Construct: sgRNA BRDN0001147887
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTCAGGGATCCTTTACAGAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PSKH2 (85481)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000008.11 | 8 | 86064349 | - | PSKH2 | NNNAGGGATCCTTTACAGAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 3523026 | + | MEGF6 | NNNAGGGAAACTTTACAGAG | NGG | 2 | 0.8048 | Tier II |
3 | NC_000008.11 | 8 | 122808768 | + | ZHX2 | NNNAGGAATCCATTACAGAG | NGG | 2 | 0.8 | Tier II |
4 | NC_000020.11 | 20 | 31537774 | - | HM13 | NNNAGGGATCCCCTACAGAG | NGG | 2 | 0.7479 | Tier II |
5 | NC_000017.11 | 17 | 56395201 | + | ANKFN1 | NNNAGGGATTATTTACAGAG | NGG | 2 | 0.7059 | Tier II |
6 | NC_000017.11 | 17 | 49752414 | + | FAM117A | NNNAGGGGTCCCTTACAGAG | NGG | 2 | 0.6947 | Tier II |
7 | NC_000001.11 | 1 | 237645610 | + | RYR2 | NNNAGGGGTCCTTTACAGAA | NGG | 2 | 0.6875 | Tier II |
8 | NC_000009.12 | 9 | 28258660 | + | LINGO2 | NNNAGAGAGCCTTTACAGAG | NGG | 2 | 0.619 | Tier II |
9 | NC_000008.11 | 8 | 123229462 | - | C8orf76 | NNNAGGAAGCCTTTACAGAG | NGG | 2 | 0.619 | Tier II |
10 | NC_000008.11 | 8 | 123229462 | - | ZHX1-C8orf76 | NNNAGGAAGCCTTTACAGAG | NGG | 2 | 0.619 | Tier II |
11 | NC_000010.11 | 10 | 14655935 | + | FAM107B | NNNAGGAAGCCTTTACAGAG | NGG | 2 | 0.619 | Tier II |
12 | NC_000010.11 | 10 | 96579576 | + | TM9SF3 | NNNAGGAATCCTTAACAGAG | NGG | 2 | 0.619 | Tier II |
13 | NC_000015.10 | 15 | 60697467 | + | RORA | NNNAAGGATCCTTTACAAAG | NGG | 2 | 0.6 | Tier II |
14 | NC_000003.12 | 3 | 32137878 | + | GPD1L | NNNTGGGATCATTTACAGAG | NGG | 2 | 0.4773 | Tier II |
15 | NC_000022.11 | 22 | 17095919 | - | IL17RA | NNNAGGGTTCATTTACAGAG | NGG | 2 | 0.3214 | Tier II |
16 | NC_000019.10 | 19 | 45449252 | + | ERCC1 | NNNCGTGATCCTTTACAGAG | NGG | 2 | 0.2353 | Tier II |
17 | NC_000002.12 | 2 | 158245807 | + | CCDC148 | NNNAGGGATCATTTATAGAG | NGG | 2 | 0.2308 | Tier II |
18 | NC_000005.10 | 5 | 9790139 | + | TAS2R1 | NNNAGGGATCCAGTACAGAG | NGG | 2 | 0.2087 | Tier II |
19 | NC_000021.9 | 21 | 46362922 | - | PCNT | NNNAGGGATCCTGTGCAGAG | NGG | 2 | 0.1696 | Tier II |
20 | NC_000010.11 | 10 | 94166630 | - | PLCE1 | NNNAGGGATCCTTTGCAGAG | NAG | 2 | 0.1685 | Tier II |
21 | NC_000017.11 | 17 | 56068195 | - | ANKFN1 | NNNAGGGATGCTTCACAGAG | NGG | 2 | 0.1111 | Tier II |
22 | NC_000002.12 | 2 | 111997691 | + | MERTK | NNNAGGGTTCCTTTACAGAG | NAG | 2 | 0.1111 | Tier II |
23 | NC_000005.10 | 5 | 90727707 | - | ADGRV1 | NNNAGGGATCCTTTAAAGAG | NGA | 2 | 0.0694 | Tier II |
24 | NC_000003.12 | 3 | 138220405 | + | ARMC8 | NNNAGGGATACTTTACAGAG | NGA | 2 | 0.0602 | Tier II |
25 | NC_000017.11 | 17 | 17173756 | - | MPRIP | NNNAGGGATCCCTTACAGAG | NTG | 2 | 0.0369 | Tier II |
26 | NC_000010.11 | 10 | 14655935 | + | LOC105376429 | NNNAGGAAGCCTTTACAGAG | NGG | 2 | 0.619 | Tier III |
27 | NC_000020.11 | 20 | 48399887 | + | LOC105372643 | NNNAGGGACCCTTTGCAGAG | NGG | 2 | 0.6 | Tier III |
28 | NC_000009.12 | 9 | 79836340 | + | LINC01507 | NNNAGGGATCCTGTACAGAA | NGG | 2 | 0.2446 | Tier III |
29 | NC_000005.10 | 5 | 9790139 | + | LINC02112 | NNNAGGGATCCAGTACAGAG | NGG | 2 | 0.2087 | Tier III |
30 | NC_000005.10 | 5 | 90727707 | - | LOC105379077 | NNNAGGGATCCTTTAAAGAG | NGA | 2 | 0.0694 | Tier III |
31 | NC_000001.11 | 1 | 211541362 | + | LOC107985260 | NNNAGGGATCCTTTACAAAG | NGA | 2 | 0.0481 | Tier III |
32 | NC_000001.11 | 1 | 211541362 | + | LOC107985261 | NNNAGGGATCCTTTACAAAG | NGA | 2 | 0.0481 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 20351880 | - | Zfp560 | NNNACGGAACCTTTACAGAG | NGG | 2 | 0.7296 | Tier I |
2 | NC_000077.6 | 11 | 114897715 | - | Cd300a | NNNTGGGAGCCTTTACAGAG | NGG | 2 | 0.3939 | Tier I |
3 | NC_000070.6 | 4 | 108853349 | + | Txndc12 | NNNTGGAATCCTTTACAGAG | NGG | 2 | 0.6364 | Tier II |
4 | NC_000083.6 | 17 | 8753513 | + | Pde10a | NNNAGTGATCCCTTACAGAG | NGG | 2 | 0.6316 | Tier II |
5 | NC_000086.7 | X | 99832019 | + | Tmem28 | NNNAGGCATCATTTACAGAG | NGG | 2 | 0.5156 | Tier II |
6 | NC_000076.6 | 10 | 120088403 | + | Helb | NNNAGGGAGCCTTTACACAG | NGG | 2 | 0.2948 | Tier II |
7 | NC_000076.6 | 10 | 77512527 | - | Fam207a | NNNAGGGAACCTTTATAGAG | NGG | 2 | 0.2857 | Tier II |
8 | NC_000085.6 | 19 | 42965503 | - | Hpse2 | NNNATGGAACCTTTACAGAG | NGG | 2 | 0.2786 | Tier II |
9 | NC_000067.6 | 1 | 8747281 | - | Sntg1 | NNNAAGGATCCTTCACAGAG | NGG | 2 | 0.2476 | Tier II |
10 | NC_000082.6 | 16 | 41693868 | - | Lsamp | NNNATGGTTCCTTTACAGAG | NGG | 2 | 0.1286 | Tier II |
11 | NC_000086.7 | X | 70470553 | + | Tmem185a | NNNAGGGATCCTGTACAGAC | NGG | 2 | 0.1118 | Tier II |
12 | NC_000067.6 | 1 | 13633887 | + | Lactb2 | NNNAGAGATCCTTTACAGAG | NCG | 2 | 0.1071 | Tier II |
13 | NC_000073.6 | 7 | 117405841 | - | Xylt1 | NNNAGGGATCCTTCACAGAG | NAG | 2 | 0.0741 | Tier II |
14 | NC_000074.6 | 8 | 119271032 | - | Cdh13 | NNNAGGGATCCTTTACTGAG | NAG | 2 | 0.0346 | Tier II |
15 | NC_000073.6 | 7 | 67024793 | + | Adamts17 | NNNAGGGAGCCTTTACAGAG | NTG | 2 | 0.0241 | Tier II |
16 | NC_000078.6 | 12 | 17223368 | - | Gm36568 | NNNGGGGATTCTTTACAGAG | NGG | 2 | 0.5882 | Tier III |