Construct: sgRNA BRDN0001147924
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCTTCCCTTTCACACTAACT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TEC (7006)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77023
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000004.12 |
4 |
48146372 |
+ |
TEC |
NNNTCCCTTTCACACTAACT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000006.12 |
6 |
138181239 |
- |
ARFGEF3 |
NNNTCCCCTACACACTAACT |
NGG |
2 |
0.8571 |
Tier II |
3 |
NC_000011.10 |
11 |
108565379 |
+ |
EXPH5 |
NNNTCTATTTCACACTAACT |
NGG |
2 |
0.6964 |
Tier II |
4 |
NC_000005.10 |
5 |
111477964 |
+ |
CAMK4 |
NNNTCCCTTTCACACTAAAT |
NGG |
1 |
0.4286 |
Tier II |
5 |
NC_000015.10 |
15 |
45469475 |
- |
SLC30A4-AS1 |
NNNTTCCTTTCACACTAGCT |
NGG |
2 |
0.2545 |
Tier II |
6 |
NC_000003.12 |
3 |
120410097 |
+ |
FSTL1 |
NNNTCCCTTTCTCACCAACT |
NGG |
2 |
0.2222 |
Tier II |
7 |
NC_000002.12 |
2 |
148984166 |
- |
KIF5C |
NNNTCACTTTCACACTGACT |
NGG |
2 |
0.1639 |
Tier II |
8 |
NC_000007.14 |
7 |
154173480 |
+ |
DPP6 |
NNNTCCCTTTCACCCTAACA |
NGG |
2 |
0.1205 |
Tier II |
9 |
NC_000012.12 |
12 |
132506547 |
- |
FBRSL1 |
NNNTACCTTTCACAGTAACT |
NGG |
2 |
0.0286 |
Tier II |
10 |
NC_000012.12 |
12 |
51334957 |
+ |
CELA1 |
NNNTCCCATTCACACTAACT |
NGT |
2 |
0.0129 |
Tier II |
11 |
NC_000001.11 |
1 |
213457521 |
+ |
RPS6KC1 |
NNNTCCCTTTCACACTCACT |
NGT |
2 |
0.0028 |
Tier II |
12 |
NC_000023.11 |
X |
65797215 |
+ |
ETF1P3 |
NNNTCACTTCCACACTAACT |
NGG |
2 |
0.4952 |
Tier III |
13 |
NC_000003.12 |
3 |
120410097 |
+ |
BTNL12P |
NNNTCCCTTTCTCACCAACT |
NGG |
2 |
0.2222 |
Tier III |
14 |
NC_000007.14 |
7 |
32624082 |
+ |
DPY19L1P1 |
NNNTCCCTTTCCCACCAACT |
NGG |
2 |
0.1754 |
Tier III |
15 |
NC_000005.10 |
5 |
25206175 |
- |
LINC02211 |
NNNTCCCTTTCACCCTAAAT |
NGG |
2 |
0.0918 |
Tier III |
16 |
NC_000005.10 |
5 |
118534923 |
+ |
LINC02208 |
NNNTCCCTTTCACACTGACT |
NGA |
2 |
0.0123 |
Tier III |
17 |
NC_000007.14 |
7 |
150838304 |
- |
LOC105375567 |
NNNTCCCTTTCACATTAACT |
NGA |
2 |
0.0046 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000073.6 |
7 |
127473719 |
- |
Prr14 |
NNNTCCCTTTCACACTTACC |
NGG |
2 |
0.0121 |
Tier I |
2 |
NC_000073.6 |
7 |
102001799 |
- |
Numa1 |
NNNTCTCTTTCACACAAACT |
NGG |
2 |
0.8442 |
Tier II |
3 |
NC_000077.6 |
11 |
113556960 |
+ |
Slc39a11 |
NNNACCCCTTCACACTAACT |
NGG |
2 |
0.4762 |
Tier II |
4 |
NC_000067.6 |
1 |
54689957 |
- |
Ankrd44 |
NNNTCCCCTTCACACTAAAT |
NGG |
2 |
0.4286 |
Tier II |
5 |
NC_000083.6 |
17 |
32016504 |
- |
Hsf2bp |
NNNTCCCTTTCAAACAAACT |
NGG |
2 |
0.3497 |
Tier II |
6 |
NC_000082.6 |
16 |
34037197 |
- |
Kalrn |
NNNTCCCTTTCACACCAGCT |
NGG |
2 |
0.2667 |
Tier II |
7 |
NC_000070.6 |
4 |
141492861 |
+ |
Spen |
NNNTCACTTTCACACTAACT |
NAG |
2 |
0.2407 |
Tier II |
8 |
NC_000085.6 |
19 |
46783899 |
- |
Cnnm2 |
NNNTCCCTTTCACACTAGCA |
NGG |
2 |
0.225 |
Tier II |
9 |
NC_000071.6 |
5 |
114788687 |
- |
Ankrd13a |
NNNTCCCTTCCACACGAACT |
NGG |
2 |
0.1846 |
Tier II |
10 |
NC_000072.6 |
6 |
32349123 |
+ |
Plxna4 |
NNNTCCCTTGCTCACTAACT |
NGG |
2 |
0.1667 |
Tier II |
11 |
NC_000067.6 |
1 |
138501195 |
+ |
Nek7 |
NNNTTCCTTTCACACTAACT |
NAG |
2 |
0.165 |
Tier II |
12 |
NC_000074.6 |
8 |
93529350 |
- |
Ces5a |
NNNTCCCTTACACACTCACT |
NGG |
2 |
0.1513 |
Tier II |
13 |
NC_000067.6 |
1 |
179226037 |
+ |
Smyd3 |
NNNGCCCTTTCACACTGACT |
NGG |
2 |
0.1103 |
Tier II |
14 |
NC_000084.6 |
18 |
78003990 |
- |
Epg5 |
NNNTCCCTTTCACGATAACT |
NGG |
2 |
0.1037 |
Tier II |
15 |
NC_000085.6 |
19 |
31681132 |
+ |
Prkg1 |
NNNTCCTTTTCACATTAACT |
NGG |
2 |
0.0542 |
Tier II |
16 |
NC_000069.6 |
3 |
89438836 |
- |
Pbxip1 |
NNNTCCCTTTCACAATACCT |
NGG |
2 |
0.0423 |
Tier II |
17 |
NC_000072.6 |
6 |
122282836 |
+ |
Klrg1 |
NNNTCCCTTTCACACTCAGT |
NGG |
2 |
0.0221 |
Tier II |
18 |
NC_000077.6 |
11 |
52933993 |
- |
Fstl4 |
NNNTCCCTTTCACACTAACT |
NTC |
2 |
0.0 |
Tier II |
19 |
NC_000067.6 |
1 |
54689957 |
- |
4930444A19Rik |
NNNTCCCCTTCACACTAAAT |
NGG |
2 |
0.4286 |
Tier III |
20 |
NC_000075.6 |
9 |
91351309 |
+ |
Gm40545 |
NNNTCCCTTTCACTCTCACT |
NGG |
2 |
0.0941 |
Tier III |
21 |
NC_000075.6 |
9 |
91351309 |
+ |
Gm40546 |
NNNTCCCTTTCACTCTCACT |
NGG |
2 |
0.0941 |
Tier III |
22 |
NC_000068.7 |
2 |
118998275 |
+ |
Gm14089 |
NNNTCCCTTTCACACTCACT |
NCG |
2 |
0.0189 |
Tier III |
Other clones with same target sequence:
(none)