Construct: sgRNA BRDN0001147014
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTTTCAAGAAGCCCCCATTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CDK17 (5128)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76787
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000012.12 |
12 |
96324024 |
- |
CDK17 |
NNNTCAAGAAGCCCCCATTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000001.11 |
1 |
167125923 |
- |
STYXL2 |
NNNTCAGGAAGCCCTCATTG |
NGG |
2 |
0.0471 |
Tier I |
3 |
NC_000002.12 |
2 |
178597667 |
- |
TTN |
NNNTCAAGAAGCCACCATTG |
NGA |
2 |
0.0243 |
Tier I |
4 |
NC_000005.10 |
5 |
52899899 |
- |
ITGA1 |
NNNTCAAGAAGCCTCAATTG |
NGG |
2 |
0.7333 |
Tier II |
5 |
NC_000009.12 |
9 |
84918341 |
- |
NTRK2 |
NNNCAAAGAAGCCCCCATTG |
NGG |
2 |
0.3697 |
Tier II |
6 |
NC_000006.12 |
6 |
25577873 |
- |
CARMIL1 |
NNNTCAATAAGTCCCCATTG |
NGG |
2 |
0.3365 |
Tier II |
7 |
NC_000011.10 |
11 |
118081001 |
- |
TMPRSS4 |
NNNTCAAGAAGCTCCCATTC |
NGG |
2 |
0.3 |
Tier II |
8 |
NC_000011.10 |
11 |
118081001 |
- |
SMIM35 |
NNNTCAAGAAGCTCCCATTC |
NGG |
2 |
0.3 |
Tier II |
9 |
NC_000002.12 |
2 |
25129796 |
- |
EFR3B |
NNNTAAAGAAGCCCCCACTG |
NGG |
2 |
0.2449 |
Tier II |
10 |
NC_000012.12 |
12 |
11838970 |
+ |
ETV6 |
NNNTCGAGAAGCCCCCAGTG |
NGG |
2 |
0.2381 |
Tier II |
11 |
NC_000002.12 |
2 |
31202764 |
+ |
CAPN14 |
NNNTCAAGAAGGACCCATTG |
NGG |
2 |
0.1709 |
Tier II |
12 |
NC_000019.10 |
19 |
21084487 |
- |
ZNF714 |
NNNTCAAGAAGCACCCATTC |
NGG |
2 |
0.1648 |
Tier II |
13 |
NC_000008.11 |
8 |
27512464 |
+ |
EPHX2 |
NNNTCAAGGAGCCCACATTG |
NGG |
2 |
0.1481 |
Tier II |
14 |
NC_000004.12 |
4 |
76512494 |
- |
SHROOM3 |
NNNTGAAGAAGCCCACATTG |
NGG |
2 |
0.1333 |
Tier II |
15 |
NC_000004.12 |
4 |
113114166 |
- |
ANK2 |
NNNTCAAAAAGCCCTCATTG |
NGG |
2 |
0.0667 |
Tier II |
16 |
NC_000010.11 |
10 |
67035022 |
+ |
CTNNA3 |
NNNTCAAGAAGCCCTTATTG |
NGG |
2 |
0.0205 |
Tier II |
17 |
NC_000010.11 |
10 |
67035022 |
+ |
LRRTM3 |
NNNTCAAGAAGCCCTTATTG |
NGG |
2 |
0.0205 |
Tier II |
18 |
NC_000003.12 |
3 |
128745926 |
- |
RAB7A |
NNNTCAAGAAGCCCACATTG |
NTG |
2 |
0.0087 |
Tier II |
19 |
NC_000002.12 |
2 |
43691960 |
+ |
PLEKHH2 |
NNNTCAAGAAGCCCTCATTG |
NGT |
2 |
0.0011 |
Tier II |
20 |
NC_000001.11 |
1 |
81680937 |
- |
ADGRL2 |
NNNTCAAGAAGCTGCCATTG |
NGG |
2 |
0.0 |
Tier II |
21 |
NC_000008.11 |
8 |
12390886 |
- |
FAM66A |
NNNTCATGAGGCCCCCATTG |
NGG |
2 |
0.2431 |
Tier III |
22 |
NC_000022.11 |
22 |
24423231 |
- |
SPECC1L-ADORA2A |
NNNTTAAGAAGCCCCCATTG |
NCG |
2 |
0.0682 |
Tier III |
23 |
NC_000002.12 |
2 |
178597667 |
- |
TTN-AS1 |
NNNTCAAGAAGCCACCATTG |
NGA |
2 |
0.0243 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000076.6 |
10 |
93212000 |
+ |
Cdk17 |
NNNTCAAGAAGCCCCCGTTG |
NGG |
1 |
0.1765 |
Tier I |
2 |
NC_000074.6 |
8 |
31096325 |
- |
Dusp26 |
NNNTCAAGAAGCCCCGGTTG |
NGG |
2 |
0.0271 |
Tier I |
3 |
NC_000078.6 |
12 |
75927396 |
- |
Syne2 |
NNNTCAAGAAGCCCCCTTTG |
NGT |
2 |
0.0022 |
Tier I |
4 |
NC_000086.7 |
X |
99067352 |
- |
Stard8 |
NNNTCAAGAAGCTCCCATGG |
NGG |
2 |
0.175 |
Tier II |
5 |
NC_000067.6 |
1 |
191180134 |
+ |
Atf3 |
NNNTTAAGAAGCCCCCATGG |
NGG |
2 |
0.1591 |
Tier II |
6 |
NC_000083.6 |
17 |
84219478 |
- |
Thada |
NNNACAAGAAGCCCCCTTTG |
NGG |
2 |
0.0635 |
Tier II |
7 |
NC_000068.7 |
2 |
14273720 |
+ |
Mrc1 |
NNNACAAGAAGCCCTCATTG |
NGG |
2 |
0.0317 |
Tier II |
8 |
NC_000075.6 |
9 |
18533709 |
+ |
Muc16 |
NNNTCAATAAGCCCCCATTG |
NTG |
2 |
0.0244 |
Tier II |
9 |
NC_000068.7 |
2 |
3220727 |
- |
Fam171a1 |
NNNTCAAGAAGCCCCCAGTG |
NTG |
2 |
0.013 |
Tier II |
10 |
NC_000073.6 |
7 |
118406669 |
+ |
Syt17 |
NNNTCAAGAAGCCCCCAGTG |
NTG |
2 |
0.013 |
Tier II |
11 |
NC_000080.6 |
14 |
53875906 |
- |
Tcra |
NNNTCAAGAAGCCTCCTTTG |
NGG |
2 |
0.0978 |
Tier III |
12 |
NC_000082.6 |
16 |
29834262 |
+ |
Gm32679 |
NNNTGAAGAAGCCCCCTTTG |
NGG |
2 |
0.08 |
Tier III |
13 |
NC_000084.6 |
18 |
62865396 |
+ |
Gm41752 |
NNNTCAAGAAGCCAACATTG |
NGG |
2 |
0.0778 |
Tier III |
14 |
NC_000069.6 |
3 |
50014487 |
- |
Gm40042 |
NNNTCATGAAGCCCCCATTG |
NTG |
2 |
0.017 |
Tier III |
15 |
NC_000077.6 |
11 |
34032085 |
+ |
4930469K13Rik |
NNNCCAAGAAGCCCCCATTG |
NGC |
2 |
0.0144 |
Tier III |
16 |
NC_000067.6 |
1 |
76016608 |
+ |
Gm32622 |
NNNTCAAGAAGCCCCCATTT |
NGT |
2 |
0.0113 |
Tier III |
17 |
NC_000067.6 |
1 |
76016608 |
+ |
Gm29065 |
NNNTCAAGAAGCCCCCATTT |
NGT |
2 |
0.0113 |
Tier III |
Other clones with same target sequence:
(none)