Construct: sgRNA BRDN0001148062
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCCCTGTGCAATTACCTCAG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TBCK (93627)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75565
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000004.12 |
4 |
106251985 |
+ |
TBCK |
NNNCTGTGCAATTACCTCAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000002.12 |
2 |
197495308 |
+ |
HSPD1 |
NNNCTGTGCAATTTCTTCAG |
NGG |
2 |
0.1641 |
Tier I |
3 |
NC_000008.11 |
8 |
59070850 |
+ |
TOX |
NNNATGTACAATTACCTCAG |
NGG |
2 |
0.8421 |
Tier II |
4 |
NC_000002.12 |
2 |
149384612 |
- |
LYPD6 |
NNNCTGTGCTATTACCTCTG |
NGG |
2 |
0.4751 |
Tier II |
5 |
NC_000001.11 |
1 |
31208657 |
- |
NKAIN1 |
NNNCTGTGCACTTACATCAG |
NGG |
2 |
0.4 |
Tier II |
6 |
NC_000020.11 |
20 |
61433279 |
+ |
CDH4 |
NNNCTGTGAAATTACCTCGG |
NGG |
2 |
0.3214 |
Tier II |
7 |
NC_000020.11 |
20 |
61862984 |
- |
CDH4 |
NNNCTGTGCATTAACCTCAG |
NGG |
2 |
0.213 |
Tier II |
8 |
NC_000005.10 |
5 |
84265864 |
+ |
EDIL3 |
NNNCTGAGCAATTAACTCAG |
NGG |
2 |
0.1944 |
Tier II |
9 |
NC_000008.11 |
8 |
39673022 |
+ |
ADAM18 |
NNNTTGTGCAATTCCCTCAG |
NGG |
2 |
0.1714 |
Tier II |
10 |
NC_000005.10 |
5 |
21883087 |
- |
CDH12 |
NNNCTGTGCAATTTCTTCAG |
NGG |
2 |
0.1641 |
Tier II |
11 |
NC_000004.12 |
4 |
175770742 |
+ |
GPM6A |
NNNCTGTGCAATTTCCTCAG |
NAG |
2 |
0.1383 |
Tier II |
12 |
NC_000011.10 |
11 |
74913256 |
- |
XRRA1 |
NNNCTCTGCAATTACCTCAG |
NGA |
2 |
0.0473 |
Tier II |
13 |
NC_000019.10 |
19 |
31397620 |
+ |
TSHZ3-AS1 |
NNNCTGTGGAAATACCTCAG |
NGG |
2 |
0.4952 |
Tier III |
14 |
NC_000020.11 |
20 |
61433279 |
+ |
LOC105372703 |
NNNCTGTGAAATTACCTCGG |
NGG |
2 |
0.3214 |
Tier III |
15 |
NC_000007.14 |
7 |
27734335 |
+ |
TAX1BP1-AS1 |
NNNCTGAGCAATTACTTCAG |
NGG |
2 |
0.2692 |
Tier III |
16 |
NC_000005.10 |
5 |
21883087 |
- |
HSPD1P1 |
NNNCTGTGCAATTTCTTCAG |
NGG |
2 |
0.1641 |
Tier III |
17 |
NC_000012.12 |
12 |
8015516 |
- |
HSPD1P12 |
NNNCTGTGCAATTTCTTCAG |
NGG |
2 |
0.1641 |
Tier III |
18 |
NC_000012.12 |
12 |
56511501 |
- |
HSPD1P4 |
NNNCTGTGCAATTTCTTCAG |
NGG |
2 |
0.1641 |
Tier III |
19 |
NC_000006.12 |
6 |
155795962 |
+ |
LOC105378072 |
NNNCTGTGAAATTAGCTCAG |
NGG |
2 |
0.0429 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000076.6 |
10 |
29346988 |
+ |
Rnf146 |
NNNCTGTGCAACTACCACAG |
NGG |
2 |
0.5053 |
Tier I |
2 |
NC_000069.6 |
3 |
132715612 |
- |
Tbck |
NNNTTGTGCAATTACCTCAG |
NTG |
2 |
0.0312 |
Tier I |
3 |
NC_000073.6 |
7 |
43694986 |
+ |
Klk14 |
NNNCTGTGCAATTACCACAG |
NTG |
2 |
0.0208 |
Tier I |
4 |
NC_000080.6 |
14 |
29680648 |
- |
Cacna2d3 |
NNNCTCTGAAATTACCTCAG |
NGG |
2 |
0.5844 |
Tier II |
5 |
NC_000068.7 |
2 |
58642840 |
- |
Upp2 |
NNNTTGTGGAATTACCTCAG |
NGG |
2 |
0.4952 |
Tier II |
6 |
NC_000070.6 |
4 |
102110096 |
+ |
Pde4b |
NNNCTCTGCAGTTACCTCAG |
NGG |
2 |
0.4432 |
Tier II |
7 |
NC_000068.7 |
2 |
73368274 |
+ |
Gpr155 |
NNNCAGTGCAATAACCTCAG |
NGG |
2 |
0.3462 |
Tier II |
8 |
NC_000070.6 |
4 |
121616652 |
+ |
Gm12887 |
NNNGTGTGCAATAACCTCAG |
NGG |
2 |
0.3462 |
Tier II |
9 |
NC_000085.6 |
19 |
38305337 |
+ |
Lgi1 |
NNNCTGTGCATTTACATCAG |
NGG |
2 |
0.3077 |
Tier II |
10 |
NC_000080.6 |
14 |
117505156 |
+ |
Gpc6 |
NNNCTGTGCAATGACCTCAG |
NGG |
1 |
0.2609 |
Tier II |
11 |
NC_000077.6 |
11 |
68456591 |
- |
Pik3r5 |
NNNGTGTGCAAGTACCTCAG |
NGG |
2 |
0.25 |
Tier II |
12 |
NC_000071.6 |
5 |
106621381 |
- |
Zfp644 |
NNNCTGTGGATTTACCTCAG |
NGG |
2 |
0.1905 |
Tier II |
13 |
NC_000072.6 |
6 |
49155575 |
+ |
Igf2bp3 |
NNNCTGGGCATTTACCTCAG |
NGG |
2 |
0.181 |
Tier II |
14 |
NC_000069.6 |
3 |
55275130 |
+ |
Dclk1 |
NNNCTGTGCAAGGACCTCAG |
NGG |
2 |
0.1304 |
Tier II |
15 |
NC_000080.6 |
14 |
99220106 |
- |
Pibf1 |
NNNCTGTGCCATTCCCTCAG |
NGG |
2 |
0.0714 |
Tier II |
16 |
NC_000086.7 |
X |
169798162 |
+ |
Mid1 |
NNNCTGTGCAATTTCCGCAG |
NGG |
2 |
0.0627 |
Tier II |
17 |
NC_000081.6 |
15 |
52333859 |
- |
Slc30a8 |
NNNCTGTGCAATCAGCTCAG |
NGG |
2 |
0.0395 |
Tier II |
18 |
NC_000084.6 |
18 |
24839069 |
+ |
Fhod3 |
NNNCTGTGCAATTACCTCAA |
NGC |
2 |
0.0208 |
Tier II |
19 |
NC_000069.6 |
3 |
100580836 |
+ |
Man1a2 |
NNNCTGTGCAATGACCTCAG |
NGC |
2 |
0.0058 |
Tier II |
20 |
NC_000067.6 |
1 |
93170252 |
+ |
Crocc2 |
NNNCTGTGCAATTACCTGAG |
NTG |
2 |
0.0052 |
Tier II |
21 |
NC_000078.6 |
12 |
46008981 |
- |
Gm33811 |
NNNCTGTGCTGTTACCTCAG |
NGG |
2 |
0.5735 |
Tier III |
22 |
NC_000071.6 |
5 |
93391369 |
- |
Kat2b-ps |
NNNCTGTGCAGTAACCTCAG |
NGG |
2 |
0.45 |
Tier III |
23 |
NC_000068.7 |
2 |
73368274 |
+ |
Gm13709 |
NNNCAGTGCAATAACCTCAG |
NGG |
2 |
0.3462 |
Tier III |
24 |
NC_000078.6 |
12 |
72817976 |
- |
Gm33785 |
NNNCTGTACAATTAGCTCAG |
NGG |
2 |
0.05 |
Tier III |
25 |
NC_000067.6 |
1 |
51331917 |
+ |
9330175M20Rik |
NNNCTGTGCACTTACCTCAG |
NGT |
2 |
0.0065 |
Tier III |
Other clones with same target sequence:
(none)