Construct: sgRNA BRDN0001147929
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGGAGGTGGCTTTAGGTTTT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000013.11 | 13 | 30659061 | + | USPL1 | NNNAGGTGACTTTAGGTATT | NGG | 2 | 0.4286 | Tier I |
2 | NC_000006.12 | 6 | 150843287 | + | PLEKHG1 | NNNACATGGCTTTAGGTTTT | NGG | 2 | 0.7857 | Tier II |
3 | NC_000012.12 | 12 | 86206461 | + | MGAT4C | NNNAGGTGGTATTAGGTTTT | NGG | 2 | 0.7059 | Tier II |
4 | NC_000004.12 | 4 | 88622412 | + | HERC3 | NNNGGGTGGTTTTAGGTTTT | NGG | 2 | 0.5882 | Tier II |
5 | NC_000006.12 | 6 | 110854090 | + | AMD1 | NNNAGATGGCTTTTGGTTTT | NGG | 2 | 0.5333 | Tier II |
6 | NC_000014.9 | 14 | 90052605 | + | LOC124903406 | NNNAGGTGACTTCAGGTTTT | NGG | 2 | 0.5075 | Tier II |
7 | NC_000004.12 | 4 | 176235614 | + | ASB5 | NNNAGGTGGCTTTTAGTTTT | NGG | 2 | 0.502 | Tier II |
8 | NC_000005.10 | 5 | 127548372 | + | PRRC1 | NNNACGTGTCTTTAGGTTTT | NGG | 2 | 0.419 | Tier II |
9 | NC_000005.10 | 5 | 43676519 | + | NNT | NNNAGGTGGATTTGGGTTTT | NGG | 2 | 0.4044 | Tier II |
10 | NC_000003.12 | 3 | 2984695 | + | CNTN4 | NNNCGATGGCTTTAGGTTTT | NGG | 2 | 0.3529 | Tier II |
11 | NC_000011.10 | 11 | 66281042 | - | CNIH2 | NNNAGGTGGCTTCAGGTGTT | NGG | 2 | 0.2632 | Tier II |
12 | NC_000020.11 | 20 | 19502585 | - | SLC24A3 | NNNAGGTGGTTTTAGGTTTT | NAG | 2 | 0.244 | Tier II |
13 | NC_000009.12 | 9 | 94444277 | + | MFSD14B | NNNAGGTGGCTTCAGGTTGT | NGG | 2 | 0.1974 | Tier II |
14 | NC_000016.10 | 16 | 1588186 | + | IFT140 | NNNAGGTGGCTTTGGGTTTT | NAG | 2 | 0.121 | Tier II |
15 | NC_000006.12 | 6 | 108317697 | + | AFG1L | NNNAGGTGGCTTTTGGTTTT | NGA | 2 | 0.037 | Tier II |
16 | NC_000003.12 | 3 | 28379866 | + | ZCWPW2 | NNNAGGTGGCTTTCTGTTTT | NGG | 2 | 0.0306 | Tier II |
17 | NC_000001.11 | 1 | 48774182 | - | BEND5 | NNNAGGTGGCTTTATGTTTG | NGG | 2 | 0.0252 | Tier II |
18 | NC_000001.11 | 1 | 48774182 | - | AGBL4 | NNNAGGTGGCTTTATGTTTG | NGG | 2 | 0.0252 | Tier II |
19 | NC_000007.14 | 7 | 77544628 | + | PTPN12 | NNNAGGTGGCTGTAGGTTTT | NTG | 2 | 0.0195 | Tier II |
20 | NC_000023.11 | X | 36011534 | + | CFAP47 | NNNAGGTGGCTTTGGGTTTT | NTG | 2 | 0.0182 | Tier II |
21 | NC_000011.10 | 11 | 118312385 | - | CD3E | NNNAGGTGGCTTTAGGGTTT | NCG | 2 | 0.0126 | Tier II |
22 | NC_000005.10 | 5 | 22625597 | + | CDH12 | NNNAGCTGGCTTTAGCTTTT | NGG | 2 | 0.0 | Tier II |
23 | NC_000012.12 | 12 | 99558791 | - | ANKS1B | NNNAGGAGGCTTTAGCTTTT | NGG | 2 | 0.0 | Tier II |
24 | NC_000005.10 | 5 | 64285775 | - | RNF180 | NNNAGGTGGCTTTAGCATTT | NGG | 2 | 0.0 | Tier II |
25 | NC_000005.10 | 5 | 131857430 | + | MEIKIN | NNNAGGTGGCTTTAGCTTTT | NGG | 1 | 0.0 | Tier II |
26 | NC_000004.12 | 4 | 88502442 | + | HERC5 | NNNAGGTGGCTTTAGTTTTT | NTG | 2 | 0.0 | Tier II |
27 | NC_000009.12 | 9 | 16034716 | + | CCDC171 | NNNAGGTGGCTTTAGTTTTT | NGG | 1 | 0.0 | Tier II |
28 | NC_000004.12 | 4 | 13862532 | + | LINC01182 | NNNAGGTGGTTTTTGGTTTT | NGG | 2 | 0.502 | Tier III |
29 | NC_000004.12 | 4 | 13862532 | + | LOC107986182 | NNNAGGTGGTTTTTGGTTTT | NGG | 2 | 0.502 | Tier III |
30 | NC_000015.10 | 15 | 45800167 | + | LOC105370802 | NNNAGTTTGCTTTAGGTTTT | NGG | 2 | 0.4167 | Tier III |
31 | NC_000002.12 | 2 | 60380117 | - | MIR4432HG | NNNAGGTGGCATTTGGTTTT | NGG | 2 | 0.4 | Tier III |
32 | NC_000016.10 | 16 | 1588186 | + | LOC105371046 | NNNAGGTGGCTTTGGGTTTT | NAG | 2 | 0.121 | Tier III |
33 | NC_000021.9 | 21 | 30395111 | - | LOC105372772 | NNNAGGTGGATTTAGGTTTT | NTG | 2 | 0.0338 | Tier III |
34 | NC_000015.10 | 15 | 65797229 | - | LOC105370866 | NNNAGGCGGCTTTAGCTTTT | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 142312490 | + | Slco1a5 | NNNAGATGGTTTTAGGTTTT | NGG | 2 | 0.9412 | Tier II |
2 | NC_000081.6 | 15 | 97017933 | + | Slc38a4 | NNNAGCTGGTTTTAGGTTTT | NGG | 2 | 0.6417 | Tier II |
3 | NC_000069.6 | 3 | 87851442 | - | Sh2d2a | NNNAGGAGGCTTTAGGCTTT | NGG | 2 | 0.6176 | Tier II |
4 | NC_000076.6 | 10 | 78346704 | - | Agpat3 | NNNAGGTAGCTTTGGGTTTT | NGG | 2 | 0.4667 | Tier II |
5 | NC_000082.6 | 16 | 36544393 | + | Casr | NNNAGATGGCTTTAGGTCTT | NGG | 2 | 0.4286 | Tier II |
6 | NC_000076.6 | 10 | 75424014 | + | Upb1 | NNNAGGTGACTTTAGGTTTA | NGG | 2 | 0.3616 | Tier II |
7 | NC_000084.6 | 18 | 66102783 | + | Ccbe1 | NNNAGGTGTCTTTAGGTATT | NGG | 2 | 0.3556 | Tier II |
8 | NC_000076.6 | 10 | 45443161 | + | Lin28b | NNNAGGTTGCTTTAGGATTT | NGG | 2 | 0.3333 | Tier II |
9 | NC_000079.6 | 13 | 76441725 | + | Mctp1 | NNNATGTGGCCTTAGGTTTT | NGG | 2 | 0.2 | Tier II |
10 | NC_000086.7 | X | 13168018 | + | Usp9x | NNNAGGTGGCCTTACGTTTT | NGG | 2 | 0.1818 | Tier II |
11 | NC_000067.6 | 1 | 162863224 | + | Fmo1 | NNNAGGTTGCTTTAGGTTTT | NAG | 2 | 0.162 | Tier II |
12 | NC_000070.6 | 4 | 104523780 | - | Dab1 | NNNACGTGGCTTTAGGTTTG | NGG | 2 | 0.1387 | Tier II |
13 | NC_000075.6 | 9 | 105063918 | + | Mrpl3 | NNNAGATGGCTTTAGGGTTT | NGG | 2 | 0.1176 | Tier II |
14 | NC_000073.6 | 7 | 134436983 | + | D7Ertd443e | NNNAGGTGGCTTTACGTCTT | NGG | 2 | 0.1169 | Tier II |
15 | NC_000075.6 | 9 | 118660251 | + | Itga9 | NNNTGGTGGCTTTAGGTTTG | NGG | 2 | 0.1123 | Tier II |
16 | NC_000077.6 | 11 | 119954129 | + | Baiap2 | NNNAGCTGGCTTTAGGTTTC | NGG | 2 | 0.062 | Tier II |
17 | NC_000068.7 | 2 | 70225525 | - | Myo3b | NNNAGGTGACTTTAGGTTTC | NGG | 2 | 0.0584 | Tier II |
18 | NC_000069.6 | 3 | 119408890 | - | Dpyd | NNNAGGTGGCTTTAGGATTT | NGA | 2 | 0.037 | Tier II |
19 | NC_000085.6 | 19 | 25617826 | + | Dmrt3 | NNNAGGTGGGTTTAGGTTTT | NTG | 2 | 0.0152 | Tier II |
20 | NC_000082.6 | 16 | 88041745 | - | Grik1 | NNNAGGTGGCTTTAGGTTGT | NGC | 2 | 0.0056 | Tier II |
21 | NC_000080.6 | 14 | 49722322 | - | Armh4 | NNNAGGTGGCTTTATGTTTT | NGT | 2 | 0.0023 | Tier II |
22 | NC_000072.6 | 6 | 129012388 | + | Clec2f | NNNAGGTGGCTTTCGCTTTT | NGG | 2 | 0.0 | Tier II |
23 | NC_000071.6 | 5 | 125784493 | - | Tmem132b | NNNAGGTGGGTTTAGCTTTT | NGG | 2 | 0.0 | Tier II |
24 | NC_000074.6 | 8 | 10732152 | - | Gm30666 | NNNAGGTGGGTTTAGGTTTT | NGG | 1 | 0.3889 | Tier III |
25 | NC_000077.6 | 11 | 113105223 | + | 2610035D17Rik | NNNCGGTGGCTTTTGGTTTT | NGG | 2 | 0.1882 | Tier III |
26 | NC_000070.6 | 4 | 30804186 | - | 4930556G01Rik | NNNAGTTGGCTTTAGGTTTT | NAG | 2 | 0.1728 | Tier III |
27 | NC_000078.6 | 12 | 80075899 | - | Gm36660 | NNNAGGTGGCTTTAGGTTAC | NGG | 2 | 0.026 | Tier III |
28 | NC_000080.6 | 14 | 49722322 | - | Gm36146 | NNNAGGTGGCTTTATGTTTT | NGT | 2 | 0.0023 | Tier III |