Construct: sgRNA BRDN0001147207
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAGAACGTGTAGCAATAAAA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- STK39 (27347)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76072
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000002.12 |
2 |
168182026 |
- |
STK39 |
NNNAACGTGTAGCAATAAAA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000018.10 |
18 |
63554116 |
+ |
SERPINB12 |
NNNAAAATGTAGCAATAAAA |
NGG |
2 |
0.9286 |
Tier II |
3 |
NC_000001.11 |
1 |
246645964 |
- |
CNST |
NNNAAAGGGTAGCAATAAAA |
NGG |
2 |
0.681 |
Tier II |
4 |
NC_000005.10 |
5 |
78902565 |
+ |
ARSB |
NNNAATGTATAGCAATAAAA |
NGG |
2 |
0.5969 |
Tier II |
5 |
NC_000023.11 |
X |
133313328 |
+ |
GPC4 |
NNNTACGTGTAACAATAAAA |
NGG |
2 |
0.5939 |
Tier II |
6 |
NC_000004.12 |
4 |
21907445 |
- |
KCNIP4 |
NNNAATTTGTAGCAATAAAA |
NGG |
2 |
0.5306 |
Tier II |
7 |
NC_000018.10 |
18 |
69643602 |
- |
DOK6 |
NNNAATGTTTAGCAATAAAA |
NGG |
2 |
0.4952 |
Tier II |
8 |
NC_000020.11 |
20 |
14915200 |
+ |
MACROD2 |
NNNAAGGTGTAACAATAAAA |
NGG |
2 |
0.4667 |
Tier II |
9 |
NC_000021.9 |
21 |
41186010 |
+ |
BACE2 |
NNNAAAGTGGAGCAATAAAA |
NGG |
2 |
0.4643 |
Tier II |
10 |
NC_000007.14 |
7 |
147123687 |
- |
CNTNAP2 |
NNNAAAGTGTAGCAATATAA |
NGG |
2 |
0.4643 |
Tier II |
11 |
NC_000001.11 |
1 |
220198477 |
- |
RAB3GAP2 |
NNNAATGTGTAGCAATATAA |
NGG |
2 |
0.4643 |
Tier II |
12 |
NC_000002.12 |
2 |
112578507 |
- |
POLR1B |
NNNACTGTGTAGCAATAAAA |
NGG |
2 |
0.4643 |
Tier II |
13 |
NC_000011.10 |
11 |
59855177 |
- |
TCN1 |
NNNAACGTTAAGCAATAAAA |
NGG |
2 |
0.4571 |
Tier II |
14 |
NC_000020.11 |
20 |
19819496 |
- |
RIN2 |
NNNAAAGTGTATCAATAAAA |
NGG |
2 |
0.3571 |
Tier II |
15 |
NC_000019.10 |
19 |
34437767 |
+ |
UBA2 |
NNNAATGTGTATCAATAAAA |
NGG |
2 |
0.3571 |
Tier II |
16 |
NC_000010.11 |
10 |
87782655 |
+ |
ATAD1 |
NNNAACCTGTAGCAAGAAAA |
NGG |
2 |
0.238 |
Tier II |
17 |
NC_000013.11 |
13 |
66707198 |
+ |
PCDH9 |
NNNAACATGTAGCAATAACA |
NGG |
2 |
0.2069 |
Tier II |
18 |
NC_000007.14 |
7 |
120380637 |
- |
KCND2 |
NNNAATGTGTAGCAATAAAA |
NGC |
2 |
0.0206 |
Tier II |
19 |
NC_000002.12 |
2 |
227392124 |
+ |
LOC124907993 |
NNNAACTTGAAGCAATAAAA |
NGG |
2 |
0.4898 |
Tier III |
20 |
NC_000020.11 |
20 |
14915200 |
+ |
MACROD2-AS1 |
NNNAAGGTGTAACAATAAAA |
NGG |
2 |
0.4667 |
Tier III |
21 |
NC_000010.11 |
10 |
87782655 |
+ |
LOC124902476 |
NNNAACCTGTAGCAAGAAAA |
NGG |
2 |
0.238 |
Tier III |
22 |
NC_000014.9 |
14 |
49009528 |
- |
LOC105378178 |
NNNTACGTGTAGCAATAACA |
NGG |
2 |
0.1317 |
Tier III |
23 |
NC_000002.12 |
2 |
207675205 |
- |
LINC01857 |
NNNAACATGTAGCAATAAAA |
NGT |
2 |
0.0161 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000078.6 |
12 |
78610883 |
+ |
Gphn |
NNNAACATGTAGTAATAAAA |
NGG |
2 |
0.7 |
Tier II |
2 |
NC_000086.7 |
X |
104616052 |
+ |
Zdhhc15 |
NNNAACCAGTAGCAATAAAA |
NGG |
2 |
0.55 |
Tier II |
3 |
NC_000075.6 |
9 |
53518693 |
- |
Atm |
NNNAAATTGTAGCAATAAAA |
NGG |
2 |
0.5306 |
Tier II |
4 |
NC_000081.6 |
15 |
77390630 |
- |
Apol7a |
NNNAATGTCTAGCAATAAAA |
NGG |
2 |
0.5 |
Tier II |
5 |
NC_000080.6 |
14 |
105143083 |
- |
Rbm26 |
NNNAAAGTGTAGAAATAAAA |
NGG |
2 |
0.3571 |
Tier II |
6 |
NC_000069.6 |
3 |
123537858 |
- |
Ndst3 |
NNNATAGTGTAGCAATAAAA |
NGG |
2 |
0.3377 |
Tier II |
7 |
NC_000067.6 |
1 |
176963236 |
+ |
Sdccag8 |
NNNAACGTGGAGCAGTAAAA |
NGG |
2 |
0.325 |
Tier II |
8 |
NC_000086.7 |
X |
52107637 |
- |
Gpc4 |
NNNAACGTGTAGCAAAAACA |
NGG |
2 |
0.1881 |
Tier II |
9 |
NC_000083.6 |
17 |
47293481 |
+ |
Trerf1 |
NNNAACGTGTAGCATCAAAA |
NGG |
2 |
0.1333 |
Tier II |
10 |
NC_000068.7 |
2 |
33576309 |
+ |
Lmx1b |
NNNAACGAGTAGCAATTAAA |
NGG |
2 |
0.1067 |
Tier II |
11 |
NC_000080.6 |
14 |
70692286 |
- |
Xpo7 |
NNNAACGTGTAGAAATTAAA |
NGG |
2 |
0.0513 |
Tier II |
12 |
NC_000071.6 |
5 |
4001173 |
- |
Akap9 |
NNNAACCTGTAGCAATAAAA |
NGA |
2 |
0.0477 |
Tier II |
13 |
NC_000079.6 |
13 |
117664003 |
- |
Hcn1 |
NNNAACCTGTAGCAATAAAA |
NGA |
2 |
0.0477 |
Tier II |
14 |
NC_000072.6 |
6 |
104745791 |
- |
Cntn6 |
NNNAACTTGTAGCAATAAAA |
NGA |
2 |
0.0397 |
Tier II |
15 |
NC_000069.6 |
3 |
136908267 |
- |
Ppp3ca |
NNNAACGTGTAGCAATGACA |
NGG |
2 |
0.0365 |
Tier II |
16 |
NC_000069.6 |
3 |
51475965 |
+ |
Naa15 |
NNNAACTTGTAGCAATAAAA |
NGC |
2 |
0.0127 |
Tier II |
17 |
NC_000082.6 |
16 |
94487787 |
+ |
Gm31323 |
NNNAACCTGTAGCTATAAAA |
NGG |
2 |
0.3667 |
Tier III |
Other clones with same target sequence:
(none)