Construct: sgRNA BRDN0001148547
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACTAAACTGTACATCATGCA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PIK3C2A (5286)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000011.10 | 11 | 17117652 | + | PIK3C2A | NNNAAACTGTACATCATGCA | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 171512632 | + | PRRC2C | NNNAAACTGAAAATCATGCA | NGG | 2 | 0.6122 | Tier II |
3 | NC_000007.14 | 7 | 39285294 | - | POU6F2 | NNNAATCTGTGCATCATGCA | NGG | 2 | 0.4643 | Tier II |
4 | NC_000016.10 | 16 | 3314047 | + | ZNF75A | NNNAAAATGTATATCATGCA | NGG | 2 | 0.4038 | Tier II |
5 | NC_000007.14 | 7 | 105994868 | - | CDHR3 | NNNAAACAGTACTTCATGCA | NGG | 2 | 0.24 | Tier II |
6 | NC_000001.11 | 1 | 32078983 | - | TMEM39B | NNNAAATTGTACATCATGCA | NAG | 2 | 0.2106 | Tier II |
7 | NC_000010.11 | 10 | 95367530 | + | SORBS1 | NNNAAACTGTACATCATTCA | NAG | 2 | 0.1728 | Tier II |
8 | NC_000006.12 | 6 | 65562826 | - | EYS | NNNAAACTGTACTTCATGCA | NAG | 2 | 0.0778 | Tier II |
9 | NC_000002.12 | 2 | 169657904 | + | CFAP210 | NNNAAACTGTAAATCATGCA | NGA | 2 | 0.0496 | Tier II |
10 | NC_000002.12 | 2 | 135660403 | - | R3HDM1 | NNNAAACTTTACATCATGCA | NGA | 2 | 0.037 | Tier II |
11 | NC_000003.12 | 3 | 14993912 | + | NR2C2 | NNNAAACTGTACCTCAGGCA | NGG | 2 | 0.0248 | Tier II |
12 | NC_000010.11 | 10 | 47535789 | + | ANXA8 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier II |
13 | NC_000017.11 | 17 | 48046750 | + | COPZ2 | NNNAAACTGTACATCCTCCA | NGG | 2 | 0.0 | Tier II |
14 | NC_000008.11 | 8 | 70341054 | + | NCOA2 | NNNAAACTGTACATCCTGCA | NGT | 2 | 0.0 | Tier II |
15 | NC_000023.11 | X | 7193430 | + | STS | NNNAAACTGTACATTTTGCA | NGG | 2 | 0.0 | Tier II |
16 | NC_000009.12 | 9 | 118520416 | + | LOC105376248 | NNNAAAGTGAACATCATGCA | NGG | 2 | 0.4034 | Tier III |
17 | NC_000016.10 | 16 | 60518892 | + | LOC101927605 | NNNAAACTGTACATAATACA | NGG | 2 | 0.1538 | Tier III |
18 | NC_000008.11 | 8 | 2720789 | - | LINC03021 | NNNAAACTGCACACCATGCA | NGG | 2 | 0.1524 | Tier III |
19 | NC_000024.10 | Y | 18503180 | - | LOC124905304 | NNNAAACTGTACATCAGACA | NGG | 2 | 0.0814 | Tier III |
20 | NC_000024.10 | Y | 18817227 | + | LOC124905305 | NNNAAACTGTACATCAGACA | NGG | 2 | 0.0814 | Tier III |
21 | NC_000005.10 | 5 | 13447477 | - | LOC105374660 | NNNAAACTGCACATCATGCA | NTG | 2 | 0.0208 | Tier III |
22 | NC_000010.11 | 10 | 45859704 | + | PARGP1 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
23 | NC_000010.11 | 10 | 45859704 | + | PARGP1-AGAP4 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
24 | NC_000010.11 | 10 | 46804153 | - | BMS1P1 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
25 | NC_000010.11 | 10 | 47535789 | + | BMS1P2 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
26 | NC_000010.11 | 10 | 47535789 | + | BMS1P2-AGAP9 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
27 | NC_000010.11 | 10 | 49976391 | - | TIMM23B-AGAP6 | NNNAAACGGTACATCATGCA | NGT | 2 | 0.0118 | Tier III |
28 | NC_000004.12 | 4 | 188739245 | + | LOC285442 | NNNAAACTGTACAGCATGCA | NGT | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000083.6 | 17 | 24385497 | - | Abca3 | NNNAAACAGTACATCATGCT | NGG | 2 | 0.48 | Tier I |
2 | NC_000067.6 | 1 | 11862464 | - | A830018L16Rik | NNNAAACTGTATATCATCCA | NGG | 2 | 0.2564 | Tier II |
3 | NC_000069.6 | 3 | 54699615 | - | Supt20 | NNNCAACTATACATCATGCA | NGG | 2 | 0.2269 | Tier II |
4 | NC_000070.6 | 4 | 111557660 | - | Agbl4 | NNNAATCTGTACACCATGCA | NGG | 2 | 0.2041 | Tier II |
5 | NC_000074.6 | 8 | 33301228 | - | Wrn | NNNAAACTGTGCACCATGCA | NGG | 2 | 0.1857 | Tier II |
6 | NC_000073.6 | 7 | 16377740 | - | Sae1 | NNNAAACTGTACATCATACA | NAG | 2 | 0.1795 | Tier II |
7 | NC_000074.6 | 8 | 28974178 | - | Unc5d | NNNCACCTGTACATCATGCA | NGG | 2 | 0.1604 | Tier II |
8 | NC_000074.6 | 8 | 13887917 | - | Coprs | NNNAAACTCTACATCGTGCA | NGG | 2 | 0.1036 | Tier II |
9 | NC_000076.6 | 10 | 58370725 | - | Lims1 | NNNAAACAGTACATCAGGCA | NGG | 2 | 0.0941 | Tier II |
10 | NC_000077.6 | 11 | 48914714 | + | Gm12185 | NNNAAACTGGACATCAGGCA | NGG | 2 | 0.0588 | Tier II |
11 | NC_000067.6 | 1 | 124357852 | - | Dpp10 | NNNAAACTGGACATTATGCA | NGG | 2 | 0.0333 | Tier II |
12 | NC_000079.6 | 13 | 49883293 | - | Gm272 | NNNATACTGTACATCATGCA | NGA | 2 | 0.0253 | Tier II |
13 | NC_000069.6 | 3 | 100065828 | - | Spag17 | NNNAAACTGTTCATTATGCA | NGG | 2 | 0.0205 | Tier II |
14 | NC_000075.6 | 9 | 31437097 | - | Tmem45b | NNNAACCTGTACATCATGCA | NGT | 2 | 0.0073 | Tier II |
15 | NC_000071.6 | 5 | 116002917 | - | Cit | NNNAAACTGTACACCTTGCA | NGG | 2 | 0.0 | Tier II |
16 | NC_000086.7 | X | 75618758 | - | LOC115489104 | NNNAAACTGTAGATCATGAA | NGG | 2 | 0.1905 | Tier III |
17 | NC_000079.6 | 13 | 49883293 | - | Gm19011 | NNNATACTGTACATCATGCA | NGA | 2 | 0.0253 | Tier III |
18 | NC_000079.6 | 13 | 50859820 | + | Gm19009 | NNNATACTGTACATCATGCA | NGA | 2 | 0.0253 | Tier III |
19 | NC_000079.6 | 13 | 50859820 | + | Gm40947 | NNNATACTGTACATCATGCA | NGA | 2 | 0.0253 | Tier III |