Construct: sgRNA BRDN0001149133
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTTTGTGAAGGATCCTAAGA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PI4K2B (55300)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000004.12 | 4 | 25252471 | + | PI4K2B | NNNTGTGAAGGATCCTAAGA | NGG | 0 | 1.0 | Tier I |
2 | NC_000006.12 | 6 | 38686932 | - | GLO1 | NNNAGTGAAGGATCCTAAGA | NGT | 2 | 0.0077 | Tier I |
3 | NC_000022.11 | 22 | 21802114 | + | MAPK1 | NNNTCAGAAGGATCCTAAGA | NGG | 2 | 0.681 | Tier II |
4 | NC_000006.12 | 6 | 47803244 | + | OPN5 | NNNTGTGAAGGAACCAAAGA | NGG | 2 | 0.6294 | Tier II |
5 | NC_000020.11 | 20 | 38575912 | + | RALGAPB | NNNTGTGAAGGATTCTAATA | NGG | 2 | 0.4889 | Tier II |
6 | NC_000022.11 | 22 | 21438065 | + | HIC2 | NNNTGAGAAGGATCCTAGGA | NGG | 2 | 0.3467 | Tier II |
7 | NC_000003.12 | 3 | 111932593 | - | PHLDB2 | NNNTGTGAAGGATTCTAACA | NGG | 2 | 0.3287 | Tier II |
8 | NC_000014.9 | 14 | 33366633 | - | NPAS3 | NNNTGTTAAGCATCCTAAGA | NGG | 2 | 0.2449 | Tier II |
9 | NC_000010.11 | 10 | 97852079 | + | GOLGA7B | NNNTGTGAAGGAGCCAAAGA | NGG | 2 | 0.2372 | Tier II |
10 | NC_000003.12 | 3 | 158706199 | + | RARRES1 | NNNTGTGAAGGATACCAAGA | NGG | 2 | 0.2333 | Tier II |
11 | NC_000012.12 | 12 | 51487752 | - | SLC4A8 | NNNTGAGAAGGAGCCTAAGA | NGG | 2 | 0.2261 | Tier II |
12 | NC_000017.11 | 17 | 57569881 | + | MSI2 | NNNAGTGCAGGATCCTAAGA | NGG | 2 | 0.2041 | Tier II |
13 | NC_000023.11 | X | 148992734 | - | AFF2 | NNNTGTGAAGGATCATAAGG | NGG | 2 | 0.1699 | Tier II |
14 | NC_000016.10 | 16 | 70781779 | + | VAC14 | NNNTGTGATGGATCCTAAGA | NAG | 2 | 0.1556 | Tier II |
15 | NC_000010.11 | 10 | 5012397 | + | AKR1C2 | NNNTGTTAAGGATCCTAAGA | NAG | 2 | 0.1481 | Tier II |
16 | NC_000002.12 | 2 | 112585542 | - | CHCHD5 | NNNTCTGAAGGATCCTGAGA | NGG | 2 | 0.1387 | Tier II |
17 | NC_000008.11 | 8 | 25883927 | - | EBF2 | NNNTGGGAAGGATCCTGAGA | NGG | 2 | 0.1008 | Tier II |
18 | NC_000005.10 | 5 | 38453917 | - | EGFLAM | NNNTTTGAAGGATCCTAAGC | NGG | 2 | 0.0682 | Tier II |
19 | NC_000007.14 | 7 | 66930412 | + | TMEM248 | NNNTTTGAAGGATCCTGAGA | NGG | 2 | 0.0529 | Tier II |
20 | NC_000012.12 | 12 | 110690297 | - | HVCN1 | NNNTGTGAAGGATCCTGAGC | NGG | 2 | 0.0401 | Tier II |
21 | NC_000011.10 | 11 | 1109015 | - | MUC2 | NNNAGTGAAGGATCCTAAGA | NGA | 2 | 0.0331 | Tier II |
22 | NC_000002.12 | 2 | 109670168 | - | RANBP2 | NNNTGTGAAGGATGCTAAGG | NGG | 2 | 0.0 | Tier II |
23 | NC_000003.12 | 3 | 33013306 | - | GLB1 | NNNTGTGATGGATGCTAAGA | NGG | 2 | 0.0 | Tier II |
24 | NC_000019.10 | 19 | 19483503 | + | GATAD2A | NNNTGTGATGGATGCTAAGA | NGG | 2 | 0.0 | Tier II |
25 | NC_000009.12 | 9 | 2900807 | - | ATP5PDP2 | NNNGGTGAAGGATCCCAAGA | NGG | 2 | 0.4167 | Tier III |
26 | NC_000009.12 | 9 | 14068930 | + | ATP5PDP3 | NNNGGTGAAGGATCCCAAGA | NGG | 2 | 0.4167 | Tier III |
27 | NC_000011.10 | 11 | 102823483 | - | WTAPP1 | NNNAGTGGAGGATCCTAAGA | NGG | 2 | 0.3492 | Tier III |
28 | NC_000022.11 | 22 | 18557276 | - | LOC124905077 | NNNTGAGAAGGATCCTAGGA | NGG | 2 | 0.3467 | Tier III |
29 | NC_000022.11 | 22 | 21496801 | - | PI4KAP2 | NNNTGAGAAGGATCCTAGGA | NGG | 2 | 0.3467 | Tier III |
30 | NC_000017.11 | 17 | 57569881 | + | LOC107984993 | NNNAGTGCAGGATCCTAAGA | NGG | 2 | 0.2041 | Tier III |
31 | NC_000003.12 | 3 | 4852506 | + | LOC124906209 | NNNTGAGAAGGATCCTGAGA | NGG | 2 | 0.1529 | Tier III |
32 | NC_000002.12 | 2 | 30861086 | - | LOC124905982 | NNNTGTGAAGGATCCTCAGG | NGG | 2 | 0.1349 | Tier III |
33 | NC_000011.10 | 11 | 112535656 | - | LINC02764 | NNNTGTCAAGGATCCTCAGA | NGG | 2 | 0.1213 | Tier III |
34 | NC_000011.10 | 11 | 112535656 | - | LINC02763 | NNNTGTCAAGGATCCTCAGA | NGG | 2 | 0.1213 | Tier III |
35 | NC_000002.12 | 2 | 3020374 | + | LINC01250 | NNNAGTGAAGGATCCTGAGA | NGG | 2 | 0.084 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000080.6 | 14 | 33142397 | - | Wdfy4 | NNNTGTGCAGGATCCTGAGA | NGG | 2 | 0.0756 | Tier I |
2 | NC_000068.7 | 2 | 69095929 | + | Cers6 | NNNTGAGAAGGATTCTAAGA | NGG | 2 | 0.6356 | Tier II |
3 | NC_000081.6 | 15 | 94807560 | - | Tmem117 | NNNTCTGAGGGATCCTAAGA | NGG | 2 | 0.5238 | Tier II |
4 | NC_000067.6 | 1 | 190825985 | - | Rps6kc1 | NNNTGTGAAAGATCCTATGA | NGG | 2 | 0.4667 | Tier II |
5 | NC_000082.6 | 16 | 26664570 | - | Il1rap | NNNTGAGAAGTATCCTAAGA | NGG | 2 | 0.3333 | Tier II |
6 | NC_000071.6 | 5 | 102760688 | + | Arhgap24 | NNNTTTGAAGGATCCAAAGA | NGG | 2 | 0.2727 | Tier II |
7 | NC_000074.6 | 8 | 47206266 | - | Stox2 | NNNTTTGAAGGATCCAAAGA | NGG | 2 | 0.2727 | Tier II |
8 | NC_000067.6 | 1 | 135546873 | - | Nav1 | NNNTGTGAAGGATCCTGAGT | NGG | 2 | 0.1059 | Tier II |
9 | NC_000080.6 | 14 | 93634431 | + | Pcdh9 | NNNTGTGAAGTCTCCTAAGA | NGG | 2 | 0.1012 | Tier II |
10 | NC_000080.6 | 14 | 115104415 | - | Gpc5 | NNNTGTGAAGGATACTGAGA | NGG | 2 | 0.0618 | Tier II |
11 | NC_000075.6 | 9 | 66036957 | - | Csnk1g1 | NNNTGTGGAGGATCCTAAGA | NGA | 2 | 0.0509 | Tier II |
12 | NC_000071.6 | 5 | 71646617 | - | Gabra4 | NNNTGTGAAGGATCCCAAGA | NGA | 2 | 0.0463 | Tier II |
13 | NC_000082.6 | 16 | 42150242 | + | Lsamp | NNNTGTGAAGGATCTGAAGA | NGG | 2 | 0.0231 | Tier II |
14 | NC_000074.6 | 8 | 115323676 | - | Wwox | NNNTGGGAAGGATCCTAAGA | NGC | 2 | 0.0127 | Tier II |
15 | NC_000070.6 | 4 | 98465897 | + | Patj | NNNTGTGAAGGATGCTATGA | NGG | 2 | 0.0 | Tier II |
16 | NC_000079.6 | 13 | 10450524 | + | Gm26861 | NNNTGTGAAGGATCCTAAGA | NGG | 0 | 1.0 | Tier III |
17 | NC_000067.6 | 1 | 190825985 | - | Gm51740 | NNNTGTGAAAGATCCTATGA | NGG | 2 | 0.4667 | Tier III |
18 | NC_000073.6 | 7 | 100203047 | + | Gm34877 | NNNTGTGAAGGATCCTAGGA | NGA | 2 | 0.0278 | Tier III |