Construct: sgRNA BRDN0001149391
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGTGCCGGGAGAAGAGCACG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- DAPK2 (23604)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76021
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000015.10 |
15 |
63983715 |
- |
DAPK2 |
NNNGCCGGGAGAAGAGCACG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000005.10 |
5 |
152404590 |
+ |
NMUR2 |
NNNGCAGGGAGAAGAGCACG |
NAG |
2 |
0.2407 |
Tier I |
3 |
NC_000022.11 |
22 |
49886507 |
+ |
ZBED4 |
NNNGCCGGGAGATGAGCACG |
NAG |
2 |
0.0778 |
Tier I |
4 |
NC_000002.12 |
2 |
71564144 |
- |
DYSF |
NNNGCCGGGAGAAGAGGACT |
NGG |
2 |
0.0412 |
Tier I |
5 |
NC_000002.12 |
2 |
101267577 |
- |
CNOT11 |
NNNGCTGGGAGAAGAGCACG |
NGG |
1 |
0.9286 |
Tier II |
6 |
NC_000006.12 |
6 |
35479635 |
+ |
TEAD3 |
NNNGCAGGGAGAAGAGCACA |
NGG |
2 |
0.8705 |
Tier II |
7 |
NC_000017.11 |
17 |
6118542 |
+ |
WSCD1 |
NNNGCTGGGAGAAGAGCACA |
NGG |
2 |
0.8705 |
Tier II |
8 |
NC_000017.11 |
17 |
65736344 |
+ |
CEP112 |
NNNGCTGGGAGAAGAGCAAG |
NGG |
2 |
0.398 |
Tier II |
9 |
NC_000009.12 |
9 |
37956640 |
- |
SHB |
NNNGCGGGGAGAAGAGCATG |
NGG |
2 |
0.2308 |
Tier II |
10 |
NC_000011.10 |
11 |
65998093 |
+ |
EIF1AD |
NNNGCGGGGAGAACAGCACG |
NGG |
2 |
0.2143 |
Tier II |
11 |
NC_000019.10 |
19 |
1819428 |
+ |
REXO1 |
NNNGCGGGGAGAACAGCACG |
NGG |
2 |
0.2143 |
Tier II |
12 |
NC_000022.11 |
22 |
25784887 |
+ |
MYO18B |
NNNGCCGGGAGAGGTGCACG |
NGG |
2 |
0.1304 |
Tier II |
13 |
NC_000020.11 |
20 |
61636682 |
- |
CDH4 |
NNNGCTGGGAGAAGAGCAGG |
NGG |
2 |
0.1161 |
Tier II |
14 |
NC_000014.9 |
14 |
74612020 |
- |
LTBP2 |
NNNGCCGGGAGAACAGCCCG |
NGG |
2 |
0.0816 |
Tier II |
15 |
NC_000022.11 |
22 |
49886507 |
+ |
ALG12 |
NNNGCCGGGAGATGAGCACG |
NAG |
2 |
0.0778 |
Tier II |
16 |
NC_000014.9 |
14 |
35290838 |
- |
PSMA6 |
NNNTCCGGGAGAAGAGCAGG |
NGG |
2 |
0.0455 |
Tier II |
17 |
NC_000002.12 |
2 |
241610611 |
- |
THAP4 |
NNNGCCGGGAGAAGACCCCG |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000014.9 |
14 |
35290838 |
- |
PRORP-PSMA6 |
NNNTCCGGGAGAAGAGCAGG |
NGG |
2 |
0.0455 |
Tier III |
19 |
NC_000023.11 |
X |
74162610 |
+ |
MKRN5P |
NNNGCTGGGAGAAGACCACG |
NGG |
2 |
0.0 |
Tier III |
20 |
NC_000023.11 |
X |
74162610 |
+ |
FTX |
NNNGCTGGGAGAAGACCACG |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000075.6 |
9 |
66220574 |
+ |
Dapk2 |
NNNGCCGGGAGAAGAGCACG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000083.6 |
17 |
43450751 |
- |
Adgrf5 |
NNNGCCGGTAGAAGAGCATG |
NGG |
2 |
0.2462 |
Tier I |
3 |
NC_000077.6 |
11 |
107703734 |
+ |
Cacng1 |
NNNGCAGGGAGAAGAGCAGG |
NGG |
2 |
0.1161 |
Tier I |
4 |
NC_000084.6 |
18 |
31971575 |
+ |
Myo7b |
NNNGCCGGGAGAAGAGCAGG |
NGC |
2 |
0.0028 |
Tier I |
5 |
NC_000075.6 |
9 |
104594785 |
- |
Cpne4 |
NNNGCCGAGAGAAGAGCACA |
NGG |
2 |
0.9375 |
Tier II |
6 |
NC_000068.7 |
2 |
31208087 |
- |
Gpr107 |
NNNGCCTGGAGAAGAGCACA |
NGG |
2 |
0.5357 |
Tier II |
7 |
NC_000085.6 |
19 |
37543296 |
- |
Exoc6 |
NNNGCTGGGAGTAGAGCACG |
NGG |
2 |
0.3095 |
Tier II |
8 |
NC_000074.6 |
8 |
90348562 |
- |
Tox3 |
NNNGCCGGGAGAGGAGCGCG |
NGG |
2 |
0.2609 |
Tier II |
9 |
NC_000077.6 |
11 |
88199368 |
+ |
Mrps23 |
NNNGCCTGGAGAAGAGCAAG |
NGG |
2 |
0.2449 |
Tier II |
10 |
NC_000070.6 |
4 |
152270247 |
+ |
Acot7 |
NNNGCCGGCAGAAGAGCAAG |
NGG |
2 |
0.2308 |
Tier II |
11 |
NC_000068.7 |
2 |
140395965 |
- |
Macrod2 |
NNNGCCGGGAGGCGAGCACG |
NGG |
2 |
0.152 |
Tier II |
12 |
NC_000067.6 |
1 |
59237176 |
- |
Als2 |
NNNGCCGGGAGAAGAGCGCG |
NAG |
2 |
0.1037 |
Tier II |
13 |
NC_000071.6 |
5 |
136819773 |
- |
Col26a1 |
NNNGCCGGGAGAAGAGAAGG |
NGG |
2 |
0.0583 |
Tier II |
14 |
NC_000074.6 |
8 |
28593829 |
- |
Gm26795 |
NNNGCCGGGAGAGGAGAACG |
NGG |
2 |
0.3043 |
Tier III |
15 |
NC_000085.6 |
19 |
58456657 |
+ |
Gm41876 |
NNNGCCGGGAGAAGAGGAGG |
NGG |
2 |
0.0074 |
Tier III |
Other clones with same target sequence:
(none)