Construct: sgRNA BRDN0001148486
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AATCTCATCAGTCTTTCCAT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NME9 (347736)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 138306424 | + | NME9 | NNNCTCATCAGTCTTTCCAT | NGG | 0 | 1.0 | Tier I |
2 | NC_000003.12 | 3 | 52199216 | + | ALAS1 | NNNTTCATCAGTCTTTCCAC | NGG | 2 | 0.0727 | Tier I |
3 | NC_000010.11 | 10 | 62808406 | - | ADO | NNNCTCATTAGTCTTTCCAA | NGG | 2 | 0.4922 | Tier II |
4 | NC_000013.11 | 13 | 51145697 | - | C13orf42 | NNNCTCATTAGTCTTTCCAA | NGG | 2 | 0.4922 | Tier II |
5 | NC_000009.12 | 9 | 28056447 | + | LINGO2 | NNNCTCAGCACTCTTTCCAT | NGG | 2 | 0.3143 | Tier II |
6 | NC_000007.14 | 7 | 157585137 | - | PTPRN2 | NNNCTCATCAGCCTTTCCAT | NAG | 2 | 0.2456 | Tier II |
7 | NC_000017.11 | 17 | 41763624 | + | JUP | NNNCTCATCAGCCTTTCCCT | NGG | 2 | 0.196 | Tier II |
8 | NC_000001.11 | 1 | 212618827 | + | ATF3 | NNNCTCAGCAGTCTTTCCAG | NGG | 2 | 0.1294 | Tier II |
9 | NC_000016.10 | 16 | 57515725 | + | CCDC102A | NNNCCCATCAGTCTGTCCAT | NGG | 2 | 0.05 | Tier II |
10 | NC_000001.11 | 1 | 49060845 | - | AGBL4 | NNNCTCCTCAGTCTTTCCAC | NGG | 2 | 0.0398 | Tier II |
11 | NC_000022.11 | 22 | 29023775 | + | ZNRF3 | NNNCTCATCAGTCTTTCCAA | NTG | 2 | 0.0219 | Tier II |
12 | NC_000017.11 | 17 | 9298371 | - | STX8 | NNNCTCATCAGCCTTTCCAT | NGC | 2 | 0.0211 | Tier II |
13 | NC_000023.11 | X | 13658393 | - | TCEANC | NNNCTCTTCAGTCTTTCCAT | NTG | 2 | 0.017 | Tier II |
14 | NC_000012.12 | 12 | 1071684 | + | ERC1 | NNNCTCATCACTCTTTCCAT | NTG | 2 | 0.0167 | Tier II |
15 | NC_000022.11 | 22 | 26333936 | - | SEZ6L | NNNCTCATCAGTCTTTCCAA | NGC | 2 | 0.0125 | Tier II |
16 | NC_000003.12 | 3 | 73607515 | + | PDZRN3 | NNNCTCATCAGTCTCTCCAT | NTG | 2 | 0.0106 | Tier II |
17 | NC_000005.10 | 5 | 61450371 | + | ZSWIM6 | NNNCTCATCAGTCTTTCCAT | NCT | 2 | 0.0 | Tier II |
18 | NC_000023.11 | X | 153344639 | - | ZNF275 | NNNCTCATCAGTCTTTCCAT | NTA | 2 | 0.0 | Tier II |
19 | NC_000003.12 | 3 | 117520786 | - | LOC105374056 | NNNCTAATCAGACTTTCCAT | NGG | 2 | 0.7429 | Tier III |
20 | NC_000008.11 | 8 | 128513275 | - | LINC00824 | NNNCTCAGCACTCTTTCCAT | NGG | 2 | 0.3143 | Tier III |
21 | NC_000008.11 | 8 | 64043311 | - | LINC01414 | NNNCTCTTCAGTCTTTCAAT | NGG | 2 | 0.2356 | Tier III |
22 | NC_000007.14 | 7 | 156589978 | - | RNF32-DT | NNNCGCATCAGTCTTTCCAG | NGG | 2 | 0.1129 | Tier III |
23 | NC_000008.11 | 8 | 24179388 | - | LOC107986931 | NNNCTCATCAGTCCTTCCAT | NAG | 2 | 0.0741 | Tier III |
24 | NC_000001.11 | 1 | 38368080 | + | LOC105378657 | NNNCTCATCAGTCTTGCCAG | NGG | 2 | 0.0611 | Tier III |
25 | NC_000004.12 | 4 | 137074475 | + | LINC02511 | NNNCTCCTCAGTCTTTCCAT | NTG | 2 | 0.017 | Tier III |
26 | NC_000023.11 | X | 38919089 | + | LOC124905177 | NNNTTCATCAGTCTTTCCAT | NGT | 2 | 0.0129 | Tier III |
27 | NC_000009.12 | 9 | 89698577 | - | LINC03062 | NNNCTCATCAGTCATTCCAT | NGT | 2 | 0.01 | Tier III |
28 | NC_000009.12 | 9 | 89698577 | - | LOC105376140 | NNNCTCATCAGTCATTCCAT | NGT | 2 | 0.01 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000067.6 | 1 | 100481914 | - | Cntnap5b | NNNCTCATCTGTCTTTCCAA | NGG | 2 | 0.4963 | Tier I |
2 | NC_000073.6 | 7 | 24399107 | + | Smg9 | NNNCTCAGCTGTCTTTCCAT | NGG | 2 | 0.6471 | Tier II |
3 | NC_000067.6 | 1 | 135574926 | - | Nav1 | NNNCTCATCTGTCTTTCTAT | NGG | 2 | 0.5672 | Tier II |
4 | NC_000073.6 | 7 | 58818787 | + | Atp10a | NNNCTCATTAGTCTTTCCTT | NGG | 2 | 0.4712 | Tier II |
5 | NC_000076.6 | 10 | 109696606 | - | Nav3 | NNNCTCATCTGGCTTTCCAT | NGG | 2 | 0.4412 | Tier II |
6 | NC_000067.6 | 1 | 24298319 | + | Col19a1 | NNNCTCAACAGTCTTTCCTT | NGG | 2 | 0.4308 | Tier II |
7 | NC_000084.6 | 18 | 42831278 | - | Ppp2r2b | NNNCTCATCAGTCTTAACAT | NGG | 2 | 0.4242 | Tier II |
8 | NC_000082.6 | 16 | 17366888 | - | Pi4ka | NNNCTATTCAGTCTTTCCAT | NGG | 2 | 0.4062 | Tier II |
9 | NC_000077.6 | 11 | 78359344 | + | Foxn1 | NNNGTCATCAGACTTTCCAT | NGG | 2 | 0.4 | Tier II |
10 | NC_000086.7 | X | 113450199 | + | Dach2 | NNNTTCATCACTCTTTCCAT | NGG | 2 | 0.3429 | Tier II |
11 | NC_000072.6 | 6 | 5938555 | - | Dync1i1 | NNNCTCATGAGGCTTTCCAT | NGG | 2 | 0.3095 | Tier II |
12 | NC_000083.6 | 17 | 49821802 | + | Kif6 | NNNCTCATCACTCTTTCAAT | NGG | 2 | 0.2308 | Tier II |
13 | NC_000081.6 | 15 | 66893351 | - | Ccn4 | NNNCACATCATTCTTTCCAT | NGG | 2 | 0.1923 | Tier II |
14 | NC_000074.6 | 8 | 17123777 | + | Csmd1 | NNNCTCATCAGTCTTTCTAG | NGG | 2 | 0.1134 | Tier II |
15 | NC_000069.6 | 3 | 156811097 | - | Negr1 | NNNCTCATCAGTCTTTACCT | NGG | 2 | 0.0966 | Tier II |
16 | NC_000077.6 | 11 | 31979285 | + | 4930524B15Rik | NNNCTCTTCAGTCTTTCCAC | NGG | 2 | 0.0398 | Tier II |
17 | NC_000080.6 | 14 | 29663130 | + | Cacna2d3 | NNNCTCATCAGTCTTTGCAT | NGA | 2 | 0.0041 | Tier II |
18 | NC_000067.6 | 1 | 10579888 | + | Cpa6 | NNNCTCATCAGTCTTTCCAT | NCT | 2 | 0.0 | Tier II |
19 | NC_000079.6 | 13 | 80960624 | + | Gm4211 | NNNCTCATCAGTCTTACCAT | NGG | 1 | 0.9091 | Tier III |
20 | NC_000070.6 | 4 | 142352896 | + | Gm46875 | NNNCACATCTGTCTTTCCAT | NGG | 2 | 0.4412 | Tier III |
21 | NC_000080.6 | 14 | 98944272 | + | Gm41228 | NNNCTCATCAGTCTCTCCAT | NGG | 1 | 0.2727 | Tier III |
22 | NC_000083.6 | 17 | 49821802 | + | Gm16555 | NNNCTCATCACTCTTTCAAT | NGG | 2 | 0.2308 | Tier III |
23 | NC_000074.6 | 8 | 34386357 | - | Gm33831 | NNNCTCCTCAGTCTCTCCAT | NGG | 2 | 0.1193 | Tier III |