Construct: sgRNA BRDN0001149383
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCTCCCATCCATAGTAAAAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000007.14 | 7 | 84474802 | + | SEMA3A | NNNCCCATACACAGTAAAAA | NGG | 2 | 0.812 | Tier II |
2 | NC_000002.12 | 2 | 98630419 | + | MGAT4A | NNNTCCATACATAGTAAAAA | NGG | 2 | 0.6857 | Tier II |
3 | NC_000011.10 | 11 | 40929553 | + | LRRC4C | NNNTCCGTCCATAGTAAAAA | NGG | 2 | 0.5647 | Tier II |
4 | NC_000010.11 | 10 | 125907453 | - | FANK1 | NNNCCCATCCACACTAAAAA | NGG | 2 | 0.406 | Tier II |
5 | NC_000009.12 | 9 | 19084138 | + | HAUS6 | NNNTCCATCCAGAGTAAAAA | NGG | 2 | 0.4 | Tier II |
6 | NC_000005.10 | 5 | 38335450 | - | EGFLAM | NNNCCCATCCACAGTAAAGA | NGG | 2 | 0.3553 | Tier II |
7 | NC_000006.12 | 6 | 132354372 | - | MOXD1 | NNNCACATCCATAGAAAAAA | NGG | 2 | 0.3308 | Tier II |
8 | NC_000005.10 | 5 | 147622879 | + | JAKMIP2 | NNNCCCATCAATAGTAAAGA | NGG | 2 | 0.325 | Tier II |
9 | NC_000005.10 | 5 | 55938325 | + | IL6ST | NNNCTGATCCATAGTAAAAA | NGG | 2 | 0.3182 | Tier II |
10 | NC_000004.12 | 4 | 118303557 | + | PRSS12 | NNNGCCATCCATAGAAAAAA | NGG | 2 | 0.2895 | Tier II |
11 | NC_000017.11 | 17 | 80039207 | + | CCDC40 | NNNCCCATCCCTACTAAAAA | NGG | 2 | 0.1714 | Tier II |
12 | NC_000004.12 | 4 | 153171054 | - | TRIM2 | NNNCCCATCCTTACTAAAAA | NGG | 2 | 0.1319 | Tier II |
13 | NC_000003.12 | 3 | 131936357 | - | CPNE4 | NNNCCCATCCATTGCAAAAA | NGG | 2 | 0.0818 | Tier II |
14 | NC_000003.12 | 3 | 169172549 | + | MECOM | NNNCCCATACATAGGAAAAA | NGG | 2 | 0.0429 | Tier II |
15 | NC_000004.12 | 4 | 168952635 | - | CBR4 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
16 | NC_000007.14 | 7 | 50514273 | + | DDC | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
17 | NC_000011.10 | 11 | 85423159 | - | DLG2 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
18 | NC_000012.12 | 12 | 10941940 | - | PRH1 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
19 | NC_000012.12 | 12 | 10941940 | - | PRH1-TAS2R14 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
20 | NC_000023.11 | X | 118418401 | - | WDR44 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier II |
21 | NC_000016.10 | 16 | 74647770 | - | RFWD3 | NNNCCCATCCCTAGTAAAAA | NGC | 2 | 0.0089 | Tier II |
22 | NC_000004.12 | 4 | 53163571 | + | SCFD2 | NNNCCCATCCATAGTAAAAA | NAT | 2 | 0.0 | Tier II |
23 | NC_000014.9 | 14 | 44994297 | - | TOGARAM1 | NNNCCCATCCATAGTAAAAA | NAC | 2 | 0.0 | Tier II |
24 | NC_000015.10 | 15 | 41730278 | + | MGA | NNNCCCATCCATAGTAAAAA | NAC | 2 | 0.0 | Tier II |
25 | NC_000010.11 | 10 | 31223586 | + | LINC02664 | NNNACAATCCATAGTAAAAA | NGG | 2 | 0.782 | Tier III |
26 | NC_000005.10 | 5 | 113649421 | + | LOC107986441 | NNNCCAATCCATAGTAAAAG | NGG | 2 | 0.7101 | Tier III |
27 | NC_000014.9 | 14 | 76260253 | - | LOC105370575 | NNNCATATCCATAGTAAAAA | NGG | 2 | 0.5306 | Tier III |
28 | NC_000002.12 | 2 | 167890676 | - | B3GALT1-AS1 | NNNCCCATCCATAGAAAAAG | NGG | 2 | 0.4427 | Tier III |
29 | NC_000002.12 | 2 | 168384020 | + | LOC105373734 | NNNCACATCCATAGTAAAAG | NGG | 2 | 0.437 | Tier III |
30 | NC_000004.12 | 4 | 156120423 | - | LOC102724785 | NNNGCCAACCATAGTAAAAA | NGG | 2 | 0.4 | Tier III |
31 | NC_000005.10 | 5 | 147622879 | + | JAKMIP2-AS1 | NNNCCCATCAATAGTAAAGA | NGG | 2 | 0.325 | Tier III |
32 | NC_000012.12 | 12 | 11476464 | + | LOC440084 | NNNCCCATCCAAAGTAAAAA | NAG | 2 | 0.2074 | Tier III |
33 | NC_000010.11 | 10 | 63996283 | - | LOC124902439 | NNNCCCATCCATCCTAAAAA | NGG | 2 | 0.0902 | Tier III |
34 | NC_000004.12 | 4 | 157824896 | + | LOC105377509 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier III |
35 | NC_000012.12 | 12 | 10941940 | - | PRH1-PRR4 | NNNCACATCCATAGGAAAAA | NGG | 2 | 0.0286 | Tier III |
36 | NC_000007.14 | 7 | 98268356 | + | LOC124901705 | NNNCCCGTCCATAGTAAAAA | NTG | 2 | 0.0275 | Tier III |
37 | NC_000005.10 | 5 | 119912711 | - | LOC105379144 | NNNCCCATCCATAGGAGAAA | NGG | 2 | 0.0088 | Tier III |
38 | NC_000003.12 | 3 | 164181880 | - | LOC102724419 | NNNCCCAGCCATAGTTAAAA | NGG | 2 | 0.0 | Tier III |
39 | NC_000022.11 | 22 | 45500705 | + | LOC105373066 | NNNCCCATCCAAAGTCAAAA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 128513813 | + | Pzp | NNNCTCATCCGTAGTAAAAA | NGG | 2 | 0.4136 | Tier I |
2 | NC_000084.6 | 18 | 45431293 | + | Kcnn2 | NNNTCCATACATAGTAAAAA | NGG | 2 | 0.6857 | Tier II |
3 | NC_000078.6 | 12 | 52223425 | + | Nubpl | NNNACCTTCCATAGTAAAAA | NGG | 2 | 0.3684 | Tier II |
4 | NC_000080.6 | 14 | 11938498 | - | Ptprg | NNNCCCATCCATAATAAAGA | NGG | 2 | 0.2813 | Tier II |
5 | NC_000081.6 | 15 | 80550848 | + | Enthd1 | NNNCCCATCCATGGTAAGAA | NGG | 2 | 0.2609 | Tier II |
6 | NC_000074.6 | 8 | 61262602 | - | Sh3rf1 | NNNCCAATCCATAGTACAAA | NGG | 2 | 0.1639 | Tier II |
7 | NC_000075.6 | 9 | 119076337 | - | Plcd1 | NNNCCCATCCATAGTAAGGA | NGG | 2 | 0.15 | Tier II |
8 | NC_000079.6 | 13 | 18213609 | - | Pou6f2 | NNNCCCATCCATACTAAAAA | NAG | 2 | 0.1111 | Tier II |
9 | NC_000073.6 | 7 | 143285240 | + | Kcnq1 | NNNCCCACCCATAGGAAAAA | NGG | 2 | 0.05 | Tier II |
10 | NC_000075.6 | 9 | 81902676 | - | Mei4 | NNNCCCATCCATAGTACAAA | NAG | 2 | 0.0458 | Tier II |
11 | NC_000085.6 | 19 | 11792719 | - | Stx3 | NNNCCCATCCATTGGAAAAA | NGG | 2 | 0.015 | Tier II |
12 | NC_000074.6 | 8 | 108376511 | - | Zfhx3 | NNNCCCATCCATAGGAAAAA | NGA | 2 | 0.0035 | Tier II |
13 | NC_000075.6 | 9 | 82948804 | - | Phip | NNNCCCATCCACAGTCAAAA | NGG | 2 | 0.0 | Tier II |
14 | NC_000084.6 | 18 | 45431293 | + | Gm31907 | NNNTCCATACATAGTAAAAA | NGG | 2 | 0.6857 | Tier III |
15 | NC_000075.6 | 9 | 119076337 | - | Gm51697 | NNNCCCATCCATAGTAAGGA | NGG | 2 | 0.15 | Tier III |
16 | NC_000075.6 | 9 | 73197836 | + | Gm27211 | NNNCCCATACATAGTAAAAA | NGA | 2 | 0.0595 | Tier III |
17 | NC_000073.6 | 7 | 143285240 | + | Kcnq1ot1 | NNNCCCACCCATAGGAAAAA | NGG | 2 | 0.05 | Tier III |