Construct: sgRNA BRDN0001147698
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGAAACTTCAGCCAACTGTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- MAPK9 (5601)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000005.10 | 5 | 180242679 | - | MAPK9 | NNNAACTTCAGCCAACTGTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 39189461 | - | MACF1 | NNNAACTTCTGCCAACTTTG | NGG | 2 | 0.5882 | Tier II |
3 | NC_000005.10 | 5 | 73885210 | - | ARHGEF28 | NNNAACTTAAGCCAGCTGTG | NGG | 2 | 0.5571 | Tier II |
4 | NC_000012.12 | 12 | 85180217 | + | LRRIQ1 | NNNAAGTTCAACCAACTGTG | NGG | 2 | 0.5 | Tier II |
5 | NC_000016.10 | 16 | 10117171 | - | GRIN2A | NNNAACTAGAGCCAACTGTG | NGG | 2 | 0.4952 | Tier II |
6 | NC_000006.12 | 6 | 151862395 | - | ESR1 | NNNAACTCCAGCCAACTCTG | NGG | 2 | 0.4762 | Tier II |
7 | NC_000007.14 | 7 | 38872181 | - | VPS41 | NNNAACTTCTGCCAACAGTG | NGG | 2 | 0.4706 | Tier II |
8 | NC_000009.12 | 9 | 133544708 | + | ADAMTSL2 | NNNAACTTGAGCCAGCTGTG | NGG | 2 | 0.4024 | Tier II |
9 | NC_000006.12 | 6 | 82920135 | - | UBE3D | NNNAGCTTCAGTCAACTGTG | NGG | 2 | 0.3877 | Tier II |
10 | NC_000004.12 | 4 | 183924272 | - | STOX2 | NNNATCTCCAGCCAACTGTG | NGG | 2 | 0.3636 | Tier II |
11 | NC_000015.10 | 15 | 41818806 | + | MAPKBP1 | NNNTCCTTCAGCCAACTGTG | NGG | 2 | 0.3182 | Tier II |
12 | NC_000009.12 | 9 | 130611079 | - | FUBP3 | NNNCACTTTAGCCAACTGTG | NGG | 2 | 0.3088 | Tier II |
13 | NC_000002.12 | 2 | 111000251 | - | ACOXL | NNNAACTTCAGGCAACAGTG | NGG | 2 | 0.237 | Tier II |
14 | NC_000001.11 | 1 | 214611841 | - | CENPF | NNNAACTTCAGCCAACTCTC | NGG | 2 | 0.2041 | Tier II |
15 | NC_000004.12 | 4 | 97856521 | - | STPG2 | NNNAACTTCAGCAAACTCTG | NGG | 2 | 0.1832 | Tier II |
16 | NC_000004.12 | 4 | 37498690 | - | C4orf19 | NNNAACTTCAGCAAACTGTC | NGG | 2 | 0.1648 | Tier II |
17 | NC_000011.10 | 11 | 62389847 | - | ASRGL1 | NNNAACTTCAGTCACCTGTG | NGG | 2 | 0.1469 | Tier II |
18 | NC_000020.11 | 20 | 2876354 | - | PTPRA | NNNAACTTCAGCCATCTCTG | NGG | 2 | 0.0952 | Tier II |
19 | NC_000002.12 | 2 | 76932990 | - | LRRTM4 | NNNAACTTCAACCAACTGTG | NGA | 2 | 0.0694 | Tier II |
20 | NC_000002.12 | 2 | 239361282 | - | HDAC4 | NNNAACTTCAGCCCCCTGTG | NGG | 2 | 0.0584 | Tier II |
21 | NC_000023.11 | X | 96973068 | - | DIAPH2 | NNNAACTTCAGCCAACTGTA | NGC | 2 | 0.0208 | Tier II |
22 | NC_000015.10 | 15 | 71031883 | + | LRRC49 | NNNAACTTCAGCCTACTGTG | NTG | 2 | 0.0208 | Tier II |
23 | NC_000019.10 | 19 | 41276139 | + | HNRNPUL1 | NNNAACATCAGCCAACTGTG | NGC | 2 | 0.0194 | Tier II |
24 | NC_000010.11 | 10 | 66783942 | + | CTNNA3 | NNNAACTTCAGCCAACAGTG | NGT | 2 | 0.0086 | Tier II |
25 | NC_000010.11 | 10 | 132865826 | + | CFAP46 | NNNAACTTCAGCAAACTGTG | NGT | 2 | 0.0062 | Tier II |
26 | NC_000011.10 | 11 | 99591049 | + | CNTN5 | NNNAACTTCAGCCCACTGTG | NGT | 2 | 0.0035 | Tier II |
27 | NC_000024.10 | Y | 21293610 | - | LOC107987347 | NNNAATTTCTGCCAACTGTG | NGG | 2 | 0.8193 | Tier III |
28 | NC_000005.10 | 5 | 66401381 | - | LOC105379003 | NNNAACTTCAGCAAACTGTC | NGG | 2 | 0.1648 | Tier III |
29 | NC_000021.9 | 21 | 29256195 | - | LINC00189 | NNNAATTTCAGCCAAGTGTG | NGG | 2 | 0.1429 | Tier III |
30 | NC_000001.11 | 1 | 117140092 | - | LOC124904387 | NNNATCTTCAGCCATCTGTG | NGG | 2 | 0.0727 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000077.6 | 11 | 49878308 | + | Mapk9 | NNNAACTTCAGCCAACTGTA | NGG | 1 | 0.9375 | Tier I |
2 | NC_000072.6 | 6 | 124850652 | - | P3h3 | NNNAACTTCAGCCGAGTGTG | NGG | 2 | 0.0718 | Tier I |
3 | NC_000069.6 | 3 | 95194802 | + | Gabpb2 | NNNGACTTCAGCCAACTGTG | NGG | 1 | 0.625 | Tier II |
4 | NC_000068.7 | 2 | 53037080 | - | Fmnl2 | NNNAGCTTAAGCCAACTGTG | NGG | 2 | 0.6171 | Tier II |
5 | NC_000068.7 | 2 | 181197588 | + | Ptk6 | NNNAACCTCAGCTAACTGTG | NGG | 2 | 0.4812 | Tier II |
6 | NC_000085.6 | 19 | 34819688 | + | Pank1 | NNNCACTCCAGCCAACTGTG | NGG | 2 | 0.3529 | Tier II |
7 | NC_000076.6 | 10 | 59704476 | - | Micu1 | NNNATATTCAGCCAACTGTG | NGG | 2 | 0.3377 | Tier II |
8 | NC_000077.6 | 11 | 51973360 | + | Cdkn2aipnl | NNNAACTTCAGCCAGCTCTG | NGG | 2 | 0.3095 | Tier II |
9 | NC_000078.6 | 12 | 81090495 | - | Smoc1 | NNNAACTTCACACAACTGTG | NGG | 2 | 0.3061 | Tier II |
10 | NC_000074.6 | 8 | 45008633 | + | Fat1 | NNNAACCTCAGGCAACTGTG | NGG | 2 | 0.3056 | Tier II |
11 | NC_000076.6 | 10 | 86701518 | + | Hsp90b1 | NNNAACTGCAGCCAACTGTG | NAG | 2 | 0.1901 | Tier II |
12 | NC_000073.6 | 7 | 139898749 | - | Kndc1 | NNNATCTTCAGCCAACTCTG | NGG | 2 | 0.1732 | Tier II |
13 | NC_000071.6 | 5 | 128386377 | - | Tmem132d | NNNGACTTCAGCCAACTGTG | NAG | 2 | 0.162 | Tier II |
14 | NC_000071.6 | 5 | 142438138 | - | Foxk1 | NNNAACTCCAGCCAAGTGTG | NGG | 2 | 0.1538 | Tier II |
15 | NC_000077.6 | 11 | 88619692 | - | Msi2 | NNNCACTTCCGCCAACTGTG | NGG | 2 | 0.1176 | Tier II |
16 | NC_000079.6 | 13 | 73494509 | + | Lpcat1 | NNNAAGTTCAGCCCACTGTG | NGG | 2 | 0.1071 | Tier II |
17 | NC_000074.6 | 8 | 16772627 | - | Csmd1 | NNNACCTTCAGCCATCTGTG | NGG | 2 | 0.1 | Tier II |
18 | NC_000068.7 | 2 | 18962971 | - | Pip4k2a | NNNAAGTTCAGCCAAGTGTG | NGG | 2 | 0.0769 | Tier II |
19 | NC_000067.6 | 1 | 40812494 | + | Tmem182 | NNNAACATCAGCCAACTGTG | NGT | 2 | 0.0141 | Tier II |
20 | NC_000077.6 | 11 | 23273803 | - | Xpo1 | NNNAACTTCAGCCAAGTGTG | NTG | 2 | 0.006 | Tier II |
21 | NC_000084.6 | 18 | 34365340 | + | Reep5 | NNNAACTTCAGCCAAGTGTG | NTG | 2 | 0.006 | Tier II |
22 | NC_000078.6 | 12 | 115041705 | - | Igh | NNNAACTTCAGCCAACTGTT | NAG | 2 | 0.1815 | Tier III |
23 | NC_000077.6 | 11 | 88619692 | - | 0610039H22Rik | NNNCACTTCCGCCAACTGTG | NGG | 2 | 0.1176 | Tier III |
24 | NC_000083.6 | 17 | 45722111 | + | Gm35456 | NNNAACTTCAGCCAACTGGG | NAG | 2 | 0.0648 | Tier III |
25 | NC_000077.6 | 11 | 86012107 | + | Gm20759 | NNNAACTTCAGCCAAGTGTG | NTG | 2 | 0.006 | Tier III |