Construct: sgRNA BRDN0001149000
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCAAAATGGAGTTCCCACAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- STK26 (51765)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000023.11 | X | 132068511 | - | STK26 | NNNAAATGGAGTTCCCACAA | NGG | 0 | 1.0 | Tier I |
2 | NC_000005.10 | 5 | 81335785 | + | ACOT12 | NNNAAATGGGGGTCCCACAA | NGG | 2 | 0.2778 | Tier I |
3 | NC_000005.10 | 5 | 58726996 | + | RAB3C | NNNAAATGGAGCTCCCAAAA | NGG | 2 | 0.5101 | Tier II |
4 | NC_000006.12 | 6 | 16143631 | + | MYLIP | NNNAAATGGGGATCCCACAA | NGG | 2 | 0.4444 | Tier II |
5 | NC_000001.11 | 1 | 201192320 | + | IGFN1 | NNNAAATGGAGTCCCCAAAA | NGG | 2 | 0.4251 | Tier II |
6 | NC_000008.11 | 8 | 64648464 | + | CYP7B1 | NNNAAATGCAGTTTCCACAA | NGG | 2 | 0.3949 | Tier II |
7 | NC_000004.12 | 4 | 53039188 | - | SCFD2 | NNNAAATGGGGTTCCCATAA | NGG | 2 | 0.3571 | Tier II |
8 | NC_000007.14 | 7 | 821829 | + | SUN1 | NNNAAAGGGAGTTCCCACAT | NGG | 2 | 0.3529 | Tier II |
9 | NC_000003.12 | 3 | 136489163 | - | STAG1 | NNNAAATAGAGTTACCACAA | NGG | 2 | 0.35 | Tier II |
10 | NC_000002.12 | 2 | 224787786 | - | DOCK10 | NNNTACTGGAGTTCCCACAA | NGG | 2 | 0.2893 | Tier II |
11 | NC_000012.12 | 12 | 2241007 | + | CACNA1C | NNNAAATGGAGTTACCACAG | NGG | 2 | 0.2676 | Tier II |
12 | NC_000003.12 | 3 | 61687795 | - | PTPRG | NNNAAATGGATTTCCCAAAA | NGG | 2 | 0.2071 | Tier II |
13 | NC_000009.12 | 9 | 104789742 | + | ABCA1 | NNNAAATGTATTTCCCACAA | NGG | 2 | 0.2051 | Tier II |
14 | NC_000009.12 | 9 | 104789742 | + | NIPSNAP3B | NNNAAATGTATTTCCCACAA | NGG | 2 | 0.2051 | Tier II |
15 | NC_000020.11 | 20 | 46270652 | + | CDH22 | NNNAAATGGAGTTCCCATAC | NGG | 2 | 0.1461 | Tier II |
16 | NC_000019.10 | 19 | 54617261 | - | LILRB1 | NNNCAATGGAGTGCCCACAA | NGG | 2 | 0.0921 | Tier II |
17 | NC_000010.11 | 10 | 87820549 | + | ATAD1 | NNNAAATGGAGTTCCCAGTA | NGG | 2 | 0.0718 | Tier II |
18 | NC_000004.12 | 4 | 108665320 | - | OSTC | NNNAAATGGAGTTACCTCAA | NGG | 2 | 0.0467 | Tier II |
19 | NC_000009.12 | 9 | 114064990 | + | AMBP | NNNAAATGGAGTTCACAGAA | NGG | 2 | 0.0296 | Tier II |
20 | NC_000008.11 | 8 | 98203706 | + | NIPAL2 | NNNAAATGCAGTTCCCACAA | NTG | 2 | 0.021 | Tier II |
21 | NC_000016.10 | 16 | 72903666 | - | ZFHX3 | NNNAAATGGAGTTGTCACAA | NGG | 2 | 0.0 | Tier II |
22 | NC_000012.12 | 12 | 79759502 | - | PPP1R12A-AS2 | NNNAAATGGAATTTCCACAA | NGG | 2 | 0.7333 | Tier III |
23 | NC_000009.12 | 9 | 40961103 | + | LOC107986997 | NNNGGATGGAGTTCCCACAA | NGG | 2 | 0.45 | Tier III |
24 | NC_000023.11 | X | 49149027 | - | LOC105373195 | NNNTAAGGGAGTTCCCACAA | NGG | 2 | 0.3743 | Tier III |
25 | NC_000004.12 | 4 | 53039188 | - | LOC124900701 | NNNAAATGGGGTTCCCATAA | NGG | 2 | 0.3571 | Tier III |
26 | NC_000005.10 | 5 | 128695476 | - | LOC105379168 | NNNAAATGGAGTTACCACAA | NGG | 1 | 0.35 | Tier III |
27 | NC_000003.12 | 3 | 61687795 | - | LOC124906245 | NNNAAATGGATTTCCCAAAA | NGG | 2 | 0.2071 | Tier III |
28 | NC_000002.12 | 2 | 230994172 | + | SPATA3-AS1 | NNNAAATGGAGTCCCCTCAA | NGG | 2 | 0.1053 | Tier III |
29 | NC_000003.12 | 3 | 153234170 | - | LOC105374164 | NNNAAATGGAGTTTCCAGAA | NGG | 2 | 0.0978 | Tier III |
30 | NC_000010.11 | 10 | 87820549 | + | CFL1P1 | NNNAAATGGAGTTCCCAGTA | NGG | 2 | 0.0718 | Tier III |
31 | NC_000008.11 | 8 | 98203706 | + | NIPAL2-AS1 | NNNAAATGCAGTTCCCACAA | NTG | 2 | 0.021 | Tier III |
32 | NC_000011.10 | 11 | 4666712 | - | LOC105376528 | NNNAAATGGAGCTCCCACAA | NGT | 2 | 0.0153 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000073.6 | 7 | 97904695 | - | Pak1 | NNNATATGGAGTTCCCACCA | NGG | 2 | 0.0752 | Tier I |
2 | NC_000067.6 | 1 | 124306668 | + | Dpp10 | NNNGAATGGTGTTCCCACAA | NGG | 2 | 0.5515 | Tier II |
3 | NC_000074.6 | 8 | 121745824 | - | Jph3 | NNNAAATGGTGTTCCCACCA | NGG | 2 | 0.1826 | Tier II |
4 | NC_000070.6 | 4 | 103743279 | - | Dab1 | NNNAAATGAAGTGCCCACAA | NGG | 2 | 0.1677 | Tier II |
5 | NC_000083.6 | 17 | 84377500 | + | Thada | NNNAAATGTAGTTCCCTCAA | NGG | 2 | 0.0711 | Tier II |
6 | NC_000083.6 | 17 | 17407367 | - | Lix1 | NNNAAATGGAGTTCCTTCAA | NGG | 2 | 0.041 | Tier II |
7 | NC_000069.6 | 3 | 20115988 | - | Hltf | NNNAAATGAAGTTCCCACAA | NTG | 2 | 0.025 | Tier II |
8 | NC_000079.6 | 13 | 113041834 | - | Cdc20b | NNNAAATGGCGTTCTCACAA | NGG | 2 | 0.0222 | Tier II |
9 | NC_000072.6 | 6 | 72305206 | + | Sftpb | NNNAATTGGAGTTCCCACAA | NGC | 2 | 0.0159 | Tier II |
10 | NC_000083.6 | 17 | 75544936 | + | Fam98a | NNNAAATGGAGTTCCCACTA | NGC | 2 | 0.012 | Tier II |
11 | NC_000072.6 | 6 | 146471042 | + | Itpr2 | NNNCAATGGAGTTCCCACAA | NGC | 2 | 0.0078 | Tier II |
12 | NC_000079.6 | 13 | 88843448 | + | Edil3 | NNNAAATGGAGTTCCCAGAA | NGC | 2 | 0.003 | Tier II |
13 | NC_000067.6 | 1 | 168676145 | - | Gm34320 | NNNAAAGGGAGTACCCACAA | NGG | 2 | 0.4072 | Tier III |
14 | NC_000080.6 | 14 | 84424418 | + | Gm32498 | NNNATATGGAGTTCCAACAA | NGG | 2 | 0.3636 | Tier III |
15 | NC_000068.7 | 2 | 106411766 | - | Gm36036 | NNNAAAGGGAGTTCCCACAA | NTG | 2 | 0.0229 | Tier III |
16 | NC_000068.7 | 2 | 106411766 | - | Gm46755 | NNNAAAGGGAGTTCCCACAA | NTG | 2 | 0.0229 | Tier III |
17 | NC_000075.6 | 9 | 89838952 | + | 4930524O08Rik | NNNACATGGAGTTCCCACAA | NTG | 2 | 0.0195 | Tier III |
18 | NC_000069.6 | 3 | 121564355 | + | Gm33547 | NNNAAATGGAGTGGCCACAA | NGG | 2 | 0.0 | Tier III |