Construct: sgRNA BRDN0001149255
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TTTCTTTGTAGACGGGAAGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PDXK (8566)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000021.9 | 21 | 43749015 | - | PDXK | NNNCTTTGTAGACGGGAAGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000011.10 | 11 | 133934122 | + | IGSF9B | NNNCTTTGAAGACAGGAAGG | NGG | 2 | 0.6964 | Tier II |
3 | NC_000020.11 | 20 | 5953164 | - | MCM8 | NNNCTTTAGAGACGGGAAGG | NGG | 2 | 0.619 | Tier II |
4 | NC_000003.12 | 3 | 10523233 | + | ATP2B2 | NNNTTTTGTAGATGGGAAGG | NGG | 2 | 0.56 | Tier II |
5 | NC_000015.10 | 15 | 99109482 | + | SYNM | NNNTTTTGTAGATGGGAAGG | NGG | 2 | 0.56 | Tier II |
6 | NC_000011.10 | 11 | 847728 | + | TSPAN4 | NNNCTTTGTAGATGGGAAAG | NGG | 2 | 0.5 | Tier II |
7 | NC_000012.12 | 12 | 118983371 | + | SRRM4 | NNNGTTTGCAGACGGGAAGG | NGG | 2 | 0.4615 | Tier II |
8 | NC_000011.10 | 11 | 66627059 | + | RBM14 | NNNCTTTTTAGATGGGAAGG | NGG | 2 | 0.4375 | Tier II |
9 | NC_000011.10 | 11 | 66627059 | + | RBM14-RBM4 | NNNCTTTTTAGATGGGAAGG | NGG | 2 | 0.4375 | Tier II |
10 | NC_000009.12 | 9 | 2085979 | + | SMARCA2 | NNNCTGTGTAGACAGGAAGG | NGG | 2 | 0.4286 | Tier II |
11 | NC_000016.10 | 16 | 1505224 | - | TELO2 | NNNCTTGGTAGGCGGGAAGG | NGG | 2 | 0.4248 | Tier II |
12 | NC_000007.14 | 7 | 5494632 | + | FBXL18 | NNNCTTTGCAGACCGGAAGG | NGG | 2 | 0.3956 | Tier II |
13 | NC_000007.14 | 7 | 117278130 | + | WNT2 | NNNCCTTGTAGAAGGGAAGG | NGG | 2 | 0.3846 | Tier II |
14 | NC_000018.10 | 18 | 37364858 | + | CELF4 | NNNCTCTGTAGACTGGAAGG | NGG | 2 | 0.2424 | Tier II |
15 | NC_000010.11 | 10 | 72111084 | - | ASCC1 | NNNCTTTGCAGAGGGGAAGG | NGG | 2 | 0.1259 | Tier II |
16 | NC_000010.11 | 10 | 11582990 | - | USP6NL | NNNCTTTGTAGAATGGAAGG | NGG | 2 | 0.1026 | Tier II |
17 | NC_000006.12 | 6 | 42395187 | - | TRERF1 | NNNCTTTGTAGAGGGGAAGT | NGG | 2 | 0.0955 | Tier II |
18 | NC_000006.12 | 6 | 34041771 | + | GRM4 | NNNCTTTGTGGAGGGGAAGG | NGG | 2 | 0.0758 | Tier II |
19 | NC_000020.11 | 20 | 15004885 | + | MACROD2 | NNNCTTTGTAGACTTGAAGG | NGG | 2 | 0.0381 | Tier II |
20 | NC_000014.9 | 14 | 103668145 | + | KLC1 | NNNCTTTGTAGATGGGAAGG | NTG | 2 | 0.0273 | Tier II |
21 | NC_000012.12 | 12 | 121549161 | + | KDM2B | NNNCTTTGTAGAAGGGAAGG | NGA | 2 | 0.0267 | Tier II |
22 | NC_000015.10 | 15 | 78174161 | + | ACSBG1 | NNNCTTTGTAGACGGGAAAG | NGC | 2 | 0.0159 | Tier II |
23 | NC_000004.12 | 4 | 167023924 | - | SPOCK3 | NNNCTTTGTAGAGGGCAAGG | NGG | 2 | 0.0 | Tier II |
24 | NC_000010.11 | 10 | 123391161 | + | LINC02641 | NNNCTTCGTAGAAGGGAAGG | NGG | 2 | 0.2644 | Tier III |
25 | NC_000009.12 | 9 | 40491632 | + | AQP7P5 | NNNCTTTGCAGACGGGCAGG | NGG | 2 | 0.1629 | Tier III |
26 | NC_000009.12 | 9 | 40491632 | + | LOC124902160 | NNNCTTTGCAGACGGGCAGG | NGG | 2 | 0.1629 | Tier III |
27 | NC_000009.12 | 9 | 43119962 | + | LOC102724922 | NNNCTTTGCAGACGGGCAGG | NGG | 2 | 0.1629 | Tier III |
28 | NC_000009.12 | 9 | 63133323 | - | LOC105379814 | NNNCTTTGCAGACGGGCAGG | NGG | 2 | 0.1629 | Tier III |
29 | NC_000009.12 | 9 | 63327135 | + | AQP7P1 | NNNCTTTGCAGACGGGCAGG | NGG | 2 | 0.1629 | Tier III |
30 | NC_000004.12 | 4 | 22693746 | - | GBA3 | NNNCTTTGTGGAGGGGAAGG | NGG | 2 | 0.0758 | Tier III |
31 | NC_000001.11 | 1 | 152945114 | - | LINC01527 | NNNCTTTGTAGATGGGAAGG | NGC | 2 | 0.0156 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 5039875 | + | Ppp1r9a | NNNCAATGTAGACGGGAAGG | NGG | 2 | 0.4333 | Tier II |
2 | NC_000076.6 | 10 | 25180482 | - | Akap7 | NNNGTTTGTAGACAGGAAGG | NGG | 2 | 0.375 | Tier II |
3 | NC_000068.7 | 2 | 168636981 | + | Atp9a | NNNCTTTGTACCCGGGAAGG | NGG | 2 | 0.1128 | Tier II |
4 | NC_000086.7 | X | 7862360 | + | Otud5 | NNNCTTTGTAGGGGGGAAGG | NGG | 2 | 0.0985 | Tier II |
5 | NC_000085.6 | 19 | 31558654 | + | Prkg1 | NNNCTTTGTAGAAGGGAAGG | NTG | 2 | 0.015 | Tier II |
6 | NC_000075.6 | 9 | 58837953 | - | Hcn4 | NNNCTTTCTAGACGGGAAGG | NGC | 2 | 0.0137 | Tier II |