Construct: sgRNA BRDN0001149034
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGAATCCTTCTGGTACACGA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PANK4 (55229)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 2520827 | + | PANK4 | NNNATCCTTCTGGTACACGA | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 106072819 | + | NUAK1 | NNNATCCTTCTGGTACAGGT | NGG | 2 | 0.08 | Tier I |
3 | NC_000006.12 | 6 | 161941533 | + | PRKN | NNNATTCTTCTGGTACACAA | NGG | 2 | 0.6633 | Tier II |
4 | NC_000007.14 | 7 | 100058959 | - | ZSCAN21 | NNNATCCTTCTGGTAAATGA | NGG | 2 | 0.6429 | Tier II |
5 | NC_000005.10 | 5 | 96924130 | + | ERAP1 | NNNATCCTGCTAGTACACGA | NGG | 2 | 0.5778 | Tier II |
6 | NC_000017.11 | 17 | 79940169 | - | TBC1D16 | NNNGTCCTCCTGGTACACGA | NGG | 2 | 0.5769 | Tier II |
7 | NC_000011.10 | 11 | 119009618 | - | CENATAC | NNNATCCTCCTGGAACACGA | NGG | 2 | 0.5714 | Tier II |
8 | NC_000005.10 | 5 | 31466092 | - | DROSHA | NNNATACTTCTGGTACAAGA | NGG | 2 | 0.5 | Tier II |
9 | NC_000001.11 | 1 | 93728501 | - | BCAR3 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
10 | NC_000001.11 | 1 | 227754035 | - | SNAP47 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
11 | NC_000002.12 | 2 | 98172165 | - | VWA3B | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
12 | NC_000002.12 | 2 | 154191944 | - | GALNT13 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
13 | NC_000002.12 | 2 | 233766121 | - | UGT1A10 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
14 | NC_000002.12 | 2 | 233766121 | - | UGT1A8 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
15 | NC_000002.12 | 2 | 233766121 | - | UGT1A7 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
16 | NC_000002.12 | 2 | 233766121 | - | UGT1A6 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
17 | NC_000002.12 | 2 | 233766121 | - | UGT1A5 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
18 | NC_000002.12 | 2 | 233766121 | - | UGT1A9 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
19 | NC_000002.12 | 2 | 233766121 | - | UGT1A4 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
20 | NC_000002.12 | 2 | 233766121 | - | UGT1A1 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
21 | NC_000002.12 | 2 | 233766121 | - | UGT1A3 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
22 | NC_000004.12 | 4 | 56617753 | - | SPMAP2L | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
23 | NC_000004.12 | 4 | 143351218 | - | GAB1 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
24 | NC_000006.12 | 6 | 3396895 | + | SLC22A23 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
25 | NC_000006.12 | 6 | 64999965 | + | EYS | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
26 | NC_000006.12 | 6 | 107079359 | + | BEND3 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
27 | NC_000006.12 | 6 | 111309230 | - | REV3L | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
28 | NC_000006.12 | 6 | 162023336 | - | PRKN | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
29 | NC_000007.14 | 7 | 15443136 | + | AGMO | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
30 | NC_000008.11 | 8 | 41499407 | - | GOLGA7 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
31 | NC_000009.12 | 9 | 34797381 | - | PHF24 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
32 | NC_000010.11 | 10 | 67551480 | + | CTNNA3 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
33 | NC_000011.10 | 11 | 86413004 | - | CCDC81 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
34 | NC_000012.12 | 12 | 104828390 | + | SLC41A2 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
35 | NC_000020.11 | 20 | 8005970 | + | TMX4 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
36 | NC_000023.11 | X | 74496705 | - | SLC16A2 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
37 | NC_000023.11 | X | 81229447 | - | SH3BGRL | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
38 | NC_000023.11 | X | 86349096 | - | DACH2 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier II |
39 | NC_000007.14 | 7 | 129407567 | + | AHCYL2 | NNNATCCTTCTGGTACACTA | NGA | 2 | 0.0463 | Tier II |
40 | NC_000017.11 | 17 | 57001565 | - | SCPEP1 | NNNATCCTTCTGGTTCACGA | NGC | 2 | 0.0044 | Tier II |
41 | NC_000019.10 | 19 | 12000089 | + | ZNF433-AS1 | NNNATTCTTCTGGTACACTA | NGG | 2 | 0.619 | Tier III |
42 | NC_000001.11 | 1 | 23838377 | + | LOC105376861 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
43 | NC_000002.12 | 2 | 233766121 | - | UGT1A | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
44 | NC_000003.12 | 3 | 7959011 | - | LOC101927394 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
45 | NC_000003.12 | 3 | 59385527 | + | CFAP20DC-DT | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
46 | NC_000003.12 | 3 | 118595692 | - | LOC105374060 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
47 | NC_000004.12 | 4 | 88454670 | + | LOC102723458 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
48 | NC_000005.10 | 5 | 38797655 | - | OSMR-DT | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
49 | NC_000005.10 | 5 | 72802568 | + | TNPO1-DT | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
50 | NC_000005.10 | 5 | 169521988 | + | LOC105377714 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
51 | NC_000005.10 | 5 | 169521988 | + | LOC105377715 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
52 | NC_000008.11 | 8 | 126820799 | - | LOC105375751 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
53 | NC_000008.11 | 8 | 126820799 | - | LOC105375753 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
54 | NC_000010.11 | 10 | 65733707 | + | LINC01515 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
55 | NC_000011.10 | 11 | 102664344 | + | MMP20-AS1 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
56 | NC_000012.12 | 12 | 131484334 | + | LOC101929974 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
57 | NC_000013.11 | 13 | 79882615 | - | LINC00382 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
58 | NC_000017.11 | 17 | 44985909 | + | LOC112268183 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
59 | NC_000018.10 | 18 | 39707881 | - | MIR924HG | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
60 | NC_000021.9 | 21 | 15523954 | + | LOC105369302 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
61 | NC_000022.11 | 22 | 19296658 | - | LOC105372859 | NNNATTCTTCTGGTACACCA | NGG | 2 | 0.4163 | Tier III |
62 | NC_000012.12 | 12 | 85456845 | + | LINC02820 | NNNATGCTTCTGGTACACTA | NGG | 2 | 0.3333 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000082.6 | 16 | 22588368 | + | Dgkg | NNNATCCTTCAGGTACACTA | NGG | 2 | 0.5 | Tier I |
2 | NC_000083.6 | 17 | 36965470 | - | Znrd1as | NNNATCCTACTGGTACAGGA | NGG | 2 | 0.1238 | Tier I |
3 | NC_000071.6 | 5 | 121566820 | + | Aldh2 | NNNAACCTTCTGGTACAAGA | NGG | 2 | 0.2692 | Tier II |
4 | NC_000070.6 | 4 | 57657071 | + | Pakap | NNNCTCCTTCAGGTACACGA | NGG | 2 | 0.2647 | Tier II |
5 | NC_000081.6 | 15 | 77819683 | - | Myh9 | NNNATCCTTCTGGTACCCAA | NGG | 2 | 0.1261 | Tier II |
6 | NC_000072.6 | 6 | 140065833 | - | Gm45959 | NNNATACTTCTGGTACATGA | NGG | 2 | 0.5969 | Tier III |
7 | NC_000082.6 | 16 | 22588368 | + | Gm41433 | NNNATCCTTCAGGTACACTA | NGG | 2 | 0.5 | Tier III |