Construct: sgRNA BRDN0001148014
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CAGCAAACATAACAACCACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CKM (1158)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000019.10 | 19 | 45319629 | - | CKM | NNNCAAACATAACAACCACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000022.11 | 22 | 50128123 | - | MOV10L1 | NNNCAAACAAAACAACCACA | NGG | 1 | 0.8571 | Tier II |
3 | NC_000010.11 | 10 | 32454329 | - | CCDC7 | NNNAAAACATAATAACCACA | NGG | 2 | 0.5895 | Tier II |
4 | NC_000014.9 | 14 | 93112924 | + | ITPK1 | NNNCAAACAAAACAACCTCA | NGG | 2 | 0.4286 | Tier II |
5 | NC_000003.12 | 3 | 19928449 | - | EFHB | NNNCAAACAAAACAACAACA | NGG | 2 | 0.4 | Tier II |
6 | NC_000007.14 | 7 | 140053895 | + | PARP12 | NNNCAAATATCACAACCACA | NGG | 2 | 0.35 | Tier II |
7 | NC_000002.12 | 2 | 199668635 | - | FTCDNL1 | NNNCAAACATAACAACCAAG | NGG | 2 | 0.3277 | Tier II |
8 | NC_000008.11 | 8 | 100920550 | + | YWHAZ | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier II |
9 | NC_000011.10 | 11 | 3971904 | + | STIM1 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier II |
10 | NC_000015.10 | 15 | 45056607 | - | SORD | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier II |
11 | NC_000009.12 | 9 | 122746503 | - | OR1L6 | NNNCAAACAAAACAACCACA | NAG | 2 | 0.2222 | Tier II |
12 | NC_000005.10 | 5 | 178483623 | + | COL23A1 | NNNCAAACCTAAAAACCACA | NGG | 2 | 0.2198 | Tier II |
13 | NC_000008.11 | 8 | 123814180 | - | FAM91A1 | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier II |
14 | NC_000020.11 | 20 | 53359685 | - | TSHZ2 | NNNCGAACATACCAACCACA | NGG | 2 | 0.1895 | Tier II |
15 | NC_000004.12 | 4 | 38880263 | - | FAM114A1 | NNNCAAACATTACAACCACT | NGG | 2 | 0.1846 | Tier II |
16 | NC_000002.12 | 2 | 1172132 | - | SNTG2 | NNNCAATCATCACAACCACA | NGG | 2 | 0.175 | Tier II |
17 | NC_000007.14 | 7 | 36272568 | - | EEPD1 | NNNCAAAGATACCAACCACA | NGG | 2 | 0.1692 | Tier II |
18 | NC_000002.12 | 2 | 229075665 | + | PID1 | NNNCAAACACAACAATCACA | NGG | 2 | 0.1641 | Tier II |
19 | NC_000001.11 | 1 | 81339575 | - | ADGRL2 | NNNCAAACAAAACAACCCCA | NGG | 2 | 0.1633 | Tier II |
20 | NC_000006.12 | 6 | 20128388 | + | MBOAT1 | NNNTAAACATAACAACCCCA | NGG | 2 | 0.1524 | Tier II |
21 | NC_000004.12 | 4 | 93316489 | + | GRID2 | NNNCACACATATCAACCACA | NGG | 2 | 0.1515 | Tier II |
22 | NC_000013.11 | 13 | 25500031 | + | ATP8A2 | NNNCAAACATGACAACCCCA | NGG | 2 | 0.1238 | Tier II |
23 | NC_000010.11 | 10 | 24412116 | - | KIAA1217 | NNNCAAACATAAAAATCACA | NGG | 2 | 0.1183 | Tier II |
24 | NC_000017.11 | 17 | 81036725 | - | BAIAP2 | NNNCAAACCTAACAACCCCA | NGG | 2 | 0.1088 | Tier II |
25 | NC_000002.12 | 2 | 211433079 | + | ERBB4 | NNNCAAACAGAACAAGCACA | NGG | 2 | 0.0769 | Tier II |
26 | NC_000001.11 | 1 | 177206984 | + | BRINP2 | NNNAAAACATAACAACCACA | NGA | 2 | 0.0585 | Tier II |
27 | NC_000001.11 | 1 | 74151391 | + | LRRIQ3 | NNNCAAACATAACAACTAGA | NGG | 2 | 0.0583 | Tier II |
28 | NC_000015.10 | 15 | 62778188 | + | TLN2 | NNNCAAACATAACAAGCCCA | NGG | 2 | 0.0293 | Tier II |
29 | NC_000010.11 | 10 | 101113698 | + | TLX1NB | NNNCAAAAATAACAAACACA | NGG | 2 | 0.65 | Tier III |
30 | NC_000013.11 | 13 | 94888811 | - | LOC101927284 | NNNTAAACATAACAACAACA | NGG | 2 | 0.3733 | Tier III |
31 | NC_000011.10 | 11 | 30277788 | - | ARL14EP-DT | NNNTAAACATAACAACTACA | NGG | 2 | 0.3733 | Tier III |
32 | NC_000002.12 | 2 | 51771306 | - | NRXN1-DT | NNNCAAAGACAACAACCACA | NGG | 2 | 0.3429 | Tier III |
33 | NC_000009.12 | 9 | 127883669 | + | ST6GALNAC4-ST6GALNAC6-AK1 | NNNCAAACAAAAAAACCACA | NGG | 2 | 0.3297 | Tier III |
34 | NC_000011.10 | 11 | 41832639 | - | LINC01499 | NNNCAAACAAAAAAACCACA | NGG | 2 | 0.3297 | Tier III |
35 | NC_000002.12 | 2 | 126557287 | + | YWHAZP2 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
36 | NC_000002.12 | 2 | 126557287 | + | LOC105373602 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
37 | NC_000006.12 | 6 | 127356933 | - | YWHAZP4 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
38 | NC_000010.11 | 10 | 105687202 | - | YWHAZP5 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
39 | NC_000010.11 | 10 | 105687202 | - | LINC02627 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
40 | NC_000011.10 | 11 | 60078597 | - | YWHAZP9 | NNNTAAACATAAAAACCACA | NGG | 2 | 0.3077 | Tier III |
41 | NC_000006.12 | 6 | 7682169 | - | LOC105374906 | NNNCAAAGATATCAACCACA | NGG | 2 | 0.2143 | Tier III |
42 | NC_000001.11 | 1 | 120987437 | - | FAM91A4P | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier III |
43 | NC_000001.11 | 1 | 120987437 | - | PDE4DIPP4 | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier III |
44 | NC_000001.11 | 1 | 143770562 | - | FAM91A3P | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier III |
45 | NC_000001.11 | 1 | 149679221 | - | LINC00869 | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier III |
46 | NC_000001.11 | 1 | 149679221 | - | FAM91A2P | NNNCAAACATAACATACACA | NGG | 2 | 0.2 | Tier III |
47 | NC_000008.11 | 8 | 64332567 | - | LINC01414 | NNNCAAACAAAACATCCACA | NGG | 2 | 0.1714 | Tier III |
48 | NC_000002.12 | 2 | 104152988 | - | LOC105373523 | NNNCAAACATAGCAACCAGA | NGG | 2 | 0.0903 | Tier III |
49 | NC_000006.12 | 6 | 84778905 | - | LOC124901494 | NNNCAAAAATAACAACCACA | NGC | 2 | 0.0144 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000068.7 | 2 | 87810475 | - | Olfr1145 | NNNCAACCATAACAACCACA | NAG | 2 | 0.1134 | Tier I |
2 | NC_000071.6 | 5 | 44020884 | + | Prom1 | NNNCAAACGTAAGAACCACA | NGG | 2 | 0.0909 | Tier I |
3 | NC_000081.6 | 15 | 43157374 | - | Rspo2 | NNNCAAAGATAACAAACACA | NGG | 2 | 0.6429 | Tier II |
4 | NC_000068.7 | 2 | 29976504 | - | Sptan1 | NNNCAAACATAACAAACACT | NGG | 2 | 0.6 | Tier II |
5 | NC_000068.7 | 2 | 68893818 | - | Cers6 | NNNCAAATCTAACAACCACA | NGG | 2 | 0.5 | Tier II |
6 | NC_000073.6 | 7 | 58767197 | + | Atp10a | NNNCAAACAAAACAACCTCA | NGG | 2 | 0.4286 | Tier II |
7 | NC_000080.6 | 14 | 47269045 | + | Wdhd1 | NNNCAAACAAAACAACTACA | NGG | 2 | 0.4 | Tier II |
8 | NC_000071.6 | 5 | 34467243 | - | Fam193a | NNNCAAACAAAACAACCAAA | NGG | 2 | 0.3673 | Tier II |
9 | NC_000077.6 | 11 | 75154495 | - | Smg6 | NNNGAAACATAGCAACCACA | NGG | 2 | 0.3611 | Tier II |
10 | NC_000081.6 | 15 | 76278214 | - | Spatc1 | NNNCAAACATAGCAACCATA | NGG | 2 | 0.3333 | Tier II |
11 | NC_000072.6 | 6 | 114703519 | - | Atg7 | NNNCAAACAAAAAAACCACA | NGG | 2 | 0.3297 | Tier II |
12 | NC_000076.6 | 10 | 74598516 | - | Pcdh15 | NNNCAAACAAAAAAACCACA | NGG | 2 | 0.3297 | Tier II |
13 | NC_000081.6 | 15 | 36772574 | + | Ywhaz | NNNAAAACATAAAAACCACA | NGG | 2 | 0.3239 | Tier II |
14 | NC_000086.7 | X | 143788072 | - | Pak3 | NNNCAAACATGACAACCAAA | NGG | 2 | 0.2786 | Tier II |
15 | NC_000075.6 | 9 | 40361873 | + | Gramd1b | NNNCAAACATAGAAACCACA | NGG | 2 | 0.2778 | Tier II |
16 | NC_000080.6 | 14 | 52464806 | - | Olfr1508 | NNNCAAACATCACAGCCACA | NGG | 2 | 0.26 | Tier II |
17 | NC_000070.6 | 4 | 32929046 | + | Ankrd6 | NNNCAAACATAAAAGCCACA | NGG | 2 | 0.25 | Tier II |
18 | NC_000068.7 | 2 | 132256638 | - | Cds2 | NNNCAATCCTAACAACCACA | NGG | 2 | 0.25 | Tier II |
19 | NC_000079.6 | 13 | 75898756 | + | Rhobtb3 | NNNCAAAGATAAAAACCACA | NGG | 2 | 0.2473 | Tier II |
20 | NC_000082.6 | 16 | 48552364 | - | Morc1 | NNNCAAACAAAACAACCACA | NAG | 2 | 0.2222 | Tier II |
21 | NC_000073.6 | 7 | 141081416 | - | Pkp3 | NNNCAAACAAAACAACCACC | NGG | 2 | 0.1948 | Tier II |
22 | NC_000071.6 | 5 | 115239845 | - | Pop5 | NNNCAGACATAACAACCACC | NGG | 2 | 0.1623 | Tier II |
23 | NC_000082.6 | 16 | 40373558 | + | Lsamp | NNNCAAACATAACAAGCACA | NGG | 1 | 0.1538 | Tier II |
24 | NC_000079.6 | 13 | 106901149 | - | Ipo11 | NNNCAACCATTACAACCACA | NGG | 2 | 0.1346 | Tier II |
25 | NC_000072.6 | 6 | 143068833 | + | C2cd5 | NNNCAAACATAACAATCAAA | NGG | 2 | 0.1319 | Tier II |
26 | NC_000077.6 | 11 | 44798346 | - | Ebf1 | NNNAAAACATAACAAGCACA | NGG | 2 | 0.1296 | Tier II |
27 | NC_000069.6 | 3 | 145995803 | - | Syde2 | NNNCAAAGATAACAAGCACA | NGG | 2 | 0.0989 | Tier II |
28 | NC_000082.6 | 16 | 35240337 | + | Adcy5 | NNNCAATCATAACCACCACA | NGG | 2 | 0.0938 | Tier II |
29 | NC_000071.6 | 5 | 31457629 | - | Zfp512 | NNNCAAACATAACACCCACA | NAG | 2 | 0.0707 | Tier II |
30 | NC_000072.6 | 6 | 118807828 | + | Cacna1c | NNNCAAACATAAGAACCACA | NAG | 2 | 0.0354 | Tier II |
31 | NC_000076.6 | 10 | 128286107 | - | Stat2 | NNNCAAACAGAACAACCACA | NGA | 2 | 0.0347 | Tier II |
32 | NC_000076.6 | 10 | 90514757 | + | Anks1b | NNNCACACATAACAACCACA | NGA | 2 | 0.0316 | Tier II |
33 | NC_000086.7 | X | 83703569 | - | Dmd | NNNCAAACATAAAAACCACA | NGA | 2 | 0.0267 | Tier II |
34 | NC_000075.6 | 9 | 89604909 | + | Minar1 | NNNCAAACACAACAACCACA | NTG | 2 | 0.0208 | Tier II |
35 | NC_000070.6 | 4 | 58170816 | + | Svep1 | NNNCAAACATACCAACCACA | NTG | 2 | 0.0103 | Tier II |
36 | NC_000074.6 | 8 | 16649445 | + | Csmd1 | NNNCAAACATAACAACCACA | NAC | 2 | 0.0 | Tier II |
37 | NC_000073.6 | 7 | 94692269 | + | Gm32647 | NNNCAAACAAAACAACCACT | NGG | 2 | 0.5143 | Tier III |
38 | NC_000084.6 | 18 | 32512583 | + | Gm44577 | NNNCAAACAAAACAACAACA | NGG | 2 | 0.4 | Tier III |
39 | NC_000076.6 | 10 | 54193957 | - | Gm40651 | NNNAAAACATAACAACCAAA | NGG | 2 | 0.3609 | Tier III |
40 | NC_000080.6 | 14 | 52464806 | - | Tcra | NNNCAAACATCACAGCCACA | NGG | 2 | 0.26 | Tier III |
41 | NC_000076.6 | 10 | 118783375 | - | Gm33439 | NNNCAAACAAAACAACCACA | NAG | 2 | 0.2222 | Tier III |
42 | NC_000079.6 | 13 | 40996847 | + | A730081D07Rik | NNNCAAACAAAACAACCACA | NAG | 2 | 0.2222 | Tier III |
43 | NC_000079.6 | 13 | 84877732 | - | Gm34196 | NNNCCAACATAACAAGCACA | NGG | 2 | 0.0769 | Tier III |
44 | NC_000076.6 | 10 | 99268003 | - | Gm34921 | NNNCAAACATAAAAACCACA | NGC | 2 | 0.0085 | Tier III |