Construct: sgRNA BRDN0001147728
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGAGTGTCATGGACATGCCC
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- SCYL3 (57147)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76793
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000001.11 |
1 |
169870318 |
- |
SCYL3 |
NNNGTGTCATGGACATGCCC |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000001.11 |
1 |
92883019 |
+ |
DIPK1A |
NNNGTGTCACAGACATGCCC |
NGG |
2 |
0.5333 |
Tier II |
3 |
NC_000010.11 |
10 |
25309671 |
+ |
GPR158 |
NNNGTGTCATGGGCATGACC |
NGG |
2 |
0.3512 |
Tier II |
4 |
NC_000010.11 |
10 |
76295616 |
+ |
LRMDA |
NNNGTGTCACGGACATGCAC |
NGG |
2 |
0.2286 |
Tier II |
5 |
NC_000022.11 |
22 |
44888801 |
+ |
PHF21B |
NNNGTGTCATGCAAATGCCC |
NGG |
2 |
0.1853 |
Tier II |
6 |
NC_000007.14 |
7 |
1857381 |
+ |
MAD1L1 |
NNNGTGTCCTGGTCATGCCC |
NGG |
2 |
0.1714 |
Tier II |
7 |
NC_000015.10 |
15 |
59035197 |
- |
RNF111 |
NNNGTGTCATGGACAGGGCC |
NGG |
2 |
0.0462 |
Tier II |
8 |
NC_000020.11 |
20 |
20275031 |
- |
CFAP61 |
NNNGTGTCATGGTCATGCCC |
NTG |
2 |
0.0117 |
Tier II |
9 |
NC_000009.12 |
9 |
113109395 |
+ |
FAM225B |
NNNGTGCCATGGACAAGCCC |
NGG |
2 |
0.625 |
Tier III |
10 |
NC_000009.12 |
9 |
113115179 |
- |
FAM225A |
NNNGTGCCATGGACAAGCCC |
NGG |
2 |
0.625 |
Tier III |
11 |
NC_000018.10 |
18 |
22542256 |
+ |
LOC124904265 |
NNNAAGTCATGGACATGCCC |
NGG |
2 |
0.45 |
Tier III |
12 |
NC_000011.10 |
11 |
5929004 |
+ |
LOC112268071 |
NNNGAGTCATGCACATGCCC |
NGG |
2 |
0.2647 |
Tier III |
13 |
NC_000013.11 |
13 |
112451918 |
+ |
LOC105370372 |
NNNGTGCCATGGACAGGCCC |
NGG |
2 |
0.238 |
Tier III |
14 |
NC_000010.11 |
10 |
76295616 |
+ |
LOC124902462 |
NNNGTGTCACGGACATGCAC |
NGG |
2 |
0.2286 |
Tier III |
15 |
NC_000017.11 |
17 |
20695120 |
- |
LOC100287072 |
NNNTTGTCATGGACATGCCA |
NGG |
2 |
0.1818 |
Tier III |
16 |
NC_000022.11 |
22 |
22293226 |
- |
IGL |
NNNGTGTCATGGCCCTGCCC |
NGG |
2 |
0.0574 |
Tier III |
17 |
NC_000022.11 |
22 |
22293226 |
- |
LOC105372952 |
NNNGTGTCATGGCCCTGCCC |
NGG |
2 |
0.0574 |
Tier III |
18 |
NC_000001.11 |
1 |
69233657 |
- |
LINC02791 |
NNNGTGTCATGGAAATGCCC |
NTG |
2 |
0.0136 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000071.6 |
5 |
107603528 |
- |
Rpap2 |
NNNGTGTGATGAACATGCCC |
NGG |
2 |
0.6 |
Tier I |
2 |
NC_000069.6 |
3 |
25137199 |
- |
Naaladl2 |
NNNGTGTCAAGGACAAGCCC |
NGG |
2 |
0.7792 |
Tier II |
3 |
NC_000073.6 |
7 |
45319587 |
+ |
Trpm4 |
NNNGGGTCATGAACATGCCC |
NGG |
2 |
0.5973 |
Tier II |
4 |
NC_000076.6 |
10 |
110120822 |
+ |
Nav3 |
NNNGTATCATGGACATGCAC |
NGG |
2 |
0.4286 |
Tier II |
5 |
NC_000075.6 |
9 |
95181535 |
- |
Slc9a9 |
NNNGTGTCATGGACATGCAC |
NGG |
1 |
0.4286 |
Tier II |
6 |
NC_000081.6 |
15 |
101254694 |
+ |
Nr4a1 |
NNNGTGTAATGGGCATGCCC |
NGG |
2 |
0.4239 |
Tier II |
7 |
NC_000067.6 |
1 |
134690102 |
+ |
Syt2 |
NNNGTGTCTTGGGCATGCCC |
NGG |
2 |
0.3913 |
Tier II |
8 |
NC_000068.7 |
2 |
96497192 |
+ |
Lrrc4c |
NNNGTTTCATGCACATGCCC |
NGG |
2 |
0.3529 |
Tier II |
9 |
NC_000073.6 |
7 |
64156417 |
- |
Trpm1 |
NNNGTGTCATGATCATGCCC |
NGG |
2 |
0.28 |
Tier II |
10 |
NC_000075.6 |
9 |
108175247 |
- |
Bsn |
NNNGTTTCATGGACAGGCCC |
NGG |
2 |
0.2308 |
Tier II |
11 |
NC_000075.6 |
9 |
28120692 |
+ |
Opcml |
NNNGTGTCATGGACAGGCCA |
NGG |
2 |
0.1731 |
Tier II |
12 |
NC_000076.6 |
10 |
20690402 |
+ |
Pde7b |
NNNGTGCCATGGACATCCCC |
NGG |
2 |
0.1618 |
Tier II |
13 |
NC_000068.7 |
2 |
60494490 |
- |
Pla2r1 |
NNNGTGTCATGGCAATGCCC |
NGG |
2 |
0.0737 |
Tier II |
14 |
NC_000073.6 |
7 |
37685797 |
- |
Zfp536 |
NNNGAGTCATGGACATGCCC |
NGA |
2 |
0.0347 |
Tier II |
15 |
NC_000068.7 |
2 |
97338606 |
- |
Lrrc4c |
NNNGTGTCATGGACATGCTC |
NGA |
2 |
0.0321 |
Tier II |
16 |
NC_000069.6 |
3 |
114067280 |
+ |
Col11a1 |
NNNGTGTCATGCACATGCCC |
NTG |
2 |
0.0206 |
Tier II |
17 |
NC_000085.6 |
19 |
24688770 |
- |
Pgm5 |
NNNGTGTCATGGAAATGCCC |
NGT |
2 |
0.0056 |
Tier II |
18 |
NC_000072.6 |
6 |
118826541 |
+ |
Cacna1c |
NNNGTCTCATGGAGATGCCC |
NGG |
2 |
0.0 |
Tier II |
19 |
NC_000075.6 |
9 |
47351126 |
- |
Gm31816 |
NNNGGGTCATGGAAATGCCC |
NGG |
2 |
0.224 |
Tier III |
20 |
NC_000079.6 |
13 |
117132340 |
- |
Gm6416 |
NNNGTGTCATGCACCTGCCC |
NGG |
2 |
0.1444 |
Tier III |
21 |
NC_000070.6 |
4 |
114796727 |
+ |
Gm33655 |
NNNGTGTCATAGACATGCCG |
NGG |
2 |
0.0588 |
Tier III |
Other clones with same target sequence:
(none)