Construct: sgRNA BRDN0001147603
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GTACTCACATTCCTCAAGAC
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NTPCR (84284)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 232956435 | - | NTPCR | NNNCTCACATTCCTCAAGAC | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 166922425 | - | ILDR2 | NNNCTCACATTTGTCAAGAC | NGG | 2 | 0.0734 | Tier I |
3 | NC_000010.11 | 10 | 50817664 | - | A1CF | NNNCTCATCTTCCTCAAGAC | NGG | 2 | 0.5 | Tier II |
4 | NC_000008.11 | 8 | 55395896 | + | XKR4 | NNNCTCACAGTTCTCAAGAC | NGG | 2 | 0.2692 | Tier II |
5 | NC_000003.12 | 3 | 177025990 | + | TBL1XR1 | NNNCACACATTCCTCAACAC | NGG | 2 | 0.2381 | Tier II |
6 | NC_000010.11 | 10 | 62464069 | - | ZNF365 | NNNCTCTCATTGCTCAAGAC | NGG | 2 | 0.1944 | Tier II |
7 | NC_000005.10 | 5 | 155957431 | + | SGCD | NNNCTCCCATTCCTCAAGGC | NGG | 2 | 0.1641 | Tier II |
8 | NC_000004.12 | 4 | 151614724 | - | FHIP1A | NNNCTCACATTCCTCAAACC | NGG | 2 | 0.1432 | Tier II |
9 | NC_000003.12 | 3 | 125127130 | + | SLC12A8 | NNNCTCAGATTCCTAAAGAC | NGG | 2 | 0.1429 | Tier II |
10 | NC_000012.12 | 12 | 119495728 | + | CCDC60 | NNNCTCACTTTCCTCAAGCC | NGG | 2 | 0.1241 | Tier II |
11 | NC_000010.11 | 10 | 47732000 | - | ANXA8 | NNNCTCAGATTCCTCAGGAC | NGG | 2 | 0.1134 | Tier II |
12 | NC_000006.12 | 6 | 132817573 | + | RPS12 | NNNCTCACATTCCTCATGTC | NGG | 2 | 0.0718 | Tier II |
13 | NC_000014.9 | 14 | 59255450 | - | DAAM1 | NNNCTCACATTCCTCATGTC | NGG | 2 | 0.0718 | Tier II |
14 | NC_000012.12 | 12 | 132495118 | - | FBRSL1 | NNNCTCACATTCCCCACGAC | NGG | 2 | 0.0504 | Tier II |
15 | NC_000003.12 | 3 | 33091467 | + | GLB1 | NNNCTCACATTCCCCAGGAC | NGG | 2 | 0.0504 | Tier II |
16 | NC_000003.12 | 3 | 33091467 | + | TMPPE | NNNCTCACATTCCCCAGGAC | NGG | 2 | 0.0504 | Tier II |
17 | NC_000003.12 | 3 | 7171129 | + | GRM7 | NNNCTCACATTCCTGAAGTC | NGG | 2 | 0.0269 | Tier II |
18 | NC_000001.11 | 1 | 41032137 | - | SCMH1 | NNNCTCACAGTCCTGAAGAC | NGG | 2 | 0.025 | Tier II |
19 | NC_000006.12 | 6 | 20154799 | + | MBOAT1 | NNNCTCACATTCCCTAAGAC | NGG | 2 | 0.019 | Tier II |
20 | NC_000023.11 | X | 97140292 | - | DIAPH2 | NNNCTCACATTCCTAAAGAG | NGG | 2 | 0.0131 | Tier II |
21 | NC_000011.10 | 11 | 24989366 | + | LUZP2 | NNNCTCACATTCCTAAAGAC | NGT | 2 | 0.0036 | Tier II |
22 | NC_000006.12 | 6 | 57206698 | - | RAB23 | NNNCTCACATTCCTCAAGAC | NTA | 2 | 0.0 | Tier II |
23 | NC_000019.10 | 19 | 4058584 | + | ZBTB7A | NNNCTCACATTCCTCCAGGC | NGG | 2 | 0.0 | Tier II |
24 | NC_000001.11 | 1 | 165894460 | + | UCK2 | NNNCTGACATTCCTCTAGAC | NGG | 2 | 0.0 | Tier II |
25 | NC_000012.12 | 12 | 73003292 | - | LOC105369838 | NNNCTCACATTCCTCAAGTC | NGG | 1 | 0.5385 | Tier III |
26 | NC_000005.10 | 5 | 172630423 | - | LOC107986478 | NNNCTCACATTCTTCAAGTC | NGG | 2 | 0.3769 | Tier III |
27 | NC_000006.12 | 6 | 113365840 | - | LOC107986637 | NNNCACACATTCCTCAAAAC | NGG | 2 | 0.3462 | Tier III |
28 | NC_000003.12 | 3 | 55308153 | + | LOC124906243 | NNNCTCACAGTTCTCAAGAC | NGG | 2 | 0.2692 | Tier III |
29 | NC_000014.9 | 14 | 22481246 | - | TRA | NNNCTGACATTTCTCAAGAC | NGG | 2 | 0.2692 | Tier III |
30 | NC_000014.9 | 14 | 22481246 | - | TRD-AS1 | NNNCTGACATTTCTCAAGAC | NGG | 2 | 0.2692 | Tier III |
31 | NC_000006.12 | 6 | 167240757 | + | LOC102724220 | NNNCTCAAATTCCTCAAGGC | NGG | 2 | 0.2438 | Tier III |
32 | NC_000012.12 | 12 | 76296628 | + | LNCOG | NNNCTCACATGCCTCAAGTC | NGG | 2 | 0.2154 | Tier III |
33 | NC_000023.11 | X | 103430503 | - | LL0XNC01-250H12.3 | NNNCTCACATGCCTCAAGTC | NGG | 2 | 0.2154 | Tier III |
34 | NC_000012.12 | 12 | 119495728 | + | LOC105370027 | NNNCTCACTTTCCTCAAGCC | NGG | 2 | 0.1241 | Tier III |
35 | NC_000010.11 | 10 | 46609691 | + | LOC105378289 | NNNCTCAGATTCCTCAGGAC | NGG | 2 | 0.1134 | Tier III |
36 | NC_000010.11 | 10 | 47732000 | - | LOC124902422 | NNNCTCAGATTCCTCAGGAC | NGG | 2 | 0.1134 | Tier III |
37 | NC_000015.10 | 15 | 96691859 | - | LOC105371002 | NNNTTCACATTCCTCAAGAC | NTG | 2 | 0.0312 | Tier III |
38 | NC_000001.11 | 1 | 41032137 | - | SLFNL1-AS1 | NNNCTCACAGTCCTGAAGAC | NGG | 2 | 0.025 | Tier III |
39 | NC_000002.12 | 2 | 140089719 | + | LINC01853 | NNNCTCACTTTCCTCAAGAC | NGT | 2 | 0.0097 | Tier III |
40 | NC_000014.9 | 14 | 88042334 | + | HISLA | NNNCTCACTTTCCTCAAGAC | NGT | 2 | 0.0097 | Tier III |
41 | NC_000001.11 | 1 | 101672499 | - | LINC01709 | NNNCTCACATTTCTCTAGAC | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000084.6 | 18 | 10427712 | - | Greb1l | NNNCTAACATTCCTCAACAC | NGG | 2 | 0.4422 | Tier II |
2 | NC_000073.6 | 7 | 73393919 | - | Rgma | NNNCCCACATTCCTCAAGGC | NGG | 2 | 0.375 | Tier II |
3 | NC_000076.6 | 10 | 74283271 | + | Pcdh15 | NNNCTTACATTCATCAAGAC | NGG | 2 | 0.3571 | Tier II |
4 | NC_000076.6 | 10 | 89587324 | + | Slc17a8 | NNNCTGACATTCCTCAAAAC | NGG | 2 | 0.3462 | Tier II |
5 | NC_000075.6 | 9 | 46294594 | + | Bud13 | NNNGTCAGATTCCTCAAGAC | NGG | 2 | 0.3214 | Tier II |
6 | NC_000075.6 | 9 | 100470558 | - | Il20rb | NNNCTCTCATTCTTCAAGAC | NGG | 2 | 0.3062 | Tier II |
7 | NC_000078.6 | 12 | 85696464 | - | Batf | NNNCACACATTCCTCAAGTC | NGG | 2 | 0.2692 | Tier II |
8 | NC_000078.6 | 12 | 102161313 | + | Slc24a4 | NNNCTCACAATCCTAAAGAC | NGG | 2 | 0.1905 | Tier II |
9 | NC_000069.6 | 3 | 154935544 | - | Tnni3k | NNNCTCACATTTCTCAAGAT | NGG | 2 | 0.1615 | Tier II |
10 | NC_000077.6 | 11 | 106243792 | + | Ddx42 | NNNCACACATTCCTCAAGAC | NAG | 2 | 0.1296 | Tier II |
11 | NC_000067.6 | 1 | 38457521 | - | Aff3 | NNNCACACATTCCTCAGGAC | NGG | 2 | 0.0882 | Tier II |
12 | NC_000077.6 | 11 | 80814463 | - | Tmem98 | NNNCTGACATTCCTCATGAC | NGG | 2 | 0.0667 | Tier II |
13 | NC_000078.6 | 12 | 44546925 | - | Nrcam | NNNCTCACATTCCTGAAGAC | NGG | 1 | 0.05 | Tier II |
14 | NC_000068.7 | 2 | 125364919 | - | Fbn1 | NNNCTCACATTCTTCAAGAC | NGA | 2 | 0.0486 | Tier II |
15 | NC_000067.6 | 1 | 115701233 | + | Cntnap5a | NNNCTCACATTCTTTAAGAC | NGG | 2 | 0.0467 | Tier II |
16 | NC_000079.6 | 13 | 99217199 | + | Zfp366 | NNNCTCACTTTCCTCAAGAG | NGG | 2 | 0.0353 | Tier II |
17 | NC_000072.6 | 6 | 97937298 | + | Mitf | NNNCTCACATTCCTCAACAG | NGG | 2 | 0.028 | Tier II |
18 | NC_000068.7 | 2 | 13451103 | - | Cubn | NNNCTCACATTCCTCAAGGC | NGA | 2 | 0.026 | Tier II |
19 | NC_000080.6 | 14 | 48531369 | + | Tmem260 | NNNCTCACGTTCCTCAAGAC | NGC | 2 | 0.0148 | Tier II |
20 | NC_000068.7 | 2 | 76024201 | + | Pde11a | NNNCTCACATTCCTCAGGAC | NGA | 2 | 0.0123 | Tier II |
21 | NC_000074.6 | 8 | 32320325 | + | Nrg1 | NNNCTCACATTCCTGAAGCC | NGG | 2 | 0.0103 | Tier II |
22 | NC_000068.7 | 2 | 39153293 | - | Scai | NNNCTCACATTCCTCTACAC | NGG | 2 | 0.0 | Tier II |
23 | NC_000068.7 | 2 | 97623202 | + | Lrrc4c | NNNCTCACATTCCTCTACAC | NGG | 2 | 0.0 | Tier II |
24 | NC_000070.6 | 4 | 25217915 | + | Fhl5 | NNNCTCACATTCCTCTACAC | NGG | 2 | 0.0 | Tier II |
25 | NC_000081.6 | 15 | 43120325 | + | Rspo2 | NNNCTCACATTCCTCTACAC | NGG | 2 | 0.0 | Tier II |
26 | NC_000086.7 | X | 162622294 | - | Reps2 | NNNCTCACATTCCTCTACAC | NGG | 2 | 0.0 | Tier II |
27 | NC_000074.6 | 8 | 58854253 | - | Galntl6 | NNNCTCACATTCCTCTATAC | NGG | 2 | 0.0 | Tier II |
28 | NC_000074.6 | 8 | 125463837 | + | Sipa1l2 | NNNCTCACATTGCTCCAGAC | NGG | 2 | 0.0 | Tier II |
29 | NC_000073.6 | 7 | 73393919 | - | LOC115486533 | NNNCCCACATTCCTCAAGGC | NGG | 2 | 0.375 | Tier III |
30 | NC_000083.6 | 17 | 46351757 | + | BC040756 | NNNCTCAAATTCCTCAAGCC | NGG | 2 | 0.1345 | Tier III |
31 | NC_000081.6 | 15 | 61723937 | + | D030024E09Rik | NNNGTCACATTCCTCAAGCC | NGG | 2 | 0.1034 | Tier III |
32 | NC_000077.6 | 11 | 80814463 | - | Gm31228 | NNNCTGACATTCCTCATGAC | NGG | 2 | 0.0667 | Tier III |