Construct: sgRNA BRDN0001147772
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ATAGCACTTTAAAAAAGGCA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- BMPR1A (657)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000010.11 | 10 | 86890164 | - | BMPR1A | NNNGCACTTTAAAAAAGGCA | NGG | 0 | 1.0 | Tier I |
2 | NC_000017.11 | 17 | 64213391 | + | TEX2 | NNNGCACTTTAAAAAAGGAA | NGA | 2 | 0.0298 | Tier I |
3 | NC_000010.11 | 10 | 12232146 | - | CDC123 | NNNGCATTTAAAAAAAGGCA | NGG | 2 | 0.6964 | Tier II |
4 | NC_000002.12 | 2 | 211995441 | - | ERBB4 | NNNGTATTTTAAAAAAGGCA | NGG | 2 | 0.517 | Tier II |
5 | NC_000006.12 | 6 | 129158952 | + | LAMA2 | NNNGCACTTGAAAAAAGGCA | NGG | 1 | 0.5 | Tier II |
6 | NC_000003.12 | 3 | 169631146 | - | MECOM | NNNGCAATTTAAAAGAGGCA | NGG | 2 | 0.4875 | Tier II |
7 | NC_000012.12 | 12 | 108326829 | - | CMKLR1 | NNNGCACTTAAAATAAGGCA | NGG | 2 | 0.4571 | Tier II |
8 | NC_000004.12 | 4 | 122245400 | - | BLTP1 | NNNGCACTTTAGAAAAGGCT | NGG | 2 | 0.4333 | Tier II |
9 | NC_000006.12 | 6 | 16259006 | - | GMPR | NNNGCACATGAAAAAAGGCA | NGG | 2 | 0.4 | Tier II |
10 | NC_000002.12 | 2 | 141026397 | + | LRP1B | NNNGAACTTTAAAAAAGACA | NGG | 2 | 0.3956 | Tier II |
11 | NC_000004.12 | 4 | 142296089 | + | INPP4B | NNNGCATTTTAAAAAAGGAA | NGG | 2 | 0.3482 | Tier II |
12 | NC_000016.10 | 16 | 68776623 | - | CDH1 | NNNGCACTTTGAAAAAGCCA | NGG | 2 | 0.3095 | Tier II |
13 | NC_000010.11 | 10 | 96005389 | + | CC2D2B | NNNGCTCTTTAAAAAAGGAA | NGG | 2 | 0.3061 | Tier II |
14 | NC_000015.10 | 15 | 59179712 | + | MYO1E | NNNGCACTGTAAAAAAGCCA | NGG | 2 | 0.2948 | Tier II |
15 | NC_000010.11 | 10 | 95771521 | - | ENTPD1 | NNNGCTCTTTCAAAAAGGCA | NGG | 2 | 0.2857 | Tier II |
16 | NC_000001.11 | 1 | 153202920 | + | SPRR2G | NNNGGCCTTTAAAAAAGGCA | NGG | 2 | 0.2727 | Tier II |
17 | NC_000001.11 | 1 | 174432869 | + | RABGAP1L | NNNGTACTTTAAAAAAGGAA | NGG | 2 | 0.2727 | Tier II |
18 | NC_000003.12 | 3 | 169165562 | - | MECOM | NNNGCACTTCAAAAAAGCCA | NGG | 2 | 0.254 | Tier II |
19 | NC_000017.11 | 17 | 21205530 | - | TMEM11 | NNNACACTTTAAAAAAGGCA | NAG | 2 | 0.2333 | Tier II |
20 | NC_000007.14 | 7 | 116884157 | - | CAPZA2 | NNNGCAATTTTAAAAAGGCA | NGG | 2 | 0.2308 | Tier II |
21 | NC_000020.11 | 20 | 20329328 | + | CFAP61 | NNNCCACTTTAAAAAAGGAA | NGG | 2 | 0.2269 | Tier II |
22 | NC_000010.11 | 10 | 95980102 | - | CC2D2B | NNNGTACTTTATAAAAGGCA | NGG | 2 | 0.2121 | Tier II |
23 | NC_000013.11 | 13 | 77591534 | + | SCEL | NNNGCACATTAAAAAATGCA | NGG | 2 | 0.2 | Tier II |
24 | NC_000006.12 | 6 | 150156255 | + | PPP1R14C | NNNTCACTTTAAATAAGGCA | NGG | 2 | 0.1939 | Tier II |
25 | NC_000009.12 | 9 | 132782327 | - | AK8 | NNNTCACTTTAAAGAAGGCA | NGG | 2 | 0.1697 | Tier II |
26 | NC_000007.14 | 7 | 147510738 | + | CNTNAP2 | NNNGCACTTTACAAAAGGCT | NGG | 2 | 0.1579 | Tier II |
27 | NC_000017.11 | 17 | 63177624 | + | TANC2 | NNNGCACTTTAAAAAACTCA | NGG | 2 | 0.1569 | Tier II |
28 | NC_000001.11 | 1 | 237679965 | + | RYR2 | NNNGCACTTTAAGAAAGGCC | NGG | 2 | 0.1482 | Tier II |
29 | NC_000003.12 | 3 | 74297583 | + | CNTN3 | NNNGCACTTTACATAAGGCA | NGG | 2 | 0.1404 | Tier II |
30 | NC_000016.10 | 16 | 88201319 | + | ZNF469 | NNNGCACTTTAAAAAGGTCA | NGG | 2 | 0.1282 | Tier II |
31 | NC_000004.12 | 4 | 8404566 | - | ACOX3 | NNNGCCCTTTAAAACAGGCA | NGG | 2 | 0.124 | Tier II |
32 | NC_000008.11 | 8 | 143764064 | - | IQANK1 | NNNGAACTTTAAACAAGGCA | NGG | 2 | 0.1224 | Tier II |
33 | NC_000009.12 | 9 | 3900799 | - | GLIS3 | NNNGGACTTTAAAAAAGGGA | NGG | 2 | 0.075 | Tier II |
34 | NC_000011.10 | 11 | 32723663 | + | CCDC73 | NNNACACTTTAAAAAAGGCA | NGA | 2 | 0.0625 | Tier II |
35 | NC_000001.11 | 1 | 67381128 | - | IL12RB2 | NNNTCACTTTAAAAAAGGCA | NGA | 2 | 0.0253 | Tier II |
36 | NC_000007.14 | 7 | 48442988 | + | ABCA13 | NNNGGACTTTAAAAAAGGCA | NTG | 2 | 0.0234 | Tier II |
37 | NC_000004.12 | 4 | 157110841 | - | GLRB | NNNCCACTTTAAAAAAGGCA | NTG | 2 | 0.0206 | Tier II |
38 | NC_000002.12 | 2 | 230752119 | - | CAB39 | NNNTCACTTTAAAAAAGGCA | NTG | 2 | 0.0142 | Tier II |
39 | NC_000010.11 | 10 | 54762765 | - | PCDH15 | NNNGCACTTTAAAAAAGGCT | NGC | 2 | 0.0133 | Tier II |
40 | NC_000003.12 | 3 | 171613395 | + | PLD1 | NNNGCACTTGAAAAAAGGCA | NGC | 2 | 0.0111 | Tier II |
41 | NC_000012.12 | 12 | 29353131 | + | ERGIC2 | NNNGCACTTTAAAAAAGGCA | NTA | 2 | 0.0 | Tier II |
42 | NC_000013.11 | 13 | 112391666 | + | SPACA7 | NNNGCACTTTAAAAACCGCA | NGG | 2 | 0.0 | Tier II |
43 | NC_000005.10 | 5 | 127540679 | + | PRRC1 | NNNGCACTTTAAAAATGTCA | NGG | 2 | 0.0 | Tier II |
44 | NC_000006.12 | 6 | 129158952 | + | BMPR1AP1 | NNNGCACTTGAAAAAAGGCA | NGG | 1 | 0.5 | Tier III |
45 | NC_000010.11 | 10 | 96005389 | + | ENTPD1-AS1 | NNNGCTCTTTAAAAAAGGAA | NGG | 2 | 0.3061 | Tier III |
46 | NC_000010.11 | 10 | 95771521 | - | ENTPD1-AS1 | NNNGCTCTTTCAAAAAGGCA | NGG | 2 | 0.2857 | Tier III |
47 | NC_000013.11 | 13 | 48120945 | + | LOC105370198 | NNNGCAATTTTAAAAAGGCA | NGG | 2 | 0.2308 | Tier III |
48 | NC_000010.11 | 10 | 95980102 | - | ENTPD1-AS1 | NNNGTACTTTATAAAAGGCA | NGG | 2 | 0.2121 | Tier III |
49 | NC_000001.11 | 1 | 53337442 | - | LOC105378731 | NNNGCACTTTTAGAAAGGCA | NGG | 2 | 0.2007 | Tier III |
50 | NC_000017.11 | 17 | 79709539 | + | LINC02078 | NNNGCACTTCAAACAAGGCA | NGG | 2 | 0.1143 | Tier III |
51 | NC_000019.10 | 19 | 19946192 | - | BNIP3P12 | NNNTCACTTTAAAAAAGGCC | NGG | 2 | 0.0826 | Tier III |
52 | NC_000009.12 | 9 | 3900799 | - | GLIS3-AS1 | NNNGGACTTTAAAAAAGGGA | NGG | 2 | 0.075 | Tier III |
53 | NC_000009.12 | 9 | 80027268 | - | LINC01507 | NNNGCACTTGAAAAAAGGGA | NGG | 2 | 0.0625 | Tier III |
54 | NC_000003.12 | 3 | 145572459 | - | LOC105374143 | NNNGCACTTTAAAAAATGCC | NGG | 2 | 0.0568 | Tier III |
55 | NC_000005.10 | 5 | 17152296 | + | BASP1-AS1 | NNNGGACTTTAAAAAAGGCA | NTG | 2 | 0.0234 | Tier III |
56 | NC_000023.11 | X | 145845451 | + | LOC107985703 | NNNGCACTTTAAAAAAAGCA | NGT | 2 | 0.0151 | Tier III |
57 | NC_000010.11 | 10 | 79909921 | - | BMS1P21 | NNNGCACTTTAAAAAAGGCT | NGT | 2 | 0.0097 | Tier III |
58 | NC_000007.14 | 7 | 13644948 | + | LOC107986770 | NNNCCACTTTAAAAAAGGCA | NGT | 2 | 0.0085 | Tier III |
59 | NC_000013.11 | 13 | 112391666 | + | LOC105370372 | NNNGCACTTTAAAAACCGCA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000080.6 | 14 | 34443880 | + | Bmpr1a | NNNGCACTTTAAGAAAGGCA | NGG | 1 | 0.6522 | Tier I |
2 | NC_000082.6 | 16 | 52047413 | + | Cblb | NNNGCTCTTTAAAGAAGGCA | NGG | 2 | 0.3333 | Tier I |
3 | NC_000077.6 | 11 | 106567779 | + | Tex2 | NNNGCACTTTAAAAAAGGAA | NGA | 2 | 0.0298 | Tier I |
4 | NC_000072.6 | 6 | 22206069 | + | Cped1 | NNNGCAATTTAAAAAAAGCA | NGG | 2 | 0.7 | Tier II |
5 | NC_000077.6 | 11 | 116930641 | + | Mgat5b | NNNGCACTTTAAAAAAAACA | NGG | 2 | 0.6462 | Tier II |
6 | NC_000075.6 | 9 | 112213057 | - | Arpp21 | NNNGCAATTAAAAAAAGGCA | NGG | 2 | 0.6429 | Tier II |
7 | NC_000068.7 | 2 | 112238293 | - | Gm52523 | NNNGCAATTTAAGAAAGGCA | NGG | 2 | 0.4891 | Tier II |
8 | NC_000067.6 | 1 | 160769458 | - | Rabgap1l | NNNGCACCTTAAAGAAGGCA | NGG | 2 | 0.4667 | Tier II |
9 | NC_000072.6 | 6 | 127136414 | - | Ccnd2 | NNNGCACTTTAAGAGAGGCA | NGG | 2 | 0.4239 | Tier II |
10 | NC_000079.6 | 13 | 81730948 | + | Mblac2 | NNNGCATTTTAAAAAAGGAA | NGG | 2 | 0.3482 | Tier II |
11 | NC_000067.6 | 1 | 163931307 | - | Scyl3 | NNNGCACCTTTAAAAAGGCA | NGG | 2 | 0.3077 | Tier II |
12 | NC_000084.6 | 18 | 21851449 | - | Ccdc178 | NNNGCACTTTAAGGAAGGCA | NGG | 2 | 0.3043 | Tier II |
13 | NC_000079.6 | 13 | 94529718 | - | Ap3b1 | NNNGCACTGTCAAAAAGGCA | NGG | 2 | 0.2476 | Tier II |
14 | NC_000086.7 | X | 169062656 | + | Arhgap6 | NNNGCACTTTCAAAAAGCCA | NGG | 2 | 0.1905 | Tier II |
15 | NC_000075.6 | 9 | 71591911 | - | Myzap | NNNTCAGTTTAAAAAAGGCA | NGG | 2 | 0.1711 | Tier II |
16 | NC_000077.6 | 11 | 115412451 | - | Mrpl58 | NNNGCACTTTAAAAAAGACC | NGG | 2 | 0.1573 | Tier II |
17 | NC_000084.6 | 18 | 84939908 | + | Fbxo15 | NNNGCAGTTTTAAAAAGGCA | NGG | 2 | 0.1448 | Tier II |
18 | NC_000076.6 | 10 | 32284365 | - | Nkain2 | NNNGCACTTTACATAAGGCA | NGG | 2 | 0.1404 | Tier II |
19 | NC_000071.6 | 5 | 117551144 | + | Ksr2 | NNNGCACTTTAAAATAGTCA | NGG | 2 | 0.1333 | Tier II |
20 | NC_000083.6 | 17 | 5235292 | + | Arid1b | NNNGCACTTTAACAAAGGCT | NGG | 2 | 0.1263 | Tier II |
21 | NC_000079.6 | 13 | 74774458 | + | Cast | NNNGCACTTTACAAAAGCCA | NGG | 2 | 0.1253 | Tier II |
22 | NC_000081.6 | 15 | 94326482 | + | Adamts20 | NNNGCACTTTAAAAAAGCCA | NAG | 2 | 0.1235 | Tier II |
23 | NC_000070.6 | 4 | 140044702 | + | Igsf21 | NNNGCACTTTAACAAAGGCA | NAG | 2 | 0.0546 | Tier II |
24 | NC_000073.6 | 7 | 29048444 | - | Ryr1 | NNNGCACTTTAAAAAAGGAA | NGA | 2 | 0.0298 | Tier II |
25 | NC_000082.6 | 16 | 30009783 | + | 4632428C04Rik | NNNACACTTTAAAAAAGGCG | NGG | 2 | 0.6882 | Tier III |
26 | NC_000070.6 | 4 | 133644971 | + | Gm13213 | NNNGCACATTAAAAAAGGAA | NGG | 2 | 0.3429 | Tier III |
27 | NC_000077.6 | 11 | 54279440 | - | LOC115487722 | NNNGCACTGTAATAAAGGCA | NGG | 2 | 0.1857 | Tier III |
28 | NC_000068.7 | 2 | 78826927 | + | Gm39865 | NNNTCAGTTTAAAAAAGGCA | NGG | 2 | 0.1711 | Tier III |