Construct: sgRNA BRDN0001147185
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CGTAGTAAATATCTAGCTAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- Negative control (unspec'd)
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000023.11 | X | 32867208 | - | DMD | NNNAGTAAAAATCTAGCAAA | NGG | 2 | 0.5714 | Tier II |
2 | NC_000007.14 | 7 | 117820355 | - | CTTNBP2 | NNNAGTAAAGATCTAACTAA | NGG | 2 | 0.5 | Tier II |
3 | NC_000004.12 | 4 | 168894057 | - | PALLD | NNNAGTAAATGTTTAGCTAA | NGG | 2 | 0.455 | Tier II |
4 | NC_000016.10 | 16 | 84135473 | + | HSDL1 | NNNAGTAAATGTCTAGCAAA | NGG | 2 | 0.4333 | Tier II |
5 | NC_000021.9 | 21 | 31524742 | - | TIAM1 | NNNTGTAATTATCTAGCTAA | NGG | 2 | 0.3818 | Tier II |
6 | NC_000001.11 | 1 | 210169678 | - | SYT14 | NNNAGTAAAAATCTAGCCAA | NGG | 2 | 0.3673 | Tier II |
7 | NC_000003.12 | 3 | 53003939 | - | SFMBT1 | NNNTGGAAATATCTAGCTAA | NGG | 2 | 0.3636 | Tier II |
8 | NC_000005.10 | 5 | 151905262 | - | GLRA1 | NNNAGTAGATATCTAGATAA | NGG | 2 | 0.3422 | Tier II |
9 | NC_000001.11 | 1 | 111782533 | - | KCND3 | NNNTGTAAATATCTAGCCAA | NGG | 2 | 0.2727 | Tier II |
10 | NC_000007.14 | 7 | 40776949 | + | SUGCT | NNNAGTAAATATCAAGCCAA | NGG | 2 | 0.2653 | Tier II |
11 | NC_000018.10 | 18 | 37443827 | - | CELF4 | NNNAGTAAATATCTGGCGAA | NGG | 2 | 0.2167 | Tier II |
12 | NC_000007.14 | 7 | 24665247 | + | PALS2 | NNNAGTAAATATCTTACTAA | NGG | 2 | 0.2 | Tier II |
13 | NC_000012.12 | 12 | 32845174 | - | PKP2 | NNNAGTAAATTTCTGGCTAA | NGG | 2 | 0.2 | Tier II |
14 | NC_000016.10 | 16 | 71535105 | - | CHST4 | NNNAGTAAATATCTAGAGAA | NGG | 2 | 0.1556 | Tier II |
15 | NC_000009.12 | 9 | 94812217 | - | AOPEP | NNNAGTAAATATCTAGCTCT | NGG | 2 | 0.1241 | Tier II |
16 | NC_000012.12 | 12 | 28437638 | + | CCDC91 | NNNAATAAATATCTAGCTAA | NGA | 2 | 0.0602 | Tier II |
17 | NC_000004.12 | 4 | 61625553 | - | ADGRL3 | NNNAGAAAATATCTAGGTAA | NGG | 2 | 0.051 | Tier II |
18 | NC_000004.12 | 4 | 105261570 | - | TET2 | NNNAGTAAATATCTAGCTAT | NTG | 2 | 0.0234 | Tier II |
19 | NC_000003.12 | 3 | 197068943 | - | DLG1 | NNNAGTAAATATCTAGTTAA | NTG | 2 | 0.0182 | Tier II |
20 | NC_000008.11 | 8 | 42723167 | - | CHRNB3 | NNNAGTAAATATCTAGGTAA | NAG | 2 | 0.0153 | Tier II |
21 | NC_000011.10 | 11 | 85013638 | + | DLG2 | NNNAGTAAATATCTAGCTCA | NGA | 2 | 0.0144 | Tier II |
22 | NC_000015.10 | 15 | 44608797 | - | SPG11 | NNNATTAAATATCTAGCTAA | NGT | 2 | 0.0048 | Tier II |
23 | NC_000007.14 | 7 | 116954644 | + | ST7 | NNNAGTAAATTTCGAGCTAA | NGG | 2 | 0.0 | Tier II |
24 | NC_000010.11 | 10 | 2472465 | - | LINC02645 | NNNAGTAAATATCTAACTAA | NGG | 1 | 1.0 | Tier III |
25 | NC_000001.11 | 1 | 96298982 | - | LINC01787 | NNNAGAAAATATCTAGCTAA | NGG | 1 | 0.8667 | Tier III |
26 | NC_000002.12 | 2 | 181174042 | + | LINC01934 | NNNGGTAAATATCTAGCAAA | NGG | 2 | 0.4167 | Tier III |
27 | NC_000004.12 | 4 | 171282242 | + | LOC105377534 | NNNAGTAAATAAATAGCTAA | NGG | 2 | 0.3077 | Tier III |
28 | NC_000018.10 | 18 | 64162320 | - | LINC01924 | NNNAGTAAGTTTCTAGCTAA | NGG | 2 | 0.2051 | Tier III |
29 | NC_000001.11 | 1 | 84637097 | + | LOC124904206 | NNNAGTAAATCTCTAGCCAA | NGG | 2 | 0.1714 | Tier III |
30 | NC_000018.10 | 18 | 35463840 | - | ZNF24TR | NNNAGTAAATAACTAGCTAA | NGA | 2 | 0.0556 | Tier III |
31 | NC_000004.12 | 4 | 105261570 | - | TET2-AS1 | NNNAGTAAATATCTAGCTAT | NTG | 2 | 0.0234 | Tier III |
32 | NC_000002.12 | 2 | 67211082 | - | LINC01829 | NNNAGTAAATTTCTAGCTAA | NGA | 2 | 0.0214 | Tier III |
33 | NC_000002.12 | 2 | 67211082 | - | LINC01828 | NNNAGTAAATTTCTAGCTAA | NGA | 2 | 0.0214 | Tier III |
34 | NC_000007.14 | 7 | 116954644 | + | ST7-OT4 | NNNAGTAAATTTCGAGCTAA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000074.6 | 8 | 93042012 | + | Ces1a | NNNAGTAAATATTTAGGTAA | NGG | 2 | 0.0412 | Tier I |
2 | NC_000079.6 | 13 | 112626749 | - | Ddx4 | NNNAGTAGAAATCTAGCTAA | NGG | 2 | 0.6286 | Tier II |
3 | NC_000070.6 | 4 | 84543497 | - | Bnc2 | NNNAGTAAAAATTTAGCTAA | NGG | 2 | 0.6 | Tier II |
4 | NC_000074.6 | 8 | 108878068 | - | Zfhx3 | NNNAGAAAATATCTGGCTAA | NGG | 2 | 0.5633 | Tier II |
5 | NC_000086.7 | X | 87052456 | + | Il1rapl1 | NNNAGTTAATATCTAACTAA | NGG | 2 | 0.4375 | Tier II |
6 | NC_000068.7 | 2 | 12985488 | + | Pter | NNNAGTAAATGTCTAGCAAA | NGG | 2 | 0.4333 | Tier II |
7 | NC_000080.6 | 14 | 124440533 | + | Fgf14 | NNNAGTAATTATCTAGCTAT | NGG | 2 | 0.36 | Tier II |
8 | NC_000075.6 | 9 | 10141517 | - | Cntn5 | NNNAATAAATATCTAGCTAA | NAG | 2 | 0.2247 | Tier II |
9 | NC_000076.6 | 10 | 100089636 | - | Kitl | NNNATTAAATATCTAGCAAA | NGG | 2 | 0.2 | Tier II |
10 | NC_000071.6 | 5 | 77038244 | - | Thegl | NNNAGTAAATATCCAGCAAA | NGG | 2 | 0.1905 | Tier II |
11 | NC_000067.6 | 1 | 92083226 | + | Hdac4 | NNNAGTAAATATCTAGTTCA | NGG | 2 | 0.0966 | Tier II |
12 | NC_000070.6 | 4 | 149250521 | - | Kif1b | NNNAGCAAATATCTAGCTAA | NTG | 2 | 0.0354 | Tier II |
13 | NC_000071.6 | 5 | 5378613 | + | Cdk14 | NNNAGTAACTATCTAGCTAA | NGT | 2 | 0.0092 | Tier II |
14 | NC_000078.6 | 12 | 85916537 | - | Ttll5 | NNNAGTAAATATCTAGCTAA | NTA | 2 | 0.0 | Tier II |
15 | NC_000077.6 | 11 | 16786364 | + | Egfr | NNNAGTAAATATCTATCTAT | NGG | 2 | 0.0 | Tier II |
16 | NC_000079.6 | 13 | 71079552 | + | Gm40997 | NNNAGCAAATACCTAGCTAA | NGG | 2 | 0.8612 | Tier III |
17 | NC_000078.6 | 12 | 12771922 | + | Gm35104 | NNNAGCAAATATTTAGCTAA | NGG | 2 | 0.6364 | Tier III |
18 | NC_000069.6 | 3 | 112052491 | - | Gm6602 | NNNTGAAAATATCTAGCTAA | NGG | 2 | 0.5515 | Tier III |
19 | NC_000082.6 | 16 | 86855715 | - | Gm32624 | NNNAGTAATTATCTGGCTAA | NGG | 2 | 0.39 | Tier III |
20 | NC_000076.6 | 10 | 78594840 | - | Gm30346 | NNNAGGAAATATCTGGCTAA | NGG | 2 | 0.3714 | Tier III |
21 | NC_000072.6 | 6 | 60442646 | - | Gm38823 | NNNATTAAATATCTAGCTAA | NGG | 1 | 0.3 | Tier III |
22 | NC_000072.6 | 6 | 135559746 | - | Gm25136 | NNNAGTAAATATCTAGCTAG | NAG | 2 | 0.1983 | Tier III |
23 | NC_000086.7 | X | 69959207 | + | 1700111N16Rik | NNNAGTAAATATCTAGATAA | NTG | 2 | 0.0182 | Tier III |
24 | NC_000077.6 | 11 | 16786364 | + | Gm39584 | NNNAGTAAATATCTATCTAT | NGG | 2 | 0.0 | Tier III |