Construct: sgRNA BRDN0001147908
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCACCCAGTTCCAAACACCT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- ULK1 (8408)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 131914473 | + | ULK1 | NNNCCCAGTTCCAAACACCT | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 104507958 | - | CHST11 | NNNCCCAATTCCATACACCT | NGG | 2 | 0.5333 | Tier II |
3 | NC_000004.12 | 4 | 17627492 | - | MED28 | NNNCCCAGGACCAAACACCT | NGG | 2 | 0.5306 | Tier II |
4 | NC_000007.14 | 7 | 148153569 | - | CNTNAP2 | NNNCCCAGGTCCGAACACCT | NGG | 2 | 0.4037 | Tier II |
5 | NC_000015.10 | 15 | 69395549 | + | PAQR5 | NNNCACAGTTCTAAACACCT | NGG | 2 | 0.3077 | Tier II |
6 | NC_000019.10 | 19 | 38354677 | + | CATSPERG | NNNCCCAGATCCAACCACCT | NGG | 2 | 0.2532 | Tier II |
7 | NC_000005.10 | 5 | 20024320 | - | CDH18 | NNNCCCAGTCCCAGACACCT | NGG | 2 | 0.2489 | Tier II |
8 | NC_000003.12 | 3 | 64141690 | + | PRICKLE2 | NNNCCCAGTTCTAAACACAT | NGG | 2 | 0.2308 | Tier II |
9 | NC_000019.10 | 19 | 34664980 | - | SCGB2B2 | NNNCCCTGTGCCAAACACCT | NGG | 2 | 0.2188 | Tier II |
10 | NC_000012.12 | 12 | 612366 | + | NINJ2 | NNNCCCAATTCCACACACCT | NGG | 2 | 0.2143 | Tier II |
11 | NC_000015.10 | 15 | 84607955 | + | ZSCAN2 | NNNCCCAGTTCCACACACCT | NGG | 1 | 0.2143 | Tier II |
12 | NC_000020.11 | 20 | 38489159 | - | RALGAPB | NNNCCCAATTCCAATCACCT | NGG | 2 | 0.2 | Tier II |
13 | NC_000007.14 | 7 | 89247143 | + | ZNF804B | NNNCCTAGTTCCACACACCT | NGG | 2 | 0.199 | Tier II |
14 | NC_000001.11 | 1 | 93498909 | + | FNBP1L | NNNCCCAGTTTCAAACATCT | NGG | 2 | 0.1978 | Tier II |
15 | NC_000003.12 | 3 | 45950291 | + | FYCO1 | NNNCCAAGTTCCCAACACCT | NGG | 2 | 0.1955 | Tier II |
16 | NC_000007.14 | 7 | 95100754 | - | PPP1R9A | NNNCCCAGTTCCAAAAGCCT | NGG | 2 | 0.1765 | Tier II |
17 | NC_000009.12 | 9 | 133117561 | - | RALGDS | NNNCCCAGTTCCGCACACCT | NGG | 2 | 0.1398 | Tier II |
18 | NC_000011.10 | 11 | 119687249 | + | NECTIN1 | NNNCCCAGTTCCCAGCACCT | NGG | 2 | 0.1368 | Tier II |
19 | NC_000006.12 | 6 | 38990807 | + | DNAH8 | NNNCCCAGTTCCAAGCCCCT | NGG | 2 | 0.1147 | Tier II |
20 | NC_000004.12 | 4 | 101298101 | + | PPP3CA | NNNCTCAGTTCCAAAGACCT | NGG | 2 | 0.0979 | Tier II |
21 | NC_000020.11 | 20 | 61850440 | + | CDH4 | NNNCCCAGTTCCATACGCCT | NGG | 2 | 0.0941 | Tier II |
22 | NC_000009.12 | 9 | 36843876 | + | PAX5 | NNNCCCAGTTCCAAGCACCC | NGG | 2 | 0.0591 | Tier II |
23 | NC_000015.10 | 15 | 68334417 | - | ITGA11 | NNNCCCAGTTCCAACCAGCT | NGG | 2 | 0.0364 | Tier II |
24 | NC_000018.10 | 18 | 37259839 | + | CELF4 | NNNCCCAGTTCCACACACCC | NGG | 2 | 0.0195 | Tier II |
25 | NC_000011.10 | 11 | 134490567 | + | B3GAT1-DT | NNNCCCATTTCCAAACACCA | NGG | 2 | 0.3516 | Tier III |
26 | NC_000019.10 | 19 | 34664980 | - | SCGB1B2P | NNNCCCTGTGCCAAACACCT | NGG | 2 | 0.2188 | Tier III |
27 | NC_000019.10 | 19 | 34664980 | - | ZNF807P | NNNCCCTGTGCCAAACACCT | NGG | 2 | 0.2188 | Tier III |
28 | NC_000002.12 | 2 | 2914760 | - | LINC01250 | NNNCCCAGTTCCAGACACTT | NGG | 2 | 0.2154 | Tier III |
29 | NC_000015.10 | 15 | 84607955 | + | LOC105370947 | NNNCCCAGTTCCACACACCT | NGG | 1 | 0.2143 | Tier III |
30 | NC_000007.14 | 7 | 95100754 | - | PPP1R9A-AS1 | NNNCCCAGTTCCAAAAGCCT | NGG | 2 | 0.1765 | Tier III |
31 | NC_000001.11 | 1 | 27661342 | - | LINC02574 | NNNCCCAGCTCCAAACACCC | NGG | 2 | 0.0839 | Tier III |
32 | NC_000016.10 | 16 | 18388949 | - | PKD1P5 | NNNCCCAGTTCCAGACCCCT | NGG | 2 | 0.0824 | Tier III |
33 | NC_000016.10 | 16 | 18388949 | - | PKD1P5-LOC105376752 | NNNCCCAGTTCCAGACCCCT | NGG | 2 | 0.0824 | Tier III |
34 | NC_000013.11 | 13 | 19314341 | - | ANKRD26P3 | NNNCCCAGTTGCAACCACCT | NGG | 2 | 0.0682 | Tier III |
35 | NC_000003.12 | 3 | 129613690 | + | LOC124909431 | NNNCCCAGTTCTAAACACCT | NGC | 2 | 0.012 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000069.6 | 3 | 95681657 | - | Adamtsl4 | NNNCCCAGTTCCAATTACCT | NGG | 2 | 0.0615 | Tier I |
2 | NC_000070.6 | 4 | 100989325 | - | Cachd1 | NNNCCAAATTCCAAACACCT | NGG | 2 | 0.9286 | Tier II |
3 | NC_000074.6 | 8 | 17116805 | - | Csmd1 | NNNCCCAGCTACAAACACCT | NGG | 2 | 0.6923 | Tier II |
4 | NC_000086.7 | X | 12127111 | + | Bcor | NNNCCCAGCTCCAAGCACCT | NGG | 2 | 0.6 | Tier II |
5 | NC_000072.6 | 6 | 38880702 | - | Tbxas1 | NNNCCCTGCTCCAAACACCT | NGG | 2 | 0.4038 | Tier II |
6 | NC_000073.6 | 7 | 63468010 | - | Otud7a | NNNCCCAGTTCAAAACACCA | NGG | 2 | 0.4018 | Tier II |
7 | NC_000082.6 | 16 | 28557219 | - | Fgf12 | NNNCCCAGTTCAAAACACTT | NGG | 2 | 0.3297 | Tier II |
8 | NC_000081.6 | 15 | 47626444 | - | Csmd3 | NNNCCCAGTGCCATACACCT | NGG | 2 | 0.2667 | Tier II |
9 | NC_000074.6 | 8 | 119286754 | + | Cdh13 | NNNCCCCGTTCCAAACACCA | NGG | 2 | 0.2461 | Tier II |
10 | NC_000077.6 | 11 | 35480127 | + | Slit3 | NNNCCCAGGTTCAAACACCT | NGG | 2 | 0.1905 | Tier II |
11 | NC_000071.6 | 5 | 108623997 | + | Gak | NNNCCCATTTCCTAACACCT | NGG | 2 | 0.1875 | Tier II |
12 | NC_000075.6 | 9 | 29269595 | - | Ntm | NNNCCCAGTTCCAATCATCT | NGG | 2 | 0.1286 | Tier II |
13 | NC_000067.6 | 1 | 75183931 | - | Atg9a | NNNCCCACTTCCAAACAGCT | NGG | 2 | 0.0821 | Tier II |
14 | NC_000075.6 | 9 | 21287830 | + | Kri1 | NNNCCCAGTTCCCCACACCT | NGG | 2 | 0.0451 | Tier II |
15 | NC_000073.6 | 7 | 130874584 | + | Plekha1 | NNNCCCAGTTCCAAACAACT | NGA | 2 | 0.0374 | Tier II |
16 | NC_000077.6 | 11 | 72318675 | + | Fbxo39 | NNNCCCAGTCCCAAACACCT | NGA | 2 | 0.037 | Tier II |
17 | NC_000076.6 | 10 | 62749708 | - | Ccar1 | NNNCCCAGTTCCCAACACCC | NGG | 2 | 0.0191 | Tier II |
18 | NC_000067.6 | 1 | 120091116 | + | Gm41938 | NNNCTCAGTTCCAAACACAT | NGG | 2 | 0.2727 | Tier III |
19 | NC_000072.6 | 6 | 127189104 | - | 9330179D12Rik | NNNCCCAGTTCCAGACACCT | NGT | 2 | 0.0075 | Tier III |