Construct: sgRNA BRDN0001148538
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTGGGGTCAAGAACACTGGT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CDC42BPB (9578)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77777
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000014.9 |
14 |
102966283 |
- |
CDC42BPB |
NNNGGGTCAAGAACACTGGT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000011.10 |
11 |
67674379 |
- |
ALDH3B2 |
NNNGGGTAAAGGACACTGGT |
NGG |
2 |
0.4694 |
Tier II |
3 |
NC_000008.11 |
8 |
95249990 |
- |
CFAP418 |
NNNGGGTCAAGAGCACTGAT |
NGG |
2 |
0.4658 |
Tier II |
4 |
NC_000001.11 |
1 |
232586884 |
+ |
SIPA1L2 |
NNNGGGGAAAGAACACTGGT |
NGG |
2 |
0.3824 |
Tier II |
5 |
NC_000011.10 |
11 |
59795787 |
- |
STX3 |
NNNGGCTCAAGAACACAGGT |
NGG |
2 |
0.3636 |
Tier II |
6 |
NC_000010.11 |
10 |
21729593 |
+ |
MLLT10 |
NNNGTGTCAAGAACACTAGT |
NGG |
2 |
0.2077 |
Tier II |
7 |
NC_000005.10 |
5 |
53578365 |
- |
NDUFS4 |
NNNGGGTCAAGGACACTGGT |
NAG |
2 |
0.1872 |
Tier II |
8 |
NC_000014.9 |
14 |
95509419 |
- |
SYNE3 |
NNNGGGTCCAGATCACTGGT |
NGG |
2 |
0.1714 |
Tier II |
9 |
NC_000003.12 |
3 |
174442647 |
- |
NAALADL2 |
NNNGTGTCAAGAACACTGCT |
NGG |
2 |
0.1345 |
Tier II |
10 |
NC_000005.10 |
5 |
102763384 |
- |
PAM |
NNNGGGTCAAGAACAGTGCT |
NGG |
2 |
0.069 |
Tier II |
11 |
NC_000004.12 |
4 |
6592191 |
+ |
MAN2B2 |
NNNGGGTGAAGAACACTGGC |
NGG |
2 |
0.0584 |
Tier II |
12 |
NC_000019.10 |
19 |
53912760 |
+ |
CACNG7 |
NNNGGGTCAAGCACTCTGGT |
NGG |
2 |
0.0526 |
Tier II |
13 |
NC_000006.12 |
6 |
155218813 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
14 |
NC_000006.12 |
6 |
155218871 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
15 |
NC_000006.12 |
6 |
155218900 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
16 |
NC_000006.12 |
6 |
155218950 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
17 |
NC_000006.12 |
6 |
155218979 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
18 |
NC_000006.12 |
6 |
155219029 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
19 |
NC_000006.12 |
6 |
155219058 |
- |
TIAM2 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
20 |
NC_000017.11 |
17 |
32304442 |
+ |
RHBDL3 |
NNNTGGTCAAGAACACGGGT |
NGG |
2 |
0.0428 |
Tier II |
21 |
NC_000017.11 |
17 |
29842040 |
- |
SSH2 |
NNNGGGTTAAGAACACTGGT |
NTG |
2 |
0.0341 |
Tier II |
22 |
NC_000020.11 |
20 |
9697449 |
- |
PAK5 |
NNNGGGTCTAGAAGACTGGT |
NGG |
2 |
0.0 |
Tier II |
23 |
NC_000024.10 |
Y |
7343111 |
+ |
PRKY |
NNNGGGCCCAGAACACTGGT |
NGG |
2 |
0.3929 |
Tier III |
24 |
NC_000001.11 |
1 |
115975997 |
- |
LOC101928977 |
NNNGGGTTAAGTACACTGGT |
NGG |
2 |
0.2917 |
Tier III |
25 |
NC_000010.11 |
10 |
21729593 |
+ |
LOC107984214 |
NNNGTGTCAAGAACACTAGT |
NGG |
2 |
0.2077 |
Tier III |
26 |
NC_000008.11 |
8 |
19886482 |
- |
LOC105379309 |
NNNGGGTCATGAACTCTGGT |
NGG |
2 |
0.1765 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000076.6 |
10 |
4354955 |
+ |
Akap12 |
NNNGGGCCAAGAACACTGGG |
NGG |
2 |
0.1213 |
Tier I |
2 |
NC_000075.6 |
9 |
41137267 |
+ |
Ubash3b |
NNNGGGTCATGAACACTGAT |
NGG |
2 |
0.6303 |
Tier II |
3 |
NC_000068.7 |
2 |
27492108 |
- |
Brd3 |
NNNAGGTCAAGAGCACTGGT |
NGG |
2 |
0.587 |
Tier II |
4 |
NC_000068.7 |
2 |
155247693 |
- |
Dynlrb1 |
NNNGGGTTAAGAGCACTGGT |
NGG |
2 |
0.5707 |
Tier II |
5 |
NC_000081.6 |
15 |
9126665 |
- |
Skp2 |
NNNGGGTCAAGAACACTCGT |
NGG |
1 |
0.4762 |
Tier II |
6 |
NC_000074.6 |
8 |
68694191 |
- |
Csgalnact1 |
NNNGGGTCAAGAACACTTAT |
NGG |
2 |
0.4762 |
Tier II |
7 |
NC_000073.6 |
7 |
123043626 |
- |
Tnrc6a |
NNNGGCTGAAGAACACTGGT |
NGG |
2 |
0.4383 |
Tier II |
8 |
NC_000068.7 |
2 |
169921552 |
+ |
Tshz2 |
NNNGGGTCAAGAAAAATGGT |
NGG |
2 |
0.35 |
Tier II |
9 |
NC_000067.6 |
1 |
74741984 |
- |
Prkag3 |
NNNTGGTTAAGAACACTGGT |
NGG |
2 |
0.3182 |
Tier II |
10 |
NC_000081.6 |
15 |
71540414 |
+ |
Fam135b |
NNNGGTTCAAGAACACTGCT |
NGG |
2 |
0.2989 |
Tier II |
11 |
NC_000085.6 |
19 |
38686622 |
+ |
Plce1 |
NNNGGGTAAAGAACATTGGT |
NGG |
2 |
0.2 |
Tier II |
12 |
NC_000073.6 |
7 |
113363137 |
+ |
Btbd10 |
NNNGTTTCAAGAACACTGGT |
NGG |
2 |
0.2 |
Tier II |
13 |
NC_000071.6 |
5 |
72725003 |
- |
Txk |
NNNGGGTCAGGAACATTGGT |
NGG |
2 |
0.1709 |
Tier II |
14 |
NC_000079.6 |
13 |
102694293 |
- |
Cd180 |
NNNGGGTCAAGGACAGTGGT |
NGG |
2 |
0.1111 |
Tier II |
15 |
NC_000074.6 |
8 |
46533834 |
- |
Acsl1 |
NNNGGGTTAAGAACACTGGC |
NGG |
2 |
0.0795 |
Tier II |
16 |
NC_000069.6 |
3 |
84205180 |
- |
Trim2 |
NNNGGGGCAAGAACACGGGT |
NGG |
2 |
0.0692 |
Tier II |
17 |
NC_000071.6 |
5 |
96784588 |
- |
Fras1 |
NNNGGGTCAAGAACACAGGT |
NGA |
2 |
0.037 |
Tier II |
18 |
NC_000067.6 |
1 |
192636457 |
- |
Hhat |
NNNGGGTCAAGAACTCTGGG |
NGG |
2 |
0.0353 |
Tier II |
19 |
NC_000084.6 |
18 |
24629219 |
- |
Elp2 |
NNNGGGTCAAGAACACTGGC |
NGC |
2 |
0.002 |
Tier II |
20 |
NC_000071.6 |
5 |
144181972 |
+ |
Lmtk2 |
NNNGGGTTAAGAAGACTGGT |
NGG |
2 |
0.0 |
Tier II |
21 |
NC_000077.6 |
11 |
60817430 |
+ |
Gm12611 |
NNNGGATCAAGAACAATGGT |
NGG |
2 |
1.0 |
Tier III |
22 |
NC_000068.7 |
2 |
169487218 |
- |
Gm34112 |
NNNCGGTCTAGAACACTGGT |
NGG |
2 |
0.3176 |
Tier III |
23 |
NC_000068.7 |
2 |
169487218 |
- |
Gm14249 |
NNNCGGTCTAGAACACTGGT |
NGG |
2 |
0.3176 |
Tier III |
24 |
NC_000076.6 |
10 |
23698961 |
+ |
Gm35291 |
NNNGGGTCAAGAACACTGCT |
NGC |
2 |
0.01 |
Tier III |
Other clones with same target sequence:
(none)