Construct: sgRNA BRDN0001147634
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TAGTTGTGTCCCCTGCATGT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- GTF2H1 (2965)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76601
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000011.10 |
11 |
18335809 |
- |
GTF2H1 |
NNNTTGTGTCCCCTGCATGT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000014.9 |
14 |
104869587 |
+ |
CEP170B |
NNNTTGTGTCCCCTGCAATT |
NGG |
2 |
0.4444 |
Tier I |
3 |
NC_000003.12 |
3 |
196640629 |
+ |
NRROS |
NNNTCGTGGCCCCTGCATGT |
NGG |
2 |
0.619 |
Tier II |
4 |
NC_000010.11 |
10 |
113046262 |
+ |
TCF7L2 |
NNNTTGTAGCCCCTGCATGT |
NGG |
2 |
0.619 |
Tier II |
5 |
NC_000015.10 |
15 |
39904616 |
+ |
GPR176 |
NNNTTGTGTCCCCTGCAATT |
NGG |
2 |
0.4444 |
Tier II |
6 |
NC_000001.11 |
1 |
205809693 |
- |
SLC41A1 |
NNNTTTTGTCCCCTGCATTT |
NGG |
2 |
0.4444 |
Tier II |
7 |
NC_000007.14 |
7 |
746800 |
+ |
DNAAF5 |
NNNCTCTGTCCCCTGCATGT |
NGG |
2 |
0.4412 |
Tier II |
8 |
NC_000007.14 |
7 |
69828411 |
- |
AUTS2 |
NNNTGCTGTCCCCTGCATGT |
NGG |
2 |
0.4364 |
Tier II |
9 |
NC_000011.10 |
11 |
128550059 |
- |
ETS1 |
NNNTTGTGTCCACTGCATGA |
NGG |
2 |
0.4018 |
Tier II |
10 |
NC_000001.11 |
1 |
48236308 |
- |
SLC5A9 |
NNNGTGGGTCCCCTGCATGT |
NGG |
2 |
0.3676 |
Tier II |
11 |
NC_000014.9 |
14 |
69131678 |
- |
DCAF5 |
NNNTTCTGTCCTCTGCATGT |
NGG |
2 |
0.3671 |
Tier II |
12 |
NC_000008.11 |
8 |
1258113 |
- |
DLGAP2 |
NNNTTGAGTCCCCTGTATGT |
NGG |
2 |
0.2692 |
Tier II |
13 |
NC_000012.12 |
12 |
526078 |
+ |
B4GALNT3 |
NNNGTGTGTGCCCTGCATGT |
NGG |
2 |
0.2431 |
Tier II |
14 |
NC_000017.11 |
17 |
82012031 |
+ |
ASPSCR1 |
NNNTGGTGTCCCCTGCAGGT |
NGG |
2 |
0.2133 |
Tier II |
15 |
NC_000009.12 |
9 |
3447702 |
+ |
RFX3 |
NNNTTGTGTCTCCTGCATGA |
NGG |
2 |
0.1731 |
Tier II |
16 |
NC_000001.11 |
1 |
181053829 |
- |
MR1 |
NNNTTGTGTCCCCTACATGG |
NGG |
2 |
0.1661 |
Tier II |
17 |
NC_000010.11 |
10 |
1638893 |
- |
ADARB2 |
NNNTTGTGTCACCTGCATGG |
NGG |
2 |
0.1324 |
Tier II |
18 |
NC_000012.12 |
12 |
76521348 |
+ |
OSBPL8 |
NNNTTGTGTGCCCTGCAGGT |
NGG |
2 |
0.1296 |
Tier II |
19 |
NC_000002.12 |
2 |
43280720 |
+ |
THADA |
NNNTTGTGTCCCATGTATGT |
NGG |
2 |
0.1183 |
Tier II |
20 |
NC_000010.11 |
10 |
96456807 |
- |
TLL2 |
NNNTTGTGTCTCCTGCAGGT |
NGG |
2 |
0.1026 |
Tier II |
21 |
NC_000006.12 |
6 |
45882363 |
+ |
CLIC5 |
NNNTTGTGTGCCCTGCCTGT |
NGG |
2 |
0.0686 |
Tier II |
22 |
NC_000011.10 |
11 |
78223157 |
- |
GAB2 |
NNNTTGTGCCCCCTGCATGT |
NGA |
2 |
0.0641 |
Tier II |
23 |
NC_000011.10 |
11 |
78223157 |
- |
USP35 |
NNNTTGTGCCCCCTGCATGT |
NGA |
2 |
0.0641 |
Tier II |
24 |
NC_000003.12 |
3 |
11810145 |
+ |
TAMM41 |
NNNTTGTGTCTCCTGCCTGT |
NGG |
2 |
0.0543 |
Tier II |
25 |
NC_000002.12 |
2 |
191389897 |
+ |
MYO1B |
NNNTTGTGTCCCTTGCATGT |
NGA |
2 |
0.0486 |
Tier II |
26 |
NC_000005.10 |
5 |
172174527 |
- |
STK10 |
NNNTTGTGTCCCCTGCATTT |
NGA |
2 |
0.0463 |
Tier II |
27 |
NC_000009.12 |
9 |
123579748 |
- |
DENND1A |
NNNTTGTGTCCCCTGCATTT |
NGC |
2 |
0.0148 |
Tier II |
28 |
NC_000014.9 |
14 |
103020279 |
- |
CDC42BPB |
NNNTTGTGTCCTCTGCATGT |
NGC |
2 |
0.012 |
Tier II |
29 |
NC_000012.12 |
12 |
54634505 |
- |
LACRT |
NNNTGGTGTCCCCTGCATGT |
NGT |
2 |
0.0103 |
Tier II |
30 |
NC_000004.12 |
4 |
161458063 |
- |
FSTL5 |
NNNTTGTGTCCCCTGCATGT |
NAC |
2 |
0.0 |
Tier II |
31 |
NC_000001.11 |
1 |
59023187 |
- |
LINC01358 |
NNNTTGTGCCCACTGCATGT |
NGG |
2 |
0.6593 |
Tier III |
32 |
NC_000016.10 |
16 |
49092675 |
+ |
LOC105371241 |
NNNTTCTGTCCCCTGCAGGT |
NGG |
2 |
0.2273 |
Tier III |
33 |
NC_000009.12 |
9 |
123579748 |
- |
LOC105376266 |
NNNTTGTGTCCCCTGCATTT |
NGC |
2 |
0.0148 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000073.6 |
7 |
83609281 |
- |
Tmc3 |
NNNTTGTGGGCCCTGCATGT |
NGG |
2 |
0.2407 |
Tier I |
2 |
NC_000073.6 |
7 |
46803872 |
- |
Gtf2h1 |
NNNTTGTGTCCCCTGCATGC |
NGG |
1 |
0.0909 |
Tier I |
3 |
NC_000075.6 |
9 |
28484557 |
- |
Opcml |
NNNTCCTGTCCCCTGCATGT |
NGG |
2 |
0.6818 |
Tier II |
4 |
NC_000071.6 |
5 |
139170455 |
- |
Dnaaf5 |
NNNTTGTGACCCCAGCATGT |
NGG |
2 |
0.5748 |
Tier II |
5 |
NC_000069.6 |
3 |
98148198 |
+ |
Notch2 |
NNNTTCTCTCCCCTGCATGT |
NGG |
2 |
0.4196 |
Tier II |
6 |
NC_000074.6 |
8 |
115201260 |
+ |
Wwox |
NNNTTTTTTCCCCTGCATGT |
NGG |
2 |
0.4167 |
Tier II |
7 |
NC_000080.6 |
14 |
20300939 |
+ |
Nudt13 |
NNNCTGTGTCCCCAGCATGT |
NGG |
2 |
0.4006 |
Tier II |
8 |
NC_000067.6 |
1 |
136426237 |
+ |
Ddx59 |
NNNTTCTGTCCTCTGCATGT |
NGG |
2 |
0.3671 |
Tier II |
9 |
NC_000074.6 |
8 |
16423024 |
- |
Csmd1 |
NNNTTGTGTCTCCTGCATGT |
NGG |
1 |
0.3077 |
Tier II |
10 |
NC_000070.6 |
4 |
32909579 |
- |
Ankrd6 |
NNNTTCTGTCCCCTGCATCT |
NGG |
2 |
0.3056 |
Tier II |
11 |
NC_000072.6 |
6 |
96117272 |
- |
Tafa1 |
NNNTTGTGTTCCCTCCATGT |
NGG |
2 |
0.2567 |
Tier II |
12 |
NC_000082.6 |
16 |
96047818 |
+ |
Brwd1 |
NNNTTGTGACCCCTCCATGT |
NGG |
2 |
0.2532 |
Tier II |
13 |
NC_000076.6 |
10 |
81470285 |
- |
Celf5 |
NNNTTGTGTCCCCTGCAGAT |
NGG |
2 |
0.2381 |
Tier II |
14 |
NC_000076.6 |
10 |
70128676 |
+ |
Ccdc6 |
NNNTTGTGTCCCCTGCAGGA |
NGG |
2 |
0.1875 |
Tier II |
15 |
NC_000076.6 |
10 |
64502336 |
- |
Ctnna3 |
NNNTTGTTTCCCCTGCATGT |
NAG |
2 |
0.162 |
Tier II |
16 |
NC_000079.6 |
13 |
117244342 |
- |
Emb |
NNNTTGTTTCCCCTGCATGT |
NAG |
2 |
0.162 |
Tier II |
17 |
NC_000075.6 |
9 |
107693133 |
- |
Sema3f |
NNNCTGTGTCCCCTGCATGG |
NGG |
2 |
0.1142 |
Tier II |
18 |
NC_000073.6 |
7 |
120008632 |
+ |
Dnah3 |
NNNTTGTGTCCCCTGGATAT |
NGG |
2 |
0.1099 |
Tier II |
19 |
NC_000078.6 |
12 |
116366246 |
+ |
Esyt2 |
NNNTTGTGTCACCTGCATGC |
NGG |
2 |
0.0682 |
Tier II |
20 |
NC_000068.7 |
2 |
134974291 |
- |
Plcb1 |
NNNTTGTGTCTCCTGCATGG |
NGG |
2 |
0.0543 |
Tier II |
21 |
NC_000085.6 |
19 |
22862461 |
+ |
Trpm3 |
NNNTTGTGGCCCCTGCATGT |
NGA |
2 |
0.043 |
Tier II |
22 |
NC_000072.6 |
6 |
103536220 |
+ |
Chl1 |
NNNTTGTATCCCCTGCATGT |
NTG |
2 |
0.039 |
Tier II |
23 |
NC_000080.6 |
14 |
24464125 |
- |
Polr3a |
NNNTTGTGTCCCCTTCATGT |
NAG |
2 |
0.037 |
Tier II |
24 |
NC_000077.6 |
11 |
19997078 |
- |
Spred2 |
NNNTTCTGTCCCCTGCATGT |
NTG |
2 |
0.0266 |
Tier II |
25 |
NC_000077.6 |
11 |
60147331 |
+ |
Rai1 |
NNNTTGTGTCCCCTTCCTGT |
NGG |
2 |
0.0252 |
Tier II |
26 |
NC_000075.6 |
9 |
67311142 |
+ |
Tln2 |
NNNGTGTGTCCCCTGCATGT |
NGC |
2 |
0.0139 |
Tier II |
27 |
NC_000073.6 |
7 |
132679185 |
- |
Lhpp |
NNNTTGGGTCCCCTGCATGT |
NGT |
2 |
0.0095 |
Tier II |
28 |
NC_000072.6 |
6 |
96117272 |
- |
2900060L22Rik |
NNNTTGTGTTCCCTCCATGT |
NGG |
2 |
0.2567 |
Tier III |
29 |
NC_000073.6 |
7 |
83609281 |
- |
Gm16638 |
NNNTTGTGGGCCCTGCATGT |
NGG |
2 |
0.2407 |
Tier III |
30 |
NC_000085.6 |
19 |
43627562 |
+ |
Gm34922 |
NNNTTGTGTCCCCTGTAAGT |
NGG |
2 |
0.2051 |
Tier III |
31 |
NC_000071.6 |
5 |
117002329 |
+ |
Gm30028 |
NNNTTCTGTCCCCTGCATGT |
NAG |
2 |
0.1768 |
Tier III |
Other clones with same target sequence:
(none)