Construct: sgRNA BRDN0001148051
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACAAGCTCAAATTCTTCTAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- SNX16 (64089)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000008.11 | 8 | 81839868 | - | SNX16 | NNNAGCTCAAATTCTTCTAA | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 119712679 | + | CIT | NNNAGCTCAAATTCTTCCAC | NGG | 2 | 0.0974 | Tier I |
3 | NC_000012.12 | 12 | 112021494 | - | ERP29 | NNNAGCTCATATTCTTCTAA | NGG | 1 | 0.8824 | Tier II |
4 | NC_000014.9 | 14 | 33670218 | + | NPAS3 | NNNAGCTAAAATTCTTCTAA | NGG | 1 | 0.65 | Tier II |
5 | NC_000010.11 | 10 | 129492299 | - | MGMT | NNNAGCTCAAAACCTTCTAA | NGG | 2 | 0.6316 | Tier II |
6 | NC_000007.14 | 7 | 48506646 | + | ABCA13 | NNNAGCAGAAATTCTTCTAA | NGG | 2 | 0.5625 | Tier II |
7 | NC_000015.10 | 15 | 28271331 | + | HERC2 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier II |
8 | NC_000015.10 | 15 | 28628823 | - | LOC124903450 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier II |
9 | NC_000005.10 | 5 | 120588504 | - | PRR16 | NNNAGCTGAAATCCTTCTAA | NGG | 2 | 0.5075 | Tier II |
10 | NC_000002.12 | 2 | 177903011 | + | PDE11A | NNNAGCTCAAAATCATCTAA | NGG | 2 | 0.4632 | Tier II |
11 | NC_000006.12 | 6 | 136686230 | - | MAP3K5 | NNNAGCTCAAAGACTTCTAA | NGG | 2 | 0.3462 | Tier II |
12 | NC_000007.14 | 7 | 83088414 | + | PCLO | NNNTGCTCAAATTCTTCTTA | NGG | 2 | 0.3427 | Tier II |
13 | NC_000002.12 | 2 | 109469003 | + | RANBP2 | NNNAGCTCAAGGTCTTCTAA | NGG | 2 | 0.325 | Tier II |
14 | NC_000002.12 | 2 | 109469003 | + | SH3RF3 | NNNAGCTCAAGGTCTTCTAA | NGG | 2 | 0.325 | Tier II |
15 | NC_000004.12 | 4 | 113605292 | + | CAMK2D | NNNAGCCCAAATTCTTTTAA | NGG | 2 | 0.3208 | Tier II |
16 | NC_000001.11 | 1 | 229523148 | + | ABCB10 | NNNAGCTCAAATTCTACTAA | NAG | 2 | 0.2357 | Tier II |
17 | NC_000003.12 | 3 | 3152886 | + | TRNT1 | NNNAACTCAAATGCTTCTAA | NGG | 2 | 0.2261 | Tier II |
18 | NC_000003.12 | 3 | 3152886 | + | CRBN | NNNAACTCAAATGCTTCTAA | NGG | 2 | 0.2261 | Tier II |
19 | NC_000006.12 | 6 | 20596174 | - | CDKAL1 | NNNTGCTCAAATTCTGCTAA | NGG | 2 | 0.2203 | Tier II |
20 | NC_000012.12 | 12 | 103293519 | + | C12orf42 | NNNAGTTCAAATTCTTCTAC | NGG | 2 | 0.211 | Tier II |
21 | NC_000003.12 | 3 | 140130612 | + | CLSTN2 | NNNGGCTCACATTCTTCTAA | NGG | 2 | 0.2083 | Tier II |
22 | NC_000012.12 | 12 | 44163072 | - | TMEM117 | NNNAGCTCAATTTCTTCAAA | NGG | 2 | 0.2051 | Tier II |
23 | NC_000021.9 | 21 | 33850133 | - | ITSN1 | NNNAGATCAAATTCTTCTCA | NGG | 2 | 0.1921 | Tier II |
24 | NC_000007.14 | 7 | 105246937 | + | SRPK2 | NNNAGCTCAAATTCTTCCAA | NAG | 2 | 0.1111 | Tier II |
25 | NC_000004.12 | 4 | 24147645 | + | PPARGC1A | NNNAGCTCAAATTCTTCTGA | NAG | 2 | 0.0972 | Tier II |
26 | NC_000003.12 | 3 | 151500157 | + | IGSF10 | NNNAGCTCAAATTATTCTAC | NGG | 2 | 0.0795 | Tier II |
27 | NC_000003.12 | 3 | 13003918 | + | IQSEC1 | NNNATCTCAAATGCTTCTAA | NGG | 2 | 0.0783 | Tier II |
28 | NC_000013.11 | 13 | 40571160 | + | FOXO1 | NNNAGCTAAAATTCTTCTAA | NTG | 2 | 0.0253 | Tier II |
29 | NC_000006.12 | 6 | 51981263 | + | PKHD1 | NNNAGCTCAAATTCTTCAAA | NGC | 2 | 0.0148 | Tier II |
30 | NC_000002.12 | 2 | 124332918 | - | CNTNAP5 | NNNAGCTCAAATGCTTCTAA | NGT | 2 | 0.0042 | Tier II |
31 | NC_000012.12 | 12 | 112021494 | - | LOC124903021 | NNNAGCTCATATTCTTCTAA | NGG | 1 | 0.8824 | Tier III |
32 | NC_000015.10 | 15 | 20466825 | + | HERC2P3 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
33 | NC_000015.10 | 15 | 22533614 | - | HERC2P2 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
34 | NC_000016.10 | 16 | 32180018 | + | HERC2P4 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
35 | NC_000016.10 | 16 | 32749410 | - | HERC2P5 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
36 | NC_000016.10 | 16 | 33120999 | + | HERC2P8 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
37 | NT_187383.1 | 16 | 1009730 | - | LOC102723753 | NNNAGTTCTAATTCTTCTAA | NGG | 2 | 0.5571 | Tier III |
38 | NC_000023.11 | X | 80333895 | + | CHMP1B2P | NNNACCTCAAATACTTCTAA | NGG | 2 | 0.544 | Tier III |
39 | NC_000012.12 | 12 | 58985914 | + | LRIG3-DT | NNNAGCTCAAATTCTTCTTA | NGG | 1 | 0.5385 | Tier III |
40 | NC_000002.12 | 2 | 13154960 | - | LOC105373436 | NNNTGCTCAAAATCTTCTAA | NGG | 2 | 0.5091 | Tier III |
41 | NC_000002.12 | 2 | 13154960 | - | LOC105373484 | NNNTGCTCAAAATCTTCTAA | NGG | 2 | 0.5091 | Tier III |
42 | NC_000009.12 | 9 | 103920278 | - | LOC105376192 | NNNAGCTCAGATTCTTCTAG | NGG | 2 | 0.4248 | Tier III |
43 | NC_000005.10 | 5 | 98106285 | + | LINC01846 | NNNAGCCCAAATTCTTATAA | NGG | 2 | 0.3208 | Tier III |
44 | NC_000006.12 | 6 | 142983984 | - | LINC01277 | NNNAGTTCAAATTCTTCTAA | NAG | 2 | 0.2407 | Tier III |
45 | NC_000006.12 | 6 | 137707074 | + | PTPN11P3 | NNNAGCTCTATTTCTTCTAA | NGG | 2 | 0.1846 | Tier III |
46 | NC_000005.10 | 5 | 23305007 | + | PTPN11P4 | NNNAGCTCCATTTCTTCTAA | NGG | 2 | 0.1758 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000073.6 | 7 | 110044730 | + | Ipo7 | NNNAGCTGAAATACTTCTAA | NGG | 2 | 0.4451 | Tier I |
2 | NC_000071.6 | 5 | 115986576 | - | Cit | NNNAGCTCAAATTCTTCCAC | NGG | 2 | 0.0974 | Tier I |
3 | NC_000076.6 | 10 | 33087629 | + | Trdn | NNNAGCTCAAATCTTTCTAA | NGG | 2 | 0.5789 | Tier II |
4 | NC_000067.6 | 1 | 174764051 | + | Fmn2 | NNNAGCTCAAGTTCATCTAA | NGG | 2 | 0.3763 | Tier II |
5 | NC_000084.6 | 18 | 77661635 | + | 8030462N17Rik | NNNAACTCAAATTATTCTAA | NGG | 2 | 0.3033 | Tier II |
6 | NC_000068.7 | 2 | 30419706 | - | Ptpa | NNNAACTCACATTCTTCTAA | NGG | 2 | 0.2889 | Tier II |
7 | NC_000074.6 | 8 | 60669590 | - | Mfap3l | NNNAGCTCAACTACTTCTAA | NGG | 2 | 0.2769 | Tier II |
8 | NC_000069.6 | 3 | 62570004 | - | Gpr149 | NNNGGCTCAAATTCTTCCAA | NGG | 2 | 0.2679 | Tier II |
9 | NC_000083.6 | 17 | 30552999 | + | Btbd9 | NNNAGCTCAAATTCTTCAGA | NGG | 2 | 0.25 | Tier II |
10 | NC_000069.6 | 3 | 129326358 | + | Enpep | NNNAGCTCAAACTCTTCTAA | NAG | 2 | 0.2456 | Tier II |
11 | NC_000080.6 | 14 | 66116974 | + | Ephx2 | NNNAGCTCACATTCTTCAAA | NGG | 2 | 0.2222 | Tier II |
12 | NC_000072.6 | 6 | 121678771 | + | A2m | NNNAGCTCACATTCTTTTAA | NGG | 2 | 0.1556 | Tier II |
13 | NC_000081.6 | 15 | 33129340 | - | Cpq | NNNAGCTAAAATTCTTCTCA | NGG | 2 | 0.1345 | Tier II |
14 | NC_000069.6 | 3 | 59744941 | + | Aadacl2fm2 | NNNAGTTCAAATTCTTCTAA | NTG | 2 | 0.0362 | Tier II |
15 | NC_000079.6 | 13 | 48485333 | - | Zfp169 | NNNAGCTCAAATGCTTCTAA | NCG | 2 | 0.028 | Tier II |
16 | NC_000080.6 | 14 | 109402797 | + | Gm30216 | NNNAGCAAAAATTCTTCTAA | NGG | 2 | 0.5688 | Tier III |
17 | NC_000076.6 | 10 | 15564218 | + | Gm46188 | NNNAGTTCAAATTATTCTAA | NGG | 2 | 0.325 | Tier III |
18 | NC_000084.6 | 18 | 43451979 | - | Gm41714 | NNNAGCTCAAATAATTCTAA | NGG | 2 | 0.2423 | Tier III |
19 | NC_000078.6 | 12 | 5660592 | - | Gm32398 | NNNAGCTCAAATGCTACTAA | NGG | 2 | 0.2372 | Tier III |
20 | NC_000077.6 | 11 | 18486973 | - | Gm12022 | NNNAGCTGAAATTCTTCTAA | NGT | 2 | 0.0104 | Tier III |