Construct: sgRNA BRDN0001147240
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACTAAATGAAGTCTTCATTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NADK2 (133686)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000005.10 | 5 | 36211866 | - | NADK2 | NNNAAATGAAGTCTTCATTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 91261317 | - | HFM1 | NNNAAATGAAGTCTTTATTG | NGA | 2 | 0.0214 | Tier I |
3 | NC_000008.11 | 8 | 73269071 | + | C8orf89 | NNNAAATGTAGACTTCATTG | NGG | 2 | 0.48 | Tier II |
4 | NC_000012.12 | 12 | 32590985 | - | FGD4 | NNNAACTGAAGCCTTCATTG | NGG | 2 | 0.4306 | Tier II |
5 | NC_000010.11 | 10 | 127415475 | - | DOCK1 | NNNAAATGAAATCTTCATTC | NGG | 2 | 0.4286 | Tier II |
6 | NC_000010.11 | 10 | 132273061 | - | STK32C | NNNAATTGCAGTCTTCATTG | NGG | 2 | 0.4082 | Tier II |
7 | NC_000010.11 | 10 | 34405966 | - | PARD3 | NNNAACAGAAGTCTTCATTG | NGG | 2 | 0.3977 | Tier II |
8 | NC_000001.11 | 1 | 209603406 | + | CAMK1G | NNNAAATGAAGACTTCATTC | NGG | 2 | 0.3429 | Tier II |
9 | NC_000004.12 | 4 | 150544511 | - | LRBA | NNNAAAGGAAGGCTTCATTG | NGG | 2 | 0.2941 | Tier II |
10 | NC_000007.14 | 7 | 18686035 | + | HDAC9 | NNNAAATGAAGACTTCAGTG | NGG | 2 | 0.2667 | Tier II |
11 | NC_000009.12 | 9 | 3446316 | + | RFX3 | NNNAAATGAAGTCTTCATTG | NAG | 1 | 0.2593 | Tier II |
12 | NC_000002.12 | 2 | 85864818 | - | ST3GAL5 | NNNAAATGTAGTCTTCATTC | NGG | 2 | 0.2571 | Tier II |
13 | NC_000014.9 | 14 | 23076308 | - | ACIN1 | NNNAAATGCAGTCTTCACTG | NGG | 2 | 0.2449 | Tier II |
14 | NC_000011.10 | 11 | 4943992 | + | MMP26 | NNNAAATGAAGTCTTCATAT | NGG | 2 | 0.2 | Tier II |
15 | NC_000011.10 | 11 | 4943992 | + | OR51A4 | NNNAAATGAAGTCTTCATAT | NGG | 2 | 0.2 | Tier II |
16 | NC_000008.11 | 8 | 51819953 | + | PCMTD1 | NNNAAATGAAGTTTTCATAG | NGG | 2 | 0.2 | Tier II |
17 | NC_000012.12 | 12 | 61718038 | - | TAFA2 | NNNAAATGAAGTCTTCAAAG | NGG | 2 | 0.1905 | Tier II |
18 | NC_000016.10 | 16 | 7382192 | - | RBFOX1 | NNNAAATGGAGTCTTCATAG | NGG | 2 | 0.1905 | Tier II |
19 | NC_000002.12 | 2 | 230787503 | + | CAB39 | NNNAATTGAAGTCTTCATTG | NAG | 2 | 0.1852 | Tier II |
20 | NC_000001.11 | 1 | 177132382 | + | ASTN1 | NNNAAATGAAGTCATCATAG | NGG | 2 | 0.1769 | Tier II |
21 | NC_000004.12 | 4 | 118713805 | - | METTL14 | NNNAAATGAAGTCTTCAATG | NAG | 2 | 0.1728 | Tier II |
22 | NC_000004.12 | 4 | 796334 | - | CPLX1 | NNNACATGAAGTCTTCAGTG | NGG | 2 | 0.1667 | Tier II |
23 | NC_000015.10 | 15 | 52622435 | - | ATOSA | NNNAAATGAAGTCTACATAG | NGG | 2 | 0.1654 | Tier II |
24 | NC_000015.10 | 15 | 57283896 | - | TCF12 | NNNAAATGAAATCTTCTTTG | NGG | 2 | 0.1333 | Tier II |
25 | NC_000004.12 | 4 | 153177335 | + | TRIM2 | NNNAAATGAAGTCTTTATTC | NGG | 2 | 0.1319 | Tier II |
26 | NC_000003.12 | 3 | 189743554 | + | TP63 | NNNAAATGAAGGCTTCATTG | NAG | 2 | 0.1296 | Tier II |
27 | NC_000006.12 | 6 | 55484440 | - | HMGCLL1 | NNNATATGAAGTCTTCAGTG | NGG | 2 | 0.1212 | Tier II |
28 | NC_000004.12 | 4 | 62056639 | + | ADGRL3 | NNNAAATGAAGTCTCCACTG | NGG | 2 | 0.1169 | Tier II |
29 | NC_000002.12 | 2 | 50450507 | + | NRXN1 | NNNAAATGAAGACTTCTTTG | NGG | 2 | 0.1067 | Tier II |
30 | NC_000002.12 | 2 | 209831073 | + | UNC80 | NNNAAATGAATTCTCCATTG | NGG | 2 | 0.1049 | Tier II |
31 | NC_000006.12 | 6 | 114336754 | - | HS3ST5 | NNNAAATGAAGTATTCATTG | NAG | 2 | 0.0997 | Tier II |
32 | NC_000020.11 | 20 | 38829533 | + | PPP1R16B | NNNAAATGAGGTCTTCCTTG | NGG | 2 | 0.098 | Tier II |
33 | NC_000020.11 | 20 | 38831221 | + | PPP1R16B | NNNAAATGAGGTCTTCCTTG | NGG | 2 | 0.098 | Tier II |
34 | NC_000008.11 | 8 | 118201472 | - | SAMD12 | NNNAATTGAAGTGTTCATTG | NGG | 2 | 0.0974 | Tier II |
35 | NC_000020.11 | 20 | 6779200 | - | BMP2 | NNNAAATAAAGTCTTCATTG | NGA | 2 | 0.0694 | Tier II |
36 | NC_000003.12 | 3 | 94001470 | - | ARL13B | NNNAAATGAAGACTTCATTG | NGA | 2 | 0.0556 | Tier II |
37 | NC_000009.12 | 9 | 124471882 | + | ADGRD2 | NNNAAATGAAGTGTTCAGTG | NGG | 2 | 0.0455 | Tier II |
38 | NC_000006.12 | 6 | 117685132 | + | NUS1 | NNNAAATGAAGTCTTCATTT | NGC | 2 | 0.0156 | Tier II |
39 | NC_000003.12 | 3 | 42845008 | - | ACKR2 | NNNAAATGAAGTCTTCAATG | NGC | 2 | 0.0148 | Tier II |
40 | NC_000023.11 | X | 17132072 | - | REPS2 | NNNAAATGAAGACTTCATTG | NGT | 2 | 0.0129 | Tier II |
41 | NC_000001.11 | 1 | 114509812 | + | TRIM33 | NNNGAATGAAGTCTTCATTG | NGT | 2 | 0.0101 | Tier II |
42 | NC_000002.12 | 2 | 214130409 | - | SPAG16 | NNNAAATGAAGTCTTCATGG | NTG | 2 | 0.0097 | Tier II |
43 | NC_000011.10 | 11 | 125405378 | + | PKNOX2 | NNNAAATGAAGTCTTCCTTG | NGT | 2 | 0.0028 | Tier II |
44 | NC_000012.12 | 12 | 80663937 | - | PTPRQ | NNNAAATGAAGTCTTGATTG | NGT | 2 | 0.0025 | Tier II |
45 | NC_000003.12 | 3 | 61303729 | + | LOC105377114 | NNNAAATGAAATCATCATTG | NGG | 2 | 0.619 | Tier III |
46 | NC_000003.12 | 3 | 61303729 | + | LOC105377115 | NNNAAATGAAATCATCATTG | NGG | 2 | 0.619 | Tier III |
47 | NC_000001.11 | 1 | 189499409 | + | LOC105371657 | NNNAAATTAAGACTTCATTG | NGG | 2 | 0.5 | Tier III |
48 | NC_000005.10 | 5 | 131024535 | + | LOC105379172 | NNNAAATGAAGTCTTCATTC | NGG | 1 | 0.4286 | Tier III |
49 | NC_000002.12 | 2 | 113997845 | - | LINC01191 | NNNAAATGAAGGCTTCATTT | NGG | 2 | 0.35 | Tier III |
50 | NC_000005.10 | 5 | 54681636 | + | LINC02998 | NNNAACTGAAGTTTTCATTG | NGG | 2 | 0.3182 | Tier III |
51 | NC_000013.11 | 13 | 81553358 | - | LOC105370283 | NNNCAATGATGTCTTCATTG | NGG | 2 | 0.3114 | Tier III |
52 | NC_000023.11 | X | 128582252 | + | LOC107985698 | NNNGAATGAAGTCTTCATTC | NGG | 2 | 0.2679 | Tier III |
53 | NC_000001.11 | 1 | 203271251 | + | LOC124904486 | NNNAAATGCAGTCTTCATTC | NGG | 2 | 0.2449 | Tier III |
54 | NC_000012.12 | 12 | 69717917 | + | LOC101928002 | NNNGTATGAAGTCTTCATTG | NGG | 2 | 0.2273 | Tier III |
55 | NC_000004.12 | 4 | 796334 | - | LOC105374339 | NNNACATGAAGTCTTCAGTG | NGG | 2 | 0.1667 | Tier III |
56 | NC_000018.10 | 18 | 42322316 | + | LINC00907 | NNNAGATGAAGTCTTCCTTG | NGG | 2 | 0.1271 | Tier III |
57 | NC_000015.10 | 15 | 51923739 | - | LOC100422556 | NNNAAATGAAGTCTACCTTG | NGG | 2 | 0.1022 | Tier III |
58 | NC_000015.10 | 15 | 51923739 | - | LOC112268148 | NNNAAATGAAGTCTACCTTG | NGG | 2 | 0.1022 | Tier III |
59 | NC_000004.12 | 4 | 113984894 | + | LOC124900762 | NNNCAATGAAGTCCTCATTG | NGG | 2 | 0.1008 | Tier III |
60 | NC_000006.12 | 6 | 114336754 | - | HDAC2-AS2 | NNNAAATGAAGTATTCATTG | NAG | 2 | 0.0997 | Tier III |
61 | NC_000012.12 | 12 | 126697242 | + | LINC02824 | NNNAAATGAAGTCTTCAGGG | NGG | 2 | 0.0833 | Tier III |
62 | NC_000011.10 | 11 | 78154701 | - | KCTD21-AS1 | NNNAACTGAAGTCTTCCTTG | NGG | 2 | 0.0802 | Tier III |
63 | NC_000016.10 | 16 | 60484950 | + | LOC101927605 | NNNAAAAGAAGTCTGCATTG | NGG | 2 | 0.0438 | Tier III |
64 | NC_000011.10 | 11 | 28004468 | + | LOC124902655 | NNNAAATGTAGTCTTCATTG | NGA | 2 | 0.0417 | Tier III |
65 | NC_000008.11 | 8 | 24431023 | + | ADAM7-AS1 | NNNAAATGAAGTCTTCATTG | NGC | 1 | 0.0222 | Tier III |
66 | NC_000003.12 | 3 | 42845008 | - | LOC124909373 | NNNAAATGAAGTCTTCAATG | NGC | 2 | 0.0148 | Tier III |
67 | NC_000023.11 | X | 153051496 | - | HMGN2P48 | NNNAGATGAAGTCTTCATTG | NGT | 2 | 0.0116 | Tier III |
68 | NC_000012.12 | 12 | 80663937 | - | LOC105369867 | NNNAAATGAAGTCTTGATTG | NGT | 2 | 0.0025 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000081.6 | 15 | 9096071 | + | Nadk2 | NNNCAATGAAGTCTTCATTG | NGG | 1 | 0.3529 | Tier I |
2 | NC_000067.6 | 1 | 181182798 | + | Wdr26 | NNNCAATGAAGTCTTCATTA | NGG | 2 | 0.3309 | Tier I |
3 | NC_000068.7 | 2 | 113491996 | - | Fmn1 | NNNAAATGAAGTCTTAATTG | NGG | 1 | 1.0 | Tier II |
4 | NC_000068.7 | 2 | 17639562 | + | Nebl | NNNAAACGAAATCTTCATTG | NGG | 2 | 0.6875 | Tier II |
5 | NC_000082.6 | 16 | 72438730 | + | Robo1 | NNNAGATGAAGCCTTCATTG | NGG | 2 | 0.6821 | Tier II |
6 | NC_000075.6 | 9 | 66957287 | + | Lactb | NNNAGATGAAGTCTTCATTA | NGG | 2 | 0.675 | Tier II |
7 | NC_000074.6 | 8 | 111541779 | - | Znrf1 | NNNAAATCAAGTCTTCATTA | NGG | 2 | 0.5769 | Tier II |
8 | NC_000077.6 | 11 | 32572935 | + | Stk10 | NNNAGATGAAGACTTCATTG | NGG | 2 | 0.576 | Tier II |
9 | NC_000082.6 | 16 | 41203403 | - | Lsamp | NNNAAATGAAGATTTCATTG | NGG | 2 | 0.56 | Tier II |
10 | NC_000073.6 | 7 | 64213951 | + | Trpm1 | NNNTGATGAAGTCTTCATTG | NGG | 2 | 0.4582 | Tier II |
11 | NC_000072.6 | 6 | 34307242 | - | Akr1b3 | NNNAAATTAAGTCTTCATTT | NGG | 2 | 0.4375 | Tier II |
12 | NC_000073.6 | 7 | 35537225 | - | Tdrd12 | NNNAAATGAAATATTCATTG | NGG | 2 | 0.3846 | Tier II |
13 | NC_000076.6 | 10 | 60732695 | - | Slc29a3 | NNNAAAGGCAGTCTTCATTG | NGG | 2 | 0.3361 | Tier II |
14 | NC_000071.6 | 5 | 109347011 | + | Vmn2r16 | NNNACATGGAGTCTTCATTG | NGG | 2 | 0.3333 | Tier II |
15 | NC_000085.6 | 19 | 19061834 | + | Rorb | NNNAAATGAACTCTTCATTT | NGG | 2 | 0.3 | Tier II |
16 | NC_000081.6 | 15 | 58573153 | + | Fer1l6 | NNNAACTTAAGTCTTCATTG | NGG | 2 | 0.2841 | Tier II |
17 | NC_000079.6 | 13 | 109205991 | - | Pde4d | NNNAAATGAAGTCTCCATTG | NGG | 1 | 0.2727 | Tier II |
18 | NC_000083.6 | 17 | 91013503 | - | Nrxn1 | NNNAAATGAAGCCTTCATTG | NAG | 2 | 0.2456 | Tier II |
19 | NC_000069.6 | 3 | 68956184 | + | Ift80 | NNNAACTGAAGTCTTCACTG | NGG | 2 | 0.1948 | Tier II |
20 | NC_000067.6 | 1 | 93220552 | - | Crocc2 | NNNAATTGAAGTCTTCATTG | NAG | 2 | 0.1852 | Tier II |
21 | NC_000069.6 | 3 | 141774243 | + | Unc5c | NNNAAATGAAGTCTTCATTT | NAG | 2 | 0.1815 | Tier II |
22 | NC_000071.6 | 5 | 147546949 | - | Pan3 | NNNAGATGAAGTCTTCATGG | NGG | 2 | 0.18 | Tier II |
23 | NC_000072.6 | 6 | 56135150 | - | Pde1c | NNNAAAGGAAGTCTTCATGG | NGG | 2 | 0.1471 | Tier II |
24 | NC_000082.6 | 16 | 6619572 | - | Rbfox1 | NNNAAAAGAAGTGTTCATTG | NGG | 2 | 0.1193 | Tier II |
25 | NC_000068.7 | 2 | 133561822 | - | Bmp2 | NNNAAATAAAGTCTTCATTG | NGA | 2 | 0.0694 | Tier II |
26 | NC_000075.6 | 9 | 48379203 | - | Nxpe4 | NNNAAATGAAGTCTGAATTG | NGG | 2 | 0.05 | Tier II |
27 | NC_000069.6 | 3 | 24395297 | + | Naaladl2 | NNNAAATGAAGTCTTCATTT | NGA | 2 | 0.0486 | Tier II |
28 | NC_000080.6 | 14 | 48476629 | - | Tmem260 | NNNAAATGAAGTGTTCATTG | NAG | 2 | 0.0354 | Tier II |
29 | NC_000073.6 | 7 | 87596322 | - | Grm5 | NNNAAATCAAGTCTTCATTG | NGT | 2 | 0.0099 | Tier II |
30 | NC_000074.6 | 8 | 90940383 | - | Chd9 | NNNAAATGAAGTGTTCATTG | NGA | 2 | 0.0095 | Tier II |
31 | NC_000071.6 | 5 | 125740574 | + | Tmem132b | NNNAAATGAAGTTGTCATTG | NGG | 2 | 0.0 | Tier II |
32 | NC_000078.6 | 12 | 113361564 | - | Igh | NNNAAATGAAGGCTTCATTG | NGG | 1 | 0.5 | Tier III |
33 | NC_000069.6 | 3 | 94295472 | - | Gm36010 | NNNAATTGAAGTCTTCATTG | NAG | 2 | 0.1852 | Tier III |
34 | NC_000083.6 | 17 | 52154685 | - | Gm19585 | NNNCTATGAAGTCTTCATTG | NGG | 2 | 0.1283 | Tier III |
35 | NC_000085.6 | 19 | 56665161 | - | Gm52389 | NNNAAATGAAGCCTTCTTTG | NGG | 2 | 0.1263 | Tier III |
36 | NC_000080.6 | 14 | 123095887 | + | Gm33906 | NNNAAATGAAGTATTGATTG | NGG | 2 | 0.0592 | Tier III |
37 | NC_000076.6 | 10 | 126960873 | + | Gm30539 | NNNAAATGAAGTCTGCATTT | NGG | 2 | 0.035 | Tier III |
38 | NC_000072.6 | 6 | 137857313 | - | Gm38552 | NNNAAATGAAGTCTTTATTG | NGA | 2 | 0.0214 | Tier III |
39 | NC_000077.6 | 11 | 110550535 | + | Gm46300 | NNNAAATGATGTCTTCATTG | NGT | 2 | 0.0142 | Tier III |