Construct: sgRNA BRDN0001148060
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGGATCCTGGGACATTAGGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- EPHB1 (2047)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 134951547 | - | EPHB1 | NNNATCCTGGGACATTAGGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 146156467 | + | NOTCH2NLA | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier I |
3 | NC_000001.11 | 1 | 148607397 | + | NOTCH2NLB | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier I |
4 | NC_000002.12 | 2 | 229040964 | + | PID1 | NNNACCCTGGGACATTAGAG | NGG | 2 | 0.7143 | Tier II |
5 | NC_000020.11 | 20 | 38026726 | + | TTI1 | NNNATCCTGGAACATTAAGG | NGG | 2 | 0.6923 | Tier II |
6 | NC_000011.10 | 11 | 83600056 | - | DLG2 | NNNAACCTGGGACATTAGGG | NGG | 1 | 0.5 | Tier II |
7 | NC_000005.10 | 5 | 6732862 | - | TENT4A | NNNATCCTGGGACATTAGCA | NGG | 2 | 0.4203 | Tier II |
8 | NC_000016.10 | 16 | 15446668 | - | BMERB1 | NNNATCCTGGGAAATTAGGA | NGG | 2 | 0.3606 | Tier II |
9 | NC_000016.10 | 16 | 15446668 | - | MPV17L-BMERB1 | NNNATCCTGGGAAATTAGGA | NGG | 2 | 0.3606 | Tier II |
10 | NC_000006.12 | 6 | 128883757 | + | LAMA2 | NNNATCCTGGGACTTTATGG | NGG | 2 | 0.3556 | Tier II |
11 | NC_000015.10 | 15 | 75467085 | - | PTPN9 | NNNAGCCTGGGACATGAGGG | NGG | 2 | 0.2215 | Tier II |
12 | NC_000003.12 | 3 | 195893031 | + | TNK2 | NNNCTCCTGGGACTTTAGGG | NGG | 2 | 0.1882 | Tier II |
13 | NC_000006.12 | 6 | 155219697 | + | TIAM2 | NNNATCCTTGGTCATTAGGG | NGG | 2 | 0.1778 | Tier II |
14 | NC_000005.10 | 5 | 127421490 | - | MEGF10 | NNNATCCTGGGAAATGAGGG | NGG | 2 | 0.1331 | Tier II |
15 | NC_000018.10 | 18 | 57438916 | - | ONECUT2 | NNNAGCCTGGGACATTCGGG | NGG | 2 | 0.1129 | Tier II |
16 | NC_000002.12 | 2 | 182996975 | + | NCKAP1 | NNNATCCTGGGAAATTTGGG | NGG | 2 | 0.0513 | Tier II |
17 | NC_000001.11 | 1 | 212585959 | - | ATF3 | NNNATCCTGGGTCATTTGGG | NGG | 2 | 0.0444 | Tier II |
18 | NC_000008.11 | 8 | 70804140 | + | XKR9 | NNNATCCTGGGACATTAGGA | NGC | 2 | 0.0208 | Tier II |
19 | NC_000015.10 | 15 | 42386949 | - | CAPN3 | NNNATCCTGGGACATGAGGG | NGC | 2 | 0.0077 | Tier II |
20 | NC_000001.11 | 1 | 119996984 | + | NOTCH2 | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier II |
21 | NC_000001.11 | 1 | 120793510 | - | NBPF26 | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier II |
22 | NC_000001.11 | 1 | 120793510 | - | NOTCH2NLR | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier II |
23 | NC_000001.11 | 1 | 149463840 | - | NOTCH2NLC | NNNATCCTGGGACACTAGGG | NGC | 2 | 0.0061 | Tier II |
24 | NC_000022.11 | 22 | 43276568 | - | SCUBE1 | NNNATCCTGGGTCATTAGGG | NGT | 2 | 0.0054 | Tier II |
25 | NC_000008.11 | 8 | 126655545 | - | LOC105375751 | NNNATCCTGGGACATTTGGC | NGG | 2 | 0.0571 | Tier III |
26 | NC_000008.11 | 8 | 78876464 | - | MITA1 | NNNATCCTGGGACAGAAGGG | NGG | 2 | 0.0455 | Tier III |
27 | NC_000001.11 | 1 | 151942061 | + | LOC124904421 | NNNATCCTAGGACATTAGGG | NTG | 2 | 0.025 | Tier III |
28 | NC_000022.11 | 22 | 43276568 | - | SCUBE1-AS1 | NNNATCCTGGGTCATTAGGG | NGT | 2 | 0.0054 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000073.6 | 7 | 49464071 | + | Nav2 | NNNACTCTGGGACATTAGGG | NGG | 2 | 0.9286 | Tier II |
2 | NC_000080.6 | 14 | 70545775 | - | Reep4 | NNNATCCTGGGACAAAAGGG | NGG | 2 | 0.5263 | Tier II |
3 | NC_000077.6 | 11 | 89597558 | + | Ankfn1 | NNNATCCTGGGACTTCAGGG | NGG | 2 | 0.3556 | Tier II |
4 | NC_000067.6 | 1 | 156816370 | - | Ralgps2 | NNNATACTGGGACCTTAGGG | NGG | 2 | 0.199 | Tier II |
5 | NC_000072.6 | 6 | 145938187 | - | Sspn | NNNATCCTGGGACGTGAGGG | NGG | 2 | 0.1615 | Tier II |
6 | NC_000082.6 | 16 | 91373591 | - | Ifnar2 | NNNATCCTGGGACCTTAGGT | NGG | 2 | 0.15 | Tier II |
7 | NC_000082.6 | 16 | 90788851 | - | Urb1 | NNNATCCTGGGACATTGGGT | NGG | 2 | 0.1235 | Tier II |
8 | NC_000067.6 | 1 | 153901664 | + | Glul | NNNATCCGGGGAGATTAGGG | NGG | 2 | 0.1 | Tier II |
9 | NC_000078.6 | 12 | 101659713 | + | Tc2n | NNNATCCTGGGACCTTTGGG | NGG | 2 | 0.0286 | Tier II |
10 | NC_000068.7 | 2 | 125949819 | + | Galk2 | NNNATCCTGGGACATTAAGG | NTG | 2 | 0.027 | Tier II |
11 | NC_000071.6 | 5 | 130040764 | - | Crcp | NNNATCCTGGGACATGAGGG | NGA | 2 | 0.024 | Tier II |
12 | NC_000076.6 | 10 | 80060121 | - | Sbno2 | NNNATCCTGGGACAGTTGGG | NGG | 2 | 0.0067 | Tier II |
13 | NC_000075.6 | 9 | 100179518 | - | 4930540E01Rik | NNNATCCTAGGACATTAGTG | NGG | 2 | 0.4286 | Tier III |
14 | NC_000075.6 | 9 | 94114821 | - | Gm31847 | NNNATCCTGGGACACTAGGA | NGG | 2 | 0.2557 | Tier III |
15 | NC_000075.6 | 9 | 94114821 | - | Gm39403 | NNNATCCTGGGACACTAGGA | NGG | 2 | 0.2557 | Tier III |
16 | NC_000082.6 | 16 | 91373591 | - | Gm36587 | NNNATCCTGGGACCTTAGGT | NGG | 2 | 0.15 | Tier III |
17 | NC_000077.6 | 11 | 107195483 | + | Gm39425 | NNNATCCTGGGAGTTTAGGG | NGG | 2 | 0.0727 | Tier III |
18 | NC_000086.7 | X | 99560231 | - | Gm31155 | NNNATCCTGGGAGATGAGGG | NGG | 2 | 0.0472 | Tier III |