Construct: sgRNA BRDN0001148085
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGAACATGCTGATTGGCGTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- DGKB (1607)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76917
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000007.14 |
7 |
14685273 |
- |
DGKB |
NNNACATGCTGATTGGCGTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000010.11 |
10 |
86687192 |
- |
LDB3 |
NNNACATGCTGATGGGCGTG |
NTG |
2 |
0.0 |
Tier I |
3 |
NC_000001.11 |
1 |
28048311 |
- |
EYA3 |
NNNACATGCTGATTAGCGTA |
NGG |
2 |
0.8824 |
Tier II |
4 |
NC_000023.11 |
X |
31581198 |
+ |
DMD |
NNNACATGCTGATTGGCTTG |
NGG |
1 |
0.6667 |
Tier II |
5 |
NC_000007.14 |
7 |
31885590 |
- |
PDE1C |
NNNACATGTTGATTGGTGTG |
NGG |
2 |
0.4083 |
Tier II |
6 |
NC_000002.12 |
2 |
111815004 |
- |
ANAPC1 |
NNNACATGCTGATTGGTCTG |
NGG |
2 |
0.2222 |
Tier II |
7 |
NC_000002.12 |
2 |
87725351 |
+ |
ANAPC1P4 |
NNNACATGCTGATTGGTCTG |
NGG |
2 |
0.2222 |
Tier III |
8 |
NC_000002.12 |
2 |
87725351 |
+ |
NCAL1 |
NNNACATGCTGATTGGTCTG |
NGG |
2 |
0.2222 |
Tier III |
9 |
NC_000002.12 |
2 |
87726574 |
+ |
ANAPC1P4 |
NNNACATGCTGATTGGTCTG |
NGG |
2 |
0.2222 |
Tier III |
10 |
NC_000002.12 |
2 |
87726574 |
+ |
NCAL1 |
NNNACATGCTGATTGGTCTG |
NGG |
2 |
0.2222 |
Tier III |
11 |
NC_000006.12 |
6 |
156684290 |
- |
LOC124901444 |
NNNACATGCTGATTGGAGGG |
NGG |
2 |
0.1167 |
Tier III |
12 |
NC_000013.11 |
13 |
60221474 |
- |
LINC00434 |
NNNACATGCTGATTGGCTTG |
NGA |
2 |
0.0463 |
Tier III |
13 |
NC_000013.11 |
13 |
58655071 |
- |
LOC105370219 |
NNNACATGCTCATTGGCGTG |
NGA |
2 |
0.0298 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000078.6 |
12 |
38136631 |
+ |
Dgkb |
NNNACATGCTGATTGGCGTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000074.6 |
8 |
72380927 |
- |
Eps15l1 |
NNNACATGCTGAGTGACGTG |
NGG |
2 |
0.2609 |
Tier I |
3 |
NC_000078.6 |
12 |
103442844 |
+ |
Ifi27l2a |
NNNACCTGCTGATTGGAGTG |
NGG |
2 |
0.2121 |
Tier I |
4 |
NC_000083.6 |
17 |
47416033 |
- |
1700001C19Rik |
NNNACATGCAGATTGGCTTG |
NGG |
2 |
0.5714 |
Tier II |
5 |
NC_000072.6 |
6 |
54276325 |
+ |
Chn2 |
NNNACATACTGATTGGAGTG |
NGG |
2 |
0.4667 |
Tier II |
6 |
NC_000073.6 |
7 |
65928771 |
+ |
Pcsk6 |
NNNACATGGCGATTGGCGTG |
NGG |
2 |
0.3302 |
Tier II |
7 |
NC_000083.6 |
17 |
25630866 |
+ |
Lmf1 |
NNNACATGCTGATTGGTATG |
NGG |
2 |
0.3231 |
Tier II |
8 |
NC_000077.6 |
11 |
60519573 |
+ |
Myo15 |
NNNACCTGCTGATTGGCTTG |
NGG |
2 |
0.303 |
Tier II |
9 |
NC_000067.6 |
1 |
9115280 |
- |
Sntg1 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier II |
10 |
NC_000067.6 |
1 |
150884971 |
- |
Hmcn1 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier II |
11 |
NC_000069.6 |
3 |
31949223 |
- |
Kcnmb2 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier II |
12 |
NC_000072.6 |
6 |
76898737 |
+ |
Ctnna2 |
NNNAGATGCTCATTGGCGTG |
NGG |
2 |
0.2571 |
Tier II |
13 |
NC_000084.6 |
18 |
63800467 |
- |
Wdr7 |
NNNCCATTCTGATTGGCGTG |
NGG |
2 |
0.2206 |
Tier II |
14 |
NC_000069.6 |
3 |
133021773 |
- |
Gstcd |
NNNACATGCTGATTGGTGTG |
NGA |
2 |
0.0324 |
Tier II |
15 |
NC_000081.6 |
15 |
64134665 |
+ |
Asap1 |
NNNACATGCTGAGTGGGGTG |
NGG |
2 |
0.0153 |
Tier II |
16 |
NC_000080.6 |
14 |
47398214 |
- |
Dlgap5 |
NNNACATTCTGATTGCCGTG |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000078.6 |
12 |
113809871 |
+ |
Igh |
NNNACATTCTGACTGGCGTG |
NGG |
2 |
0.4934 |
Tier III |
18 |
NC_000072.6 |
6 |
54276325 |
+ |
9130019P16Rik |
NNNACATACTGATTGGAGTG |
NGG |
2 |
0.4667 |
Tier III |
19 |
NC_000073.6 |
7 |
65928771 |
+ |
Gm51486 |
NNNACATGGCGATTGGCGTG |
NGG |
2 |
0.3302 |
Tier III |
20 |
NC_000068.7 |
2 |
95551347 |
+ |
Gm13794 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
21 |
NC_000073.6 |
7 |
3794707 |
- |
Gm15925 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
22 |
NC_000078.6 |
12 |
115108217 |
- |
Igh |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
23 |
NC_000078.6 |
12 |
115326604 |
- |
Igh |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
24 |
NC_000080.6 |
14 |
53363742 |
+ |
Tcra |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
25 |
NC_000080.6 |
14 |
53363742 |
+ |
Trav13n-4 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
26 |
NC_000081.6 |
15 |
70505130 |
- |
Gm18282 |
NNNACATTCTGATTGGTGTG |
NGG |
2 |
0.2917 |
Tier III |
27 |
NC_000075.6 |
9 |
36679077 |
- |
1700027I24Rik |
NNNCCATTCTGATTGGCGTG |
NGG |
2 |
0.2206 |
Tier III |
Other clones with same target sequence:
(none)