Construct: sgRNA BRDN0001147225
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCTCTGACCATCAGAAAGGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PTK7 (5754)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000006.12 | 6 | 43130265 | - | PTK7 | NNNCTGACCATCAGAAAGGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000016.10 | 16 | 6209702 | + | RBFOX1 | NNNCTGATCTTCAGAAAGGG | NGG | 2 | 0.7721 | Tier II |
3 | NC_000001.11 | 1 | 111571380 | - | RAP1A | NNNCTGAACTTCAGAAAGGG | NGG | 2 | 0.5735 | Tier II |
4 | NC_000010.11 | 10 | 11206907 | - | CELF2 | NNNCTGAGCATCAGAAAGGT | NGG | 2 | 0.45 | Tier II |
5 | NC_000005.10 | 5 | 5316824 | + | ADAMTS16 | NNNCGGACCACCAGAAAGGG | NGG | 2 | 0.4267 | Tier II |
6 | NC_000012.12 | 12 | 124141463 | - | ZNF664-RFLNA | NNNATGACCATCAGAAAGGC | NGG | 2 | 0.3609 | Tier II |
7 | NC_000007.14 | 7 | 132787187 | + | CHCHD3 | NNNCTGACCAAGAGAAAGGG | NGG | 2 | 0.3333 | Tier II |
8 | NC_000013.11 | 13 | 35461261 | - | NBEA | NNNCTGACCATAACAAAGGG | NGG | 2 | 0.3061 | Tier II |
9 | NC_000009.12 | 9 | 127837465 | - | ENG | NNNCTGACCACCAGAAAGGC | NGG | 2 | 0.2857 | Tier II |
10 | NC_000010.11 | 10 | 18010677 | + | SLC39A12 | NNNCTGACCATCAGAAATGC | NGG | 2 | 0.2857 | Tier II |
11 | NC_000005.10 | 5 | 7797042 | - | ADCY2 | NNNCTCACCAGCAGAAAGGG | NGG | 2 | 0.2727 | Tier II |
12 | NC_000023.11 | X | 155005646 | + | F8 | NNNCTGAGCAGCAGAAAGGG | NGG | 2 | 0.2571 | Tier II |
13 | NC_000001.11 | 1 | 84209428 | - | PRKACB | NNNCTGACCAACTGAAAGGG | NGG | 2 | 0.225 | Tier II |
14 | NC_000002.12 | 2 | 120969601 | - | GLI2 | NNNCTGACCCTCAGAAATGG | NGG | 2 | 0.2222 | Tier II |
15 | NC_000005.10 | 5 | 176493638 | - | FAF2 | NNNCTGACCATATGAAAGGG | NGG | 2 | 0.2143 | Tier II |
16 | NC_000004.12 | 4 | 142154119 | - | INPP4B | NNNCTCACCATCAGAAAGGG | NAG | 2 | 0.1768 | Tier II |
17 | NC_000003.12 | 3 | 141354609 | - | ZBTB38 | NNNCTGACCATGAGCAAGGG | NGG | 2 | 0.1212 | Tier II |
18 | NC_000001.11 | 1 | 27555727 | - | AHDC1 | NNNCTGACCCTCAGTAAGGG | NGG | 2 | 0.0667 | Tier II |
19 | NC_000001.11 | 1 | 218399590 | - | TGFB2 | NNNCTGACCATCAGAAAAGG | NGA | 2 | 0.0481 | Tier II |
20 | NC_000008.11 | 8 | 143735021 | - | IQANK1 | NNNATGACCATCAGAAAGGG | NTG | 2 | 0.0328 | Tier II |
21 | NC_000006.12 | 6 | 34523659 | - | PACSIN1 | NNNCTCACCATCAGAAAGGG | NTG | 2 | 0.0266 | Tier II |
22 | NC_000012.12 | 12 | 123050191 | - | PITPNM2 | NNNCTGCCCATCAGAAAGGG | NTG | 2 | 0.017 | Tier II |
23 | NC_000001.11 | 1 | 14784383 | + | KAZN | NNNCTGACCATCAGAGAGGG | NGT | 2 | 0.0031 | Tier II |
24 | NC_000003.12 | 3 | 107327797 | - | CSP2 | NNNCTGACTATCAGAAAGTG | NGG | 2 | 0.5833 | Tier III |
25 | NC_000010.11 | 10 | 11206907 | - | LOC124902375 | NNNCTGAGCATCAGAAAGGT | NGG | 2 | 0.45 | Tier III |
26 | NC_000002.12 | 2 | 12335807 | - | MIR3681HG | NNNCTGAGCATCAGAAAAGG | NGG | 2 | 0.4451 | Tier III |
27 | NC_000005.10 | 5 | 5316824 | + | LOC101929200 | NNNCGGACCACCAGAAAGGG | NGG | 2 | 0.4267 | Tier III |
28 | NC_000023.11 | X | 38974030 | - | LOC124905177 | NNNCTGACCCTCAGAAAGGG | NGG | 1 | 0.3333 | Tier III |
29 | NC_000006.12 | 6 | 74434765 | - | LOC101928516 | NNNCAGAGCATCAGAAAGGG | NGG | 2 | 0.3214 | Tier III |
30 | NC_000006.12 | 6 | 44001044 | - | LINC03040 | NNNCTGACCATCAGTAAGGT | NGG | 2 | 0.14 | Tier III |
31 | NC_000006.12 | 6 | 44001044 | - | SCIRT | NNNCTGACCATCAGTAAGGT | NGG | 2 | 0.14 | Tier III |
32 | NC_000016.10 | 16 | 20597269 | + | LOC112267906 | NNNCTGACCATCAGAAAGTG | NGA | 2 | 0.0463 | Tier III |
33 | NC_000001.11 | 1 | 190661637 | + | LINC01720 | NNNCTGACCATCAGAAATGG | NGA | 2 | 0.0463 | Tier III |
34 | NC_000013.11 | 13 | 50265088 | - | DLEU1 | NNNCTGACCATCAGAAAAGG | NGC | 2 | 0.0154 | Tier III |
35 | NC_000017.11 | 17 | 34726611 | - | LOC105371740 | NNNCTGACCATCAGACAGGG | NGG | 1 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000083.6 | 17 | 46590417 | + | Ptk7 | NNNCTGATCATCAGAGAGGG | NGG | 2 | 0.1683 | Tier I |
2 | NC_000085.6 | 19 | 36563152 | - | Hectd2 | NNNCTGACCATCAGAAAGTA | NGG | 2 | 0.625 | Tier II |
3 | NC_000069.6 | 3 | 151803105 | - | Ptgfr | NNNCTGATCATCAGAAAGGT | NGG | 2 | 0.6125 | Tier II |
4 | NC_000068.7 | 2 | 130278053 | + | Nop56 | NNNCTGACCTTCAGAAATGG | NGG | 2 | 0.5882 | Tier II |
5 | NC_000082.6 | 16 | 44401112 | + | Cfap44 | NNNCTGACCAAAAGAAAGGG | NGG | 2 | 0.5357 | Tier II |
6 | NC_000086.7 | X | 83302113 | - | Dmd | NNNCTGACCACCAAAAAGGG | NGG | 2 | 0.5 | Tier II |
7 | NC_000073.6 | 7 | 144317343 | + | Shank2 | NNNCTGACCACCAGAAAGTG | NGG | 2 | 0.4444 | Tier II |
8 | NC_000074.6 | 8 | 48424297 | - | Tenm3 | NNNCTGACCATGAGAAAGGA | NGG | 2 | 0.4167 | Tier II |
9 | NC_000076.6 | 10 | 12650909 | + | Utrn | NNNCTGACAATGAGAAAGGG | NGG | 2 | 0.381 | Tier II |
10 | NC_000077.6 | 11 | 113373282 | - | Slc39a11 | NNNCTGACCAGCAGAAAGGA | NGG | 2 | 0.375 | Tier II |
11 | NC_000081.6 | 15 | 59419781 | - | Nsmce2 | NNNCAGACCATCAGAAATGG | NGG | 2 | 0.3333 | Tier II |
12 | NC_000067.6 | 1 | 90058056 | - | Iqca | NNNCAGACCATCAGGAAGGG | NGG | 2 | 0.325 | Tier II |
13 | NC_000085.6 | 19 | 57302532 | - | Ablim1 | NNNCTGACCATCACAAAAGG | NGG | 2 | 0.2967 | Tier II |
14 | NC_000068.7 | 2 | 172465417 | - | Rtf2 | NNNCAGACCATCAGAAAGGC | NGG | 2 | 0.2143 | Tier II |
15 | NC_000075.6 | 9 | 107668010 | + | Slc38a3 | NNNCTGCCCATCAGAAACGG | NGG | 2 | 0.2083 | Tier II |
16 | NC_000069.6 | 3 | 30409316 | - | Mecom | NNNCTGACCATCAGTAAGTG | NGG | 2 | 0.1333 | Tier II |
17 | NC_000070.6 | 4 | 151118559 | - | Camta1 | NNNCTGACCATCAGAGAGGC | NGG | 2 | 0.0824 | Tier II |
18 | NC_000084.6 | 18 | 76120354 | + | Zbtb7c | NNNCTGACCATCTGAAAGGG | NGC | 2 | 0.0067 | Tier II |
19 | NC_000080.6 | 14 | 96198118 | + | Klhl1 | NNNCTGACCATCAGCAAGGG | NGT | 2 | 0.0044 | Tier II |
20 | NC_000075.6 | 9 | 69905240 | - | Gm39368 | NNNCTAGCCATCAGAAAGGG | NGG | 2 | 0.7059 | Tier III |
21 | NC_000068.7 | 2 | 130278053 | + | Snord57 | NNNCTGACCTTCAGAAATGG | NGG | 2 | 0.5882 | Tier III |
22 | NC_000072.6 | 6 | 41257727 | - | Tcrb | NNNCTGACAATCTGAAAGGG | NGG | 2 | 0.2571 | Tier III |
23 | NC_000074.6 | 8 | 77766116 | + | LOC108167319 | NNNCTGACCATCAACAAGGG | NGG | 2 | 0.2045 | Tier III |
24 | NC_000076.6 | 10 | 24448241 | + | Gm15270 | NNNCAGACCATCTGAAAGGG | NGG | 2 | 0.15 | Tier III |
25 | NC_000072.6 | 6 | 96060754 | - | 2900060L22Rik | NNNCTGTCCATCAGACAGGG | NGG | 2 | 0.0 | Tier III |