Construct: sgRNA BRDN0001149355
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGGACAACAGCAATATCCTA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- MAP3K3 (4215)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76017
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000077.6 |
11 |
69742910 |
+ |
Polr2a |
NNNACAACAGCAATGACCTA |
NGG |
2 |
0.5909 |
Tier I |
2 |
NC_000068.7 |
2 |
69908931 |
- |
Ubr3 |
NNNACAACAGAAATATCCTT |
NGG |
2 |
0.45 |
Tier II |
3 |
NC_000070.6 |
4 |
112741495 |
+ |
Skint10 |
NNNACAAAAGCAATACCCTA |
NGG |
2 |
0.4333 |
Tier II |
4 |
NC_000080.6 |
14 |
87005296 |
- |
Diaph3 |
NNNACAACTGCAATATTCTA |
NGG |
2 |
0.28 |
Tier II |
5 |
NC_000071.6 |
5 |
17656909 |
+ |
Sema3c |
NNNACAACAACAATATCCCA |
NGG |
2 |
0.2575 |
Tier II |
6 |
NC_000070.6 |
4 |
102405602 |
- |
Pde4b |
NNNACAACAGCAATAACCTA |
NAG |
2 |
0.2357 |
Tier II |
7 |
NC_000069.6 |
3 |
152276027 |
+ |
Miga1 |
NNNACAACAGTAATATCCTG |
NGG |
2 |
0.2353 |
Tier II |
8 |
NC_000076.6 |
10 |
83602102 |
+ |
Appl2 |
NNNACAACAGAAATATCCCA |
NGG |
2 |
0.2069 |
Tier II |
9 |
NC_000077.6 |
11 |
59793706 |
+ |
Flcn |
NNNACAACAGCAAACTCCTA |
NGG |
2 |
0.1688 |
Tier II |
10 |
NC_000070.6 |
4 |
77787289 |
+ |
Ptprd |
NNNGCAACAGCAATATCCTA |
NAG |
2 |
0.162 |
Tier II |
11 |
NC_000067.6 |
1 |
167697947 |
- |
Lmx1a |
NNNACAACAGCACTGTCCTA |
NGG |
2 |
0.1368 |
Tier II |
12 |
NC_000075.6 |
9 |
28579577 |
+ |
Opcml |
NNNACATCAGCAATATCCTC |
NGG |
2 |
0.0994 |
Tier II |
13 |
NC_000079.6 |
13 |
108801469 |
+ |
Pde4d |
NNNACAACAGCAATAGCCTA |
NAG |
2 |
0.0897 |
Tier II |
14 |
NC_000068.7 |
2 |
164075532 |
- |
Stk4 |
NNNACACCAGCAATTTCCTA |
NGG |
2 |
0.0875 |
Tier II |
15 |
NC_000083.6 |
17 |
64688434 |
- |
Man2a1 |
NNNACAACAGCAATTTCCTA |
NAG |
2 |
0.0519 |
Tier II |
16 |
NC_000074.6 |
8 |
16942980 |
- |
Csmd1 |
NNNACAACAGCAATGTCCTA |
NTG |
2 |
0.0253 |
Tier II |
17 |
NC_000072.6 |
6 |
33265238 |
- |
Exoc4 |
NNNACAACAGCAATAACCTA |
NGC |
2 |
0.0202 |
Tier II |
18 |
NC_000068.7 |
2 |
66533562 |
- |
Scn9a |
NNNACAACAGCAATATCCAA |
NGA |
2 |
0.0198 |
Tier II |
19 |
NC_000067.6 |
1 |
84769973 |
+ |
Trip12 |
NNNACAATAGCAATATCCTA |
NGT |
2 |
0.0141 |
Tier II |
20 |
NC_000070.6 |
4 |
86288568 |
+ |
Adamtsl1 |
NNNACAACAGCAATAGCCTA |
NGT |
2 |
0.0056 |
Tier II |
21 |
NC_000071.6 |
5 |
45772983 |
- |
Lcorl |
NNNACAACAGCAATAGCCTA |
NGT |
2 |
0.0056 |
Tier II |
22 |
NC_000080.6 |
14 |
22742637 |
+ |
Lrmda |
NNNACAACAGCAATATCCTA |
NAA |
2 |
0.0 |
Tier II |
23 |
NC_000068.7 |
2 |
136473679 |
- |
Gm32546 |
NNNACAACAACAAAATCCTA |
NGG |
2 |
0.5778 |
Tier III |
24 |
NC_000084.6 |
18 |
6290255 |
+ |
Gm41664 |
NNNACAACAGCAAAATCCTT |
NGG |
2 |
0.3714 |
Tier III |
25 |
NC_000074.6 |
8 |
115868540 |
+ |
Gm31037 |
NNNACAATAGCAATATCCTC |
NGG |
2 |
0.1989 |
Tier III |
26 |
NC_000077.6 |
11 |
25673594 |
+ |
5730522E02Rik |
NNNGCAACAGCAACATCCTA |
NGG |
2 |
0.1786 |
Tier III |
27 |
NC_000067.6 |
1 |
109833236 |
- |
Gm8141 |
NNNACAACAGCATCATCCTA |
NGG |
2 |
0.0857 |
Tier III |
28 |
NC_000068.7 |
2 |
66533562 |
- |
Gm13629 |
NNNACAACAGCAATATCCAA |
NGA |
2 |
0.0198 |
Tier III |
29 |
NC_000080.6 |
14 |
22742637 |
+ |
Gm30926 |
NNNACAACAGCAATATCCTA |
NAA |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)