGAGAACTG | NGG | 2 | 0.1003 | Tier III |
33 | NC_000017.11 | 17 | 17715063 | + | LOC124903943 | NNNGAGAGGGTGTAGAACTG | NCC | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000071.6 | 5 | 31651851 | + | Rbks | NNNGAGAGGGTATAGAACTG | NGG | 1 | 0.9333 | Tier I |
2 | NC_000083.6 | 17 | 25845885 | - | Wdr90 | NNNTAGAGGGTGTAGAACTG | NGG | 1 | 0.3636 | Tier I |
3 | NC_000082.6 | 16 | 45825747 | + | Phldb2 | NNNGAGAGGCTGCAGAACTG | NGG | 2 | 0.3158 | Tier I |
4 | NC_000068.7 | 2 | 180177792 | + | Lama5 | NNNGAGAGGGTGTAGGGCTG | NGG | 2 | 0.0339 | Tier I |
5 | NC_000068.7 | 2 | 76935361 | + | Ttn | NNNGAGTAGGTGTAGAACTG | NGG | 2 | 0.4375 | Tier II |
6 | NC_000081.6 | 15 | 87568930 | + | Tafa5 | NNNGGGAGGGTCTAGAACTG | NGG | 2 | 0.3812 | Tier II |
7 | NC_000075.6 | 9 | 72706883 | + | Nedd4 | NNNCAGAGAGTGTAGAACTG | NGG | 2 | 0.3403 | Tier II |
8 | NC_000067.6 | 1 | 163988824 | + | BC055324 | NNNGAGAGGGTGAAGAACTC | NGG | 2 | 0.2967 | Tier II |
9 | NC_000081.6 | 15 | 96160294 | + | Gm38469 | NNNGAGAAGGTGTACAACTG | NGG | 2 | 0.2727 | Tier II |
10 | NC_000077.6 | 11 | 80077592 | + | Crlf3 | NNNGAGAGGGTGTAGAACTG | NAG | 1 | 0.2593 | Tier II |
11 | NC_000070.6 | 4 | 46680509 | - | Gabbr2 | NNNGTGAGGGTGAAGAACTG | NGG | 2 | 0.2517 | Tier II |
12 | NC_000077.6 | 11 | 35907543 | - | Wwc1 | NNNGAGAGGGTGTGGAAATG | NGG | 2 | 0.2513 | Tier II |
13 | NC_000068.7 | 2 | 168483652 | + | Nfatc2 | NNNGTGAGTGTGTAGAACTG | NGG | 2 | 0.1939 | Tier II |
14 | NC_000072.6 | 6 | 52177845 | - | Hoxa3 | NNNGAGAGGCTGTGGAACTG | NGG | 2 | 0.1867 | Tier II |
15 | NC_000085.6 | 19 | 5150445 | - | Pacs1 | NNNGTGTGGGTGTAGAACTG | NGG | 2 | 0.1591 | Tier II |
16 | NC_000068.7 | 2 | 121550136 | - | Frmd5 | NNNGAGAGGGTGGAGAAATG | NGG | 2 | 0.1405 | Tier II |
17 | NC_000072.6 | 6 | 90311738 | + | Chst13 | NNNGAGAGGGTGAAGAGCTG | NGG | 2 | 0.1222 | Tier II |
18 | NC_000070.6 | 4 | 43145313 | - | Unc13b | NNNAAGAGGGTGTAGATCTG | NGG | 2 | 0.12 | Tier II |
19 | NC_000075.6 | 9 | 107446439 | - | Cacna2d2 | NNNGAGAGGCTGGAGAACTG | NGG | 2 | 0.1043 | Tier II |
20 | NC_000085.6 | 19 | 55863463 | - | Tcf7l2 | NNNGAGGGGGTGTAGAAGTG | NGG | 2 | 0.0941 | Tier II |
21 | NC_000073.6 | 7 | 130695393 | + | Tacc2 | NNNGAGAGGGTGAAGATCTG | NGG | 2 | 0.0923 | Tier II |
22 | NC_000071.6 | 5 | 151212258 | + | Stard13 | NNNGAGAGGGGGTAGGACTG | NGG | 2 | 0.0769 | Tier II |
23 | NC_000075.6 | 9 | 109942131 | + | Map4 | NNNGAGAGGGGGTAGATCTG | NGG | 2 | 0.0533 | Tier II |
24 | NC_000082.6 | 16 | 12738452 | - | LOC108167340 | NNNCAGAGGGTGTAGAACTG | NGA | 2 | 0.0368 | Tier II |
25 | NC_000080.6 | 14 | 59678046 | - | Atp8a2 | NNNGAGAGGGTGTAGAAGTG | NCG | 2 | 0.0143 | Tier II |
26 | NC_000076.6 | 10 | 101762612 | - | Mgat4c | NNNGAGAGGGAGTAGTACTG | NGG | 2 | 0.0 | Tier II |
27 | NC_000071.6 | 5 | 31651851 | + | Gm38424 | NNNGAGAGGGTATAGAACTG | NGG | 1 | 0.9333 | Tier III |
28 | NC_000082.6 | 16 | 31528235 | - | Gm34032 | NNNGAGATGGTGTTGAACTG | NGG | 2 | 0.3333 | Tier III |
29 | NC_000072.6 | 6 | 52177845 | - | 5730596B20Rik | NNNGAGAGGCTGTGGAACTG | NGG | 2 | 0.1867 | Tier III |
30 | NC_000072.6 | 6 | 52177845 | - | LOC115490409 | NNNGAGAGGCTGTGGAACTG | NGG | 2 | 0.1867 | Tier III |
31 | NC_000073.6 | 7 | 101549145 | - | Gm19765 | NNNGAGAGGATGTAGATCTG | NGG | 2 | 0.1244 | Tier III |
32 | NC_000070.6 | 4 | 111704408 | + | Gm33192 | NNNAAGAGGGTGTAGATCTG | NGG | 2 | 0.12 | Tier III |