Construct: sgRNA BRDN0001148926
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACCTGTGTACATATCCCATG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- STRADA (92335)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000017.11 | 17 | 63710506 | + | STRADA | NNNTGTGTACATATCCCATG | NGG | 0 | 1.0 | Tier I |
2 | NC_000018.10 | 18 | 58953777 | + | ZNF532 | NNNTGTGTACATATCCCACG | NGA | 2 | 0.0192 | Tier I |
3 | NC_000008.11 | 8 | 14424539 | + | SGCZ | NNNTGTGTATATATCCCATA | NGG | 2 | 0.8824 | Tier II |
4 | NC_000011.10 | 11 | 30523008 | - | MPPED2 | NNNTGTGAACATGTCCCATG | NGG | 2 | 0.5217 | Tier II |
5 | NC_000019.10 | 19 | 13285551 | - | CACNA1A | NNNTGTGTTAATATCCCATG | NGG | 2 | 0.52 | Tier II |
6 | NC_000011.10 | 11 | 67901513 | - | LOC112268076 | NNNTGTGTCCAAATCCCATG | NGG | 2 | 0.4571 | Tier II |
7 | NC_000022.11 | 22 | 32732659 | + | SYN3 | NNNTGTCTACATATCCTATG | NGG | 2 | 0.3208 | Tier II |
8 | NC_000017.11 | 17 | 58392133 | - | RNF43 | NNNTGTGTGCATATCCCGTG | NGG | 2 | 0.2667 | Tier II |
9 | NC_000018.10 | 18 | 26273392 | - | TAF4B | NNNTGTGTACATATCACATG | NAG | 2 | 0.2593 | Tier II |
10 | NC_000016.10 | 16 | 5567253 | + | RBFOX1 | NNNTGTGTGGATATCCCATG | NGG | 2 | 0.2593 | Tier II |
11 | NC_000003.12 | 3 | 192433821 | - | FGF12 | NNNTGTGAACATACCCCATG | NGG | 2 | 0.2286 | Tier II |
12 | NC_000019.10 | 19 | 11016136 | + | SMARCA4 | NNNTGTGTAGAGATCCCATG | NGG | 2 | 0.1944 | Tier II |
13 | NC_000008.11 | 8 | 41992578 | - | KAT6A | NNNTGTGTACATATCCCTCG | NGG | 2 | 0.1379 | Tier II |
14 | NC_000013.11 | 13 | 111233743 | + | ARHGEF7 | NNNTGTGTACATATCACATG | NCG | 2 | 0.1071 | Tier II |
15 | NC_000006.12 | 6 | 40436360 | + | LRFN2 | NNNTGTTTACATATCGCATG | NGG | 2 | 0.0879 | Tier II |
16 | NC_000007.14 | 7 | 131189000 | + | MKLN1 | NNNTGTGTACATATCACATG | NGA | 2 | 0.0694 | Tier II |
17 | NC_000004.12 | 4 | 140944398 | - | RNF150 | NNNTGTGTACATCTACCATG | NGG | 2 | 0.0468 | Tier II |
18 | NC_000003.12 | 3 | 23326754 | + | UBE2E2 | NNNTGTGTACATGTCCCATG | NTG | 2 | 0.0254 | Tier II |
19 | NC_000011.10 | 11 | 14882468 | - | PDE3B | NNNTGTGTATATATCCCATG | NGC | 2 | 0.0209 | Tier II |
20 | NC_000011.10 | 11 | 14882468 | - | CYP2R1 | NNNTGTGTATATATCCCATG | NGC | 2 | 0.0209 | Tier II |
21 | NC_000009.12 | 9 | 68836604 | - | PIP5K1B | NNNTGTGTACATATCCCATA | NGC | 2 | 0.0208 | Tier II |
22 | NC_000004.12 | 4 | 90691556 | + | CCSER1 | NNNTGTGTACATATCACATG | NGT | 2 | 0.0161 | Tier II |
23 | NC_000016.10 | 16 | 47298994 | - | ITFG1 | NNNTGTGTACATCTGCCATG | NGG | 2 | 0.0105 | Tier II |
24 | NC_000008.11 | 8 | 33440435 | + | FUT10 | NNNTGTGTACATATCTCATG | NGC | 2 | 0.0068 | Tier II |
25 | NC_000005.10 | 5 | 111810214 | + | NREP | NNNTGTGTACAGAGCCCATG | NGG | 2 | 0.0 | Tier II |
26 | NC_000018.10 | 18 | 52793164 | + | DCC | NNNTGTTTACATAGCCCATG | NGG | 2 | 0.0 | Tier II |
27 | NC_000004.12 | 4 | 18607342 | + | LOC105374510 | NNNTATGTACACATCCCATG | NGG | 2 | 0.8211 | Tier III |
28 | NC_000004.12 | 4 | 101730685 | - | LOC107986297 | NNNTCTGTTCATATCCCATG | NGG | 2 | 0.4714 | Tier III |
29 | NC_000003.12 | 3 | 130195834 | - | LOC107986133 | NNNTGTGTCCAAATCCCATG | NGG | 2 | 0.4571 | Tier III |
30 | NC_000011.10 | 11 | 3527537 | - | LOC101927708 | NNNTGTGTCCAAATCCCATG | NGG | 2 | 0.4571 | Tier III |
31 | NC_000001.11 | 1 | 75991509 | + | LOC105378806 | NNNTGTCTTCATATCCCATG | NGG | 2 | 0.4125 | Tier III |
32 | NC_000023.11 | X | 23196791 | + | PTCHD1-AS | NNNTGTGTACATAACCCATC | NGG | 2 | 0.2653 | Tier III |
33 | NC_000010.11 | 10 | 77734004 | + | LOC399783 | NNNTGTGTACATATCCCACG | NGA | 2 | 0.0192 | Tier III |
34 | NC_000016.10 | 16 | 47298994 | - | LOC101927080 | NNNTGTGTACATCTGCCATG | NGG | 2 | 0.0105 | Tier III |
35 | NC_000010.11 | 10 | 15761164 | + | LOC124902383 | NNNTGTGTACATATGCCATG | NTG | 2 | 0.0019 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000071.6 | 5 | 6796847 | + | Zfp804b | NNNTGTGTAAATATCCCATA | NGG | 2 | 0.8125 | Tier II |
2 | NC_000068.7 | 2 | 106756624 | + | Mpped2 | NNNTGTGAACATGTCCCATG | NGG | 2 | 0.5217 | Tier II |
3 | NC_000077.6 | 11 | 101428606 | + | Rundc1 | NNNTGTGTACATATCACATC | NGG | 2 | 0.4286 | Tier II |
4 | NC_000070.6 | 4 | 25221053 | - | Fhl5 | NNNTGTTGACATATCCCATG | NGG | 2 | 0.419 | Tier II |
5 | NC_000067.6 | 1 | 136851894 | - | Nr5a2 | NNNTGTGTTCATGTCCCATG | NGG | 2 | 0.3913 | Tier II |
6 | NC_000074.6 | 8 | 3631600 | + | Stxbp2 | NNNTGTGCACATACCCCATG | NGG | 2 | 0.2857 | Tier II |
7 | NC_000085.6 | 19 | 46134897 | - | Elovl3 | NNNAGGGTACATATCCCATG | NGG | 2 | 0.2721 | Tier II |
8 | NC_000075.6 | 9 | 48267075 | - | Nxpe4 | NNNTGTGCACATATCCCATG | NAG | 2 | 0.2593 | Tier II |
9 | NC_000084.6 | 18 | 30341324 | + | Pik3c3 | NNNTGTGTGCATATCCCATG | NAG | 2 | 0.1728 | Tier II |
10 | NC_000083.6 | 17 | 30444889 | + | Btbd9 | NNNTGTGTAGCTATCCCATG | NGG | 2 | 0.1556 | Tier II |
11 | NC_000075.6 | 9 | 96891087 | - | Pxylp1 | NNNTGTCTACATATCCCATG | NGA | 2 | 0.0477 | Tier II |
12 | NC_000083.6 | 17 | 80565780 | + | Cdkl4 | NNNTGTGTACATCTCCCCTG | NGG | 2 | 0.0401 | Tier II |
13 | NC_000071.6 | 5 | 101732875 | + | Gm42134 | NNNTGGGTACATATTCCATG | NGG | 2 | 0.0381 | Tier II |
14 | NC_000076.6 | 10 | 40423665 | - | Cdk19 | NNNTGTGTACATATCCCATT | NTG | 2 | 0.0273 | Tier II |
15 | NC_000080.6 | 14 | 72707110 | - | Fndc3a | NNNTGTGTACATTTGCCATG | NGG | 2 | 0.015 | Tier II |
16 | NC_000083.6 | 17 | 42407766 | + | Ptchd4 | NNNTGTGTACAAATCCCATG | NGT | 2 | 0.0129 | Tier II |
17 | NC_000077.6 | 11 | 72717195 | - | Ankfy1 | NNNTGTGTACATATGCCATG | NTG | 2 | 0.0019 | Tier II |
18 | NC_000082.6 | 16 | 4775964 | + | Cdip1 | NNNTGTGTACATATGCCATG | NTG | 2 | 0.0019 | Tier II |
19 | NC_000073.6 | 7 | 132660648 | + | Lhpp | NNNTGTGTACATATGCCATG | NGC | 2 | 0.0011 | Tier II |
20 | NC_000070.6 | 4 | 19428214 | - | Cngb3 | NNNTGTGTACATATGCCATG | NGT | 2 | 0.0008 | Tier II |
21 | NC_000072.6 | 6 | 21693502 | - | Kcnd2 | NNNTGTGTACATAGCACATG | NGG | 2 | 0.0 | Tier II |
22 | NC_000081.6 | 15 | 53877885 | + | Samd12 | NNNTGTGTACATATCCCATG | NAT | 2 | 0.0 | Tier II |
23 | NC_000070.6 | 4 | 54888579 | - | Gm34133 | NNNTGTGTACTTATCACATG | NGG | 2 | 0.3077 | Tier III |
24 | NC_000075.6 | 9 | 48267075 | - | Gm51672 | NNNTGTGCACATATCCCATG | NAG | 2 | 0.2593 | Tier III |
25 | NC_000077.6 | 11 | 25622203 | - | 5730522E02Rik | NNNTGTGAACATATCCCAAG | NGG | 2 | 0.2286 | Tier III |
26 | NC_000071.6 | 5 | 101732875 | + | 9430085M18Rik | NNNTGGGTACATATTCCATG | NGG | 2 | 0.0381 | Tier III |
27 | NC_000074.6 | 8 | 107213029 | - | 4930517G24Rik | NNNTGTGAACATATCCCATG | NTG | 2 | 0.0312 | Tier III |
28 | NC_000069.6 | 3 | 103726964 | - | LOC108168889 | NNNTGTGTTCATATCCCATG | NGC | 2 | 0.0133 | Tier III |
29 | NC_000076.6 | 10 | 98844976 | + | Gm34346 | NNNTGTGTACATATTCCATG | NGC | 2 | 0.0015 | Tier III |
30 | NC_000072.6 | 6 | 39244819 | + | Gm38794 | NNNTGTGTACATATGCCATG | NGT | 2 | 0.0008 | Tier III |