Construct: sgRNA BRDN0001147317
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGATGAATATGGTTATGAGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TSSK4 (283629)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77045
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000014.9 |
14 |
24206000 |
+ |
TSSK4 |
NNNTGAATATGGTTATGAGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000006.12 |
6 |
55804774 |
+ |
BMP5 |
NNNTGAATATGGTTATGATG |
NGG |
1 |
0.6667 |
Tier II |
3 |
NC_000006.12 |
6 |
57103860 |
- |
ZNF451 |
NNNTGAATATGGTTATGATG |
NGG |
1 |
0.6667 |
Tier II |
4 |
NC_000001.11 |
1 |
151538219 |
+ |
CGN |
NNNTGGATATGGTTATAAGG |
NGG |
2 |
0.6667 |
Tier II |
5 |
NC_000015.10 |
15 |
50208238 |
- |
SLC27A2 |
NNNTGAATATGGTTAAGAAG |
NGG |
2 |
0.6494 |
Tier II |
6 |
NC_000017.11 |
17 |
35815715 |
- |
TAF15 |
NNNTGAAAAGGGTTATGAGG |
NGG |
2 |
0.4 |
Tier II |
7 |
NC_000010.11 |
10 |
87786342 |
- |
ATAD1 |
NNNTGAATATGTTTATGAAG |
NGG |
2 |
0.2747 |
Tier II |
8 |
NC_000002.12 |
2 |
160112530 |
+ |
ITGB6 |
NNNTGATTATGGTAATGAGG |
NGG |
2 |
0.2708 |
Tier II |
9 |
NC_000005.10 |
5 |
128467093 |
- |
FBN2 |
NNNTGAATTTGGTTATGAGG |
NAG |
2 |
0.1556 |
Tier II |
10 |
NC_000001.11 |
1 |
28491487 |
- |
PHACTR4 |
NNNTGATTATGGTTATCAGG |
NGG |
2 |
0.1029 |
Tier II |
11 |
NC_000003.12 |
3 |
169923086 |
- |
SAMD7 |
NNNTGAATATGGTTTTGGGG |
NGG |
2 |
0.08 |
Tier II |
12 |
NC_000020.11 |
20 |
14429410 |
- |
MACROD2 |
NNNTGAATATGGTTATCAGG |
NTG |
2 |
0.0092 |
Tier II |
13 |
NC_000005.10 |
5 |
125127812 |
- |
LOC101927421 |
NNNTGTATATGGTTATGGGG |
NGG |
2 |
0.2857 |
Tier III |
14 |
NC_000010.11 |
10 |
87786342 |
- |
LOC124902476 |
NNNTGAATATGTTTATGAAG |
NGG |
2 |
0.2747 |
Tier III |
15 |
NC_000017.11 |
17 |
57081957 |
- |
AKAP1-DT |
NNNTGAATATGGTTATGAGA |
NAG |
2 |
0.2431 |
Tier III |
16 |
NC_000020.11 |
20 |
35753489 |
+ |
RPF2P1 |
NNNTGAATCTGGTTCTGAGG |
NGG |
2 |
0.1558 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000080.6 |
14 |
55650425 |
+ |
Tssk4 |
NNNGGAGTATGGTTATGAGG |
NGG |
2 |
0.4412 |
Tier I |
2 |
NC_000080.6 |
14 |
23690647 |
- |
Kcnma1 |
NNNTGTATATGGTAATGAGG |
NGG |
2 |
0.4422 |
Tier II |
3 |
NC_000077.6 |
11 |
47644936 |
- |
Sgcd |
NNNTGAATATGGTTATGAGC |
NGG |
1 |
0.4286 |
Tier II |
4 |
NC_000076.6 |
10 |
92859555 |
- |
Cfap54 |
NNNTGAATATGCCTATGAGG |
NGG |
2 |
0.418 |
Tier II |
5 |
NC_000067.6 |
1 |
140524558 |
- |
Kcnt2 |
NNNTGAATATATTTATGAGG |
NGG |
2 |
0.3846 |
Tier II |
6 |
NC_000075.6 |
9 |
34928958 |
+ |
Kirrel3 |
NNNTGAATATGATTATGGGG |
NGG |
2 |
0.3733 |
Tier II |
7 |
NC_000082.6 |
16 |
88073607 |
+ |
Grik1 |
NNNTGAATTTGGTTATGTGG |
NGG |
2 |
0.3 |
Tier II |
8 |
NC_000068.7 |
2 |
60611809 |
+ |
Itgb6 |
NNNTGATTATGGTAATGAGG |
NGG |
2 |
0.2708 |
Tier II |
9 |
NC_000070.6 |
4 |
59544785 |
- |
Ptbp3 |
NNNTGAATATGTTTATGAGT |
NGG |
2 |
0.2692 |
Tier II |
10 |
NC_000075.6 |
9 |
48300997 |
+ |
Nxpe4 |
NNNTGAACATGGTTATGAGG |
NAG |
2 |
0.2593 |
Tier II |
11 |
NC_000073.6 |
7 |
62766259 |
- |
A26c2 |
NNNTGAATATGGTTATGTCG |
NGG |
2 |
0.2241 |
Tier II |
12 |
NC_000070.6 |
4 |
20578327 |
- |
Nkain3 |
NNNTGAAAATGGGTATGAGG |
NGG |
2 |
0.2087 |
Tier II |
13 |
NC_000074.6 |
8 |
108319800 |
- |
Zfhx3 |
NNNTAAATATGGTTATCAGG |
NGG |
2 |
0.2039 |
Tier II |
14 |
NC_000068.7 |
2 |
105353921 |
+ |
Them7 |
NNNTGAATATGGTTATGAAG |
NAG |
2 |
0.1852 |
Tier II |
15 |
NC_000068.7 |
2 |
110871835 |
+ |
Ano3 |
NNNTGAATATGGGTATGATG |
NGG |
2 |
0.1739 |
Tier II |
16 |
NC_000073.6 |
7 |
136935695 |
+ |
Mgmt |
NNNTGAATATGGTTATCAGG |
NAG |
2 |
0.061 |
Tier II |
17 |
NC_000069.6 |
3 |
26655018 |
- |
Spata16 |
NNNTGAATATGGTTATGAGA |
NTG |
2 |
0.0365 |
Tier II |
18 |
NC_000081.6 |
15 |
18090624 |
- |
4921515E04Rik |
NNNAGAATATGGCTATGAGG |
NGG |
2 |
0.3759 |
Tier III |
19 |
NC_000075.6 |
9 |
34928958 |
+ |
Kirrel3os |
NNNTGAATATGATTATGGGG |
NGG |
2 |
0.3733 |
Tier III |
20 |
NC_000068.7 |
2 |
138425674 |
- |
LOC102636024 |
NNNTGATTATGGTTATGGGG |
NGG |
2 |
0.175 |
Tier III |
Other clones with same target sequence:
(none)