Construct: sgRNA BRDN0001147091
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCTATGTTGCTGGTTAACAT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- PANK1 (53354)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76558
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000010.11 |
10 |
89599321 |
- |
PANK1 |
NNNATGTTGCTGGTTAACAT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000014.9 |
14 |
23273296 |
- |
HOMEZ |
NNNATATTGCTCGTTAACAT |
NGG |
2 |
0.5294 |
Tier II |
3 |
NC_000014.9 |
14 |
23273296 |
- |
RNF212B |
NNNATATTGCTCGTTAACAT |
NGG |
2 |
0.5294 |
Tier II |
4 |
NC_000002.12 |
2 |
69207015 |
- |
ANTXR1 |
NNNATGTTGCTGGATAAAAT |
NGG |
2 |
0.3333 |
Tier II |
5 |
NC_000010.11 |
10 |
69935547 |
- |
COL13A1 |
NNNATGGTGCTGTTTAACAT |
NGG |
2 |
0.1765 |
Tier II |
6 |
NC_000017.11 |
17 |
30469509 |
- |
CPD |
NNNATGATGCTGGTTACCAT |
NGG |
2 |
0.1544 |
Tier II |
7 |
NC_000007.14 |
7 |
96308188 |
- |
SLC25A13 |
NNNATGCTGCTGGTTAACAG |
NGG |
2 |
0.1213 |
Tier II |
8 |
NC_000001.11 |
1 |
237185871 |
- |
RYR2 |
NNNATGTTGCTGTTTAACCT |
NGG |
2 |
0.0621 |
Tier II |
9 |
NC_000018.10 |
18 |
50577558 |
- |
MAPK4 |
NNNATTTTGCTGGTTAACAC |
NGG |
2 |
0.0606 |
Tier II |
10 |
NC_000001.11 |
1 |
42497415 |
- |
CCDC30 |
NNNATGTTGCTGTTTAGCAT |
NGG |
2 |
0.0529 |
Tier II |
11 |
NC_000004.12 |
4 |
118060889 |
+ |
NDST3 |
NNNATGTTGCTGTTTAACAC |
NGG |
2 |
0.0273 |
Tier II |
12 |
NC_000002.12 |
2 |
69546825 |
+ |
AAK1 |
NNNATGTTACTGGTTAACAT |
NTG |
2 |
0.025 |
Tier II |
13 |
NC_000010.11 |
10 |
20090329 |
- |
PLXDC2 |
NNNATGTTGCTGGTGAACAT |
NAG |
2 |
0.013 |
Tier II |
14 |
NC_000006.12 |
6 |
34610217 |
- |
ILRUN |
NNNATGTTGCTAGTTTACAT |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000002.12 |
2 |
69207015 |
- |
LOC124906019 |
NNNATGTTGCTGGATAAAAT |
NGG |
2 |
0.3333 |
Tier III |
16 |
NC_000004.12 |
4 |
118060889 |
+ |
LOC107986307 |
NNNATGTTGCTGTTTAACAC |
NGG |
2 |
0.0273 |
Tier III |
17 |
NC_000002.12 |
2 |
68337525 |
- |
LOC102724389 |
NNNATGTTGCTGGTTAAAAT |
NTG |
2 |
0.021 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000085.6 |
19 |
34827189 |
- |
Pank1 |
NNNATGTTGCTGGTTAACAT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000081.6 |
15 |
58796741 |
- |
Tmem65 |
NNNATATTGCAGGTTAACAT |
NGG |
2 |
0.75 |
Tier II |
3 |
NC_000070.6 |
4 |
134258771 |
- |
Grrp1 |
NNNACGTTGCTGGTTAATAT |
NGG |
2 |
0.6429 |
Tier II |
4 |
NC_000083.6 |
17 |
74786164 |
+ |
Ttc27 |
NNNATTTTACTGGTTAACAT |
NGG |
2 |
0.4286 |
Tier II |
5 |
NC_000075.6 |
9 |
110587865 |
+ |
Setd2 |
NNNATCTTGCTGGTTAACAA |
NGG |
2 |
0.3835 |
Tier II |
6 |
NC_000069.6 |
3 |
76375043 |
+ |
Fstl5 |
NNNATGTTACTGGTTAAAAT |
NGG |
2 |
0.3462 |
Tier II |
7 |
NC_000084.6 |
18 |
67883713 |
+ |
Cep192 |
NNNATGTTGCTCTTTAACAT |
NGG |
2 |
0.1588 |
Tier II |
8 |
NC_000068.7 |
2 |
132290192 |
- |
Cds2 |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier II |
9 |
NC_000083.6 |
17 |
24425738 |
+ |
Rnps1 |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier II |
10 |
NC_000086.7 |
X |
157944430 |
+ |
Cnksr2 |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier II |
11 |
NC_000067.6 |
1 |
34467759 |
- |
Ptpn18 |
NNNATGTGGCTGGTTACCAT |
NGG |
2 |
0.1294 |
Tier II |
12 |
NC_000083.6 |
17 |
8628159 |
+ |
Pde10a |
NNNATTTTGCTGGTTGACAT |
NGG |
2 |
0.1282 |
Tier II |
13 |
NC_000082.6 |
16 |
63682113 |
- |
Epha3 |
NNNATTTTGCTGGTTAACAG |
NGG |
2 |
0.1176 |
Tier II |
14 |
NC_000071.6 |
5 |
127898394 |
- |
Tmem132d |
NNNATGATGCTGGTTAAGAT |
NGG |
2 |
0.1167 |
Tier II |
15 |
NC_000072.6 |
6 |
71822056 |
+ |
Mrpl35 |
NNNATGTTCCTGGTTAACCT |
NGG |
2 |
0.1114 |
Tier II |
16 |
NC_000078.6 |
12 |
89910231 |
- |
Nrxn3 |
NNNATGTTGCTGGTTAAAAC |
NGG |
2 |
0.049 |
Tier II |
17 |
NC_000074.6 |
8 |
9277201 |
+ |
Fam155a |
NNNATGTTGCTGGTCATCAT |
NGG |
2 |
0.0364 |
Tier II |
18 |
NC_000082.6 |
16 |
40308169 |
+ |
Lsamp |
NNNATGTTGCTGTTTAACAT |
NGT |
2 |
0.0048 |
Tier II |
19 |
NC_000083.6 |
17 |
7072487 |
+ |
Gm1604b |
NNNATGTTGCTGGGTTACAT |
NGG |
2 |
0.0 |
Tier II |
20 |
NC_000070.6 |
4 |
134258771 |
- |
Gm42325 |
NNNACGTTGCTGGTTAATAT |
NGG |
2 |
0.6429 |
Tier III |
21 |
NC_000081.6 |
15 |
66299591 |
+ |
Gm27242 |
NNNCTGTAGCTGGTTAACAT |
NGG |
2 |
0.2824 |
Tier III |
22 |
NC_000069.6 |
3 |
122221851 |
+ |
Gm46822 |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier III |
23 |
NC_000072.6 |
6 |
7981986 |
- |
Rnps1-ps |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier III |
24 |
NC_000072.6 |
6 |
7981986 |
- |
Gm35446 |
NNNATGTTGCAGGTTAACCT |
NGG |
2 |
0.1552 |
Tier III |
25 |
NC_000072.6 |
6 |
132258012 |
+ |
Gm43979 |
NNNATGTTTCTGGTTAACAT |
NCG |
2 |
0.0571 |
Tier III |
26 |
NC_000072.6 |
6 |
132292556 |
- |
Gm43979 |
NNNATGTTTCTGGTTAACAT |
NCG |
2 |
0.0571 |
Tier III |
27 |
NC_000083.6 |
17 |
8053650 |
- |
Gm1604a |
NNNATGTTGCTGGGTTACAT |
NGG |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)