Construct: sgRNA BRDN0001147180
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CAGCCAACTCAGGTAAACAC
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- STK17B (9262)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76799
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000002.12 |
2 |
196146026 |
+ |
STK17B |
NNNCCAACTCAGGTAAACAC |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000012.12 |
12 |
40528313 |
+ |
MUC19 |
NNNCCAACTCAGGTAAGCAC |
NGA |
2 |
0.0123 |
Tier I |
3 |
NC_000011.10 |
11 |
83248050 |
+ |
ANKRD42 |
NNNTCAACTCAGGGAAACAC |
NGG |
2 |
0.0 |
Tier I |
4 |
NC_000004.12 |
4 |
75980668 |
+ |
SDAD1 |
NNNCCAACACAGGAAAACAC |
NGG |
2 |
0.5748 |
Tier II |
5 |
NC_000015.10 |
15 |
81103677 |
- |
CFAP161 |
NNNAGAACTCAGGTAAACAC |
NGG |
2 |
0.5053 |
Tier II |
6 |
NC_000001.11 |
1 |
64953481 |
+ |
JAK1 |
NNNCCCACACAGGTAAACAC |
NGG |
2 |
0.4221 |
Tier II |
7 |
NC_000014.9 |
14 |
50631821 |
+ |
ATL1 |
NNNCCCACTCAGGAAAACAC |
NGG |
2 |
0.2814 |
Tier II |
8 |
NC_000006.12 |
6 |
45534671 |
+ |
RUNX2 |
NNNCCCTCTCAGGTAAACAC |
NGG |
2 |
0.1989 |
Tier II |
9 |
NC_000001.11 |
1 |
245696130 |
- |
KIF26B |
NNNCCAACTCTGGTAAATAC |
NGG |
2 |
0.1978 |
Tier II |
10 |
NC_000015.10 |
15 |
38548877 |
+ |
RASGRP1 |
NNNCCATCTCAGGTAGACAC |
NGG |
2 |
0.0841 |
Tier II |
11 |
NC_000003.12 |
3 |
159470970 |
- |
SCHIP1 |
NNNCCAACTCAGGCAACCAC |
NGG |
2 |
0.0504 |
Tier II |
12 |
NC_000003.12 |
3 |
159470970 |
- |
IQCJ-SCHIP1 |
NNNCCAACTCAGGCAACCAC |
NGG |
2 |
0.0504 |
Tier II |
13 |
NC_000010.11 |
10 |
5648943 |
+ |
ASB13 |
NNNCCCACTCAGGTAAACAC |
NCG |
2 |
0.0487 |
Tier II |
14 |
NC_000007.14 |
7 |
44963960 |
+ |
MYO1G |
NNNCCATCTCAGGTAAACAG |
NGG |
2 |
0.0257 |
Tier II |
15 |
NC_000020.11 |
20 |
63533992 |
+ |
PTK6 |
NNNCCAACTCAGGCAAACAC |
NTG |
2 |
0.0111 |
Tier II |
16 |
NC_000001.11 |
1 |
245696130 |
- |
LOC105373265 |
NNNCCAACTCTGGTAAATAC |
NGG |
2 |
0.1978 |
Tier III |
17 |
NC_000009.12 |
9 |
119434510 |
+ |
LOC105376250 |
NNNCCAACTCTGGTAAACTC |
NGG |
2 |
0.1657 |
Tier III |
18 |
NC_000021.9 |
21 |
7637929 |
+ |
CTBP2P9 |
NNNCCAACTCAGGAAACCAC |
NGG |
2 |
0.1092 |
Tier III |
19 |
NC_000007.14 |
7 |
8275954 |
+ |
ICA1-AS1 |
NNNCCAAATCAGGTAAACAC |
NTG |
2 |
0.0253 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000067.6 |
1 |
53766036 |
+ |
Stk17b |
NNNCTAACTCAGGTAAACAC |
NGG |
1 |
0.6364 |
Tier I |
2 |
NC_000083.6 |
17 |
21314411 |
- |
Vmn1r237 |
NNNCCAACTCATGTACACAC |
NGG |
2 |
0.0 |
Tier I |
3 |
NC_000085.6 |
19 |
5117507 |
+ |
Klc2 |
NNNCCAAGTTAGGTAAACAC |
NGG |
2 |
0.605 |
Tier II |
4 |
NC_000081.6 |
15 |
35977408 |
- |
Rgs22 |
NNNCCAACTCAAGAAAACAC |
NGG |
2 |
0.5778 |
Tier II |
5 |
NC_000074.6 |
8 |
78648512 |
- |
Slc10a7 |
NNNCGAACTCAGATAAACAC |
NGG |
2 |
0.5538 |
Tier II |
6 |
NC_000079.6 |
13 |
64862837 |
+ |
Cntnap3 |
NNNCCAAAGCAGGTAAACAC |
NGG |
2 |
0.4024 |
Tier II |
7 |
NC_000074.6 |
8 |
75759832 |
- |
Iqcm |
NNNCCAACTGAGGTAAACAC |
NGG |
1 |
0.3889 |
Tier II |
8 |
NC_000076.6 |
10 |
70131331 |
- |
Ccdc6 |
NNNCCAACCCAGGCAAACAC |
NGG |
2 |
0.2637 |
Tier II |
9 |
NC_000076.6 |
10 |
84925783 |
- |
Ric8b |
NNNCCAACTCATGTAAGCAC |
NGG |
2 |
0.0679 |
Tier II |
10 |
NC_000072.6 |
6 |
12592663 |
+ |
Thsd7a |
NNNCCAACTCAGGCAAACCC |
NGG |
2 |
0.0591 |
Tier II |
11 |
NC_000080.6 |
14 |
117532237 |
+ |
Gpc6 |
NNNCCAACTCAGGTAAAGAC |
NGA |
2 |
0.0093 |
Tier II |
12 |
NC_000075.6 |
9 |
64455131 |
- |
Megf11 |
NNNCCAACACAGGGAAACAC |
NGG |
2 |
0.0 |
Tier II |
13 |
NC_000074.6 |
8 |
65035514 |
- |
Apela |
NNNCCAACTCAGCTACACAC |
NGG |
2 |
0.0 |
Tier II |
14 |
NC_000086.7 |
X |
155615855 |
- |
Ptchd1 |
NNNCCAACTCAGGGAGACAC |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000075.6 |
9 |
109601669 |
- |
Fbxw24 |
NNNCCCACTCAGGTACACAC |
NGG |
2 |
0.0 |
Tier II |
16 |
NC_000085.6 |
19 |
5117507 |
+ |
LOC115489018 |
NNNCCAAGTTAGGTAAACAC |
NGG |
2 |
0.605 |
Tier III |
17 |
NC_000084.6 |
18 |
38172090 |
- |
Gm38566 |
NNNACAGCTCAGGTAAACAC |
NGG |
2 |
0.5944 |
Tier III |
18 |
NC_000080.6 |
14 |
103721529 |
+ |
Gm35197 |
NNNCCAACTTAGGAAAACAC |
NGG |
2 |
0.5826 |
Tier III |
19 |
NC_000079.6 |
13 |
44635111 |
+ |
Gm40931 |
NNNCCAACTAAGGTAAACAC |
NGC |
2 |
0.0193 |
Tier III |
20 |
NC_000081.6 |
15 |
102760931 |
+ |
Gm36560 |
NNNCCAACTCAGGTAAACAA |
NGC |
2 |
0.0111 |
Tier III |
Other clones with same target sequence:
(none)