Construct: sgRNA BRDN0001148500
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTGAAGGTGTCTGGCAGAGC
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000011.10 | 11 | 75089645 | + | OR2AT4 | NNNAAGGTCTCTGGCAGAGA | NGG | 2 | 0.2692 | Tier I |
2 | NC_000011.10 | 11 | 64598527 | + | SLC22A12 | NNNAAGGTGGCTGGCAGAGT | NGG | 2 | 0.15 | Tier I |
3 | NC_000010.11 | 10 | 45787218 | - | WASHC2C | NNNAAGGTGTCTGCCTGAGC | NGG | 2 | 0.0 | Tier I |
4 | NC_000010.11 | 10 | 50127766 | - | WASHC2A | NNNAAGGTGTCTGCCTGAGC | NGG | 2 | 0.0 | Tier I |
5 | NC_000007.14 | 7 | 30781086 | - | MINDY4 | NNNAAGGAGTCTGGCAGAGC | NGG | 1 | 0.8 | Tier II |
6 | NC_000008.11 | 8 | 91339418 | - | SLC26A7 | NNNAAGGTGAATGGCAGAGC | NGG | 2 | 0.6429 | Tier II |
7 | NC_000010.11 | 10 | 116263472 | + | GFRA1 | NNNAAGGTGAATGGCAGAGC | NGG | 2 | 0.6429 | Tier II |
8 | NC_000012.12 | 12 | 119128697 | + | SRRM4 | NNNGAAGTGTCTGGCAGAGC | NGG | 2 | 0.625 | Tier II |
9 | NC_000011.10 | 11 | 124642993 | - | SIAE | NNNAAGGTGTCAGACAGAGC | NGG | 2 | 0.6 | Tier II |
10 | NC_000003.12 | 3 | 94088541 | + | NSUN3 | NNNAAGGTAACTGGCAGAGC | NGG | 2 | 0.551 | Tier II |
11 | NC_000005.10 | 5 | 64899322 | + | CWC27 | NNNAAGGTGCCTGGCAGAGC | NGG | 1 | 0.5333 | Tier II |
12 | NC_000010.11 | 10 | 103703920 | - | SH3PXD2A | NNNAATCTGTCTGGCAGAGC | NGG | 2 | 0.4583 | Tier II |
13 | NC_000005.10 | 5 | 10476247 | - | ROPN1L | NNNGAGGGGTCTGGCAGAGC | NGG | 2 | 0.4583 | Tier II |
14 | NC_000012.12 | 12 | 121782573 | - | RHOF | NNNGAGGTGTCTGGCAGAGA | NGG | 2 | 0.3125 | Tier II |
15 | NC_000009.12 | 9 | 117411067 | + | ASTN2 | NNNTAGGTGTCTGGCAGACC | NGG | 2 | 0.2853 | Tier II |
16 | NC_000017.11 | 17 | 82445580 | - | CYBC1 | NNNCAGGGGTCTGGCAGAGC | NGG | 2 | 0.2588 | Tier II |
17 | NC_000013.11 | 13 | 113227041 | + | CUL4A | NNNAAGGTGTCTGGCAGTGA | NGG | 2 | 0.25 | Tier II |
18 | NC_000003.12 | 3 | 202004 | + | CHL1 | NNNAAAGTGTCTGGCACAGC | NGG | 2 | 0.2353 | Tier II |
19 | NC_000006.12 | 6 | 33695900 | - | ITPR3 | NNNAGGGTGTCTGGCAGAGT | NGG | 2 | 0.216 | Tier II |
20 | NC_000008.11 | 8 | 58835822 | + | TOX | NNNAAGGTGAGTGGCAGAGC | NGG | 2 | 0.2143 | Tier II |
21 | NC_000005.10 | 5 | 122825383 | - | SNX2 | NNNAAGGAGTCTGGCAGAGC | NAG | 2 | 0.2074 | Tier II |
22 | NC_000017.11 | 17 | 6610385 | - | KIAA0753 | NNNAAGGTGTCAGGCAGAGC | NAG | 2 | 0.2074 | Tier II |
23 | NC_000008.11 | 8 | 143573229 | - | NAPRT | NNNAAGGTGTCTGACAGAGC | NAG | 2 | 0.1944 | Tier II |
24 | NC_000002.12 | 2 | 69745226 | + | ANXA4 | NNNGAGGTGTTTGGCAGAGC | NGG | 2 | 0.1923 | Tier II |
25 | NC_000017.11 | 17 | 76685936 | + | MXRA7 | NNNCAGGTGTCGGGCAGAGC | NGG | 2 | 0.1765 | Tier II |
26 | NC_000017.11 | 17 | 33382102 | - | ASIC2 | NNNCCGGTGTCTGGCAGAGC | NGG | 2 | 0.1765 | Tier II |
27 | NC_000007.14 | 7 | 134533653 | + | AKR1B10 | NNNAATGTGTGTGGCAGAGC | NGG | 2 | 0.1667 | Tier II |
28 | NC_000007.14 | 7 | 134572265 | + | AKR1B15 | NNNAATGTGTGTGGCAGAGC | NGG | 2 | 0.1667 | Tier II |
29 | NC_000017.11 | 17 | 72752020 | + | SLC39A11 | NNNCAGGTGTCTCGCAGAGC | NGG | 2 | 0.1486 | Tier II |
30 | NC_000007.14 | 7 | 15128163 | - | AGMO | NNNAAGGTGTCTGCCAGAGT | NGG | 2 | 0.1286 | Tier II |
31 | NC_000003.12 | 3 | 124153043 | + | KALRN | NNNAAGGTTTCTGGCACAGC | NGG | 2 | 0.1255 | Tier II |
32 | NC_000007.14 | 7 | 74056961 | + | ELN | NNNAAGGTGTCTGGCAGGGT | NGG | 2 | 0.12 | Tier II |
33 | NC_000001.11 | 1 | 53528397 | - | GLIS1 | NNNCAGGTGTGTGGCAGAGC | NGG | 2 | 0.0882 | Tier II |
34 | NC_000011.10 | 11 | 47344445 | + | MYBPC3 | NNNCAGGTGTGTGGCAGAGC | NGG | 2 | 0.0882 | Tier II |
35 | NC_000001.11 | 1 | 160681075 | - | CD48 | NNNAAGGTGTCTGGGAGAGC | NGG | 1 | 0.05 | Tier II |
36 | NC_000004.12 | 4 | 176754422 | + | VEGFC | NNNAAGGTGTCTGGCAAAGC | NTG | 2 | 0.0364 | Tier II |
37 | NC_000015.10 | 15 | 52292935 | + | MYO5C | NNNAAGGAGTCTGGCAGAGC | NTG | 2 | 0.0312 | Tier II |
38 | NC_000009.12 | 9 | 19856738 | + | SLC24A2 | NNNAAGGTGTCTGGCAGTGC | NTG | 2 | 0.0195 | Tier II |
39 | NC_000001.11 | 1 | 9328125 | - | SPSB1 | NNNAAGGTGTGTGGCAGAGC | NGA | 2 | 0.0174 | Tier II |
40 | NC_000002.12 | 2 | 290009 | + | LOC101927262 | NNNAAAGTGTCCGGCAGAGC | NGG | 2 | 0.9474 | Tier III |
41 | NC_000007.14 | 7 | 30781086 | - | INMT-MINDY4 | NNNAAGGAGTCTGGCAGAGC | NGG | 1 | 0.8 | Tier III |
42 | NC_000005.10 | 5 | 100247640 | + | LOC105379101 | NNNAAGGTGTCAGGCAAAGC | NGG | 2 | 0.7467 | Tier III |
43 | NC_000010.11 | 10 | 33002581 | + | ITGB1-DT | NNNAAGAGGTCTGGCAGAGC | NGG | 2 | 0.7333 | Tier III |
44 | NC_000006.12 | 6 | 29263001 | + | OR2U1P | NNNAAGGTTTCTGACAGAGC | NGG | 2 | 0.4 | Tier III |
45 | NC_000006.12 | 6 | 29263001 | + | LINC03003 | NNNAAGGTTTCTGACAGAGC | NGG | 2 | 0.4 | Tier III |
46 | NC_000001.11 | 1 | 89756218 | - | LOC107985743 | NNNAAGTTGCCTGGCAGAGC | NGG | 2 | 0.3048 | Tier III |
47 | NC_000005.10 | 5 | 122825383 | - | LOC105379154 | NNNAAGGAGTCTGGCAGAGC | NAG | 2 | 0.2074 | Tier III |
48 | NC_000001.11 | 1 | 219459826 | + | LYPLAL1-AS1 | NNNATGGTGCCTGGCAGAGC | NGG | 2 | 0.1939 | Tier III |
49 | NC_000008.11 | 8 | 93565897 | - | CIBAR1-DT | NNNAAGGTTTCTTGCAGAGC | NGG | 2 | 0.16 | Tier III |
50 | NC_000015.10 | 15 | 81329882 | - | TMC3-AS1 | NNNCAGGTGTCTGCCAGAGC | NGG | 2 | 0.1513 | Tier III |
51 | NC_000010.11 | 10 | 35697334 | - | RPL7P37 | NNNAAGGTTTCTGGCACAGC | NGG | 2 | 0.1255 | Tier III |
52 | NC_000010.11 | 10 | 110550819 | + | RPL7P35 | NNNAAGGTTTCTGGCACAGC | NGG | 2 | 0.1255 | Tier III |
53 | NC_000013.11 | 13 | 40439909 | - | LINC00598 | NNNAAGGTGTCTTGGAGAGC | NGG | 2 | 0.015 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000067.6 | 1 | 43049783 | + | Tgfbrap1 | NNNAAGGGTTCTGGCAGAGC | NGG | 2 | 0.3911 | Tier I |
2 | NC_000083.6 | 17 | 34449253 | - | BC051142 | NNNAAGGTGTCTGGCGGAGC | NGA | 2 | 0.0134 | Tier I |
3 | NC_000077.6 | 11 | 93581497 | - | Car10 | NNNAACGTGTCTGGCAGAGC | NGG | 1 | 0.6818 | Tier II |
4 | NC_000078.6 | 12 | 78871501 | + | Eif2s1 | NNNAGGGTGACTGGCAGAGC | NGG | 2 | 0.6171 | Tier II |
5 | NC_000077.6 | 11 | 100118676 | - | Krt13 | NNNACAGTGTCTGGCAGAGC | NGG | 2 | 0.5 | Tier II |
6 | NC_000073.6 | 7 | 127244122 | + | Zfp771 | NNNAAGCTGTCTGGCAGATC | NGG | 2 | 0.4583 | Tier II |
7 | NC_000078.6 | 12 | 105479134 | + | D430019H16Rik | NNNGAGGGGTCTGGCAGAGC | NGG | 2 | 0.4583 | Tier II |
8 | NC_000071.6 | 5 | 127280486 | - | Tmem132c | NNNAAGGTGTCAGGCAGTGC | NGG | 2 | 0.4 | Tier II |
9 | NC_000081.6 | 15 | 36193714 | - | Spag1 | NNNAAGGAGTCTGGCAGGGC | NGG | 2 | 0.32 | Tier II |
10 | NC_000074.6 | 8 | 106260051 | - | Smpd3 | NNNCAGGAGTCTGGCAGAGC | NGG | 2 | 0.2824 | Tier II |
11 | NC_000076.6 | 10 | 76825967 | + | Pcbp3 | NNNAAGGTCTCTGGCAGGGC | NGG | 2 | 0.2154 | Tier II |
12 | NC_000085.6 | 19 | 38006340 | + | Myof | NNNAAGGTGGTTGGCAGAGC | NGG | 2 | 0.1538 | Tier II |
13 | NC_000074.6 | 8 | 9412389 | + | Fam155a | NNNAAGCTGTCTGGAAGAGC | NGG | 2 | 0.1528 | Tier II |
14 | NC_000082.6 | 16 | 31992090 | - | Senp5 | NNNAAGGTGTCTGGCAGACT | NGG | 2 | 0.1345 | Tier II |
15 | NC_000074.6 | 8 | 115206134 | - | Wwox | NNNAAGGTGGCTGGCAGAGC | NAG | 2 | 0.1296 | Tier II |
16 | NC_000074.6 | 8 | 114809056 | + | Wwox | NNNAAGGTGTCTGGCAGTGC | NAG | 2 | 0.1296 | Tier II |
17 | NC_000069.6 | 3 | 96026480 | - | Vps45 | NNNAAGGTGCCTGGCACAGC | NGG | 2 | 0.1255 | Tier II |
18 | NC_000076.6 | 10 | 128715416 | - | Pmel | NNNAAGGTGTCTGGAAGGGC | NGG | 2 | 0.0889 | Tier II |
19 | NC_000070.6 | 4 | 135336630 | + | Srrm1 | NNNAAGGTGTGTGTCAGAGC | NGG | 2 | 0.0667 | Tier II |
20 | NC_000067.6 | 1 | 73015675 | + | Tnp1 | NNNAAGGTGTCTGGAAGAGC | NAG | 2 | 0.0576 | Tier II |
21 | NC_000071.6 | 5 | 127627097 | + | Slc15a4 | NNNAAGGTGTATGGCAGAGG | NGG | 2 | 0.0441 | Tier II |
22 | NC_000073.6 | 7 | 97436481 | - | Kctd14 | NNNAAGGTGACTGGGAGAGC | NGG | 2 | 0.0429 | Tier II |
23 | NC_000069.6 | 3 | 110132482 | + | Ntng1 | NNNAGGGTGTCTGGCAGAGG | NGG | 2 | 0.0424 | Tier II |
24 | NC_000074.6 | 8 | 79057316 | + | Zfp827 | NNNAAGGTGTCTGGCAGAGC | NGC | 1 | 0.0222 | Tier II |
25 | NC_000075.6 | 9 | 37638994 | + | Siae | NNNATGGTGTCTGGCAGAGC | NTG | 2 | 0.0142 | Tier II |
26 | NC_000076.6 | 10 | 89432216 | + | Gas2l3 | NNNGAGGTGTCTGGCAGAGC | NGC | 2 | 0.0139 | Tier II |
27 | NC_000071.6 | 5 | 92931599 | - | Shroom3 | NNNAAGGTGTCTGTCAGAGC | NTG | 2 | 0.0104 | Tier II |
28 | NC_000079.6 | 13 | 59453206 | - | Agtpbp1 | NNNAAGGTGTCTGGGAGAGC | NGA | 2 | 0.0035 | Tier II |
29 | NC_000067.6 | 1 | 188937321 | + | Ush2a | NNNAAGGTGTCTGGCAGAGG | NGC | 2 | 0.0013 | Tier II |
30 | NC_000076.6 | 10 | 60080349 | + | Ascc1 | NNNAAGGTGGCTGGCTGAGC | NGG | 2 | 0.0 | Tier II |
31 | NC_000078.6 | 12 | 37294251 | + | Agmo | NNNAAGGTTTCTGGCTGAGC | NGG | 2 | 0.0 | Tier II |
32 | NC_000072.6 | 6 | 25130947 | + | Gm30658 | NNNAACATGTCTGGCAGAGC | NGG | 2 | 0.6818 | Tier III |
33 | NC_000083.6 | 17 | 14517740 | + | Gm34916 | NNNACAGTGTCTGGCAGAGC | NGG | 2 | 0.5 | Tier III |
34 | NC_000071.6 | 5 | 127280486 | - | Tmem132cos | NNNAAGGTGTCAGGCAGTGC | NGG | 2 | 0.4 | Tier III |
35 | NC_000076.6 | 10 | 60228439 | + | Gm2038 | NNNAAGGTGTCTGGAGGAGC | NGG | 2 | 0.0427 | Tier III |
36 | NC_000078.6 | 12 | 32936631 | + | 4933406C10Rik | NNNAAGGTGTCTGGCTGACC | NGG | 2 | 0.0 | Tier III |