Construct: sgRNA BRDN0001147158
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCCCTCCAGTCACGGCACTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- FLT4 (2324)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75629
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000005.10 |
5 |
180624028 |
+ |
FLT4 |
NNNCTCCAGTCACGGCACTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000009.12 |
9 |
127575110 |
+ |
NIBAN2 |
NNNCTCCAGACATGGCACTG |
NGG |
2 |
0.6 |
Tier II |
3 |
NC_000023.11 |
X |
119006350 |
+ |
LONRF3 |
NNNCCCCAGCCACGGCACTG |
NGG |
2 |
0.5333 |
Tier II |
4 |
NC_000011.10 |
11 |
1854594 |
- |
LSP1 |
NNNCTCCACTCACGGCACTC |
NGG |
2 |
0.2308 |
Tier II |
5 |
NC_000015.10 |
15 |
68406700 |
- |
ITGA11 |
NNNCTCCATTCAAGGCACTG |
NGG |
2 |
0.2051 |
Tier II |
6 |
NC_000015.10 |
15 |
32072716 |
+ |
CHRNA7 |
NNNCTCCAGTCATGGCACAG |
NGG |
2 |
0.2 |
Tier II |
7 |
NC_000016.10 |
16 |
87858506 |
+ |
SLC7A5 |
NNNCTCCAGTCACGGTATTG |
NGG |
2 |
0.1978 |
Tier II |
8 |
NC_000012.12 |
12 |
103817962 |
+ |
NT5DC3 |
NNNCTCCAGTCAGGGCACTG |
NGG |
1 |
0.1364 |
Tier II |
9 |
NC_000002.12 |
2 |
127367520 |
+ |
MAP3K2 |
NNNCTCCAGGCAGGGCACTG |
NGG |
2 |
0.0682 |
Tier II |
10 |
NC_000006.12 |
6 |
160487109 |
+ |
LPAL2 |
NNNCCCCAGACACGGCACTG |
NGG |
2 |
0.8571 |
Tier III |
11 |
NC_000010.11 |
10 |
3421113 |
- |
LOC105376360 |
NNNCTCCAGGCACAGCACTG |
NGG |
2 |
0.375 |
Tier III |
12 |
NC_000016.10 |
16 |
29602670 |
+ |
SMG1P2 |
NNNCTCCAGTCACGGTATTG |
NGG |
2 |
0.1978 |
Tier III |
13 |
NC_000016.10 |
16 |
29602670 |
+ |
LOC105371168 |
NNNCTCCAGTCACGGTATTG |
NGG |
2 |
0.1978 |
Tier III |
14 |
NC_000002.12 |
2 |
127367520 |
+ |
LOC124906074 |
NNNCTCCAGGCAGGGCACTG |
NGG |
2 |
0.0682 |
Tier III |
15 |
NC_000017.11 |
17 |
76950600 |
- |
LOC105371899 |
NNNCTGCAGTCACGGCTCTG |
NGG |
2 |
0.0667 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000077.6 |
11 |
49632013 |
- |
Flt4 |
NNNTTCCAGTCTCGGCACTG |
NGG |
2 |
0.2667 |
Tier I |
2 |
NC_000068.7 |
2 |
24623987 |
+ |
Cacna1b |
NNNCTCCAGACACGGCACTG |
NGG |
1 |
0.8571 |
Tier II |
3 |
NC_000077.6 |
11 |
76524817 |
- |
Abr |
NNNCTCCAGTCATGGAACTG |
NGG |
2 |
0.7 |
Tier II |
4 |
NC_000074.6 |
8 |
117733837 |
+ |
Hsd17b2 |
NNNCTACAGTCACAGCACTG |
NGG |
2 |
0.6964 |
Tier II |
5 |
NC_000079.6 |
13 |
100100361 |
+ |
Bdp1 |
NNNCTCTAGTCACAGCACTG |
NGG |
2 |
0.6094 |
Tier II |
6 |
NC_000072.6 |
6 |
120874482 |
+ |
Bcl2l13 |
NNNCTCCAGGCACAGCACTG |
NGG |
2 |
0.375 |
Tier II |
7 |
NC_000086.7 |
X |
73523942 |
+ |
Atp2b3 |
NNNCTGCAGTCGCGGCACTG |
NGG |
2 |
0.3611 |
Tier II |
8 |
NC_000067.6 |
1 |
38821931 |
+ |
Lonrf2 |
NNNCTGCAGTCATGGCACTG |
NGG |
2 |
0.35 |
Tier II |
9 |
NC_000077.6 |
11 |
108115691 |
+ |
Prkca |
NNNCTCCAGTCACAGCACTC |
NGG |
2 |
0.3214 |
Tier II |
10 |
NC_000076.6 |
10 |
94189640 |
- |
Nr2c1 |
NNNCTCCAATCACCGCACTG |
NGG |
2 |
0.2755 |
Tier II |
11 |
NC_000081.6 |
15 |
99795311 |
+ |
Lima1 |
NNNCTCCAGTCCCAGCACTG |
NGG |
2 |
0.1974 |
Tier II |
12 |
NC_000081.6 |
15 |
31232557 |
+ |
Dap |
NNNCTCCAGACACGGCCCTG |
NGG |
2 |
0.1513 |
Tier II |
13 |
NC_000072.6 |
6 |
86394619 |
+ |
Pcyox1 |
NNNCTCCAGACACGGCTCTG |
NGG |
2 |
0.1143 |
Tier II |
14 |
NC_000072.6 |
6 |
136697768 |
+ |
Gucy2c |
NNNTTCCAGTCAGGGCACTG |
NGG |
2 |
0.1091 |
Tier II |
15 |
NC_000074.6 |
8 |
13624207 |
- |
Rasa3 |
NNNCTCCAGGCAGGGCACTG |
NGG |
2 |
0.0682 |
Tier II |
16 |
NC_000068.7 |
2 |
9915909 |
- |
Taf3 |
NNNCTCCAGTCACAGCACTG |
NGA |
2 |
0.0521 |
Tier II |
17 |
NC_000068.7 |
2 |
157447236 |
- |
Src |
NNNCTCCAGTCAGGGCAGTG |
NGG |
2 |
0.0182 |
Tier II |
18 |
NC_000080.6 |
14 |
44954173 |
+ |
Gm16976 |
NNNCCCCAGTCACGGAACTG |
NGG |
2 |
1.0 |
Tier III |
19 |
NC_000080.6 |
14 |
44954173 |
+ |
Gm41142 |
NNNCCCCAGTCACGGAACTG |
NGG |
2 |
1.0 |
Tier III |
20 |
NC_000075.6 |
9 |
7682214 |
- |
AV064505 |
NNNCTCCGGTCACGGCACTG |
NGG |
1 |
0.7333 |
Tier III |
21 |
NC_000077.6 |
11 |
108115691 |
+ |
Gm51922 |
NNNCTCCAGTCACAGCACTC |
NGG |
2 |
0.3214 |
Tier III |
22 |
NC_000069.6 |
3 |
40426924 |
+ |
Gm30184 |
NNNCCCCAGTCACTGCACTG |
NGG |
2 |
0.2667 |
Tier III |
23 |
NC_000068.7 |
2 |
130903480 |
- |
A730017L22Rik |
NNNCTCCAGTCCCAGCACTG |
NGG |
2 |
0.1974 |
Tier III |
24 |
NC_000074.6 |
8 |
87167009 |
- |
Gm27246 |
NNNCTCCAGTGACAGCACTG |
NGG |
2 |
0.1875 |
Tier III |
25 |
NC_000077.6 |
11 |
71565442 |
- |
9230020A06Rik |
NNNCTCCAGTCACTGCAATG |
NGG |
2 |
0.1436 |
Tier III |
26 |
NC_000077.6 |
11 |
71565442 |
- |
Gm33351 |
NNNCTCCAGTCACTGCAATG |
NGG |
2 |
0.1436 |
Tier III |
27 |
NC_000075.6 |
9 |
64774584 |
+ |
Gm36365 |
NNNCTCCAGTCACGGGGCTG |
NGG |
2 |
0.0271 |
Tier III |
Other clones with same target sequence:
(none)