Construct: sgRNA BRDN0001147695
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTCCTCAAGTCCACAGACGT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- AATK (9625)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77316
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000017.11 |
17 |
81128528 |
- |
AATK |
NNNCTCAAGTCCACAGACGT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000001.11 |
1 |
42591303 |
+ |
CCDC30 |
NNNCACAGGTCCACAGACGT |
NGG |
2 |
0.3667 |
Tier II |
3 |
NC_000010.11 |
10 |
47581260 |
+ |
ANXA8 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier II |
4 |
NC_000002.12 |
2 |
205031026 |
- |
PARD3B |
NNNCTCATGTCCACAGACCT |
NGG |
2 |
0.1921 |
Tier II |
5 |
NC_000006.12 |
6 |
38501702 |
- |
BTBD9 |
NNNCTCAAGTGCACAGACAT |
NGG |
2 |
0.1786 |
Tier II |
6 |
NC_000023.11 |
X |
26138679 |
+ |
MAGEB18 |
NNNCTCAAGTCAACAGACGG |
NGG |
2 |
0.1261 |
Tier II |
7 |
NC_000017.11 |
17 |
269857 |
+ |
RPH3AL |
NNNCTCCAGTGCACAGACGT |
NGG |
2 |
0.1094 |
Tier II |
8 |
NC_000016.10 |
16 |
12385296 |
- |
SNX29 |
NNNCACAAGTCCCCAGACGT |
NGG |
2 |
0.1053 |
Tier II |
9 |
NC_000011.10 |
11 |
132101152 |
- |
NTM |
NNNCTCAAGTCCATAGAGGT |
NGG |
2 |
0.0978 |
Tier II |
10 |
NC_000002.12 |
2 |
73203577 |
- |
NOTO |
NNNCTCAAGTTCACAGACGT |
NAG |
2 |
0.0798 |
Tier II |
11 |
NC_000006.12 |
6 |
108967956 |
+ |
ARMC2 |
NNNCTCAAGCCCACAGTCGT |
NGG |
2 |
0.0711 |
Tier II |
12 |
NC_000011.10 |
11 |
133141123 |
- |
OPCML |
NNNCTCAAGTCCACACACTT |
NGG |
2 |
0.0 |
Tier II |
13 |
NC_000010.11 |
10 |
19330754 |
+ |
MALRD1 |
NNNCTGAAGTCCACACACGT |
NGG |
2 |
0.0 |
Tier II |
14 |
NC_000001.11 |
1 |
42591303 |
+ |
LOC124904162 |
NNNCACAGGTCCACAGACGT |
NGG |
2 |
0.3667 |
Tier III |
15 |
NC_000010.11 |
10 |
46759153 |
- |
GLUD1P2 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier III |
16 |
NC_000010.11 |
10 |
47581260 |
+ |
CTSLP2 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier III |
17 |
NC_000010.11 |
10 |
50707838 |
+ |
CTSLP4 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier III |
18 |
NC_000010.11 |
10 |
79872835 |
+ |
CTSLP6 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier III |
19 |
NC_000010.11 |
10 |
87389137 |
+ |
CTSLP1 |
NNNCTCCAGTCCACAGATGT |
NGG |
2 |
0.2812 |
Tier III |
20 |
NC_000002.12 |
2 |
12542509 |
- |
MIR3681HG |
NNNCTCAAGACCACAGACGT |
NAG |
2 |
0.2222 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000079.6 |
13 |
64367908 |
+ |
Ctsl |
NNNCTCCAGTCCACAGACTT |
NGG |
2 |
0.2917 |
Tier I |
2 |
NC_000077.6 |
11 |
120016786 |
- |
Aatk |
NNNCTCAAGTCCACGGACCT |
NGG |
2 |
0.2914 |
Tier I |
3 |
NC_000081.6 |
15 |
42494623 |
- |
Angpt1 |
NNNCTTAAGTACACAGACGT |
NGG |
2 |
0.6964 |
Tier II |
4 |
NC_000078.6 |
12 |
19537041 |
- |
Gm6943 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
5 |
NC_000078.6 |
12 |
19846441 |
+ |
Gm38702 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
6 |
NC_000078.6 |
12 |
19993699 |
- |
Gm40853 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
7 |
NC_000078.6 |
12 |
20122220 |
- |
Gm9265 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
8 |
NC_000078.6 |
12 |
22688058 |
+ |
Gm9295 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
9 |
NC_000078.6 |
12 |
24033820 |
+ |
Gm5954 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
10 |
NC_000078.6 |
12 |
24317368 |
+ |
Gm4120 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier II |
11 |
NC_000078.6 |
12 |
17777894 |
- |
Hpcal1 |
NNNCTCAGGTCCACAGACCT |
NGG |
2 |
0.3287 |
Tier II |
12 |
NC_000078.6 |
12 |
18890038 |
- |
Gm40847 |
NNNCTCAGGTCCACAGACCT |
NGG |
2 |
0.3287 |
Tier II |
13 |
NC_000078.6 |
12 |
22430850 |
+ |
Gm10476 |
NNNCTCAGGTCCACAGACCT |
NGG |
2 |
0.3287 |
Tier II |
14 |
NC_000078.6 |
12 |
23589880 |
+ |
Gm40862 |
NNNCTCAGGTCCACAGACCT |
NGG |
2 |
0.3287 |
Tier II |
15 |
NC_000068.7 |
2 |
173155444 |
- |
Pck1 |
NNNCTCAAGTCCCCAGATGT |
NGG |
2 |
0.1353 |
Tier II |
16 |
NC_000071.6 |
5 |
136843826 |
+ |
Col26a1 |
NNNCTCAGGTCCACAGAGGT |
NGG |
2 |
0.0978 |
Tier II |
17 |
NC_000071.6 |
5 |
75617699 |
- |
Kit |
NNNCTCAAGTCCACAGACTT |
NGA |
2 |
0.0463 |
Tier II |
18 |
NC_000075.6 |
9 |
67849609 |
- |
Vps13c |
NNNCTCAAGTCCACAGACAT |
NGC |
2 |
0.0159 |
Tier II |
19 |
NC_000075.6 |
9 |
86372665 |
- |
Ube2cbp |
NNNCTCAAGTCCTCAGACGT |
NGC |
2 |
0.0067 |
Tier II |
20 |
NC_000078.6 |
12 |
18170591 |
- |
LOC108167983 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier III |
21 |
NC_000078.6 |
12 |
20536120 |
- |
Gm4012 |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier III |
22 |
NC_000078.6 |
12 |
22969829 |
+ |
2410018L13Rik |
NNNCTCAGGTCCACAGACAT |
NGG |
2 |
0.5238 |
Tier III |
23 |
NC_000073.6 |
7 |
30996052 |
- |
Gm42377 |
NNNCTCAAGTGCACACACGT |
NGG |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)