Construct: sgRNA BRDN0001148567
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTACCATTTGGCTTGCAAAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PACSIN1 (29993)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000006.12 | 6 | 34529434 | + | PACSIN1 | NNNCCATTTGGCTTGCAAAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000013.11 | 13 | 45151785 | + | GTF2F2 | NNNCCATTTGTCTTGCAAAG | NGT | 2 | 0.0062 | Tier I |
3 | NC_000003.12 | 3 | 64240415 | - | PRICKLE2 | NNNCCATTTAGCCTGCAAAG | NGG | 2 | 0.7368 | Tier II |
4 | NC_000022.11 | 22 | 30706744 | - | OSBP2 | NNNACATGTGGCTTGCAAAG | NGG | 2 | 0.6175 | Tier II |
5 | NC_000011.10 | 11 | 131722352 | + | NTM | NNNCTATTTGGCTTGCAAAA | NGG | 2 | 0.5966 | Tier II |
6 | NC_000011.10 | 11 | 83785863 | - | DLG2 | NNNCCATATGGCTAGCAAAG | NGG | 2 | 0.4952 | Tier II |
7 | NC_000008.11 | 8 | 89977867 | + | NBN | NNNCTATGTGGCTTGCAAAG | NGG | 2 | 0.4667 | Tier II |
8 | NC_000001.11 | 1 | 14740079 | + | KAZN | NNNCCATCTGCCTTGCAAAG | NGG | 2 | 0.4286 | Tier II |
9 | NC_000003.12 | 3 | 42769407 | - | CCDC13 | NNNCCAATTGTCTTGCAAAG | NGG | 2 | 0.3365 | Tier II |
10 | NC_000001.11 | 1 | 41637010 | + | HIVEP3 | NNNCCATTTGGTTAGCAAAG | NGG | 2 | 0.3333 | Tier II |
11 | NC_000005.10 | 5 | 131999358 | - | ACSL6 | NNNCCCTTTGGCTTGCAAAG | NGA | 2 | 0.0316 | Tier II |
12 | NC_000003.12 | 3 | 1142639 | - | CNTN6 | NNNCCATATGGCTTGCAAAG | NTG | 2 | 0.0312 | Tier II |
13 | NC_000022.11 | 22 | 23226738 | + | BCR | NNNCCATGTGGCTTGCAAAG | NTG | 2 | 0.0286 | Tier II |
14 | NC_000019.10 | 19 | 4214973 | - | ANKRD24 | NNNCCATTTGGCATGCAAAG | NGC | 2 | 0.0154 | Tier II |
15 | NC_000007.14 | 7 | 129012799 | - | TNPO3 | NNNCCATATGGCTTGCAAAG | NGT | 2 | 0.0129 | Tier II |
16 | NC_000022.11 | 22 | 46685662 | + | CERK | NNNCCATTTGGCTTGCACAG | NGC | 2 | 0.0042 | Tier II |
17 | NC_000005.10 | 5 | 125213140 | - | LOC101927421 | NNNCAATTTGGCTTGCAAAT | NGG | 2 | 0.4 | Tier III |
18 | NC_000012.12 | 12 | 54097411 | - | FLJ12825 | NNNTCATTTGGCTTGTAAAG | NGG | 2 | 0.2462 | Tier III |
19 | NC_000012.12 | 12 | 95655656 | - | PGAM1P5 | NNNTCATTTGGCTTCCAAAG | NGG | 2 | 0.2182 | Tier III |
20 | NC_000002.12 | 2 | 18907455 | + | LOC105373456 | NNNCCATTTGGGTTGCAGAG | NGG | 2 | 0.1778 | Tier III |
21 | NC_000007.14 | 7 | 92907706 | + | CDK6-AS1 | NNNCCATTTGTCTTCCAAAG | NGG | 2 | 0.1049 | Tier III |
22 | NC_000014.9 | 14 | 53783425 | - | LINC02331 | NNNCCATATGGCTTGCAAAG | NGA | 2 | 0.0556 | Tier III |
23 | NC_000001.11 | 1 | 170219454 | + | LINC01681 | NNNCCATATGGCTTGCAAAG | NTG | 2 | 0.0312 | Tier III |
24 | NC_000006.12 | 6 | 104472428 | + | LOC105377918 | NNNCCATTTGGCCTGCAAAG | NTG | 2 | 0.0308 | Tier III |
25 | NC_000007.14 | 7 | 149370954 | + | LOC124901770 | NNNCCATTTGGCTTGCAAGG | NTG | 2 | 0.0146 | Tier III |
26 | NC_000017.11 | 17 | 68852247 | - | LOC105371874 | NNNCCATTTGGCTGCCAAAG | NGG | 2 | 0.0 | Tier III |
27 | NC_000010.11 | 10 | 64077059 | - | LOC124902439 | NNNCCATTTGGCTTGCAAAG | NCA | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000080.6 | 14 | 75995468 | - | Gtf2f2 | NNNCCATTTGTCTTGCAAAG | NGT | 2 | 0.0062 | Tier I |
2 | NC_000074.6 | 8 | 121085000 | + | Foxf1 | NNNCCATTTGGCTGGCAACG | NGG | 2 | 0.0 | Tier I |
3 | NC_000072.6 | 6 | 92500357 | - | Prickle2 | NNNTCATTTGGCTTGCAAAA | NGG | 2 | 0.75 | Tier II |
4 | NC_000077.6 | 11 | 49832553 | + | Gfpt2 | NNNCCATGTGACTTGCAAAG | NGG | 2 | 0.7333 | Tier II |
5 | NC_000071.6 | 5 | 62712957 | - | Arap2 | NNNCCTCTTGGCTTGCAAAG | NGG | 2 | 0.4911 | Tier II |
6 | NC_000067.6 | 1 | 20510979 | - | Pkhd1 | NNNCCAGTTGGCTTGCAAAT | NGG | 2 | 0.4118 | Tier II |
7 | NC_000072.6 | 6 | 32836761 | + | Chchd3 | NNNCCATTTGGCATGCAATG | NGG | 2 | 0.3728 | Tier II |
8 | NC_000074.6 | 8 | 58070041 | - | Galntl6 | NNNCCATCTGGCTTGCAAAG | NAG | 2 | 0.2593 | Tier II |
9 | NC_000068.7 | 2 | 179642127 | + | Cdh4 | NNNCCCTTTGGGTTGCAAAG | NGG | 2 | 0.202 | Tier II |
10 | NC_000075.6 | 9 | 47830068 | - | Cadm1 | NNNCTATTTGGCTTGCCAAG | NGG | 2 | 0.1123 | Tier II |
11 | NC_000083.6 | 17 | 62610079 | - | Efna5 | NNNCCATTTGGCTTCTAAAG | NGG | 2 | 0.0839 | Tier II |
12 | NC_000070.6 | 4 | 18807622 | + | Cnbd1 | NNNCCATTTTGCTTGCAAAG | NTG | 2 | 0.0317 | Tier II |
13 | NC_000078.6 | 12 | 74059845 | + | Syt16 | NNNCCATATGGCTTGCAAAG | NTG | 2 | 0.0312 | Tier II |
14 | NC_000086.7 | X | 167475888 | - | Frmpd4 | NNNTCATTTGGCTTGCAAAG | NGT | 2 | 0.0129 | Tier II |
15 | NC_000074.6 | 8 | 70800918 | + | Mast3 | NNNCCACTTGGCTGGCAAAG | NGG | 2 | 0.0 | Tier II |
16 | NC_000086.7 | X | 167719807 | - | Frmpd4 | NNNCCATTTGGCTGGCAAAG | NTG | 2 | 0.0 | Tier II |
17 | NC_000071.6 | 5 | 96258459 | + | Mrpl1 | NNNCCATTTGGCTTGCAAAG | NCA | 2 | 0.0 | Tier II |
18 | NC_000077.6 | 11 | 49832553 | + | Gm36507 | NNNCCATGTGACTTGCAAAG | NGG | 2 | 0.7333 | Tier III |
19 | NC_000069.6 | 3 | 151872862 | + | Gm31596 | NNNGCATTTGGCTTGCAAGG | NGG | 2 | 0.1875 | Tier III |